DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Plc21C and Plcl2

DIOPT Version :10

Sequence 1:NP_995605.1 Gene:Plc21C / 33204 FlyBaseID:FBgn0004611 Length:1318 Species:Drosophila melanogaster
Sequence 2:NP_038908.2 Gene:Plcl2 / 224860 MGIID:1352756 Length:1128 Species:Mus musculus


Alignment Length:855 Identity:257/855 - (30%)
Similarity:387/855 - (45%) Gaps:182/855 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 VDAKGFFLYW--VDQNNELDILDIATIRDVRTGQYAKRPKDNKLRQIVTLGPQDTLEEKTVTVCH 105
            :||....|.|  ..:::|...:||.:|::||||:.....:.|.:.:.::       |:...:|.:
Mouse   166 LDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISEQIS-------EDCAFSVIY 223

  Fly   106 GSDFVNMTFVNFCCTRRDIAQLWTDGLIKL----AYSLAQLNGS---------AIMFLQ-----K 152
            |.::.::..|   ....|:|.:|..||..|    .::|..|..|         :.||.:     .
Mouse   224 GENYESLDLV---ANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWISQMFSEIDVDGL 285

  Fly   153 AHTKLCLQVD---------KSGRIPVKNIIKLFAQNKEDRKRVEKALDVTGLPSGKVDSISVSKF 208
            .|..||..|.         |:.:|.:|            .|.:.|:.|..|....|         
Mouse   286 GHITLCHAVQCIRNLNPGLKTSKIELK------------FKELHKSKDKAGTEITK--------- 329

  Fly   209 QFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDPRLNEILYPYANPARA 273
              |:|..::..|..|.|:  .|..:..:|.::.:....|:.||...|....:||.:        :
Mouse   330 --EEFIEVFHELCTRPEI--YFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEI--------S 382

  Fly   274 KELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHNTYLT 338
            .|:|.:|||:|...:||.||:|||..|||..|..|..|....:|.||.||:|||||||||||||.
Mouse   383 LEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLI 447

  Fly   339 GHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEIFAKDVLEAIAESAFKTS 403
            ..|..|.|.:..|.:.|..|||.||||.|:|...||||..|:|...:|..:.|::.|.:.||..|
Mouse   448 EDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFAS 512

  Fly   404 EYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMD---LPPPAMLRRKIIIKN 465
            |||:||..||||:.:||..:..:.::|.||.|       :...|||:   ||.|.:|:.||:||.
Mouse   513 EYPLILCLENHCSIKQQKVMVQHMKKILGDKL-------YTTSPNMEESYLPSPDVLKGKILIKA 570

  Fly   466 KKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQVGLSASHEDGGVTRSTANGDVATG 530
            ||                                       :..:.|..:|.||......:::..
Mouse   571 KK---------------------------------------LSSNCSGVEGDVTDEDEGAEMSQR 596

  Fly   531 TGTGSAAGTAGHAPPLQQIRQSSKDSTGSSDSDSSSEDESLPNTTPNLPSGNEPPPEKAQKETEA 595
            .|                                 .|:...||..|             .|..:.
Mouse   597 MG---------------------------------KENVEQPNHVP-------------VKRFQL 615

  Fly   596 GAEISALVNYVQPIHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAG 660
            ..|:|.||:..:.:.|..|:.:.:..:.:|:.||:|..|:....|.|.:||||||..|:||:|:.
Mouse   616 CKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSP 680

  Fly   661 TRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFA 725
            .|.||||..||.||..|||:||:||||..|.|.||:|.|..|...||:|:|..||..........
Mouse   681 MRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNVGWFRQNGNCGYVLRPAIMREEVSFFSANT 745

  Fly   726 ESTVDGIIAGTVSITVLSGQFLTDKR--------ANTFVEVDMYGLPADTVRKKFRTKTVRDNGM 782
            :.:|.|:....:.|.::|||.....:        .:.:|.|:::|:|||...:  |||||..||.
Mouse   746 KDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQ--RTKTVNQNGD 808

  Fly   783 NPLYDEEPFVFKKVVLPELASIRIAAYEE---GGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIA 844
            .|::||. |.| ::.|||||.:|....::   |.:.||...:|...|..|||||.|:|..|:.:|
Mouse   809 APIFDES-FEF-QINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLA 871

  Fly   845 LASLFLCVVV 854
            .||||:.|.:
Mouse   872 HASLFVHVAI 881

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Plc21CNP_995605.1 PH_PLC_beta 20..145 CDD:270167 25/107 (23%)
EFh_PI-PLC21 151..305 CDD:320043 41/167 (25%)
EF-hand motif 151..180 CDD:320043 7/42 (17%)
EF-hand motif 187..216 CDD:320043 6/28 (21%)
EF-hand motif 225..255 CDD:320043 6/29 (21%)
EF-hand motif 272..305 CDD:320043 16/32 (50%)
PI-PLCc_beta 317..702 CDD:176533 129/387 (33%)
C2_PLC_like 736..855 CDD:175974 47/130 (36%)
PTZ00121 <981..>1253 CDD:173412
Plcl2NP_038908.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..129
PH_PLC_eta 144..252 CDD:270170 23/95 (24%)
EFh_PRIP2 272..415 CDD:320053 43/175 (25%)
EF-hand motif 272..301 CDD:320053 6/28 (21%)
EF-hand motif 308..340 CDD:320053 9/54 (17%)
EF-hand motif 344..372 CDD:320053 6/29 (21%)
EF-hand motif 381..415 CDD:320053 16/41 (39%)
PI-PLCc_PRIP_metazoa 426..722 CDD:176539 129/387 (33%)
C2_PLC_like 754..882 CDD:175974 47/132 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1100..1128
Blue background indicates that the domain is not in the aligned region.

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