DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Plc21C and Plcb2

DIOPT Version :10

Sequence 1:NP_995605.1 Gene:Plc21C / 33204 FlyBaseID:FBgn0004611 Length:1318 Species:Drosophila melanogaster
Sequence 2:NP_808236.2 Gene:Plcb2 / 18796 MGIID:107465 Length:1181 Species:Mus musculus


Alignment Length:1276 Identity:460/1276 - (36%)
Similarity:690/1276 - (54%) Gaps:193/1276 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 LQDGEKFIRWDDDSGTGTPVTMRVDAKGFFLYWVDQNNELDILDIATIRDVRTGQYAKRPKDNKL 84
            |..||:||:|||::...:||.:|||.||::|||..||.|::.||:.:|||.|.|::||.||..||
Mouse    17 LSQGERFIKWDDETSIASPVILRVDPKGYYLYWTYQNQEMEFLDVTSIRDTRFGKFAKIPKSQKL 81

  Fly    85 RQIVTLG-PQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDGLIKLAYSLAQLNGSAIM 148
            |::..:. |.:....||:||..|.|.|::||.||...:.::.:.|.:.::.||.....:|.....
Mouse    82 REVFNMDFPDNHFLLKTLTVVSGPDMVDLTFYNFVSYKENVGKDWAEDVLALAKHPMTVNAPRST 146

  Fly   149 FLQKAHTKLCLQVDKSGRIPVKNIIKLFAQNKEDRKRVEKALDVTGLPSGKVDSISVSKFQFEDF 213
            ||.|...||.:|::..|:|||||..::|   ..||||||.||....|..||.|:|:...|....:
Mouse   147 FLDKILVKLKMQLNPEGKIPVKNFFQMF---PADRKRVEAALGACHLAKGKNDAINPEDFPESVY 208

  Fly   214 YNLYKYLTQRSEVERLFDSIVGNSKRK-CMSIAQLVEFLNKTQRDPRLNEILYPYANPARAKELI 277
            .:....|..|.|::.:|.|.  :||.| .|:...|.:|:|:.|||||||.:|:|.|.|.:.:.||
Mouse   209 KSFLMSLCPRPEIDEIFTSY--HSKAKPYMTKEHLTKFINQKQRDPRLNSLLFPPARPEQVQVLI 271

  Fly   278 QQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHNTYLTGHQL 342
            .:|||:..|.|:||||.:|.:.:|.|.:|.::|...|.:..||.||::|||||||||||||..|.
Mouse   272 DKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAHDTLLIHQDMTQPLNHYFINSSHNTYLTAGQF 336

  Fly   343 TGKSSVEIYRQCLLAGCRCVELDFWNGR--TEEPVIVHGYTFVPEIFAKDVLEAIAESAFKTSEY 405
            :|.||.|:|||.||:||||||||.|.|:  .|||:|.||:|...:|..|:.:|||||||||||.|
Mouse   337 SGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAIEAIAESAFKTSPY 401

  Fly   406 PVILSFENHC-NPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPPPAMLRRKIIIKNKKKH 469
            |||||||||. :||||||:|.|||.:||:.||..||::.||:|.:.||.|..||.||:|||||. 
Mouse   402 PVILSFENHVDSPRQQAKMAEYCRSMFGETLLTDPLENFPLKPGIPLPSPEDLRGKILIKNKKN- 465

  Fly   470 HHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQVGLSASHEDGGVTRSTANGDVATGTGTG 534
                         |...||                     |.|.:.|||...:....|.....||
Mouse   466 -------------QFSGPA---------------------SPSKKPGGVAEGSLPSSVPVEEDTG 496

  Fly   535 SAAGTAGHAPPLQQIRQSSKDSTGSSDSDSSSEDESLPNTTPNLPSGNEPPPEKAQKETEAGAEI 599
            ..|.........:.:.:..::.:|:.|.:...:.:|...|              |..|..|..|:
Mouse   497 WTAEDRTEVEEEEVVEEEEEEESGNLDEEEIKKMQSDEGT--------------AGLEVTAYEEM 547

  Fly   600 SALVNYVQPIHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTRFD 664
            |:||||:||..|.|||.:.:|||.|.:|||.|.:|..||.:..::||:|||.|:|||||.|||.|
Mouse   548 SSLVNYIQPTKFISFEFSAQKNRSYVVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPKGTRMD 612

  Fly   665 SSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAESTV 729
            |||:|||:|||||||:|||||||:||.||.|:.:||:|.:||||||.|||||.|::.:||:...:
Mouse   613 SSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRLDKQFNPFSVDRI 677

  Fly   730 DGIIAGTVSITVLSGQFLTDKRANTFVEVDMYGLPADTVRKKFRTK-TVRDNGMNPLYDEEPFVF 793
            |.::|.|:|||::|||||:::...|:|||:::|||.|. ::::||| :...|.:||::.||||:|
Mouse   678 DVVVATTLSITIISGQFLSERSVRTYVEVELFGLPGDP-KRRYRTKLSPTANSINPVWKEEPFIF 741

  Fly   794 KKVVLPELASIRIAAYEEGGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIALASLFLCVVVKDYV 858
            :|:::|||||:|||..|||.|.:|||::|:..|..||.|:.||||....:.:.:||:.:.:|||:
Mouse   742 EKILMPELASLRIAVMEEGSKFLGHRIIPINALHSGYHHLCLRSESNMALTMPALFVFLEMKDYI 806

  Fly   859 PDDLSNFAEALANPIKYQSELEKRDIQLSVLTDEAEALGSADEDLSKSFVFVQVGGQKKELRPVE 923
            ||..::...||||||||.:..:|:.::|..:|      ||..|.|...             .||.
Mouse   807 PDTWADLTVALANPIKYFNAQDKKSVKLKGVT------GSLPEKLFSG-------------TPVA 852

  Fly   924 SLATSPKHRPSISAAAAMSVDVTVDRTDGGRGEDSISIVAPSIQHQHSLDQSVSTSIRQVESSQF 988
            |.          |..|.:|         .|.|.     .||..:   :..:..:..:.:.:::. 
Mouse   853 SQ----------SNGAPVS---------AGNGS-----TAPGTK---ATGEEATKEVTEPQTAS- 889

  Fly   989 DVDLVLAEPLEKILDHKSVKEKRLEMEKKLESLRKKHDKE---------------KIKIAGQKSS 1038
                     ||::.:.|.|.:.:...||:|..|.::..:.               :.:.||.|..
Mouse   890 ---------LEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELQTQAAGCKLR 945

  Fly  1039 PLEGKKPKFAITNKLVKRLSNKSLNCLSPHSEPGVEIPACPLDLGDSSEESAAADAGEDLAGGSS 1103
            |.:|.:.|             ::|.|     |..|..|:.|.|..|.                  
Mouse   946 PGKGSRKK-------------RTLPC-----EETVVAPSEPHDRADP------------------ 974

  Fly  1104 SLDGRTQE--SRLRSACREY-TSQYRELQEKYHEAIYSAAEKVL---KTSQTGQTKQLKASLDKV 1162
                |.||  .||....::. ..|||.:.::..:.:.....|::   :..|..:.|..|.:.:..
Mouse   975 ----RVQELKDRLEQELQQQGEEQYRSVLKRKEQHVTEQIAKMMELAREKQAAELKTFKETSETD 1035

  Fly  1163 TGEVMHQLQEARRNEVKNLATVHRDRDELIRMKREVASSVVERGVAERVRLKQTFDRRTDELQKQ 1227
            |.|:..:|:..|...::.:..|..|:....|:|||:.:|.::..|....::.:|.:|..::|:::
Mouse  1036 TKEMKKKLEAKRLERIQAMTKVTTDKVAQERLKREINNSHIQEVVQAVKQMTETLERHQEKLEER 1100

  Fly  1228 HDSV------------RNALAEHRSKARQILDKEAESRSCV 1256
            ..:.            ..||||:.:|.:.:   |||.:..|
Mouse  1101 QTACLEQIQAMEKQFQEKALAEYEAKMKGL---EAEVKESV 1138

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Plc21CNP_995605.1 PH_PLC_beta 20..145 CDD:270167 51/125 (41%)
EFh_PI-PLC21 151..305 CDD:320043 62/154 (40%)
EF-hand motif 151..180 CDD:320043 11/28 (39%)
EF-hand motif 187..216 CDD:320043 9/28 (32%)
EF-hand motif 225..255 CDD:320043 10/30 (33%)
EF-hand motif 272..305 CDD:320043 14/32 (44%)
PI-PLCc_beta 317..702 CDD:176533 182/387 (47%)
C2_PLC_like 736..855 CDD:175974 55/119 (46%)
PTZ00121 <981..>1253 CDD:173412 57/304 (19%)
Plcb2NP_808236.2 PH_14 13..141 CDD:465506 50/123 (41%)
EFh_PI-PLCbeta2 149..299 CDD:320039 62/154 (40%)
EF-hand motif 149..178 CDD:320039 11/31 (35%)
EF-hand motif 182..211 CDD:320039 9/28 (32%)
EF-hand motif 220..249 CDD:320039 10/30 (33%)
EF-hand motif 266..299 CDD:320039 14/32 (44%)
PI-PLCc_beta2 311..650 CDD:176561 182/387 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 465..534 15/103 (15%)
C2_PLC_like 682..803 CDD:175974 56/121 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 847..890 10/92 (11%)
PLC-beta_C 974..1149 CDD:462571 36/190 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1149..1181
Blue background indicates that the domain is not in the aligned region.

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