DRSC/TRiP Functional Genomics Resources

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Protein Alignment Plc21C and plch2a

DIOPT Version :10

Sequence 1:NP_995605.1 Gene:Plc21C / 33204 FlyBaseID:FBgn0004611 Length:1318 Species:Drosophila melanogaster
Sequence 2:NP_001334621.1 Gene:plch2a / 100334231 ZFINID:ZDB-GENE-030131-6367 Length:1534 Species:Danio rerio


Alignment Length:1412 Identity:368/1412 - (26%)
Similarity:592/1412 - (41%) Gaps:328/1412 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 TGTP-VTMRVDAKGFF-LYWVDQN-----------NELDILDIATIRDVRTGQYAKRPKDNKLRQ 86
            |||. |.:|..:||.. .:::|::           ||...:.|.:||:|..|      |.:::.|
Zfish    65 TGTQMVKLRGGSKGLVRFFYLDEHKSCIRWRPSRKNEKAKISIDSIREVCEG------KQSEIFQ 123

  Fly    87 IVTLGPQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDGL------IKLAYSLAQLNGS 145
            ..:.|..|  .....::.:|....::..|:   ...:.|:.|..||      |....|||:...:
Zfish   124 RYSDGSFD--PNCCFSIYYGEHMESLDLVS---GTGEEARTWITGLKYLMAGISDEDSLAKRQRT 183

  Fly   146 AIMFLQKAHTKLCLQVDKSGR--IPVKNIIKLFAQNKEDRKRVEKALDVTGLPSGKVDSI----- 203
            ...:|::...    :.||:|.  :.:..:::|..:           |:| .||..||..:     
Zfish   184 RDQWLKQTFA----EADKNGDGCLSISEVLQLLHK-----------LNV-NLPRQKVKQMFKEAD 232

  Fly   204 ---SVSKFQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDPRLNEILY 265
               :.....||:|.:.||.::.|.::..|.  :..::.:..:....|..||...|:...:::   
Zfish   233 TDDNQGTLGFEEFCSFYKMMSTRRDLYLLM--LTYSNHKDHLDTDDLKRFLETEQKMTNVSK--- 292

  Fly   266 PYANPARAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFIN 330
                 ....|::.::||...|...|.|.:|||..|:......|..|...::..||.||:|.|||.
Zfish   293 -----EHCLEIVAKFEPCPENQTSGVLGIDGFTNYMRSPAGDIFNPEHYEVNQDMTQPLSDYFIA 352

  Fly   331 SSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEIFAKDVLEAI 395
            |||||||.|.||..:|.|::|...|.|||||||:|.|:|:..||::.||||...:|..|||:|.|
Zfish   353 SSHNTYLMGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGQDGEPIVHHGYTLTSKILFKDVIETI 417

  Fly   396 AESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPPPAMLRRK 460
            .:.||..::||||||.||||:..||.|:|.|..|:.||.|   .:.|.|.:|:..||.|..|:.|
Zfish   418 NKYAFAKNQYPVILSIENHCSVPQQKKMAQYLTEVLGDKL---DVSSIPADPSGLLPSPEALKGK 479

  Fly   461 IIIKNKKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVD----------------AKAAQQVG- 508
            |:||.|            |.|:.:...|....::..:|.|                .|.|:.|. 
Zfish   480 ILIKGK------------KLPSNIDENAEEGDVSDEDSADEMEDDCKLLNGDTSMNRKQAENVAK 532

  Fly   509 ----------------------LSASHEDGGVTRSTANGDVATGTGTGSAAGTAGHAPPLQQI-- 549
                                  ::|....|...:|...|.....|.||..|...|:....:..  
Zfish   533 KKLDNLMKESKIRDREDPDSFTITALPPSGKHDKSPLKGKAEDSTDTGDEANIGGNKRLARTFMG 597

  Fly   550 ------RQSSKDSTGSSDSDSSSEDESLPNTTPNLPSGNEPPPEKAQKETEAGAEISALVNYVQP 608
                  :::||....||..|:.::.||  ::..:....:....:|..|.:.|   :|.|| |::.
Zfish   598 SFSKRKKKTSKVKKSSSFEDTDTDQES--SSGASKAQAHHSRKKKTMKLSRA---LSDLV-YMKS 656

  Fly   609 IHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLF 673
            :....||:   :...:::||..|.:|..|::::|:.|:.:|:.|||||||:..|.|||||.||.|
Zfish   657 VGMPDFES---QGVTWQVSSMSETKAHQLIQQKPVPFMRFNQRQLSRVYPSPYRVDSSNFNPQPF 718

  Fly   674 WNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTVS 738
            |||||.|||||:|:....:|||...|..|...||:.||..:  .:...:|.||..:.|.:...:.
Zfish   719 WNAGCHLVALNYQSEGRVLQLNRAKFYCNGNCGYIQKPGCL--CEGSFNPVAEDPLPGRLKKQLI 781

  Fly   739 ITVLSGQFLTDKR----------ANTFVEVDMYGLPADTVRKKFRTKTVRDNGMNPLYDEEPFVF 793
            :.|:|||.|...:          .:.||||::.|||.|..::  :|:.|.|||.||:: ||..||
Zfish   782 LKVISGQQLPKPKDSMLGDRGEIIDPFVEVEIIGLPVDCCKE--QTRVVDDNGFNPMW-EETLVF 843

  Fly   794 KKVVLPELASIRIAAYEE---GGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIALASLFLCVVVK 855
             .:.:||.|.||...::.   |...||.|.:....:.||||||.|     :.:..||:|:.|.| 
Zfish   844 -TLHMPENALIRFLVWDHDPIGQDFIGQRTIAFNSMIPGYRHVYL-----EGMEEASIFVHVAV- 901

  Fly   856 DYVPDDLSNFAEALANPIKYQSELEKRDIQLSVLTDEAEALGSADEDLSKSFVFVQVGGQKKELR 920
                :|:::.|.|::. ||   .|..|:.:.:.|...|.||      |::...|   |...  ||
Zfish   902 ----NDITSKARAVSG-IK---GLFHRNPKQASLDSHAAAL------LNRKSTF---GAHL--LR 947

  Fly   921 PVESLATSPKHRPSISAA-AAMSVDVTVDRTDGGRGEDSISIVAPSIQHQHSLDQSVSTSIRQVE 984
            ...|..|  |.:|.:... ..:|:| |.|.:..|..|:..|...|.:.|..  |.:.:.|..|..
Zfish   948 RTASAPT--KGQPKVKRGFPEISID-TKDCSSDGASEERESEEGPLVHHNG--DTASAKSWGQGT 1007

  Fly   985 SSQFDVDLVLAEPLEKILDHKSVKEKRLEMEKKLESLRKKHDKEKIKIAGQKSSPLEGKKPKFAI 1049
            :.|.               |...:::..|::....||... ..|.|....|::||          
Zfish  1008 NGQL---------------HPDDRKENSEVQSPTPSLNAS-CLESITENFQENSP---------- 1046

  Fly  1050 TNKLVKRLSNKSLNCLSPHSEPGVEIPACPLDLGDSSEESA--AADAGEDLA------------- 1099
                  ..|.:|....|||         |||    ||..:|  |:..||:|:             
Zfish  1047 ------STSTQSPVDTSPH---------CPL----SSPSTAITASSNGENLSPVKNNEDILKSFA 1092

  Fly  1100 ---------GGSSSLDGRTQESRLRSACREYTSQYRELQEKYHEAIYSAAEKVLKTSQTGQTKQL 1155
                     .|:|.::.....:.|...|...|.      ..:|.|....|::.: .:|||.|.::
Zfish  1093 LTQSTSGKDSGNSPVNSSISTNYLDIGCDTPTF------PTFHRADGEVAQETV-INQTGLTLEI 1150

  Fly  1156 KASLDKVTGEVMHQLQEARRNEVKNLATVHRDRDELIRMKREVASSVVERGVAERVRLKQTFDRR 1220
            .|      |:....:|.::|.:.                                  ||..||| 
Zfish  1151 DA------GKEPTAIQSSQRIQA----------------------------------LKAVFDR- 1174

  Fly  1221 TDELQKQHDSVRNALAEHRSKARQILDKEAESRSCV-------SSNGFLVLFHGPHHHGCTGSGS 1278
             |..:.....:|..:...:|:.:.   |:|:..|.|       :.|..|.....|..|..:.|.|
Zfish  1175 -DIGRSMQTGLRTPVRRSKSEGQM---KKADGPSVVPEVCTDATLNDRLWSKLDPSSHRDSVSSS 1235

  Fly  1279 SALSGNNLTLNLD-----------AGAAGSHS--AISPAKSHNSIAA 1312
            |::|.|:..::|.           ..||..:|  ..|...:|.|:.|
Zfish  1236 SSISSNDTVIDLSLPNLSRKSLTCLSAARDYSDKQASLTNNHRSVIA 1282

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Plc21CNP_995605.1 PH_PLC_beta 20..145 CDD:270167 29/128 (23%)
EFh_PI-PLC21 151..305 CDD:320043 31/163 (19%)
EF-hand motif 151..180 CDD:320043 4/30 (13%)
EF-hand motif 187..216 CDD:320043 9/36 (25%)
EF-hand motif 225..255 CDD:320043 4/29 (14%)
EF-hand motif 272..305 CDD:320043 10/32 (31%)
PI-PLCc_beta 317..702 CDD:176533 149/431 (35%)
C2_PLC_like 736..855 CDD:175974 44/131 (34%)
PTZ00121 <981..>1253 CDD:173412 52/295 (18%)
plch2aNP_001334621.1 PH_PLC_eta 63..169 CDD:270170 25/114 (22%)
EFh_PI-PLCeta2 187..327 CDD:320051 32/165 (19%)
EF-hand motif 187..216 CDD:320051 5/43 (12%)
EF-hand motif 223..253 CDD:320051 7/29 (24%)
EF-hand motif 257..285 CDD:320051 4/29 (14%)
EF-hand motif 294..327 CDD:320051 10/32 (31%)
PI-PLCc_GDPD_SF 339..747 CDD:472694 149/431 (35%)
C2_PLC_like 777..901 CDD:175974 44/132 (33%)

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