DRSC/TRiP Functional Genomics Resources

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Protein Alignment Plc21C and Plch1

DIOPT Version :10

Sequence 1:NP_995605.1 Gene:Plc21C / 33204 FlyBaseID:FBgn0004611 Length:1318 Species:Drosophila melanogaster
Sequence 2:XP_006501593.1 Gene:Plch1 / 269437 MGIID:2683547 Length:1694 Species:Mus musculus


Alignment Length:1381 Identity:330/1381 - (23%)
Similarity:558/1381 - (40%) Gaps:296/1381 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 SGTGTPVTMRVDAKGFF-LYWVDQNNELDILDIATIRDVRTGQYAKRPKDNKLRQIVTLGPQDTL 96
            ||| ..:.::...||.. |:::|::...     ...|..|..:.||...|:..:  ||.|.|..:
Mouse    36 SGT-QMIKLKRGTKGLVRLFYLDEHRTR-----LRWRPSRKSEKAKILIDSIYK--VTEGRQSEI 92

  Fly    97 EEKTV----------TVCHGSDFVNMTFVNFCCTRRDIAQLWTDGL------------------- 132
            ..:..          |:.||:   :|..::...:..:.|:.|..||                   
Mouse    93 FHRQAEGNFDPSCCFTIYHGN---HMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKRQRT 154

  Fly   133 ----IKLAYSLAQLNGSAIMFLQKAHTKLCLQVDKSGRIPVKNIIKLFAQNKEDRKRVEKALDVT 193
                :|..:..|..||..::.:::.|.   |....:..:|.:.:.::|.:...|..:        
Mouse   155 HDQWVKQTFEEADKNGDGLLNIEEIHQ---LMHKLNVNLPRRKVRQMFQEADTDENQ-------- 208

  Fly   194 GLPSGKVDSISVSKFQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDP 258
                        ....||:|...||.::.|.::..|..|.  :.|:..:::.:|.:||...|   
Mouse   209 ------------GTLTFEEFCVFYKMMSLRRDLYLLLLSY--SDKKDHLTVEELAQFLKVEQ--- 256

  Fly   259 RLNEILYPYANPARAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQP 323
            :::.:...|     ..::|.::|.::.|..|..|.::||..::......:..|...::..|||||
Mouse   257 KMSNVTLDY-----CLDIIMKFEVSEENKVKNVLGIEGFTNFMRSPACDVFNPLHHEVYQDMDQP 316

  Fly   324 MSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEIFA 388
            :.:|:|.|||||||||.||..:|.|::|.:.|..||||||:|.|:|...|||:.||||...:|..
Mouse   317 LCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILF 381

  Fly   389 KDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPP 453
            :||:|.|.:.||..:|:|||||.||||:.:||.|||.|.:.|..|.|   .|.|........||.
Mouse   382 RDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGILQDKL---DLSSVDTGECRQLPS 443

  Fly   454 PAMLRRKIIIKNKKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQVGLSASHEDGGV 518
            |..|:.||::|.||..:|            :|..|...:::..:|.|  ..:.......|...|.
Mouse   444 PQSLKGKILVKGKKLPYH------------LGDDAEEGEVSDEDSAD--EIEDECKFKLHYSNGT 494

  Fly   519 T---------------------RSTANGDVATGTGTGSAA--GTAGHAPPLQQIRQSSKDSTG-- 558
            |                     |...:.|..|......|.  |...|......:::|.|.|.|  
Mouse   495 TEHQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQNLDVKESGKKSHGRS 559

  Fly   559 ----------------SSDSDSSSEDESLPNTTPNLPSGNEPPPEKAQKETEAGAEISALVNYVQ 607
                            |....:..||:||.|  |....|......:.::..:...|:|.||.|..
Mouse   560 LMANFGKHKQKATKSRSKSYSTDDEDDSLQN--PGKEGGQLYRLGRRRRTMKLCRELSDLVVYTN 622

  Fly   608 PIHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQL 672
            .:   :.::.........:.||.|.:|..:::::..:|:.||:.||:|:||:..|.|||||.|..
Mouse   623 SV---AAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLP 684

  Fly   673 FWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTV 737
            :|||||||||||:|:....||:|...|:.|...||:|||:.|.:.  ..:||:...:.......:
Mouse   685 YWNAGCQLVALNYQSEGRMMQINRAKFKANGNCGYILKPQQMCKG--TFNPFSGDPLPANPKKQL 747

  Fly   738 SITVLSGQFL----------TDKRANTFVEVDMYGLPADTVRKKFRTKTVRDNGMNPLYDEEPFV 792
            .:.|:|||.|          ..:..:.||||::.|||.|..  |.:|:.|.|||.||:: ||...
Mouse   748 ILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCC--KDQTRVVDDNGFNPVW-EETLT 809

  Fly   793 FKKVVLPELASIRIAAYEE---GGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIALASLFLCVVV 854
            | .|.:||:|.:|...::.   |...:|.|.:....|.||||||.|     :.:..||:|:.:.:
Mouse   810 F-TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYL-----EGLTEASIFVHITI 868

  Fly   855 KDYVPDDLSNFAEALANPIKYQSELEKRDIQLSVLTDEAEALGSADEDLSKSFVFVQVGG--QKK 917
            .:.    ...::..:.||                                 |:..:...|  :.:
Mouse   869 NEI----FGKWSPLILNP---------------------------------SYTILHFLGATKNR 896

  Fly   918 ELRPVESLAT-SPKHRPSISAA---AAMSV-DVTVDRTDG----GRGEDSISIVAPSIQHQHSLD 973
            :|:.::.|.. :|:|..|.:.:   ...|: |..:.||..    ||.:..:     ..|....:.
Mouse   897 QLQGLKGLFNKNPRHASSENNSHYVRKRSIGDRILRRTASAPAKGRKKSKV-----GFQEMVEIK 956

  Fly   974 QSVSTSIRQVESSQFDVDLVLAEPLEKILDHKSVKEKRLEMEKKL---------ESLRKKHDKEK 1029
            .|||.:.|       |.|.||......:    .|:...:.::|.|         |:.:....||.
Mouse   957 DSVSEASR-------DQDGVLRRTTRSL----QVRPVSMPVDKSLLGALSLPISEAAKDTDGKEN 1010

  Fly  1030 IKIAGQKSSPLEG----KKPKFAITNKLVKRLSNKSLNCLSPHSEPGVEIPACPLDLGDSSEESA 1090
            . :||.|....:|    |.|.|:..|   |:||:.|...|  |.              |:::...
Mouse  1011 C-LAGDKDDRRKGAATRKDPHFSNFN---KKLSSSSSALL--HK--------------DANQGPT 1055

  Fly  1091 AADAGEDLAGGSSSLDGRTQESRLRSACREYTSQYRELQEKYHEAIYSAAEKV------LKTSQT 1149
            |:.:..:..||..:...|.:.: :.:.|:|..:..:.|..:.|.|:..|.:.:      :||::.
Mouse  1056 ASVSNPEQCGGRGAKSERIKPN-MTNDCQENHNPPKFLSPRKHLALDPATKGLQERLHGMKTNEK 1119

  Fly  1150 GQTKQLKASLDKVTGEVMHQLQEARRNEVKNLATVHRDRDELIRMKREVASS------------- 1201
            ...:........::|.|:.|    ...||:||        |..|.|...|:|             
Mouse  1120 EHAEGFLGEKSMLSGSVLSQ----SSLEVENL--------EGSRAKGRAATSFSLSDVSALCSDI 1172

  Fly  1202 --VVERGVAERVRLKQTFDRRTDELQKQHDSVRNALAEHRSKARQILDKEAESRSCVSSNGFLVL 1264
              :....:.:...:....|..|...:.|..|..:||.....::....:....|....|.......
Mouse  1173 PDLHSTAILQDTEISNLIDDVTLTNENQSGSSISALIGQFEESNHPANVTVVSHLSTSGASGSAP 1237

  Fly  1265 FHGPHHHGCTGSGSSA 1280
            |..|..||.:.....|
Mouse  1238 FQTPFKHGLSQGNQKA 1253

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Plc21CNP_995605.1 PH_PLC_beta 20..145 CDD:270167 27/145 (19%)
EFh_PI-PLC21 151..305 CDD:320043 26/153 (17%)
EF-hand motif 151..180 CDD:320043 4/28 (14%)
EF-hand motif 187..216 CDD:320043 3/28 (11%)
EF-hand motif 225..255 CDD:320043 6/29 (21%)
EF-hand motif 272..305 CDD:320043 7/32 (22%)
PI-PLCc_beta 317..702 CDD:176533 141/425 (33%)
C2_PLC_like 736..855 CDD:175974 43/131 (33%)
PTZ00121 <981..>1253 CDD:173412 56/305 (18%)
Plch1XP_006501593.1 PH-like 34..140 CDD:473070 24/114 (21%)
EFh_PI-PLCeta1 158..298 CDD:320050 30/172 (17%)
EF-hand motif 158..187 CDD:320050 6/31 (19%)
EF-hand motif 194..224 CDD:320050 7/49 (14%)
EF-hand motif 228..256 CDD:320050 6/29 (21%)
EF-hand motif 265..298 CDD:320050 8/37 (22%)
PI-PLCc_eta1 310..714 CDD:176569 141/425 (33%)
C2_PLC_like 744..868 CDD:175974 43/132 (33%)

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