Protein Alignment Plc21C and plcb2

DIOPT Version :10

• Sequence 1: NP_995605.1
• Gene: Plc21C / 33204
• FlyBaseID: FBgn0004611
• Length: 1318
• Species: Drosophila melanogaster
• Sequence 2: XP_017952419.2
• Gene: plcb2 / 101734935
• XenbaseID: XB-GENE-6045997
• Length: 1250
• Species: Xenopus tropicalis
• Alignment Length: 1264
• Identity: 457/1264 - (36%)
• Similarity: 679/1264 - (53%)
• Gaps: 202/1264 - (15%)

  Fly    14 VEVPQALQDGEKFIRWDDDSGTGTPVTMRVDAKGFFLYWVDQNNELDILDIATIRDVRTGQYAKR 78
            |||...|..||:||:|||::...:||.:|||.||::|||..|:.|::.:::.:|||.|.|::||.
 Frog    11 VEVKSYLSKGERFIKWDDETSLASPVILRVDPKGYYLYWTFQSKEMEFVELTSIRDTRFGKFAKA 75

  Fly    79 PKDNKLRQIVTLG-PQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDGLIKLAYSLAQL 142
            ||..|||::..|. |::....|.:|:..|.|.|::||.||...:.::.:.|...::.:..:....
 Frog    76 PKSQKLREVFNLDFPENNFLAKALTIVTGPDMVDLTFHNFVSYKENVGKAWAADILSVVTNPLVP 140

  Fly   143 NGSAIMFLQKAHTKLCLQVDKSGRIPVKNIIKLFAQNKEDRKRVEKALDVTGLPSGKVDSISVSK 207
            |.....|.:|.|.||.||::..|:|||:|..::|   ..||||||:||:...|..||.|:|:...
 Frog   141 NACRYSFFEKIHVKLQLQLNSEGKIPVRNFFQMF---PADRKRVEQALNSCHLSKGKNDAINPED 202

  Fly   208 FQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRK-CMSIAQLVEFLNKTQRDPRLNEILYPYANPA 271
            |....|......|..|.|::.:|.|.  :||.| .|:...|.:|:|:.|||.||||:::|.|...
 Frog   203 FPESVFRTFLMQLCPRPEIDEIFTSY--HSKAKPYMTKVHLTKFINQKQRDSRLNELIFPPAKTE 265

  Fly   272 RAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHNTY 336
            :.:.||::|||:..|.|:||||.:|.:.:|.|.:|.|.:..|:.:..||.||:||||||||||||
 Frog   266 QVQGLIEKYEPSVINVQRGQLSPEGMVWFLCGSENSITSLDKIPIYQDMSQPLSHYFINSSHNTY 330

  Fly   337 LTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGR--TEEPVIVHGYTFVPEIFAKDVLEAIAESA 399
            ||..|.:|.||.|:|||.||:||||||||.|.|:  .|||:|.||:|...||..|||:|||||||
 Frog   331 LTAGQFSGVSSPEMYRQTLLSGCRCVELDCWKGKPPEEEPIITHGFTMTTEILFKDVIEAIAESA 395

  Fly   400 FKTSEYPVILSFENHC-NPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPPPAMLRRKIII 463
            ||||.||||||||||. :|:||||:|.|||.|||||||...|:.:||:|...||.|..|..||:|
 Frog   396 FKTSPYPVILSFENHVDSPKQQAKMAEYCRTIFGDMLLTDALEKYPLKPGNLLPSPQELLGKILI 460

  Fly   464 KNKKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQVGLSASHEDGGVTRSTANGDVA 528
            ||||..                  :..|:...|||.|:.:::|            |.|.::.:..
 Frog   461 KNKKNQ------------------SFANQDKKANSCDSTSSEQ------------TSSLSSDNSG 495

  Fly   529 TGTGTGSAAGTAGHAPPLQQIRQSSKDSTGSSDSDSSSEDESLPNTTPNLPSGNEPPPEKAQKET 593
            .|...|..|              .:::.|.::|.:...:.:|...|              |.:|.
 Frog   496 EGPEEGKEA--------------ENEEMTENADEEEMKQMQSDEGT--------------ASQEA 532

  Fly   594 EAGAEISALVNYVQPIHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYP 658
            .|..|:|:||||:|||.|.|||.:.:||:.|.:|||.|.:|..||.:.|::||.|||.|:||:||
 Frog   533 TAYEEMSSLVNYIQPIKFDSFEVSAQKNQSYVVSSFVETKAYELLTKFPVQFVEYNKRQMSRIYP 597

  Fly   659 AGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDP 723
            .|||.||||:|||:|||||||:|||||||:|:.||.|:.:|::|..||||||.|||||.|::.||
 Frog   598 KGTRMDSSNYMPQMFWNAGCQMVALNFQTMDIPMQQNMALFQFNGCSGYLLKHEFMRRGDKQFDP 662

  Fly   724 FAESTVDGIIAGTVSITVLSGQFLTDKRANTFVEVDMYGLPADTVRKKFRTK-TVRDNGMNPLYD 787
            |....:|.::|.|||||:||||||.:|...|:|||:::|||.|. ::|::|| |...|.:||::.
 Frog   663 FTVDRIDVVVANTVSITILSGQFLCEKCVKTYVEVELFGLPGDP-KRKYKTKVTSVPNTINPVWK 726

  Fly   788 EEPFVFKKVVLPELASIRIAAYEEGGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIALASLFLCV 852
            ||||||:|:::|||||:|:|.:|||||.||||::|:..:..||.|:.||||...|:.:.|||:.|
 Frog   727 EEPFVFEKILMPELASLRVAVFEEGGKFIGHRIIPIDLIRSGYHHICLRSESNMPLTMPSLFVYV 791

  Fly   853 VVKDYVPDDLSNFAEALANPIKYQSELEKRDIQLSVLTDEAEALGSADEDLSKSFVFVQVGGQKK 917
            .|.|||||..::.::||:||||:....|.:  .:.|.|..:..:.||.:...       :.||
 Frog   792 EVTDYVPDVWADLSQALSNPIKHSKANECK--SMKVKTAPSGEISSASKPNG-------IPGQ-- 845

  Fly   918 ELRPVESLATSPKHRPSISAAAAMSVDVTVDRTDGGRGEDSISIVAPSIQHQHSLDQSVSTSIRQ 982
                     ..||..|                |.|
 Frog   846 ---------NGPKGLP----------------TSG------------------------------ 855

  Fly   983 VESSQFDVDLVLAEPLEKILDHKSVKEKRLEMEKKLESLRKKHDKEKIKIAGQKSSPLEGKKPKF 1047
                       :.:..::|.:.::..|:.|:.:|....|:||.:||..::..:.....|....|:
 Frog   856 -----------VQDAAKEITEPQTANEEELQKQKGFLKLQKKQEKELKELERRTLKRREEIVQKY 909

  Fly  1048 AITNKLVKRLSNKSLNCLSPHSEPGVEIPACPLDLGDSSEESAAADAGEDLAGGSSSLDGRTQES 1112
            ......:...:||..|.| |..:....||        ..:..:...|||....|...:....::.
 Frog   910 TSAFSELYTQANKRKNSL-PKGQKKKSIP--------DDDYGSVWGAGEIPGKGDPQVLEMKRKM 965

  Fly  1113 RLRSAC---REYTSQYRELQEKYHEAIYSAAE----------KVLKTSQTGQTKQLKASLDKVTG 1164
            .....|   .:|.:..::.::..:|.|....|          |:||.:....|||:|..|
 Frog   966 EEELTCLGEEQYETILKKKEQHSNEQISKLIELAQERQVAELKILKEAADSDTKQMKKKL----- 1025

  Fly  1165 EVMHQLQEARRNEVKNLATVHRDRDELIRMKREVASSVVERGV---------------------A 1208
                :::...|.|..:..|:.:...|  |:|:|:.:|.::..|                     |
 Frog  1026 ----EIKRLERLECMSKNTMEKASQE--RLKKEINNSHIQEVVQVLQLVSDKWAKNQQKLEEKQA 1084

  Fly  1209 ERV-RLKQTFDRRTDELQKQHDSVRNALA 1236
            |.: |:|:..|:...|||:::....|:||
 Frog  1085 EGLQRIKEREDQVQKELQEEYIEKLNSLA 1113

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	45/125 (36%)
		EFh_PI-PLC21	151..305	CDD:320043	62/154 (40%)
		EF-hand motif	151..180	CDD:320043	12/28 (43%)
		EF-hand motif	187..216	CDD:320043	10/28 (36%)
		EF-hand motif	225..255	CDD:320043	10/30 (33%)
		EF-hand motif	272..305	CDD:320043	14/32 (44%)
		PI-PLCc_beta	317..702	CDD:176533	183/387 (47%)
		C2_PLC_like	736..855	CDD:175974	63/119 (53%)
		PTZ00121	<981..>1253	CDD:173412	55/291 (19%)
plcb2	XP_017952419.2	PH_14	12..141	CDD:465506	46/128 (36%)
		EFh_PI-PLCbeta2	149..299	CDD:320039	62/154 (40%)
		EF-hand motif	149..178	CDD:320039	12/31 (39%)
		EF-hand motif	182..211	CDD:320039	10/28 (36%)
		EF-hand motif	220..249	CDD:320039	10/30 (33%)
		EF-hand motif	266..299	CDD:320039	14/32 (44%)
		PI-PLCc_beta2	311..641	CDD:176561	183/387 (47%)
		C2_PLC_like	675..794	CDD:175974	63/119 (53%)
		DUF1154	872..902	CDD:461969	7/29 (24%)
		PLC-beta_C	956..1131	CDD:462571	33/169 (20%)