Protein Alignment kis and Chd1

DIOPT Version :10

• Sequence 1: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Sequence 2: NP_001245851.1
• Gene: Chd1 / 33505
• FlyBaseID: FBgn0250786
• Length: 1900
• Species: Drosophila melanogaster
• Alignment Length: 2269
• Identity: 554/2269 - (24%)
• Similarity: 861/2269 - (37%)
• Gaps: 729/2269 - (32%)

  Fly  1325 PKAKKPKDPNDPNSTETPAAVKKRAGASKRRKQYGEDGAEQTGEGSEVEDNKPLVPKAGSADGEA 1389
            |...|..||......|:..::             |.|..:.|.|.:...|:      :||..|
  Fly     9 PDKSKQFDPGCRALNESANSI-------------GSDEQDDTREEANGTDH------SGSGSG-- 52

  Fly  1390 ETTSGGTGVDGESPDYDDIPVSKIPRGSNEDEKEAEAGDETVDSVPDSAGDPASTPSRRDRKRST 1454
               ||.:|.|.:|                             ||...::.|..|:|...|:..|.
  Fly    53 ---SGSSGSDSDS-----------------------------DSSSGNSSDGRSSPEPEDKSLSV 85

  Fly  1455 ARSRRNANSEEGGSARKNRGSLSAKALKKRRNRGRIVPESDGEDDTLDRTPPPSPPPDSEMDSNK 1519
            |.....|.:.:..|  |..|.                 ..|.||.:.|.:.......|:|..|::
  Fly    86 AGFPPTAAAAQADS--KTNGF-----------------TDDQEDSSSDGSSGSDSDSDAEGPSDQ 131

  Fly  1520 RRSSRNTQRKKYIDDVMLRFSDDENSLLVASPVKKDKKPSANASNSNAGSDVEKTEPQSGAEGDA 1584
            |..|.|                                      |:|..|.:.|  |:...|.|.
  Fly   132 RNQSIN--------------------------------------NANTSSSLPK--PEQNEEEDN 156

  Fly  1585 AQEVGEEKSNLPLDESSQLEASSSTSAVAEKERQISTDAANAAMSSKPNYVYINTGDEDSMVVQL 1649
            ..|.|:::   |..::|..|:|.|::.|:      .|.:::::...:.:|....|
  Fly   157 ETEAGQQQ---PASDASADESSDSSANVS------PTSSSSSSEEEEEDYRPKRT---------- 202

  Fly  1650 VLAMRMGKRELILDKPKEKAPEPKQDEEKSELDEATTDKPEGDEKFKTEGESKKDLTDSEETKLE 1714
                |..::.....:..:|||.||..::..:.|| :.:..:.|::..|..:.|...|.|     .
  Fly   203 ----RQARKPPTAAEKSKKAPAPKNKKKTWDSDE-SDESEDSDDEVSTAQKRKPAATTS-----R 257

  Fly  1715 SSAMEVDSKEESEPDDSKKSDEDNKDKDKMEVDDEVGKSDKESKPEEQSETVKTEENSKAIEEDK 1779
            |...:...:...:|..|:.||:|:..|...........|.||:..:|.:::    |:....|.|:
  Fly   258 SKLAQQQQRRRVKPFSSEDSDDDDASKRCATRRKGAAVSYKEASEDEATDS----EDLLEFEYDE 318

  Fly  1780 SSTVLTADHAKEPETVLEKMEVDEK----------ANDDQSAVSKAE--------GSDEKSTDDS 1826
            |....||..|:|.    ||.|..|:          ...:|:.:...|        |.|||.|.|:
  Fly   319 SQAATTAATAEEE----EKCETIERILAQRAGKRGCTGNQTTIYAIEENGFDPHAGFDEKQTPDA 379

  Fly  1827 NPEEATTEKNKESLEIEGEKERVKEGEESVKKENDEKTEADMENKPEPVFIDVEEYFVKYRNFSY 1891
                                                :|||              ::.:|::.:||
  Fly   380 ------------------------------------ETEA--------------QFLIKWKGWSY 394

  Fly  1892 LHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQ-----------LNIFE---NIEDEPFNQDFTEV 1942
            :|..|.:|..|.....:...|:..|.:|:.:|           ::.||   .::.| ..:.:..|
  Fly   395 IHNTWESEATLRDMKAKGMKKLDNFIKKEKEQAYWRRYAGPEDIDYFECQLELQHE-LLKSYNNV 458

  Fly  1943 DRVLDMSVHTDETSGETTKHYLVKWKSLPYEDCTWELEEDVDNDKIEQYLR----FNK------I 1997
            ||::......|    :.|:.||.||:||||.:.|||....|    :.::.|    ||.      .
  Fly   459 DRIIAKGSKPD----DGTEEYLCKWQSLPYAESTWEDAALV----LRKWQRCAEQFNDRESSKCT 515

  Fly  1998 PQRSEWKSKKRPHPELWKKLEKTPVY-KGGNSLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKT 2061
            |.|.....|.||.   :.:::..|.: ..|.:||.||::|||||..||...::.|||||||||||
  Fly   516 PSRHCRVIKYRPK---FSRIKNQPEFLSSGLTLRDYQMDGLNWLLHSWCKENSVILADEMGLGKT 577

  Fly  2062 IQSLTFVHSVYE-YGIRGPFLVIAPLSTIPNWQREFEGWT-DMNVVVYHGSVTSKQMIQDYEYYY 2124
            ||::.|::|::: :.:.||||.:.||||:..|||||:.|. |||||.|.|.:.|:::||.||:.:
  Fly   578 IQTICFLYSLFKIHHLYGPFLCVVPLSTMTAWQREFDLWAPDMNVVTYLGDIKSRELIQQYEWQF 642

  Fly  2125 KTESGKVLKEPIKFNVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLRQLNLEH 2189
              ||.|.|    |||.::||:|:::.|...|....|...::||||||||.:..|.:.|::.:..|
  Fly   643 --ESSKRL----KFNCILTTYEIVLKDKQFLGTLQWAALLVDEAHRLKNDDSLLYKSLKEFDTNH 701

  Fly  2190 RVLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSEFGSLRTEEEVNKLQALLKPMMLRRLKDD 2254
            |:|::||||||::.||::||:|:.|.:|.:.|.|..:.|:.. ::...:|...|:|.:|||:|.|
  Fly   702 RLLITGTPLQNSLKELWALLHFIMPDKFDTWENFEVQHGNAE-DKGYTRLHQQLEPYILRRVKKD 765

  Fly  2255 VEKSLAPKEETIIEVELTNIQKKYYRGILEQNFSFLKKGTTSANIPNLMNTMMELRKCCIHPYLL 2319
            |||||..|.|.|:.||:|::||:||:.||.:||..|:||...:. ...:|.::||:|||.|..|:
  Fly   766 VEKSLPAKVEQILRVEMTSLQKQYYKWILTKNFDALRKGKRGST-STFLNIVIELKKCCNHAALI 829

  Fly  2320 NGAEEQIQYDFKSQHGEDPESYYKNLILSAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLDILED 2384
            ..:|.::.       |...:...:.|:..:||:||:||||.:||..||||||||||||.||:|.|
  Fly   830 RPSEFELM-------GLQQDEALQTLLKGSGKLVLLDKLLCRLKETGHRVLIFSQMVRMLDVLAD 887

  Fly  2385 YLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWN 2449
            ||..|.:||:|:||.|:|.:|::|:|.::..||..|.|||.|:||||||||..||||||:|||||
  Fly   888 YLQKRHFPFQRLDGSIKGEMRRQALDHFNAEGSQDFCFLLSTRAGGLGINLATADTVIIFDSDWN 952

  Fly  2450 PQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQG----SKDG 2510
            ||||||||||.|||||:..|.||||:...:.|.::.::|..|:.||..|:|.|:|.|    .|.|
  Fly   953 PQNDLQAQARAHRIGQKNQVNIYRLVTARSVEEQIVERAKQKMVLDHLVIQRMDTTGRTVLDKSG 1017

  Fly  2511 -----NNKQLSKKEIEDLLKKGAYGAVMDD-DNAGDKFCEEDIDSILKRR--------------- 2554
                 |:...:|.::..:||.||.....|: ::..|..|  |||.||:|.
  Fly  1018 NGHSSNSNPFNKDDLSAILKFGAEELFKDEQEHDDDLVC--DIDEILRRAETRNEDPEMPADDLL 1080

  Fly  2555 -----TQVITMESEKGSTFSKASFAASGNRSDITIDDPDFWTKWAKKVDIDPDACER-------- 2606
                 ..:...|.|...:.||....|:|..     ||...|.      ||.|:...:
  Fly  1081 SAFKVASIAAFEEEPSDSVSKQDQNAAGEE-----DDSKDWD------DIIPEGFRKAIDDQERA 1134

  Fly  2607 DETEDLVLSEPRRRT-----QIKRYGHEDVMELNSEESSNENSDEE---GGIGLRSRRRKEKRDR 2663
            .|.|||.| .|||:|     :.||...:........:.|..:||.|   .|.|...|.||..|..
  Fly  1135 KEMEDLYL-PPRRKTAANQNEGKRGAGKGGKGKQQADDSGGDSDYELGSDGSGDDGRPRKRGRPT 1198

  Fly  2664 AREKKGNDEYIPRERDALAALGLEEIQYGNWAKSECFKVEKGLLSFGWGRWSELLELGQFKRGWR 2728
            .:||      |....||                                      ||.:|.|.::
  Fly  1199 MKEK------ITGFTDA--------------------------------------ELRRFIRSYK 1219

  Fly  2729 DVDVEDCARIILLYCLQVYKGDEKIKTFIWDLITPTEDGEVQKISRDHSGLHNLVPRGRNGGKSN 2793
            .....       |:.::....|.::           ::..:.::.|....||:...:..:..|..
  Fly  1220 KFPAP-------LHRMEAIACDAEL-----------QEKPLAELKRLGEMLHDRCVQFLHEHKEE 1266

  Fly  2794 KESTGVSTPAPGSASGSNSGNTTPAHKSSALDGSDKDSGGINASAVAAAVTSIHDPNHWSKKEKY 2858
            :..|..:...||            |.:..|........||::.:|
  Fly  1267 ESKTAATDETPG------------AKQRRARATFSVKLGGVSFNA-------------------- 1299

  Fly  2859 DADAYLEGAYKKHLGRHANKVLLRVRMLYYIQHEVIGDFVQQ-------IKDNTPISELPIRPPP 2916
                               |.||.........:|::....::       ||...|:.::.
  Fly  1300 -------------------KKLLACEQELQPLNEIMPSMPEERQQWSFNIKTRAPVFDVD----- 1340

  Fly  2917 TPDQVPSSWWNPICCDKSLLVGTYKHGCEMYRQMRADPNLCFVTHV------------------- 2962
                     |. |..|..||.|.|::|...:.||:.||.|.....:
  Fly  1341 ---------WG-IEEDTKLLCGIYQYGIGSWEQMKLDPTLKLTDKILLNDTRKPQAKQLQTRAEY 1395

  Fly  2963 ----------------------GAGAAGDDLAVTSLPINEDDANSKHDDGDEVDDDGTTTTKDSD 3005
                                  .|..|.|..|.:....:..||  |..||::...|..|..:.|:
  Fly  1396 LLKIIKKNVELTKGGQRRQRRPRASRANDAKAASQSASSTIDA--KPHDGEDAAGDARTVAESSN 1458

  Fly  3006 S--------------TKLTGGDNKDSLLDPERPSSSGKSSSENASGGNDKTESENDATTVSE--- 3053
            |              |:..|        ||.:.:...|:.|:..|..::........|..:|
  Fly  1459 SQVDPSTASPHNAPATEQHG--------DPAKKAKKSKARSKKTSASDNNGNKPMHFTANNEPRA 1515

  Fly  3054 ------------SSYKSEVLPGKGS-----DLDVSVAQQDALSATPE---------------LAN 3086
                        :..|.::.|.|.:     ..|||::.||.|..|.:               .|.
  Fly  1516 LEVLGDLDPSIFNECKEKMRPVKKALKALDQPDVSLSDQDQLQHTRDCLLQIGKQIDVCLNPYAE 1580

  Fly  3087 TSDPKMNKN------------------------------DAQVSASVSCDPADSSSPEAAGKAQG 3121
            |...:...|                              |.:....   |...|.||   .|::.
  Fly  1581 TEKKEWRSNLWYFVSKFTELDAKRLFKIYKHALKQKAGGDGEAKGK---DKGSSGSP---AKSKP 1639

  Fly  3122 TGVQTGD-AGELDIESEKKDNEKETKESTGDA---------------PAVEAKKD------SAAI 3164
            .||.|.: ..|.|....||..:.:.||.:|.|               |.::.|:|      |:.:
  Fly  1640 NGVTTEEKEKERDRSGGKKKKKDKDKERSGQARYPETGIPTSGRYADPPLKRKRDENDADASSGL 1704

  Fly  3165 ARAE----GDKTESCTNNATTNISTTTTTTTITNTTTTTNNPSSKAANSNNTTD---HANSNSHL 3222
            |.|.    ||..:|.                           |.|..|.:...|   |.....:.
  Fly  1705 AGAPGGGIGDNLKSM---------------------------SFKRLNMDRHEDRKKHHRGPDYY 1742

  Fly  3223 GLDEEESVAGSY--------------------------PPTVAAVEDATTMWPSMQDLNTRLRRV 3261
            |.......:|||                          ||..:...      |.|:...:|.|
  Fly  1743 GGSGPPMGSGSYEGGSNSRRQGPTSPSTPRTGRGGYDPPPAPSGYT------PEMERWQSRDR-- 1799

  Fly  3262 ITAYQRNYKKEELKLQQKAKLQALVSSTPPLSVPTTPTLQSMQMQLQSGSGSGGSGIGS 3320
               |.::||::.                                  ..|.|..|.|.||
  Fly  1800 ---YSQDYKRDR----------------------------------YDGYGRSGGGQGS 1821

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171	33/174 (19%)
		PTZ00121	<1419..1923	CDD:173412	97/521 (19%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	12/66 (18%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	18/61 (30%)
		PLN03142	2029..>2606	CDD:215601	259/608 (43%)
		PTZ00341	<3662..3887	CDD:173534
		BRK	4568..4611	CDD:462196
Chd1	NP_001245851.1	CD1_tandem_CHD1-2_like	339..421	CDD:349313	20/131 (15%)
		CD2_tandem	454..508	CDD:349306	19/61 (31%)
		PLN03142	531..>1066	CDD:215601	249/551 (45%)
		CDH1_2_SANT_HL1	1205..1298	CDD:465731	19/160 (12%)
		DUF4208	1521..1610	CDD:464035	13/88 (15%)