Protein Alignment Plc21C and PLCH1

DIOPT Version :10

• Sequence 1: NP_995605.1
• Gene: Plc21C / 33204
• FlyBaseID: FBgn0004611
• Length: 1318
• Species: Drosophila melanogaster
• Sequence 2: XP_005247295.1
• Gene: PLCH1 / 23007
• HGNCID: 29185
• Length: 1705
• Species: Homo sapiens
• Alignment Length: 1272
• Identity: 321/1272 - (25%)
• Similarity: 530/1272 - (41%)
• Gaps: 280/1272 - (22%)

  Fly    33 SGTGTPVTMRVDAKGFF-LYWVDQNNELDILDIATIRDVRTGQYAKRPKDNKLRQIVTLGPQDTL 96
            ||| ..:.::...||.. |:::|::...     ...|..|..:.||...|:..:  ||.|.|..:
Human    36 SGT-QMIKLKRGTKGLVRLFYLDEHRTR-----LRWRPSRKSEKAKILIDSIYK--VTEGRQSEI 92

  Fly    97 EEKTV----------TVCHGSDFVNMTFVNFCCTRRDIAQLWTDGL------------------- 132
            ..:..          |:.||:   :|..::...:..:.|:.|..||
Human    93 FHRQAEGNFDPSCCFTIYHGN---HMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKRQRT 154

  Fly   133 ----IKLAYSLAQLNGSAIMFLQKAHTKLCLQVDKSGRIPVKNIIKLFAQNKEDRKRVEKALDVT 193
                :|..:..|..||..::.:::.|.   |....:..:|.:.:.::|.:...|..:
Human   155 HDQWVKQTFEEADKNGDGLLNIEEIHQ---LMHKLNVNLPRRKVRQMFQEADTDENQ-------- 208

  Fly   194 GLPSGKVDSISVSKFQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDP 258
                        ....||:|...||.::.|.::..|..|.  :.|:..:::.:|.:||...|
Human   209 ------------GTLTFEEFCVFYKMMSLRRDLYLLLLSY--SDKKDHLTVEELAQFLKVEQ--- 256

  Fly   259 RLNEILYPYANPARAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQP 323
            ::|.:...|     ..::|:::|.::.|..|..|.::||..::......|..|...::..|||||
Human   257 KMNNVTTDY-----CLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQP 316

  Fly   324 MSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEIFA 388
            :.:|:|.|||||||||.||..:|.|::|.:.|..||||||:|.|:|...|||:.||||...:|..
Human   317 LCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILF 381

  Fly   389 KDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPP 453
            :||:|.|.:.||..:|:|||||.||||:.:||.|||.|.:.||||.|....:|:...:   .||.
Human   382 RDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECK---QLPS 443

  Fly   454 PAMLRRKIIIKNKKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVD------------------ 500
            |..|:.||::|.||..:|            :|..|...:::..:|.|
Human   444 PQSLKGKILVKGKKLPYH------------LGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTE 496

  Fly   501 --------------AKAAQ------------QVGLSASHEDGGVTRSTANGDVATGTGTGSAAGT 539
                          .|.:|            :..|.|:|| |.......:.||       ..:|.
Human   497 HQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHE-GLNAHLKQSPDV-------KESGK 553

  Fly   540 AGHAPPLQQIRQSSKDSTGSSDSDSSSEDESLPNTTPNLPSGNEPPPEKAQKETEAGAEISALVN 604
            ..|...|.......|.:|.|.....|::||.....:.....|......:.:|..:...|:|.||.
Human   554 KSHGRSLMTNFGKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVV 618

  Fly   605 YVQPIHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSSNFM 669
            |...:   :.::.........:.||.|.:|..:::::..:|:.||:.||:|:||:..|.|||||.
Human   619 YTNSV---AAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFN 680

  Fly   670 PQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAESTVDGIIA 734
            |..:|||||||||||:|:....||||...|:.|...||:|||:.|.:.  ..:||:...:.....
Human   681 PLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKG--TFNPFSGDPLPANPK 743

  Fly   735 GTVSITVLSGQFL----------TDKRANTFVEVDMYGLPADTVRKKFRTKTVRDNGMNPLYDEE 789
            ..:.:.|:|||.|          ..:..:.||||::.|||.|..  |.:|:.|.|||.||:: ||
Human   744 KQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCC--KDQTRVVDDNGFNPVW-EE 805

  Fly   790 PFVFKKVVLPELASIRIAAYEE---GGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIALASLFLC 851
            ...| .|.:||:|.:|...::.   |...:|.|.:....|.||||||.|     :.:..||:|:.
Human   806 TLTF-TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYL-----EGLTEASIFVH 864

  Fly   852 VVVKDYVPDDLSNFAEALANPIKYQSELEKRDIQLSVLTDEAEALGSADEDLSKSFVFVQVGG-- 914
            :.:.:.    ...::..:.||                                 |:..:...|
Human   865 ITINEI----YGKWSPLILNP---------------------------------SYTILHFLGAT 892

  Fly   915 QKKELRPVESLAT-SPKHRPSISAA---AAMSV-DVTVDRTDG----GRGEDSISIVAPSIQHQH 970
            :.::|:.::.|.. :|:|..|.:.:   ...|: |..:.||..    ||.:..:     ..|...
Human   893 KNRQLQGLKGLFNKNPRHSSSENNSHYVRKRSIGDRILRRTASAPAKGRKKSKM-----GFQEMV 952

  Fly   971 SLDQSVSTSIRQVESSQFDVDLVL--------AEPLEKILDHK-------SVKEKRLEMEKKLES 1020
            .:..|||.:.|       |.|.||        |.|:...:|..       .|.|...::|.|..|
Human   953 EIKDSVSEATR-------DQDGVLRRTTRSLQARPVSMPVDRNLLGALSLPVSETAKDIEGKENS 1010

  Fly  1021 LRKKHDKEKIKIAGQKSSPLEGKKPKFAITNKLVKRLSNKSLNCLSPHSEPGVEIPACPLDLGDS 1085
            |.:..|       |::......|.|.|...|   |:||:.|...|  |.:         ...||:
Human  1011 LAEDKD-------GRRKGKASIKDPHFLNFN---KKLSSSSSALL--HKD---------TSQGDT 1054

  Fly  1086 SEESAAADAGEDLAGGSSSLDGRTQESRLRSACREYTSQYRELQEKYH---EAIYSAAEKV--LK 1145
            ...:|......:..|.||...||| .|...|.|:|.....:.|..|.|   :.:.:..:.:  :|
Human  1055 IVSTAHMSVTGEQLGMSSPRGGRT-TSNATSNCQENPCPSKSLSPKQHLAPDPVVNPTQDLHGVK 1118

  Fly  1146 TSQTGQTKQLKASLDKVTGEVMHQLQEARRN-EVKNL 1181
            ..:.|..:........::|.|:     :..| |:|||
Human  1119 IKEKGNPEDFVEGKSILSGSVL-----SHSNLEIKNL 1150

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	27/145 (19%)
		EFh_PI-PLC21	151..305	CDD:320043	27/153 (18%)
		EF-hand motif	151..180	CDD:320043	4/28 (14%)
		EF-hand motif	187..216	CDD:320043	3/28 (11%)
		EF-hand motif	225..255	CDD:320043	6/29 (21%)
		EF-hand motif	272..305	CDD:320043	7/32 (22%)
		PI-PLCc_beta	317..702	CDD:176533	142/428 (33%)
		C2_PLC_like	736..855	CDD:175974	43/131 (33%)
		PTZ00121	<981..>1253	CDD:173412	51/222 (23%)
PLCH1	XP_005247295.1	PH-like	34..140	CDD:473070	24/114 (21%)
		EFh_PI-PLCeta1	158..298	CDD:320050	31/172 (18%)
		EF-hand motif	158..187	CDD:320050	6/31 (19%)
		EF-hand motif	194..224	CDD:320050	7/49 (14%)
		EF-hand motif	228..256	CDD:320050	6/29 (21%)
		EF-hand motif	265..298	CDD:320050	8/37 (22%)
		PLN02230	285..853	CDD:177875	195/599 (33%)
		PI-PLCc_eta1	310..713	CDD:176569	142/428 (33%)