Protein Alignment Plc21C and plcb1l

DIOPT Version :10

• Sequence 1: NP_995605.1
• Gene: Plc21C / 33204
• FlyBaseID: FBgn0004611
• Length: 1318
• Species: Drosophila melanogaster
• Sequence 2: XP_073789961.1
• Gene: plcb1l / 100149080
• ZFINID: ZDB-GENE-121210-1
• Length: 1199
• Species: Danio rerio
• Alignment Length: 1270
• Identity: 528/1270 - (41%)
• Similarity: 730/1270 - (57%)
• Gaps: 168/1270 - (13%)

  Fly    16 VPQALQDGEKFIRWDDDSGTGTPVTMRVDAKGFFLYWVDQNNELDILDIATIRDVRTGQYAKRPK 80
            ||:.|..||||::||||..:|||||:.||.:|::|||.|||.|.|:|||:.|:|.|||::||.|:
Zfish    18 VPERLSTGEKFMKWDDDCTSGTPVTLYVDPQGYYLYWTDQNKETDLLDISLIKDTRTGRFAKTPR 82

  Fly    81 DNKLRQIVTLGP-QDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDGLIKLAYSLAQLNG 144
            |.:||:.:.:|. |..:|::.:||..|||.||::|:|||....|:|:.|...|..||.:|...|.
Zfish    83 DVRLREQLDVGALQGQMEDRLLTVVCGSDMVNISFLNFCAFHEDVAKEWAKELFTLASNLLAQNL 147

  Fly   145 SAIMFLQKAHTKLCLQVDKSGRIPVKNIIKLFAQNKEDRKRVEKALDVTGLPSGKVDSISVSKFQ 209
            |....|:|.:::|.||:...|.||||||..|.   ..||:|||.||:|..||:|:.|||.:..|.
Zfish   148 SRESSLEKVYSRLTLQLTTWGSIPVKNIFPLL---PADRRRVESALEVCSLPTGRNDSIPLDTFT 209

  Fly   210 FEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDPRLNEILYPYANPARAK 274
            .:.:..|...:..|::::.:| |.:|...|..:::.|:.:|||..|||.||||||||:....:.:
Zfish   210 QDVYRQLLNNICPRNDIDTIF-SDIGAKSRPYLTVEQMTDFLNNKQRDSRLNEILYPHLKAEQVQ 273

  Fly   275 ELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHNTYLTG 339
            .|:::|||:...:.:||:|::||.|||.|::|.|:.|.||||.:|:.||:|||||||||||||..
Zfish   274 ALVEKYEPDSMLSSRGQISVEGFARYLSGEENCIIPPEKLDLSEDITQPLSHYFINSSHNTYLIA 338

  Fly   340 HQLTGKSSVEIYRQCLLAGCRCVELDFWNGRT--EEPVIVHGYTFVPEIFAKDVLEAIAESAFKT 402
            .||.|.||||||||.||:||||||||.|.|:.  |||:|.||:|...||..|||:|||||:||||
Zfish   339 GQLAGTSSVEIYRQVLLSGCRCVELDVWKGKAPDEEPIITHGFTMTTEISFKDVIEAIAETAFKT 403

  Fly   403 SEYPVILSFENHC-NPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPPPAMLRRKIIIKNK 466
            |:.|||||||||. :|:||||:|.|||:||||.||..||:.:|||..:.||.||.|..||:||||
Zfish   404 SQLPVILSFENHVDSPKQQAKMAEYCRKIFGDALLIDPLEKYPLEAGVPLPSPAELMGKILIKNK 468

  Fly   467 KKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQVGLSASHEDGGVTRSTANGDVATGT 531
            |..|.             ...:...:||...|....:.:....||    |.:.:..|:.|.|
Zfish   469 KSSHK-------------ADGSTRKRLTEQTSCSDSSCEPSSPSA----GSLHQEMADSDAA--- 513

  Fly   532 GTGSAAGTAGHAPPLQQIRQSSKDSTGSSDSDSSSE------DESLPNTTPNLPSGNEPPPEKAQ 590
                            :.|..:..|||||..|...|      |||..:|...          .|.
Zfish   514 ----------------ERRLKTMKSTGSSSEDRGEEELEDDNDESKKSTDEG----------SAA 552

  Fly   591 KETEAGAEISALVNYVQPIHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSR 655
            .|..|..|:|.|||||||:.|::||..:|.||.||||||.|.:|..||||.|:||:.|||.||||
Zfish   553 NEAFATEEMSNLVNYVQPVKFTNFETCKKVNRSYEMSSFVETKAMDLLKESPVEFIEYNKLQLSR 617

  Fly   656 VYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRR 720
            :||.|||.||||:.||:||||||||||||||||||.||||||:||||.|.||.||||||||.|::
Zfish   618 IYPKGTRVDSSNYNPQVFWNAGCQLVALNFQTLDLPMQLNLGVFEYNGRCGYRLKPEFMRRMDKQ 682

  Fly   721 LDPFAESTVDGIIAGTVSITVLSGQFLTDKRANTFVEVDMYGLPADTVRKKFRTKTVRDNGMNPL 785
            .|||.:||||||||.|:|:.::|||||::||...:|||:|.|||.||..|.||||:.:.|.:||:
Zfish   683 FDPFTQSTVDGIIAHTLSLKIISGQFLSEKRVGVYVEVEMIGLPVDTRWKAFRTKSSQGNAINPV 747

  Fly   786 YDEEPFVFKKVVLPELASIRIAAYEEGGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIALASLFL 850
            :||||.:||:||||.|||:||.|||:.|:.||||::||..:.||||:::||:|..|.:.|.|:|:
Zfish   748 WDEEPMIFKRVVLPTLASLRITAYEDNGRCIGHRIIPVCAIRPGYRYISLRNERNQTLTLPSIFI 812

  Fly   851 CVVVKDYVPDDLSNFAEALANPIKYQSELEKRDIQLSVLTDEAEALGSADEDLSKSFVFVQVGGQ 915
            ...|||||||..::..|||:|||.|.:.:|:|..||:|||.| |.....|.|        ||.|
Zfish   813 YSEVKDYVPDTYADVIEALSNPIHYVNLMEQRSHQLAVLTQE-EGEMETDGD--------QVNG- 867

  Fly   916 KKELRPVESLATSPKHRPSISAAAAMSVDVTVDRTDGGRGEDSISIVAPSIQ-HQHSLDQSVSTS 979
                 .|||::                   .|..::.|...:|:| ...|:| ||......|..:
Zfish   868 -----GVESVS-------------------EVKTSENGLNHNSLS-PRSSVQIHQTPSSGPVKPT 907

  Fly   980 IRQVESSQFDVDLVLAEPLEKILDHKSVKEKRLEMEKKLESLRKKHDKEKIKI-----AGQKSSP 1039
            .:....:|..:..|.|:.:|::...|:...::.:..|:|:.|.|||.|:..::     |.||...
Zfish   908 AKSESVTQSALAEVQAQSVEELKQKKAFTRQQKKQYKELKDLMKKHHKQTSELISEHAARQKQLH 972

  Fly  1040 LEGKKPKFAITNKLVKRLSNKSLNCLSPHSEPGVEIPACPLDLGDSSEESAAADAGEDLAGGSSS 1104
            .|..:.:.|:         .|:.:.||.             |.....:||:..          |.
Zfish   973 SEFLRQRVAL---------QKTRSVLSQ-------------DAALQQQESSRL----------SE 1005

  Fly  1105 LDGRTQESRLRSACREYTSQYRELQEKY----H-----EAIYSAAE-------KVLKTSQTGQTK 1153
            |..:.|:..|:....:|      .:|||    |     |.:.|.||       |.||.....::|
Zfish  1006 LKEQQQQMLLKLRQEQY------YKEKYCKQEHAKQLVEKLVSVAEHCQSNQLKKLKELSEKESK 1064

  Fly  1154 QLKASLDKVTGEVMHQLQEARRNEVKNLATVHRDRDELIRMKREVASSVVERGVAERVRLKQTFD 1218
            .||..:||...|   :|.|||. :.|.|..         ..|.|:..:.|...|....||:...:
Zfish  1065 DLKKKMDKQRQE---KLNEARA-QGKTLTE---------ETKMEMDKAHVNEVVQAVHRLQGAQN 1116

  Fly  1219 RRTDELQKQHDSVRNALAEHRSKARQILDKEAESR 1253
            .|.:.|||:|:.::..:.|.:.|.:..||:|.:.:
Zfish  1117 TRLESLQKKHEEIKQQILEEKVKLQTQLDQEYQDK 1151

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	61/125 (49%)
		EFh_PI-PLC21	151..305	CDD:320043	61/153 (40%)
		EF-hand motif	151..180	CDD:320043	12/28 (43%)
		EF-hand motif	187..216	CDD:320043	11/28 (39%)
		EF-hand motif	225..255	CDD:320043	8/29 (28%)
		EF-hand motif	272..305	CDD:320043	13/32 (41%)
		PI-PLCc_beta	317..702	CDD:176533	201/393 (51%)
		C2_PLC_like	736..855	CDD:175974	62/118 (53%)
		PTZ00121	<981..>1253	CDD:173412	67/292 (23%)
plcb1l	XP_073789961.1	None