DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Plc21C and Plcb4

DIOPT Version :10

Sequence 1:NP_995605.1 Gene:Plc21C / 33204 FlyBaseID:FBgn0004611 Length:1318 Species:Drosophila melanogaster
Sequence 2:NP_001418345.1 Gene:Plcb4 / 25031 RGDID:3345 Length:1206 Species:Rattus norvegicus


Alignment Length:1310 Identity:488/1310 - (37%)
Similarity:699/1310 - (53%) Gaps:220/1310 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 EVPQALQDGEKFIRWDDDSGTGTP-VTMRVDAKGFFLYWVDQNNELDILDIATIRDVRTGQYAKR 78
            |||..||:|..|.|::::|....| ...:||..||||.|..:..|..:|:.:.|..:|   .|..
  Rat    12 EVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVLECSLINSIR---LAAI 73

  Fly    79 PKDNK-LRQIVTLG-PQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDGLIKLAYSLAQ 141
            |||.| |..:.::| .::.||.:.:.||.|:|.||:.|........:|.:.|.:||..:.::...
  Rat    74 PKDPKILAALESVGKSENDLEGRILCVCSGTDLVNIGFTYMVAENPEITKQWVEGLRSIIHNFRA 138

  Fly   142 LNGSAIMFLQKAHTKLCLQVDKSGRIPVKNIIKLFAQNKEDRKRVEKALDVTGLPSGKVDSISVS 206
            .|.|.:..|:|...||....:.||:|||::|.:.||..|.: |.:.:||...||||||.|.|..:
  Rat   139 NNVSPMTCLKKHWMKLAFLTNTSGKIPVRSITRTFASGKTE-KVIFQALKELGLPSGKNDEIEPA 202

  Fly   207 KFQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDPRLNEILYPYANPA 271
            .|.:|.||.|.:.:..|:::|.||..|.|: |...:::.|||.|||:.||||||||||:|:.:..
  Rat   203 AFTYEKFYELTQKICPRTDIEDLFKKINGD-KTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAK 266

  Fly   272 RAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHNTY 336
            ||.::|:.|||::...:||.:|.|||.||||.|:|..:...:|:|..:||.|::||||:||||||
  Rat   267 RAMQIIEMYEPDEELKKKGLISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTY 331

  Fly   337 LTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTE--EPVIVHGYTFVPEIFAKDVLEAIAESA 399
            |||.|..||||||:|||.|||||||||||.|:|:.|  ||:|.||.....:|..|||::||.|:|
  Rat   332 LTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETA 396

  Fly   400 FKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPPPAMLRRKIIIK 464
            |.||||||||||||||:..||.|::.||.::|||:||.:.|:||||||...||.|..|:|||:||
  Rat   397 FVTSEYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIK 461

  Fly   465 NKKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQVGLSASHEDGGVTRSTANGDVAT 529
            ||:.                 .|....|...|    .|:..:.|.||:                 
  Rat   462 NKRL-----------------KPEVEKKQLEA----LKSMMEAGESAA----------------- 488

  Fly   530 GTGTGSAAGTAGHAPPLQQIRQSSKDSTGSSDSDSSSEDE--------------------SLPNT 574
                           |...:...:::...|:|.:..:..|                    |:..|
  Rat   489 ---------------PASILEDDNEEEIESADQEEEAHPEYKFGNELSADDFSHKEAVANSVKKT 538

  Fly   575 TPNLPSGNEPPPEKAQKETEA--------GAE------ISALVNYVQPIHFSSFENAEKKNRCYE 625
            :.:|...|........::.:|        ||.      :|.::||.||:.|..|..||::|..|.
  Rat   539 SDDLEHENNKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYN 603

  Fly   626 MSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDL 690
            ||||:|......||...||||||||.|:||:||.|.|.||||:|||:|||||||:|:||:||.||
  Rat   604 MSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDL 668

  Fly   691 AMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTVSITVLSGQFLTDKRANTF 755
            |||||.|.||||...||||||:||||.||..|||:|:.|||:||.|.|:.|:|||||:||:..|:
  Rat   669 AMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTY 733

  Fly   756 VEVDMYGLPADTVRKKFRTKTVRDNGMNPLYDEEPFVFKKVVLPELASIRIAAYEEGGKLIGHRV 820
            |||||||||.||:||:|||:.|.:||:||:|:||.|||:||:||:||.:|||.|::..||||.|:
  Rat   734 VEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNKLIGQRI 798

  Fly   821 LPVIGLCPGYRHVNLRSEVGQPIALASLFLCVVVKDYVPDDLSNFAEALANPIKYQSELEKRDIQ 885
            ||:.||..||||::||:|..:|::|.::|..:|:|.||||...:..:||::|.|:.|..|||..|
  Rat   799 LPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEKRADQ 863

  Fly   886 LSVLTDEAEALGSADEDLSKSFVFVQVGGQKKELRPVESLAT---SPKHRPSISAAAAMSVDVTV 947
            :..:..|...:.....|.||:       .:|.:..|.::..|   |.:.||:.:||.        
  Rat   864 MRAMGIETSDIADVPSDTSKN-------DKKGKANPAKANVTPQSSSELRPTTTAAL-------- 913

  Fly   948 DRTDGGRGEDSISIVAPSIQHQHSLDQSVSTSIRQVESSQFDVDLVLAEPLEKILDHKSVKE--K 1010
                 |.|::                            ::..::|:   |..:|.|.|.:|.  |
  Rat   914 -----GSGQE----------------------------AKKGIELI---PQVRIEDLKQMKAYLK 942

  Fly  1011 RL-EMEKKLESLRKKHDKE-----KI------KIAGQKSSPLEGKKPKFAITNKLVKRLSNKSLN 1063
            .| :.:|:|.||:|||.||     |:      ||..|..   :.|.....|..|.:|:....  |
  Rat   943 HLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYD---KEKSTHEKILEKAMKKKGGS--N 1002

  Fly  1064 CLSPHSEPGVEIPACPLDLGDSSEESAAADAGE--DLAGGSSSLDGRTQESRLRSACREYTSQYR 1126
            ||....|..::|.....|.....:|..|....|  ::....|:     :|..:|..   :.||..
  Rat  1003 CLEIKKETEIKIQTLTSDHKSKVKEIVAQHTKEWSEMINTHSA-----EEQEIRDL---HLSQQC 1059

  Fly  1127 ELQEKYHEAIYSAAEKVLKTSQTGQTKQLKASLDKVTGEV-MHQLQEARRN--------EVKNLA 1182
            ||           ..|:|..:...||:|||.|.|:.:.|: .||.:.:..|        .:||.|
  Rat  1060 EL-----------LRKLLINAHEQQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKA 1113

  Fly  1183 TVHRDRDELIRMKREVASSVVERGVAERVRLKQTFDRRTDELQKQHDSVRNALAEHRSKARQILD 1247
                   |..|..||:.||..::.:.||.||.....:..|:|:|       ...||    .:.|:
  Rat  1114 -------ERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKK-------VQLEH----LEFLE 1160

  Fly  1248 KEAES--RSC 1255
            |:.|.  :||
  Rat  1161 KQNEQLLKSC 1170

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Plc21CNP_995605.1 PH_PLC_beta 20..145 CDD:270167 39/127 (31%)
EFh_PI-PLC21 151..305 CDD:320043 68/153 (44%)
EF-hand motif 151..180 CDD:320043 11/28 (39%)
EF-hand motif 187..216 CDD:320043 14/28 (50%)
EF-hand motif 225..255 CDD:320043 12/29 (41%)
EF-hand motif 272..305 CDD:320043 16/32 (50%)
PI-PLCc_beta 317..702 CDD:176533 176/420 (42%)
C2_PLC_like 736..855 CDD:175974 68/118 (58%)
PTZ00121 <981..>1253 CDD:173412 75/298 (25%)
Plcb4NP_001418345.1 PH_PLC_beta 17..143 CDD:270167 39/128 (30%)
EFh_PI-PLCbeta4 148..300 CDD:320041 68/153 (44%)
EF-hand motif 148..177 CDD:320041 11/28 (39%)
EF-hand motif 183..212 CDD:320041 14/28 (50%)
EF-hand motif 221..250 CDD:320041 12/29 (41%)
EF-hand motif 267..300 CDD:320041 16/32 (50%)
PI-PLCc_beta 312..680 CDD:176533 176/420 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 487..512 4/56 (7%)
C2_PLC_like 714..830 CDD:175974 67/115 (58%)
PTZ00121 <859..1206 CDD:173412 94/405 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 872..916 12/63 (19%)
DUF1154 925..967 CDD:461969 17/44 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1094..1122 7/34 (21%)

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