DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbc1d15-17 and RABGAP1L

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_001353375.1	Gene:	RABGAP1L / 9910	HGNCID:	24663	Length:	1051	Species:	Homo sapiens

Alignment Length:	856	Identity:	176/856 - (20%)
Similarity:	295/856 - (34%)	Gaps:	257/856 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 PQQGTGNILFTHDGVLLKKASAEHIADLNTSGSLSLVEYSRSIAEMPRR-------RLLLEWQPN 91
            |:..:...|...|.||..|.:  ::..:..|...:.||..|::|.|...       .|.:...|.
Human   115 PRPSSPGGLPEEDSVLFNKLT--YLGCMKVSSPRNEVEALRAMATMKSSSQYPFPVTLYVPNVPE 177

  Fly    92 DSIMIADDSQDQGDWALVDRIS-----------GRTRTT-SECRAFNTRPIEPSGGA-------- 136
            .|:.|.|.|.:      |:..|           |...|| |.|.||.    |.|.|:
Human   178 GSVRIIDQSSN------VEIASFPIYKVLFCARGHDGTTESNCFAFT----ESSHGSEEFQIHVF 232

  Fly   137 -----TTRSRVMRA----------QLEDLS----------------SVEVRH---RG-------Q 160
                 ...||::.:          |:.|:.                |:||:.   :|       .
Human   233 SCEIKEAVSRILYSFCTAFKRSSRQVSDVKDSVIPTPDSDVFTFSVSLEVKEDDGKGNFSPVPKD 297

  Fly   161 TIRFMRKGANGVHSEFFF---QHGNADLFV-----------RSMR--DQHLIENAETSRS-GGEV 208
            ..:|..|...|:..:...   |..|.:|.:           |:::  |.||::.....:| .|..
Human   298 RDKFYFKLKQGIEKKVVITVQQLSNKELAIERCFGMLLSPGRNVKNSDMHLLDMESMGKSYDGRA 362

  Fly   209 YAI-------------LTTENQKLKKTFAELDIGQIKASQLPRESWLPNKLAGILGNIP------ 254
            |.|             |..|..|.|:.:..:.:..:....:....:|   |..::...|
Human   363 YVITGMWNPNAPVFLALNEETPKDKQVYMTVAVDMVVTEVVEPVRFL---LETVVRVYPANERFW 424

  Fly   255 -----DYVQPPFQRSPKSR-PGVLISGDRQTSPDNYQIIGLSGSTNSACSSNGQSRGGSAEKSPA 313
                 .:.:..|.|..:|. .|...:||.     .|:::.|...::........|.||  ..||.
Human   425 YFSRKTFTETFFMRLKQSEGKGHTNAGDA-----IYEVVSLQRESDKEEPVTPTSGGG--PMSPQ 482

  Fly   314 DSELE-----TLNAQDEKIVNNLPDRQRVERGHPLTETQWLEFQTPDGRISDSARIKEL--IFRG 371
            |.|.|     .|::....:..:.|::.....|..|  .:|        ..:..||.|.|  :.:.
Human   483 DDEAEEESDNELSSGTGDVSKDCPEKILYSWGELL--GKW--------HSNLGARPKGLSTLVKS 537

  Fly   372 GVVQSLRPEVWKFLLNYYLWSDTHVERIERRKQKSIEYYNMKAQWLAMTTTQEANFCGYRERKCQ 436
            ||.::||.|||:.|...:            ..|..::.|.:      :.|...|       ::..
Human   538 GVPEALRAEVWQLLAGCH------------DNQAMLDRYRI------LITKDSA-------QESV 577

  Fly   437 IEKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILEIQVNEVDTFW 501
            |.:|:.||..:..:|..........|..|...|.:|:.|:||.||.| .||.:|.:.:.|...|.
Human   578 ITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQS-FLAAVLLLHMPEEQAFC 641

  Fly   502 CFV------GFMELVFTNFDIDQAGMKTQFAQIRRLIEFANAPLFNYMRSHDSD-----NMYFCF 555
            ..|      |..:|...||:    .:..:|.|:.||::.....|    .||.||     :|| ..
Human   642 VLVKIMYDYGLRDLYRNNFE----DLHCKFYQLERLMQEQLPDL----HSHFSDLNLEAHMY-AS 697

  Fly   556 RWLLVWYKRELNSEDVLKLWECLWTRLPCPNFHLLFSVAILDQET-----------------RVI 603
            :|.|..:..:.....|..:.:.|.    |...:::|.||:...:|                 ||.
Human   698 QWFLTLFTAKFPLCMVFHIIDLLL----CEGLNIIFHVALALLKTSKEDLLQADFEGALKFFRVQ 758

  Fly   604 IDSQYEFTEILKHVNELSGNIDV-QKTLQVAEGIYLQLKGSETLPNDIRSIIGEPL--------- 658
            :..:|...|..:.:.|.:.||.| .|.|:..|..|..::.|:....|       |:
Human   759 LPKRYRAEENARRLMEQACNIKVPTKKLKKYEKEYQTMRESQLQQED-------PMDRYKRENRR 816

  Fly   659 LPAAAG--EEIDGGMVDEEPT----------YSDDGFDELVKEL---------TPEEKVRQQ--- 699
            |..|:.  |:.:..:..|..|          .::|..|.|.|||         |.|||.:|:
Human   817 LQEASMRLEQENDDLAHELVTSKIALRNDLDQAEDKADVLNKELLLTKQRLVETEEEKRKQEEET 881

  Fly   700 ALLEEACERSL 710
            |.|:|...:.|
Human   882 AQLKEVFRKQL 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	44/235 (19%)
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	56/239 (23%)
RABGAP1L	NP_001353375.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52
		PTB_Rab6GAP	129..257	CDD:269922	29/139 (21%)
		DUF3694	290..421	CDD:315198	21/133 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	461..503		9/43 (21%)
		RabGAP-TBC	541..744	CDD:306939	55/241 (23%)
		DUF3084	800..>1018	CDD:331293	22/100 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810