DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbc1d15-17 and SGSM2

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_011522403.1	Gene:	SGSM2 / 9905	HGNCID:	29026	Length:	1103	Species:	Homo sapiens

Alignment Length:	885	Identity:	179/885 - (20%)
Similarity:	292/885 - (32%)	Gaps:	340/885 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LGVFNESQLSSVEED---------VQNLPQQGTGNILFTHDGVLLK-KASAEHIADLNTSGSLSL 69
            ||:.......|..||         |::|.|.....:|:..:.||:: |...|.:     .|.|||
Human   269 LGIRKRHSSGSASEDRLAACARECVESLHQNSRTRLLYGKNHVLVQPKEDMEAV-----PGYLSL 328

  Fly    70 VEYSRSIAEMPRRRLLLEWQPNDSI--MIADDSQDQG---DWALV------------DRISGRTR 117
            .:.:.|        |.|:|.||..:  .:.|...::.   |:|||            .:.||.|.
Human   329 HQSAES--------LTLKWTPNQLMNGTLGDSELEKSVYWDYALVVPFSQVVCIHCHQQKSGGTL 385

  Fly   118 TTSECRAFNTRPIE-PSGGATTRSRVMRAQLEDLSSVE--VRHRGQTIRFMRKGANGVHSEFFFQ 179
            ...........|:. |.||..         |..||.:|  :..|||           :....:.|
Human   386 VLVSQDGIQRPPLHFPQGGHL---------LSFLSCLENGLLPRGQ-----------LEPPLWTQ 430

  Fly   180 HGNADLFVRSMRDQHL----IENAETSRSGGEVYAILTTENQKLKKTFAELDIGQIKASQLPRES 240
            .|...:|.:..:...:    :|...|.|:...|:.|:...::....|.....:...:|:.:..:.
Human   431 QGKGKVFPKLRKRSSIRSVDMEEMGTGRATDYVFRIIYPGHRHEHITINYHHLAASRAASVDDDE 495

  Fly   241 WLPNKLAGILGNIPDYVQPPFQRSPKSRPGVLISGDRQTSP----DNYQIIGLSG---------- 291
            ...:||..:|.                    :|.....|:|    |...:|.:.|
Human   496 EEEDKLHAMLS--------------------MICSRNLTAPNPMKDAGDMIEMQGFGPSLPAWHL 540

  Fly   292 ----STNSACSSNGQSRGGSAEKSPAD-------------------------------SELETLN 321
                |..|:|.|...|....|..|...                               ..|.|:.
Human   541 EPLCSQGSSCLSCSSSSSPHATPSHCSCIPDRLPLRLLCESMKRQIVSRAFYGWLAHCRHLSTVR 605

  Fly   322 AQDEKIVNNL---PDRQRVERGHP-----LTETQWLEFQTPDGRISDSARIKEL-----IFRGGV 373
            .....:|::.   |||.      |     ||:..|.::|      .|....|||     ::.||:
Human   606 THLSALVHHSVIPPDRP------PGASAGLTKDVWSKYQ------KDKKNYKELELLRQVYYGGI 658

  Fly   374 VQSLRPEVWKFLLNYYL-------------------------WS--------------------- 392
            ...:|.:||.|||.:|.                         |.
Human   659 EHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQVLAEWKACEVVVRQREREAHPATRTKF 723

  Fly   393 ------DTHVERIERR---------------------------------------------KQKS 406
                  |:||:|:..|                                             :|.|
Human   724 SSGSSIDSHVQRLIHRDSTISNDVFISVDDLEPPEPQDPEDSRPKPEQEAGPGTPGTAVVEQQHS 788

  Fly   407 IEY------------YNMKAQWLAMTTTQEANFCGYRERK------------------------- 434
            :|:            |::.:.  ..::..|....|:.|..
Human   789 VEFDSPDSGLPSSRNYSVASG--IQSSLDEGQSVGFEEEDGGGEEGSSGPGPAAHTLREPQDPSQ 851

  Fly   435 -----------------C-----------------QIEKDVKRTDRSLQFFAGEDNPNLTLLQGI 465
                             |                 :|:|||:|.||:..:|.   .|||..|:.:
Human   852 EKPQAGELEAGEELAAVCAAAYTIELLDTVALNLHRIDKDVQRCDRNYWYFT---PPNLERLRDV 913

  Fly   466 LMTYVMYNFDLGYVQGMSDLLAPILEIQVNEVDTFWCFVGFMELVFTNFDIDQAGMKTQFAQIRR 530
            :.:||..:.|:||||||.|||||:|....|:...:.||...|:.:..||. :...|.|.||.:|.
Human   914 MCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKRMSQNFP-NGGAMDTHFANMRS 977

  Fly   531 LIEFANAPLFNYMRSH-DSDNMYFCFRWLLVWYKRELNSEDVLKLWECLWT--RLPCPNFHLLFS 592
            ||:..::.||..|..: |..:.|||:||.|:.:||||..|||..:||.:|.  .:...:|.|..:
Human   978 LIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIA 1042

  Fly   593 VAILDQETRVIIDSQYEFTEILKHVNELSGNIDVQKTLQV 632
            :|:::....:|.|:..:||:|:|..|.|  ::..|..|.:
Human  1043 LALVEAYREIIRDNNMDFTDIIKFFNAL--HVSPQNVLSI 1080

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	37/174 (21%)
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	86/399 (22%)
SGSM2	XP_011522403.1	RUN	90..235	CDD:280855
		PH_RUTBC	302..470	CDD:275431	42/200 (21%)
		TBC	<885..1053	CDD:214540	63/171 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810