DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kis and Chd1

DIOPT Version :9

Sequence 1:	NP_001137761.1	Gene:	kis / 33185	FlyBaseID:	FBgn0266557	Length:	5517	Species:	Drosophila melanogaster
Sequence 2:	NP_001245851.1	Gene:	Chd1 / 33505	FlyBaseID:	FBgn0250786	Length:	1900	Species:	Drosophila melanogaster

Alignment Length:	2269	Identity:	554/2269 - (24%)
Similarity:	861/2269 - (37%)	Gaps:	729/2269 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1325 PKAKKPKDPNDPNSTETPAAVKKRAGASKRRKQYGEDGAEQTGEGSEVEDNKPLVPKAGSADGEA 1389
            |...|..||......|:..::             |.|..:.|.|.:...|:      :||..|
  Fly     9 PDKSKQFDPGCRALNESANSI-------------GSDEQDDTREEANGTDH------SGSGSG-- 52

  Fly  1390 ETTSGGTGVDGESPDYDDIPVSKIPRGSNEDEKEAEAGDETVDSVPDSAGDPASTPSRRDRKRST 1454
               ||.:|.|.:|                             ||...::.|..|:|...|:..|.
  Fly    53 ---SGSSGSDSDS-----------------------------DSSSGNSSDGRSSPEPEDKSLSV 85

  Fly  1455 ARSRRNANSEEGGSARKNRGSLSAKALKKRRNRGRIVPESDGEDDTLDRTPPPSPPPDSEMDSNK 1519
            |.....|.:.:..|  |..|.                 ..|.||.:.|.:.......|:|..|::
  Fly    86 AGFPPTAAAAQADS--KTNGF-----------------TDDQEDSSSDGSSGSDSDSDAEGPSDQ 131

  Fly  1520 RRSSRNTQRKKYIDDVMLRFSDDENSLLVASPVKKDKKPSANASNSNAGSDVEKTEPQSGAEGDA 1584
            |..|.|                                      |:|..|.:.|  |:...|.|.
  Fly   132 RNQSIN--------------------------------------NANTSSSLPK--PEQNEEEDN 156

  Fly  1585 AQEVGEEKSNLPLDESSQLEASSSTSAVAEKERQISTDAANAAMSSKPNYVYINTGDEDSMVVQL 1649
            ..|.|:::   |..::|..|:|.|::.|:      .|.:::::...:.:|....|
  Fly   157 ETEAGQQQ---PASDASADESSDSSANVS------PTSSSSSSEEEEEDYRPKRT---------- 202

  Fly  1650 VLAMRMGKRELILDKPKEKAPEPKQDEEKSELDEATTDKPEGDEKFKTEGESKKDLTDSEETKLE 1714
                |..::.....:..:|||.||..::..:.|| :.:..:.|::..|..:.|...|.|     .
  Fly   203 ----RQARKPPTAAEKSKKAPAPKNKKKTWDSDE-SDESEDSDDEVSTAQKRKPAATTS-----R 257

  Fly  1715 SSAMEVDSKEESEPDDSKKSDEDNKDKDKMEVDDEVGKSDKESKPEEQSETVKTEENSKAIEEDK 1779
            |...:...:...:|..|:.||:|:..|...........|.||:..:|.:::    |:....|.|:
  Fly   258 SKLAQQQQRRRVKPFSSEDSDDDDASKRCATRRKGAAVSYKEASEDEATDS----EDLLEFEYDE 318

  Fly  1780 SSTVLTADHAKEPETVLEKMEVDEK----------ANDDQSAVSKAE--------GSDEKSTDDS 1826
            |....||..|:|.    ||.|..|:          ...:|:.:...|        |.|||.|.|:
  Fly   319 SQAATTAATAEEE----EKCETIERILAQRAGKRGCTGNQTTIYAIEENGFDPHAGFDEKQTPDA 379

  Fly  1827 NPEEATTEKNKESLEIEGEKERVKEGEESVKKENDEKTEADMENKPEPVFIDVEEYFVKYRNFSY 1891
                                                :|||              ::.:|::.:||
  Fly   380 ------------------------------------ETEA--------------QFLIKWKGWSY 394

  Fly  1892 LHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQ-----------LNIFE---NIEDEPFNQDFTEV 1942
            :|..|.:|..|.....:...|:..|.:|:.:|           ::.||   .::.| ..:.:..|
  Fly   395 IHNTWESEATLRDMKAKGMKKLDNFIKKEKEQAYWRRYAGPEDIDYFECQLELQHE-LLKSYNNV 458

  Fly  1943 DRVLDMSVHTDETSGETTKHYLVKWKSLPYEDCTWELEEDVDNDKIEQYLR----FNK------I 1997
            ||::......|    :.|:.||.||:||||.:.|||....|    :.::.|    ||.      .
  Fly   459 DRIIAKGSKPD----DGTEEYLCKWQSLPYAESTWEDAALV----LRKWQRCAEQFNDRESSKCT 515

  Fly  1998 PQRSEWKSKKRPHPELWKKLEKTPVY-KGGNSLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKT 2061
            |.|.....|.||.   :.:::..|.: ..|.:||.||::|||||..||...::.|||||||||||
  Fly   516 PSRHCRVIKYRPK---FSRIKNQPEFLSSGLTLRDYQMDGLNWLLHSWCKENSVILADEMGLGKT 577

  Fly  2062 IQSLTFVHSVYE-YGIRGPFLVIAPLSTIPNWQREFEGWT-DMNVVVYHGSVTSKQMIQDYEYYY 2124
            ||::.|::|::: :.:.||||.:.||||:..|||||:.|. |||||.|.|.:.|:::||.||:.:
  Fly   578 IQTICFLYSLFKIHHLYGPFLCVVPLSTMTAWQREFDLWAPDMNVVTYLGDIKSRELIQQYEWQF 642

  Fly  2125 KTESGKVLKEPIKFNVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLRQLNLEH 2189
              ||.|.|    |||.::||:|:::.|...|....|...::||||||||.:..|.:.|::.:..|
  Fly   643 --ESSKRL----KFNCILTTYEIVLKDKQFLGTLQWAALLVDEAHRLKNDDSLLYKSLKEFDTNH 701

  Fly  2190 RVLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSEFGSLRTEEEVNKLQALLKPMMLRRLKDD 2254
            |:|::||||||::.||::||:|:.|.:|.:.|.|..:.|:.. ::...:|...|:|.:|||:|.|
  Fly   702 RLLITGTPLQNSLKELWALLHFIMPDKFDTWENFEVQHGNAE-DKGYTRLHQQLEPYILRRVKKD 765

  Fly  2255 VEKSLAPKEETIIEVELTNIQKKYYRGILEQNFSFLKKGTTSANIPNLMNTMMELRKCCIHPYLL 2319
            |||||..|.|.|:.||:|::||:||:.||.:||..|:||...:. ...:|.::||:|||.|..|:
  Fly   766 VEKSLPAKVEQILRVEMTSLQKQYYKWILTKNFDALRKGKRGST-STFLNIVIELKKCCNHAALI 829

  Fly  2320 NGAEEQIQYDFKSQHGEDPESYYKNLILSAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLDILED 2384
            ..:|.::.       |...:...:.|:..:||:||:||||.:||..||||||||||||.||:|.|
  Fly   830 RPSEFELM-------GLQQDEALQTLLKGSGKLVLLDKLLCRLKETGHRVLIFSQMVRMLDVLAD 887

  Fly  2385 YLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWN 2449
            ||..|.:||:|:||.|:|.:|::|:|.::..||..|.|||.|:||||||||..||||||:|||||
  Fly   888 YLQKRHFPFQRLDGSIKGEMRRQALDHFNAEGSQDFCFLLSTRAGGLGINLATADTVIIFDSDWN 952

  Fly  2450 PQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQG----SKDG 2510
            ||||||||||.|||||:..|.||||:...:.|.::.::|..|:.||..|:|.|:|.|    .|.|
  Fly   953 PQNDLQAQARAHRIGQKNQVNIYRLVTARSVEEQIVERAKQKMVLDHLVIQRMDTTGRTVLDKSG 1017

  Fly  2511 -----NNKQLSKKEIEDLLKKGAYGAVMDD-DNAGDKFCEEDIDSILKRR--------------- 2554
                 |:...:|.::..:||.||.....|: ::..|..|  |||.||:|.
  Fly  1018 NGHSSNSNPFNKDDLSAILKFGAEELFKDEQEHDDDLVC--DIDEILRRAETRNEDPEMPADDLL 1080

  Fly  2555 -----TQVITMESEKGSTFSKASFAASGNRSDITIDDPDFWTKWAKKVDIDPDACER-------- 2606
                 ..:...|.|...:.||....|:|..     ||...|.      ||.|:...:
  Fly  1081 SAFKVASIAAFEEEPSDSVSKQDQNAAGEE-----DDSKDWD------DIIPEGFRKAIDDQERA 1134

  Fly  2607 DETEDLVLSEPRRRT-----QIKRYGHEDVMELNSEESSNENSDEE---GGIGLRSRRRKEKRDR 2663
            .|.|||.| .|||:|     :.||...:........:.|..:||.|   .|.|...|.||..|..
  Fly  1135 KEMEDLYL-PPRRKTAANQNEGKRGAGKGGKGKQQADDSGGDSDYELGSDGSGDDGRPRKRGRPT 1198

  Fly  2664 AREKKGNDEYIPRERDALAALGLEEIQYGNWAKSECFKVEKGLLSFGWGRWSELLELGQFKRGWR 2728
            .:||      |....||                                      ||.:|.|.::
  Fly  1199 MKEK------ITGFTDA--------------------------------------ELRRFIRSYK 1219

  Fly  2729 DVDVEDCARIILLYCLQVYKGDEKIKTFIWDLITPTEDGEVQKISRDHSGLHNLVPRGRNGGKSN 2793
            .....       |:.::....|.::           ::..:.::.|....||:...:..:..|..
  Fly  1220 KFPAP-------LHRMEAIACDAEL-----------QEKPLAELKRLGEMLHDRCVQFLHEHKEE 1266

  Fly  2794 KESTGVSTPAPGSASGSNSGNTTPAHKSSALDGSDKDSGGINASAVAAAVTSIHDPNHWSKKEKY 2858
            :..|..:...||            |.:..|........||::.:|
  Fly  1267 ESKTAATDETPG------------AKQRRARATFSVKLGGVSFNA-------------------- 1299

  Fly  2859 DADAYLEGAYKKHLGRHANKVLLRVRMLYYIQHEVIGDFVQQ-------IKDNTPISELPIRPPP 2916
                               |.||.........:|::....::       ||...|:.::.
  Fly  1300 -------------------KKLLACEQELQPLNEIMPSMPEERQQWSFNIKTRAPVFDVD----- 1340

  Fly  2917 TPDQVPSSWWNPICCDKSLLVGTYKHGCEMYRQMRADPNLCFVTHV------------------- 2962
                     |. |..|..||.|.|::|...:.||:.||.|.....:
  Fly  1341 ---------WG-IEEDTKLLCGIYQYGIGSWEQMKLDPTLKLTDKILLNDTRKPQAKQLQTRAEY 1395

  Fly  2963 ----------------------GAGAAGDDLAVTSLPINEDDANSKHDDGDEVDDDGTTTTKDSD 3005
                                  .|..|.|..|.:....:..||  |..||::...|..|..:.|:
  Fly  1396 LLKIIKKNVELTKGGQRRQRRPRASRANDAKAASQSASSTIDA--KPHDGEDAAGDARTVAESSN 1458

  Fly  3006 S--------------TKLTGGDNKDSLLDPERPSSSGKSSSENASGGNDKTESENDATTVSE--- 3053
            |              |:..|        ||.:.:...|:.|:..|..::........|..:|
  Fly  1459 SQVDPSTASPHNAPATEQHG--------DPAKKAKKSKARSKKTSASDNNGNKPMHFTANNEPRA 1515

  Fly  3054 ------------SSYKSEVLPGKGS-----DLDVSVAQQDALSATPE---------------LAN 3086
                        :..|.::.|.|.:     ..|||::.||.|..|.:               .|.
  Fly  1516 LEVLGDLDPSIFNECKEKMRPVKKALKALDQPDVSLSDQDQLQHTRDCLLQIGKQIDVCLNPYAE 1580

  Fly  3087 TSDPKMNKN------------------------------DAQVSASVSCDPADSSSPEAAGKAQG 3121
            |...:...|                              |.:....   |...|.||   .|::.
  Fly  1581 TEKKEWRSNLWYFVSKFTELDAKRLFKIYKHALKQKAGGDGEAKGK---DKGSSGSP---AKSKP 1639

  Fly  3122 TGVQTGD-AGELDIESEKKDNEKETKESTGDA---------------PAVEAKKD------SAAI 3164
            .||.|.: ..|.|....||..:.:.||.:|.|               |.::.|:|      |:.:
  Fly  1640 NGVTTEEKEKERDRSGGKKKKKDKDKERSGQARYPETGIPTSGRYADPPLKRKRDENDADASSGL 1704

  Fly  3165 ARAE----GDKTESCTNNATTNISTTTTTTTITNTTTTTNNPSSKAANSNNTTD---HANSNSHL 3222
            |.|.    ||..:|.                           |.|..|.:...|   |.....:.
  Fly  1705 AGAPGGGIGDNLKSM---------------------------SFKRLNMDRHEDRKKHHRGPDYY 1742

  Fly  3223 GLDEEESVAGSY--------------------------PPTVAAVEDATTMWPSMQDLNTRLRRV 3261
            |.......:|||                          ||..:...      |.|:...:|.|
  Fly  1743 GGSGPPMGSGSYEGGSNSRRQGPTSPSTPRTGRGGYDPPPAPSGYT------PEMERWQSRDR-- 1799

  Fly  3262 ITAYQRNYKKEELKLQQKAKLQALVSSTPPLSVPTTPTLQSMQMQLQSGSGSGGSGIGS 3320
               |.::||::.                                  ..|.|..|.|.||
  Fly  1800 ---YSQDYKRDR----------------------------------YDGYGRSGGGQGS 1821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kis	NP_001137761.1	BASP1	1554..1786	CDD:283191	46/231 (20%)
		HepA	1676..2527	CDD:223627	318/904 (35%)
		SDA1	<1693..>1854	CDD:283052	35/178 (20%)
		CHROMO	<1879..1919	CDD:237991	9/39 (23%)
		Chromo	1941..1996	CDD:278797	19/58 (33%)
		DEXDc	2048..2197	CDD:238005	68/150 (45%)
		Helicase_C	2350..2464	CDD:278689	77/113 (68%)
		RR_TM4-6	3728..>3877	CDD:283990
		BRK	4569..4613	CDD:197800
Chd1	NP_001245851.1	CHROMO	374..422	CDD:237991	15/97 (15%)
		Chromo	458..509	CDD:278797	20/58 (34%)
		SNF2_N	548..829	CDD:278600	129/288 (45%)
		DEXDc	564..709	CDD:238005	68/150 (45%)
		Helicase_C	852..967	CDD:278689	77/114 (68%)
		DUF4208	1521..1610	CDD:290618	13/88 (15%)
		DUF3824	1795..>1894	CDD:289625	11/66 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467122
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	1	0.900	-	-		E2759_KOG0384
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45623
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.840