DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbc1d15-17 and Sgsm2

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_001361617.1	Gene:	Sgsm2 / 97761	MGIID:	2144695	Length:	1050	Species:	Mus musculus

Alignment Length:	883	Identity:	183/883 - (20%)
Similarity:	299/883 - (33%)	Gaps:	327/883 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LGVFNESQLSSVEED---------VQNLPQQGTGNILFTHDGVLLK-KASAEHIADLNTSGSLSL 69
            ||:.......|..||         |::|.|.....:|:..:.||:: |...|.:     .|.|||
Mouse   223 LGIRKRHSSGSASEDRLAACAREYVESLHQNSRTRLLYGKNNVLVQPKEDMEAV-----PGYLSL 282

  Fly    70 VEYSRSIAEMPRRRLLLEWQPNDSI--MIADDSQDQG---DWALV------------DRISGRTR 117
            .:.:.:        |.|:|.||..:  .:.|...::.   |:|||            .:.||.|.
Mouse   283 HQSAEN--------LTLKWTPNQLMNGTLGDSELEKSVYWDYALVVPFSQIVCIHCHQQKSGGTL 339

  Fly   118 TTSECRAFNTRPIE-PSGGATTRSRVMRAQLEDLSSVE--VRHRGQTIRFMRKGANGVHSEFFFQ 179
            ...........|:. |.||..         |..||.:|  :..|||           :....:.|
Mouse   340 VLVSQDGIQRPPLHFPQGGHL---------LSFLSCLENGLLPRGQ-----------LEPPLWTQ 384

  Fly   180 HGNADLFVRSMRDQHL----IENAETSRSGGEVYAILTTENQKLKKTFAELDIGQIKASQLPRES 240
            .|...:|.:..:...:    :|.....|:...|:.|:...::....|.....:...:|:.:..:.
Mouse   385 QGKGKVFPKLRKRSSIRSIDVEELGVGRATDYVFRIIYPGHRHEHITINYHHLAASRAASVDDDE 449

  Fly   241 WLPNKLAGILGNIPDYVQPPFQRSPKSRPGVLISGDRQTSP----DNYQIIGLSG---------- 291
            ...:||..:|.                    :|.....|:|    |...:|.:.|
Mouse   450 EEEDKLHAMLS--------------------MICSRNLTAPNPMKDAGDMIEMQGFGPSLTAWHL 494

  Fly   292 ----STNSACSSNGQSRGGSAEKSPAD-------------------------------SELETLN 321
                |..|:|.|...|....|..|...                               ..|.|:.
Mouse   495 EPLCSQGSSCLSCSSSSSPYATPSHCSCIPDRLPLRLLCESMKRQIVSRAFYGWLAYCRHLSTVR 559

  Fly   322 AQDEKIV-NNL--PDRQRVERGHPLTETQWLEFQTPDGRISDSARIKEL-----IFRGGVVQSLR 378
            .....:| :|:  |||.....| .||:..|.::|      .|....|||     ::.|||...:|
Mouse   560 THLSALVHHNIIPPDRPPGASG-GLTKDVWSKYQ------KDEKNYKELELLRQVYYGGVEHEIR 617

  Fly   379 PEVWKFLLNYYL-------------------------WS-------------------------- 392
            .:||.|||.:|.                         |.
Mouse   618 KDVWPFLLGHYKFGMSKKEMEQVDTAVAARYQQVLAEWKACEVVVRQREREAHPATLTKFSSGSS 682

  Fly   393 -DTHVERIERR--------------------------------------------KQKSIEY--- 409
             |:||:|:..|                                            :|:|:|:
Mouse   683 IDSHVQRLVHRDSTISNDVFISVDDLEPSGPQDLEDSKPKREQEPGAGTPGIAAAEQQSVEFDSP 747

  Fly   410 ---------YNMKAQWLAMTTTQEANFCGYRE--------------------------------- 432
                     |::.:.  ..::..||...|:.:
Mouse   748 DSGLPSSRNYSVASG--IQSSLDEAQSVGFEDDGAGEDGSEGPATAAHTFPGPHDPGQETLAPAS 810

  Fly   433 ---------RKC-----------------QIEKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVM 471
                     ..|                 :|:|||:|.||:..:|.   ..||..|:.|:.:||.
Mouse   811 ELEAGQELAAVCAAAYTIELLDTVALNLHRIDKDVQRCDRNYWYFT---TSNLERLRDIMCSYVW 872

  Fly   472 YNFDLGYVQGMSDLLAPILEIQVNEVDTFWCFVGFMELVFTNFDIDQAGMKTQFAQIRRLIEFAN 536
            .:.|:||||||.|||||:|.|..|:...:.||...|:.:..||....| |.:.||.:|.||:..:
Mouse   873 EHLDMGYVQGMCDLLAPLLVILDNDQLAYSCFSHLMKRMGQNFPSGGA-MDSHFANMRSLIQILD 936

  Fly   537 APLFNYMRSH-DSDNMYFCFRWLLVWYKRELNSEDVLKLWECLWT--RLPCPNFHLLFSVAILDQ 598
            :.||..|..: |..:.|||:||.|:.:||||..|||..:||.:|.  |:...:|.|..::|:::.
Mouse   937 SELFELMHQNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAARRISSEHFVLFIALALVEA 1001

  Fly   599 ETRVIIDSQYEFTEILKHVNELSGNIDVQKTLQVAEGI 636
            ...:|.|:..:||:|:|..||.:...|.|:.|::|..:
Mouse  1002 YREIIRDNNMDFTDIIKFFNERAERHDAQEILRIARDL 1039

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	36/174 (21%)
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	89/398 (22%)
Sgsm2	NP_001361617.1	RUN	42..185	CDD:367169
		PH_RUTBC	256..424	CDD:275431	40/200 (20%)
		TBC	<838..1006	CDD:214540	65/171 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810