DRSC/TRiP Functional Genomics Resources

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Protein Alignment Plc21C and plcd4

DIOPT Version :10

Sequence 1:NP_995605.1 Gene:Plc21C / 33204 FlyBaseID:FBgn0004611 Length:1318 Species:Drosophila melanogaster
Sequence 2:XP_002933984.2 Gene:plcd4 / 100379715 XenbaseID:XB-GENE-965137 Length:758 Species:Xenopus tropicalis


Alignment Length:854 Identity:264/854 - (30%)
Similarity:389/854 - (45%) Gaps:177/854 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 WDDDSGTGTPVTMRVDAKGFFLYWVDQNNELDILDIATIRDVRTGQYAKRPKDN-KLRQIVTLGP 92
            |.:...||       :.|..|          .|.||.|:|:....:..:...|. |.....|:  
 Frog    48 WYNSKKTG-------NTKSTF----------SISDIETVREGHQSEVLQSIADEFKPELCFTI-- 93

  Fly    93 QDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDGLIKLAYSLAQLNGSAIM------FLQ 151
                      |.||.. .|:..|   ....:.||.|..||.||..::..::...::      :.|
 Frog    94 ----------VFHGRR-ANLDLV---ANTPEEAQCWIQGLEKLIETVTNMDQKDLLDQWICDWFQ 144

  Fly   152 KAHTKLCLQVDKSGRIPVKNIIKLFAQNKEDRK-----RVEKALDVTGLPSGKVDSISVSKFQFE 211
            ||      ..:|.||:..|.:..|......|..     |:.:..|.:  .||.::.        |
 Frog   145 KA------DKNKDGRMNFKEVQDLLKMMNVDMSEHHAYRLFQMADKS--ESGTLEG--------E 193

  Fly   212 DFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDPRLNEILYPYANPARAKEL 276
            :|...||.||||.||.::|.....:.|:  :::.:.|:||.:.|.:....|.|        |.:|
 Frog   194 EFVLFYKALTQRDEVLKIFQDFSKDGKK--LTLLEFVDFLQQGQLEEENTEEL--------AMDL 248

  Fly   277 IQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHNTYLTGHQ 341
            |.:|||:....:...:|:|||:.||...:..|...:...|..||.||:.||||:|||||||...|
 Frog   249 IARYEPSDTAKKLHAMSIDGFVMYLCSPEGSIFNVAHEQLYQDMTQPLCHYFISSSHNTYLMEDQ 313

  Fly   342 LTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEIFAKDVLEAIAESAFKTSEYP 406
            :.|:||||.|.:.|..||||||:|.|:|...||::.||.||..:|..|||:.||.:.||:..:||
 Frog   314 IRGQSSVEGYIRALKRGCRCVEVDTWDGPNGEPIVYHGRTFTSKILFKDVISAINKYAFRVCDYP 378

  Fly   407 VILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPPPAMLRRKIIIKNKKKHHH 471
            ||||.||||...||..:|.:.:.|.|..|:...||..  .|.. ||.|..||.||::|.||    
 Frog   379 VILSLENHCGVEQQDAMAQHLKSILGTKLIMSTLDGR--IPTC-LPSPDELRGKILLKGKK---- 436

  Fly   472 HHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQVGLSASHEDGGVTRSTANGDVATGTGTGSA 536
                        :|           ..||:                                   
 Frog   437 ------------IG-----------RLVDS----------------------------------- 443

  Fly   537 AGTAGHAPPLQQIRQSSKDSTGS-SDSDSSSEDESLPNTTPNLPSGNEPPPEKAQKETEAGAE-I 599
                        :.:...||.|. :|.:.:.|.|...|          ...::|:|..|..:. :
 Frog   444 ------------LEEQPDDSVGEVTDEEENVEVEEERN----------EDKKRAKKSKERLSHLL 486

  Fly   600 SALVNYVQPIHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTRFD 664
            |..|.|.:.:.|.||:::......|||||..|.:|..|::|...:||.:|..||.||||.|.|.|
 Frog   487 SDCVIYCKSVPFVSFQHSRAHYTLYEMSSVTEYKARKLVREPGNDFVRHNAWQLMRVYPTGLRTD 551

  Fly   665 SSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAESTV 729
            |||:.||..||.|||:|||||||..:.|.||.|:|..|||.||:|||.|||..:...:|....:.
 Frog   552 SSNYNPQEMWNVGCQMVALNFQTAGVEMDLNDGLFRQNARCGYVLKPSFMRHVETTFNPDQPQST 616

  Fly   730 DGIIAGTVSITVLSGQFLTDKRANT--------FVEVDMYGLPADTVRKKFRTKTVRDNGMNPLY 786
            :|.....:||.|:|.|.| .|..|:        ||.|:::|:|.|..:::  ||.:.:||.||::
 Frog   617 EGYSPVNLSILVISAQQL-PKVENSKEGSIVDPFVRVEIFGVPIDQTKQE--TKYIENNGFNPMW 678

  Fly   787 DEEPFVFKKVVLPELASIR--IAAYEEGGK--LIGHRVLPVIGLCPGYRHVNLRSEVGQPIALAS 847
            .|.  :..|:.:||||.:|  :..|::..:  .:|...||...:..||||::|.|..|..:..||
 Frog   679 YET--LHFKIHVPELALVRFVVEDYDKTSRNDFVGQYTLPFKSIKSGYRHIHLLSRDGTKMPPAS 741

  Fly   848 LFLCVVVKD 856
            :|:.|.|.|
 Frog   742 VFVHVRVTD 750

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Plc21CNP_995605.1 PH_PLC_beta 20..145 CDD:270167 25/116 (22%)
EFh_PI-PLC21 151..305 CDD:320043 43/158 (27%)
EF-hand motif 151..180 CDD:320043 8/28 (29%)
EF-hand motif 187..216 CDD:320043 5/28 (18%)
EF-hand motif 225..255 CDD:320043 7/29 (24%)
EF-hand motif 272..305 CDD:320043 12/32 (38%)
PI-PLCc_beta 317..702 CDD:176533 137/386 (35%)
C2_PLC_like 736..855 CDD:175974 42/130 (32%)
PTZ00121 <981..>1253 CDD:173412
plcd4XP_002933984.2 PH_PLC_delta 18..133 CDD:270169 25/117 (21%)
EFh_PI-PLCdelta4 138..277 CDD:320049 43/164 (26%)
EF-hand motif 138..167 CDD:320049 8/34 (24%)
EF-hand motif 174..203 CDD:320049 8/38 (21%)
EF-hand motif 207..238 CDD:320049 8/32 (25%)
EF-hand motif 244..277 CDD:320049 13/40 (33%)
PI-PLCc_delta4 289..589 CDD:176568 137/386 (35%)
C2_PLC_like 621..749 CDD:175974 42/132 (32%)
Blue background indicates that the domain is not in the aligned region.

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