Protein Alignment kis and chd3

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: XP_009301392.1
• Gene: chd3 / 568230
• ZFINID: ZDB-GENE-121031-4
• Length: 2101
• Species: Danio rerio
• Alignment Length: 2445
• Identity: 624/2445 - (25%)
• Similarity: 928/2445 - (37%)
• Gaps: 728/2445 - (29%)

  Fly  1360 EDGAEQTGEGSEVED---------------NKPLVPKAGSADGEAETTSGGTGVD-GESPDYDDI 1408
            ::|.....||.:.::               |.|..|:..:|....:     .|.| ||:.|.|::
Zfish    11 DEGTAVNSEGGDFDEEEEDDGDLDENASDINSPAAPRETAARAAPD-----DGDDIGEASDRDNL 70

  Fly  1409 PVSKIPRGSNEDEKEAEAGDETVDSVPDSAGDPASTPSR--------RDRKRSTARSRRNANSEE 1465
              .|..||..: :||.:..|:      :..|..|....|        ||.:...|.:..:|.|:.
Zfish    71 --GKKKRGPKK-KKETKKKDK------EKEGKIAKARKRKKIESDIERDSEPDYAMNSDSAASDY 126

  Fly  1466 GGSARKNRGSLSAKALKKRRNRGRIVPESDGEDDTLDRTPPPSPPPDSEMDSNKRRSSRNTQRKK 1530
            ||..:|.:.....|..|.::.:      .:.||.|.:.|..|     .||     ::|....|:.
Zfish   127 GGEKKKKKKHKDKKEKKTKKKK------KEDEDSTHEETTKP-----VEM-----KTSAQLAREW 175

  Fly  1531 YIDDVMLRFSDDENSLLV--------ASPVKKDKKPSANASNSNAGSDVEKTEPQSGAEGDAAQE 1587
            .::||...|::::...|.        ..|:...|.|..               |.|........:
Zfish   176 GLEDVDHTFTEEDYRTLTNYKAFSQFLRPMIAKKNPKI---------------PMSKMMTILGAK 225

  Fly  1588 VGEEKSNLPLDESSQLEASSSTSAVAEKERQISTDAANAAMSSKPNYVYINTGDEDSMVVQLVLA 1652
            ..|..||.|...|:...|:::.:|.|....|:|  ||.|:....|.
Zfish   226 WREFSSNNPFKGSAAAVAAAAAAAAAAVAEQVS--AATASPEPPPQ------------------- 269

  Fly  1653 MRMGKRELILDKPKE-KAPEPKQDEEKSELDEATTDKPE------------GDEKFKTEGESKKD 1704
                ...|...|.|| |.|..|:..:...:.:....||:            |:::.|:....:.|
Zfish   270 ----PPPLRKAKTKEGKGPGYKKRSKSPRVSDKKKPKPKKMAPLRIKLGAIGNKRKKSSSSEEVD 330

  Fly  1705 LTDSEE--TKLESSAMEVDS------KEESEPDDSKKSDEDNKDKDKMEVDD------------- 1748
            ..|||:  :.:.||::..||      .:...|...||....::|.|..|.|.
Zfish   331 EDDSEQENSSVHSSSVRSDSSGRVKKNKRGRPAKKKKKALGDEDGDGYETDHQDYCEVCQQGGEI 395

  Fly  1749 -------------------EVGKSDKESKPEEQSETVKTEENSKAIEEDKSSTVLTADHAKEPET 1794
                               |.....|.|.|..:.|.::.|                   |||
Zfish   396 ILCDTCPRAYHLVCLEPELEKAPEGKWSCPHCEKEGIQWE-------------------AKE--- 438

  Fly  1795 VLEKMEVDEKANDDQSAVSKAEGSDEKSTD-----------------DSNPEEATTE-------- 1834
              |..|..|:..||...|....|.:|:..|                 ||.|......
Zfish   439 --EDFEEFEEECDDVRDVESGLGGEEEEDDHMEFCRVCKDGGELLCCDSCPSSYHIHCLNPPLPE 501

  Fly  1835 -KNKESL-------EIEGEKERV---KEGEE----SVKKENDEKTEA----DMENKPEPVFIDVE 1880
             .|.|.|       .|:|..:::   :.||.    .|....|...:|    .|:.:||      .
Zfish   502 IPNGEWLCPRCTCPPIKGRVQKILHWRWGEPPPPVPVPPPPDAPPDAPPPPPMKGRPE------R 560

  Fly  1881 EYFVKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQLNIFENIEDEPFNQDF------ 1939
            |:|||....||.||.|.||.:|   :...:...|.:|:|...         |||.:.|:
Zfish   561 EFFVKLTAQSYWHCTWITELQL---EIFHSVMFRNYQRKTDM---------DEPPSLDYGSGGEE 613

  Fly  1940 ----TEVDRVLD-------------------MSVH---TDETSGETTKHYLVKWKSLPYEDCTWE 1978
                :|..|..|                   |.||   ......:...||||||:.|.|:.||||
Zfish   614 DSGKSEKRRAKDPQYAILEEKYYRYGIKPEWMMVHRIINHSVDKKGNYHYLVKWRDLTYDQCTWE 678

  Fly  1979 LEE-DVDNDKIEQ--YLRFNKI-----PQRSEWKSKKR---------PHPELWKKLEKTP--VYK 2024
            .:| |:....:.:  |.|..:.     |::.. |.::|         |..:...|.|:.|  |.:
Zfish   679 RDELDIPEFALHKTAYWRHREAVMKEDPEKPR-KMRRREENDEAPSTPVNDPTIKYEEQPEFVTE 742

  Fly  2025 GGNSLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQSLTFVHSVYEYG-IRGPFLVIAPLST 2088
            .|.:|..|||||||||:|||....:.|||||||||||||::.|::|:::.| .:|||||.|||||
Zfish   743 TGGTLHLYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLFKEGHTKGPFLVSAPLST 807

  Fly  2089 IPNWQREFEGWT-DMNVVVYHGSVTSKQMIQDYEYYYKTESGKVLKE--------PIKFNVLITT 2144
            |.||:||||.|. |..||.|.|...|:.:|::.|:.:...:.|..|:        ||||:||:|:
Zfish   808 IINWEREFEMWAPDFYVVTYTGDKDSRAIIRENEFTFDDTAVKGGKKAFKLRREAPIKFHVLLTS 872

  Fly  2145 FEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNISELFSLL 2209
            :|::..|...||:.:|...|:||||||||...|....|....::|::||:|||||||:.|||.||
Zfish   873 YELVTIDQNVLKSIDWACLVVDEAHRLKNNQSKFFRRLNDYKIDHKLLLTGTPLQNNLEELFHLL 937

  Fly  2210 NFLEPSQFSSQEEFMSEFGSLRTEEEVNKLQALLKPMMLRRLKDDVEKSLAPKEETIIEVELTNI 2274
            |||.|::|::.|.|:.||..:..|:::.||..||.|.||||||.||.|::..|.|.|:.|||:.:
Zfish   938 NFLTPNRFNNLEGFLEEFADISKEDQIKKLHDLLGPHMLRRLKADVFKNMPAKTELIVRVELSPM 1002

  Fly  2275 QKKYYRGILEQNFSFL-KKGTTSANIPNLMNTMMELRKCCIHPYLLNGAEEQIQYDFKSQHGEDP 2338
            |||||:.||.:||..| .||  ..|..:|:|.||:|:|||.||||...|        .::..:.|
Zfish  1003 QKKYYKFILTRNFEALNSKG--GGNQVSLLNIMMDLKKCCNHPYLFPVA--------AAEAPKTP 1057

  Fly  2339 ESYYK--NLILSAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYPFERIDGRIR 2401
            ...|:  .|..::||::|:.|:|.|||..|||||:||||.:.||:|||:|....|.:|||||.|.
Zfish  1058 SGAYEGVGLTKASGKLMLLQKMLRKLKEQGHRVLVFSQMTKMLDLLEDFLDSEGYKYERIDGGIT 1122

  Fly  2402 GNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQR 2466
            |.||||||||::.||:.:|.|||.|:||||||||..||||||:||||||.||:||.:|.|||||.
Zfish  1123 GALRQEAIDRFNAPGAVQFCFLLSTRAGGLGINLATADTVIIFDSDWNPHNDIQAFSRAHRIGQA 1187

  Fly  2467 KMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGSKDGNNKQLSKKEIEDLLKKGAYGA 2531
            ..|.|||.:.|.:.|..:...|..|:.|...|::.  ..|||.|:   :||:|::|:||.|....
Zfish  1188 NKVMIYRFVTRASVEERITQVAKRKMMLTHLVVRP--GLGSKAGS---MSKQELDDILKFGTEEL 1247

  Fly  2532 VMDDDNAGDKFCEEDIDSI---------LKRRTQVITMES------EKGSTFSKASFAASGNRSD 2581
            ..|:..|||. .::|:..|         |..|:|..|.:|      |..|:|..|.:..   :.|
Zfish  1248 FKDEIEAGDN-KDDDMSVIHYDNAAIERLLDRSQDATDDSDMQNMNEYLSSFKVAQYTV---KED 1308

  Fly  2582 ITID-------------DPDFWTKWAKKVDIDPDACERDETEDLV--LSEPRR-RTQIK------ 2624
            ..|:             |||:|.|..:.       ....:.|||.  |.:.:| |.|:.
Zfish  1309 DKIEEIEREIIKQEENVDPDYWEKLLRH-------HYEQQQEDLARNLGKGKRVRKQVNYNDAAQ 1366

  Fly  2625 --RYGHEDVMELNSEES-SNENSDEEGGIGLRSRRRKEKRDRAREKKGNDEYIPRERDALAALG- 2685
              :..|.|:.:..||.| .:|..||:  ...|...|::.|.:.|.:|  |:.:|   ..||.:|
Zfish  1367 EDQEWHADISDNQSEYSVGSEEEDED--FDERPEGRRQSRRQLRNEK--DKPLP---PLLARVGG 1424

  Fly  2686 -LEEIQYGNWAKSECFKVEKGLLS--FGWGRWSELLELGQFKRGWRDVDVEDCARIILLYCLQVY 2747
             :|.:.:..       :..|..|:  ..||..::    ..|...|...|:..
Zfish  1425 NIEVLGFNT-------RQRKAFLNAIMRWGMPAQ----DAFSSQWLVRDLRG------------- 1465

  Fly  2748 KGDEKIKT----FIWDLITPTEDGEVQKISRDHSGLHNLVPRGRNGGKSNKESTGVSTPAPGSAS 2808
            |.:::.|.    |:..|..|..||
Zfish  1466 KSEKEFKAYVSLFMRHLCEPVADG----------------------------------------- 1489

  Fly  2809 GSNSGNTTPAHKSSALDGSDKDSGGINASAVAAAVTSIHDPNHWSKKEKYDADAYLEGAYKKHLG 2873
                                                               ::.:.:|..::.|.
Zfish  1490 ---------------------------------------------------SETFADGVPREGLC 1503

  Fly  2874 RHANKVLLRVRMLYYIQHEVIGDFVQQIKDNTPISELPIRPPPTPDQVPSSWWNPICCDKSLLVG 2938
            |  ..||.|:.::..::.:| .:| :.|.....:.||  :|..|.|...||
Zfish  1504 R--QPVLTRIGVMSLVKKKV-QEF-EHINGKWSMPEL--KPEITVDSKKSS-------------- 1548

  Fly  2939 TYKHGCEMYRQMRADPNLCFVTHVGAGAAGDDLAVTSLPINEDDANSKHDDGDEVDDDGTTTTKD 3003
                       ..:.|.:           ..|.....|..|.....||.......|       |.
Zfish  1549 -----------RASSPTI-----------KTDTPTPELSCNNTPCTSKPATPSPPD-------KT 1584

  Fly  3004 SDSTKLTGGDNKDSLLDPER--------PSSSGKSSSENASGGNDKTESENDATTVSESSYKSEV 3060
            ..|.|....|..:||.:|||        .:..|:|......|.....|.|.|..| ||.|..||.
Zfish  1585 EKSAKEAEKDEAESLTEPEREREKEKAKEAKEGESVESTEHGEATGNEGEKDPIT-SEKSQTSES 1648

  Fly  3061 LPGKGSDLDVSVAQQDALSATPELANTSDPKMNKNDAQVSASVSCDPADSSSPEAAGKAQGTGVQ 3125
            .....|| |....:...:|.:|........|..:.:.:.....:..|:||.|.:...|....|.:
Zfish  1649 PAAAASD-DSKTKENPDISQSPPKEKNEKEKQEEEEGKEKEPSTEKPSDSPSVKEESKEALKGDK 1712

  Fly  3126 TGDAGE--------------------LDIESEKKDNEKETKESTGDAPAVEAKKDSAAIAR---- 3166
            ...|||                    ||..||.|..|.:.:...|....|:.::....|:|
Zfish  1713 KEKAGEEKEKTEASSPPSETTEKKDKLDQSSEVKKEEVKGERDAGKEVRVQREEVPKVISRPAER 1777

  Fly  3167 -------AEGDKTESCT---NNATTNISTTTTT-----------------------TTITNTT-- 3196
                   |:|..||..|   |.....||:....                       ..|.|..
Zfish  1778 PRFMFNIADGGFTELHTLWQNEERAAISSGKINEIWHRRHDFWLLSGIVCHGYARWQDIQNDPQF 1842

  Fly  3197 TTTNNPSSKAANSNN----------------------------------TTD--H---------- 3215
            ...|.|....||..|                                  |.|  |
Zfish  1843 AIINEPFKTQANKGNFLEMKNKFLARRFKLLEQALVIEEQLRRAAYLNMTQDPTHPAMALNARFA 1907

  Fly  3216 -----ANSNSHLGLDEEESVAGSYPPTVAAVEDATTMWPSMQDLNTRLRRVITAYQRNYKKEELK 3275
                 |.|:.||   .:||:||:.|                  .|..|.:|:.      :.|||.
Zfish  1908 EVECLAESHQHL---SKESLAGNKP------------------ANAVLHKVLN------QLEELL 1945

  Fly  3276 LQQKA---KLQALVSSTPPLSVPTTPTLQSMQMQLQSGSGSGGSGIGSSAQHDASGRSLQALMQS 3337
            ...||   :|.|.:|..||:    |..||..:..:.|...:.|:...:........   .|..|:
Zfish  1946 SDMKADVTRLPATLSRVPPI----TARLQMSERSILSRLANKGNETHTPPPIPPGP---YATPQN 2003

  Fly  3338 QGASTSAAAAAAASSAGGSCSGSGQVGMGGAGVMPAMPTAADISLMLSILNTTDVNQLANLDINK 3402
            .|...:.|.:||.:.||.:.|              .||..:.||...|.|.|.:.:.|....:..
Zfish  2004 FGPPFTPAPSAALALAGANYS--------------QMPPGSFISEAPSCLKTKEHDVLQRQRVVD 2054

  Fly  3403 L-----AMYLVSMNNKMERQGKMELAAKERESQRLQLIPK 3437
            |     :...:....:|.:.....:..|.|.|..::.:|:
Zfish  2055 LWKDGKSEGTIGQELRMPKSTVHSIIVKYRLSNTVENLPR 2094

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171	34/163 (21%)
		PTZ00121	<1419..1923	CDD:173412	123/616 (20%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	21/74 (28%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	23/92 (25%)
		PLN03142	2029..>2606	CDD:215601	273/617 (44%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
chd3	XP_009301392.1	CHDNT	181..234	CDD:462357	10/67 (15%)
		PHD1_CHD_II	385..427	CDD:277006	4/41 (10%)
		PHD2_CHD_II	470..512	CDD:277007	6/41 (15%)
		CD1_tandem_CHD3-4_like	518..595	CDD:349314	22/85 (26%)
		CD2_tandem_CHD3-4_like	642..696	CDD:349309	18/53 (34%)
		PLN03142	736..>1299	CDD:215601	267/578 (46%)
		DEXHc_CHD3	747..978	CDD:350813	112/230 (49%)
		DUF1087	<1326..1369	CDD:461922	12/49 (24%)
		CHDII_SANT-like	1397..1536	CDD:461920	33/263 (13%)
		CHDCT2	1810..1955	CDD:462358	27/171 (16%)