DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Plc21C and Plcb4

DIOPT Version :10

Sequence 1:NP_995605.1 Gene:Plc21C / 33204 FlyBaseID:FBgn0004611 Length:1318 Species:Drosophila melanogaster
Sequence 2:XP_006498999.1 Gene:Plcb4 / 18798 MGIID:107464 Length:1207 Species:Mus musculus


Alignment Length:1287 Identity:491/1287 - (38%)
Similarity:700/1287 - (54%) Gaps:173/1287 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 EVPQALQDGEKFIRWDDDSGTGTP-VTMRVDAKGFFLYWVDQNNELDILDIATIRDVRTGQYAKR 78
            |||..||:|..|.|::::|....| ...:||..||||.|..:..|..:|:.:.|..:|   .|..
Mouse    12 EVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVLECSLINSIR---QAAI 73

  Fly    79 PKDNK-LRQIVTLG-PQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDGLIKLAYSLAQ 141
            |||.| |..:..:| .::.||.:.:.||.|:|.||:.|........::.:.|.:||..:.::...
Mouse    74 PKDPKILAALEAVGKSENDLEGRILCVCSGTDLVNIGFTYMVAENPEVTKQWVEGLRSIIHNFRA 138

  Fly   142 LNGSAIMFLQKAHTKLCLQVDKSGRIPVKNIIKLFAQNKEDRKRVEKALDVTGLPSGKVDSISVS 206
            .|.|.:..|:|...||....:.:|:|||::|.:.||..|.: |.:.:||...||||||.|.|..:
Mouse   139 NNVSPMTCLKKHWMKLAFLTNTTGKIPVRSITRTFASGKTE-KVIFQALKELGLPSGKNDEIEPA 202

  Fly   207 KFQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDPRLNEILYPYANPA 271
            .|.:|.||.|.:.:..|:::|.||..|.|: |...:::.|||.|||:.||||||||||:|:.:..
Mouse   203 AFTYEKFYELTQKICPRTDIEDLFKKINGD-KTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAK 266

  Fly   272 RAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHNTY 336
            ||.::|:.|||::...:||.:|.|||.||||.|:|..:...:|:|..:||.|::||||:||||||
Mouse   267 RAMQIIEMYEPDEELKKKGLISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTY 331

  Fly   337 LTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTE--EPVIVHGYTFVPEIFAKDVLEAIAESA 399
            |||.|..||||||:|||.|||||||||||.|:|:.|  ||:|.||.....:|..|||::||.|:|
Mouse   332 LTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETA 396

  Fly   400 FKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPPPAMLRRKIIIK 464
            |.||||||||||||||:..||.|::.||.::|||:||.:.|:||||||...||.|..|:|||:||
Mouse   397 FVTSEYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIK 461

  Fly   465 NKKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQVGLSASHEDGGVTRSTANGDVAT 529
            ||:.                 .|....|...|    .|:..:.|.||:  ...:.......::. 
Mouse   462 NKRL-----------------KPEVEKKQLEA----LKSMMEAGESAA--PASILEDDNEEEIE- 502

  Fly   530 GTGTGSAAGTAGHAPP-------LQQIRQSSKDSTGSSDSDSSSEDESLPNTTPNLPSGNEPPPE 587
                 |||.....|.|       |.....|.|::..:|...:|.:.|...|....:...:|....
Mouse   503 -----SAADQEEEAHPEYKFGNELSADDYSHKEAVANSVKKTSDDLEHENNKKGLVTVEDEQAWM 562

  Fly   588 KAQKETEAGAEI----SALVNYVQPIHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIEFVNY 648
            .:.|...|...|    |.::||.||:.|..|..||::|..|.||||:|......||...||||||
Mouse   563 ASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNY 627

  Fly   649 NKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEF 713
            ||.|:||:||.|.|.||||:|||:|||||||:|:||:||.|||||||.|.||||...||||||:|
Mouse   628 NKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDF 692

  Fly   714 MRRSDRRLDPFAESTVDGIIAGTVSITVLSGQFLTDKRANTFVEVDMYGLPADTVRKKFRTKTVR 778
            |||.||..|||:|:.|||:||.|.|:.|:|||||:||:..|:|||||||||.||:||:|||:.|.
Mouse   693 MRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVM 757

  Fly   779 DNGMNPLYDEEPFVFKKVVLPELASIRIAAYEEGGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPI 843
            :||:||:|:||.|||:||:||:||.:|||.|::..||||.|:||:.||..||||::||:|..:|:
Mouse   758 NNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPL 822

  Fly   844 ALASLFLCVVVKDYVPDDLSNFAEALANPIKYQSELEKRDIQLSVLTDEAEALGSADEDLSKSFV 908
            :|.::|..:|:|.||||...:..:||::|.|:.|..|||..|:..:..|...:.....|.||:  
Mouse   823 SLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKN-- 885

  Fly   909 FVQVGGQKKELRPVESLAT---SPKHRPSISAAAAMSVDVTVDRTDGGRGEDSISIVAPSIQHQH 970
                 .:|.:..|.::..|   |.:.||:.:||.             |.|::             
Mouse   886 -----DKKGKANPAKANVTPQSSSELRPTTTAAL-------------GSGQE------------- 919

  Fly   971 SLDQSVSTSIRQVESSQFDVDLVLAEPLEKILDHKSVKE--KRL-EMEKKLESLRKKHDKE---- 1028
                           ::..::|:   |..:|.|.|.:|.  |.| :.:|:|.||:|||.||    
Mouse   920 ---------------AKKGIELI---PQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTM 966

  Fly  1029 -KI------KIAGQKSSPLEGKKPKFAITNKLVKRLSNKSLNCLSPHSEPGVEIPACPLDLGDSS 1086
             |:      ||..|..   :.|.....|..|.:|:....  |||....|..::|.....|.....
Mouse   967 QKLHCTQVDKIVAQYD---KEKSTHEKILEKAMKKKGGS--NCLEIKKETEIKIQTLTTDHKSKV 1026

  Fly  1087 EESAAADAGE--DLAGGSSSLDGRTQESRLRSACREYTSQYRELQEKYHEAIYSAAEKVLKTSQT 1149
            :|..|....|  ::....|:     :|..:|..   :.||..||           ..|:|..:..
Mouse  1027 KEIVAQHTKEWSEMINTHSA-----EEQEIRDL---HLSQQCEL-----------LRKLLINAHE 1072

  Fly  1150 GQTKQLKASLDKVTGEV-MHQLQEARRN--------EVKNLATVHRDRDELIRMKREVASSVVER 1205
            .||:|||.|.|:.:.|: .||.:.:..|        .:||.|       |..|..||:.||..::
Mouse  1073 QQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKA-------ERERRVRELNSSNTKK 1130

  Fly  1206 GVAERVRLKQTFDRRTDELQKQHDSVRNALAEHRSKARQILDKEAES--RSC 1255
            .:.||.||.....:..|:|:|       ...||    .:.|:|:.|.  :||
Mouse  1131 FLEERKRLAMKQSKEMDQLKK-------VQLEH----LEFLEKQNEQLLKSC 1171

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Plc21CNP_995605.1 PH_PLC_beta 20..145 CDD:270167 38/127 (30%)
EFh_PI-PLC21 151..305 CDD:320043 67/153 (44%)
EF-hand motif 151..180 CDD:320043 10/28 (36%)
EF-hand motif 187..216 CDD:320043 14/28 (50%)
EF-hand motif 225..255 CDD:320043 12/29 (41%)
EF-hand motif 272..305 CDD:320043 16/32 (50%)
PI-PLCc_beta 317..702 CDD:176533 181/397 (46%)
C2_PLC_like 736..855 CDD:175974 68/118 (58%)
PTZ00121 <981..>1253 CDD:173412 75/298 (25%)
Plcb4XP_006498999.1 PH_PLC_beta 17..143 CDD:270167 38/128 (30%)
EFh_PI-PLCbeta4 148..300 CDD:320041 67/153 (44%)
EF-hand motif 148..177 CDD:320041 10/28 (36%)
EF-hand motif 183..212 CDD:320041 14/28 (50%)
EF-hand motif 221..250 CDD:320041 12/29 (41%)
EF-hand motif 267..300 CDD:320041 16/32 (50%)
PI-PLCc_beta 312..681 CDD:176533 181/397 (46%)
C2_PLC_like 715..831 CDD:175974 67/115 (58%)
PTZ00121 <860..1207 CDD:173412 94/405 (23%)
DUF1154 926..968 CDD:461969 17/44 (39%)

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