DRSC/TRiP Functional Genomics Resources

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Protein Alignment Plc21C and egl-8

DIOPT Version :10

Sequence 1:NP_995605.1 Gene:Plc21C / 33204 FlyBaseID:FBgn0004611 Length:1318 Species:Drosophila melanogaster
Sequence 2:NP_001300014.1 Gene:egl-8 / 178537 WormBaseID:WBGene00001177 Length:1512 Species:Caenorhabditis elegans


Alignment Length:1537 Identity:485/1537 - (31%)
Similarity:709/1537 - (46%) Gaps:358/1537 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 VPQALQDGEKFIRWDDDSG-TGTPVTMRVDAKGFFLYWVDQNNELDILDIATIRDVRTGQYAKRP 79
            :|:.|. |..|.|:||:|. ......:|:|..||||.|:.:..:..:||:..|.:.|||..   |
 Worm    14 IPELLH-GSVFDRYDDESTCLELNAQVRIDENGFFLRWLIEGKDAVVLDMGQIWEARTGGL---P 74

  Fly    80 KDNKLR-QIVTLGPQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDGLIKLAYSLAQLN 143
            ||.::. ::...|..:|:.|:|:.:.||.|.||:..........::|:....|:..:..|....:
 Worm    75 KDGRIMFELEQRGASETIAERTIWITHGQDLVNVQSFFLVAESVELAKTCRAGINDILKSSRIRH 139

  Fly   144 GSAIMFLQKAHTKLCLQVDKSGRIPVKNIIKLFAQNKEDRKRVEKALDVTGLPSGKV-------- 200
            ......|.|.||.|.:.|::..:||:|.|||.|:..|.: |.|:|.|:..||...|.        
 Worm   140 VCPTTQLMKYHTWLTMNVNERRKIPIKLIIKTFSSGKPE-KMVQKCLNDLGLGGDKYTPARVINR 203

  Fly   201 ---------------------DSISVSKFQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSI 244
                                 :.:.|....||.|..||..:..|:||:.||..:.|  :::.::.
 Worm   204 SMGKKFRNFYKCSRGRKRKEREELDVDILTFEKFQRLYNKICPRTEVQELFVKLSG--QKEYLTK 266

  Fly   245 AQLVEFLNKTQRDPRLNEILYPYANPARAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIM 309
            .:|:.|||:.||||||||||:|:.:..|...|::::|.:....:.|::|.|||||:||.|:||.:
 Worm   267 ERLINFLNEEQRDPRLNEILFPFFDSQRIVALLKKHENDIKYQEDGKMSGDGFLRFLMSDENPPV 331

  Fly   310 APSKLDLCDDMDQPMSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTE-- 372
            ...::::..|||||:.||:|||||||||||.|..||||.|||||.||:||||:|||.|:|..|  
 Worm   332 FLDRIEMFMDMDQPLCHYYINSSHNTYLTGRQYGGKSSSEIYRQVLLSGCRCIELDCWDGTGENK 396

  Fly   373 -EPVIVHGYTFVPEIFAKDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLL 436
             ||:|.||.....::|.||||..|.::||..|::||:|||||||:...|.|:|.||.:|||||||
 Worm   397 GEPIITHGKAMCTDVFFKDVLVQIRDTAFARSDFPVVLSFENHCSKSNQLKMAKYCMDIFGDMLL 461

  Fly   437 DKPLDSHPLEPNMDLPPPAMLRRKIIIKNKKKHHHHHHH---------------HHHKKPAQVG- 485
            .||.:..||:|.:.||.|..||:||:||||:.......|               ..::.|..|| 
 Worm   462 SKPFEDAPLDPGVSLPSPNRLRKKILIKNKRLKTDIERHQLDQFLREGKLDEEDELNETPEVVGE 526

  Fly   486 ----------------------------TPAANNKL----------TTANSVDAKAAQQVGLSAS 512
                                        .|:....|          ||:|:...::|:. .|...
 Worm   527 DSVSPRSGGSGGTGAPEEVDDDTSDDDDDPSVQTSLNVMRTIPTVNTTSNNGSNRSARS-SLDTP 590

  Fly   513 HEDGGVTRSTANGDVATGTGTGSAAGTAGHAPPLQQIRQ-------------------------S 552
            ...||   |....|.||.|.|.........:|....:||                         |
 Worm   591 SPSGG---SLMVPDRATSTATSIKNAVLARSPNFSSLRQKLSFKRRQSPLAGDQRAHPEVEQPVS 652

  Fly   553 SKD-------------------------STGSSDSDS-------------SSEDESLP------- 572
            |..                         :||.|.|.|             ...||:.|       
 Worm   653 SSSPATPSISGPPPCATSSGSTSSITITTTGCSTSSSGPSKHILGGEMPAKENDEAHPELKQNFI 717

  Fly   573 -----------------------NTTPN-----LPSGNEP----------PPEKAQKETEA---- 595
                                   :.||:     :.:.|.|          |.|:::.|..:    
 Worm   718 AKNLKGFGFSKKQPDSSTSLLTASPTPSSSSMAMSNANNPFSSSTLNSPQPMERSRSEKRSFRQK 782

  Fly   596 -----------------------------------------------GAE------ISALVNYVQ 607
                                                           ||.      :|:||||..
 Worm   783 KGGVFGDELHSDSAALIDFMRTASSRKKKPVLTKEEEERIFAEYHYTGATTNIHPLLSSLVNYTH 847

  Fly   608 PIHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQL 672
            |:.||.|:.||..|..:.||||.|......||:...|||||||.|.||:||.|.|.|||||:||:
 Worm   848 PVKFSGFDVAEANNLHFHMSSFSESTGLGYLKQSAPEFVNYNKRQSSRIYPKGARVDSSNFLPQI 912

  Fly   673 FWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTV 737
            |||||||:|:|||||.|:.||||:|.||||..|||||||:|:||.||..|||:||.|||:||...
 Worm   913 FWNAGCQMVSLNFQTPDVYMQLNMGKFEYNGGSGYLLKPDFLRRPDRTFDPFSESPVDGVIAAHC 977

  Fly   738 SITVLSGQFLTDKRANTFVEVDMYGLPADTVRKKFRTKTVRDNGMNPLYDEEPFVFKKVVLPELA 802
            |:.|:|||||:|::..|:|||:|||||.||:||:.:||.:..||:||:|:|:||||:||||||||
 Worm   978 SVRVISGQFLSDRKIGTYVEVEMYGLPTDTIRKEHKTKVIPGNGLNPVYNEDPFVFRKVVLPELA 1042

  Fly   803 SIRIAAYEEGGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIALAS-LFLCVVVKDYVPDDLSNFA 866
            .:|.|.|:|.||.:|.|:||:.||..||||::|||:..|...|:. ||:.:|:|.||||:||...
 Worm  1043 VLRFAVYDENGKQLGQRILPLDGLQAGYRHISLRSDTNQSFILSPVLFVQIVIKTYVPDELSGLV 1107

  Fly   867 EALANPIKYQSELEKRDIQLSVLTDEAEA-LGSADEDLSKSFVFVQVGGQKKELRPVESLATSPK 930
            :|||:|..:.||.:||        .||.| :|..|.|:             .::....::|....
 Worm  1108 DALADPRAFLSEQKKR--------QEALAHMGVDDSDI-------------PDVPNTRNMALRHV 1151

  Fly   931 HRPSISAAAAMSVDVTVDRTDGGRGEDSISIVAPSIQHQHSLDQSVSTSIRQVESSQFDVDLVLA 995
            .:|.....::..:.....:|...||:.:.|:.:.:|:..:...|.|:....:|:..:.| ||...
 Worm  1152 KQPPRQNGSSADLLANNGQTGSARGDQTSSMASSTIRSPNEQPQPVAVDKFKVDPIEVD-DLRRD 1215

  Fly   996 EPLEKILDHKSVKEKRLEMEKKLESLRKKHDKEKIKIAGQKSSPLEGKKPKFA---------ITN 1051
            :...|:|       ||  .:|:|:.|||||.|::..|  ||..|...:....|         |||
 Worm  1216 KAFAKLL-------KR--FQKELDDLRKKHQKQRDSI--QKQQPARRRNSSIAWIQTNVDKLITN 1269

  Fly  1052 KLVKRLSNK------------SLNC------------------LSPHSEPGVEIP-ACPLDLGDS 1085
            .  :|.:.|            |..|                  .|.:|..|...| ||..| |..
 Worm  1270 N--RRSTKKEKGSRRSLTASVSSGCGSASGTVTVSVCSPSGASCSGYSTGGPSTPVACNSD-GTG 1331

  Fly  1086 SEESAAADAGEDLAGGS--SSLDGRTQESRLRSACREYTSQYRELQEKYHEAIYSAAEKVLKTSQ 1148
            |..:..:...:||....  .|| ..||.....:..|.:..:..||::...:..:....|::..:|
 Worm  1332 SPATIGSPVPQDLVNNDRVRSL-VNTQTGEWSAMVRRHDEEEFELKKVQLKEQFDLLRKLMSEAQ 1395

  Fly  1149 TGQTKQLKASLDKVTGEVMHQLQEARRNEVKNLATVHR------DRDELIRMKREVASSVVERGV 1207
            ..|...||..|: ..|:.:.|.|..:..|...:..:.:      :||   |..:|:....::..|
 Worm  1396 KNQMLALKLRLE-AEGKDLKQTQTKKSMEDAKVIQLDKGIKTKAERD---RRVKELNEKNLKMFV 1456

  Fly  1208 AERVRLKQTFDRRTDELQKQHDSVRNALAEHRSKARQILDKE 1249
            .||.||.....:..::|.|:|......|.:...||   ||.|
 Worm  1457 EERKRLAMKAQKHEEQLTKRHLDQLEQLDKDFHKA---LDAE 1495

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Plc21CNP_995605.1 PH_PLC_beta 20..145 CDD:270167 35/126 (28%)
EFh_PI-PLC21 151..305 CDD:320043 59/182 (32%)
EF-hand motif 151..180 CDD:320043 12/28 (43%)
EF-hand motif 187..216 CDD:320043 9/57 (16%)
EF-hand motif 225..255 CDD:320043 9/29 (31%)
EF-hand motif 272..305 CDD:320043 12/32 (38%)
PI-PLCc_beta 317..702 CDD:176533 193/606 (32%)
C2_PLC_like 736..855 CDD:175974 65/119 (55%)
PTZ00121 <981..>1253 CDD:173412 74/317 (23%)
egl-8NP_001300014.1 PH_PLC_beta 17..142 CDD:270167 35/128 (27%)
EFh_PI-PLCbeta 147..327 CDD:320030 59/182 (32%)
EF-hand motif 147..176 CDD:320030 12/28 (43%)
EF-hand motif 182..240 CDD:320030 9/57 (16%)
EF-hand motif 249..277 CDD:320030 9/29 (31%)
EF-hand motif 294..327 CDD:320030 12/32 (38%)
PI-PLCc_beta 339..>495 CDD:176533 91/155 (59%)
Herpes_BLLF1 <528..>668 CDD:282904 20/143 (14%)
PI-PLCc_GDPD_SF <839..942 CDD:472694 61/102 (60%)
C2_PLC_like 976..1096 CDD:175974 65/119 (55%)
DUF1154 1201..1245 CDD:461969 17/55 (31%)
PLC-beta_C 1372..1511 CDD:462571 30/131 (23%)

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