Protein Alignment Tbc1d15-17 and Sgsm2

DIOPT Version :10

• Sequence 1: NP_608503.1
• Gene: Tbc1d15-17 / 33184
• FlyBaseID: FBgn0031233
• Length: 715
• Species: Drosophila melanogaster
• Sequence 2: NP_001361617.1
• Gene: Sgsm2 / 97761
• MGIID: 2144695
• Length: 1050
• Species: Mus musculus
• Alignment Length: 883
• Identity: 183/883 - (20%)
• Similarity: 299/883 - (33%)
• Gaps: 327/883 - (37%)

  Fly    15 LGVFNESQLSSVEED---------VQNLPQQGTGNILFTHDGVLLK-KASAEHIADLNTSGSLSL 69
            ||:.......|..||         |::|.|.....:|:..:.||:: |...|.:     .|.|||
Mouse   223 LGIRKRHSSGSASEDRLAACAREYVESLHQNSRTRLLYGKNNVLVQPKEDMEAV-----PGYLSL 282

  Fly    70 VEYSRSIAEMPRRRLLLEWQPNDSI--MIADDSQDQG---DWALV------------DRISGRTR 117
            .:.:.:        |.|:|.||..:  .:.|...::.   |:|||            .:.||.|.
Mouse   283 HQSAEN--------LTLKWTPNQLMNGTLGDSELEKSVYWDYALVVPFSQIVCIHCHQQKSGGTL 339

  Fly   118 TTSECRAFNTRPIE-PSGGATTRSRVMRAQLEDLSSVE--VRHRGQTIRFMRKGANGVHSEFFFQ 179
            ...........|:. |.||..         |..||.:|  :..|||           :....:.|
Mouse   340 VLVSQDGIQRPPLHFPQGGHL---------LSFLSCLENGLLPRGQ-----------LEPPLWTQ 384

  Fly   180 HGNADLFVRSMRDQHL----IENAETSRSGGEVYAILTTENQKLKKTFAELDIGQIKASQLPRES 240
            .|...:|.:..:...:    :|.....|:...|:.|:...::....|.....:...:|:.:..:.
Mouse   385 QGKGKVFPKLRKRSSIRSIDVEELGVGRATDYVFRIIYPGHRHEHITINYHHLAASRAASVDDDE 449

  Fly   241 WLPNKLAGILGNIPDYVQPPFQRSPKSRPGVLISGDRQTSP----DNYQIIGLSG---------- 291
            ...:||..:|.                    :|.....|:|    |...:|.:.|
Mouse   450 EEEDKLHAMLS--------------------MICSRNLTAPNPMKDAGDMIEMQGFGPSLTAWHL 494

  Fly   292 ----STNSACSSNGQSRGGSAEKSPAD-------------------------------SELETLN 321
                |..|:|.|...|....|..|...                               ..|.|:.
Mouse   495 EPLCSQGSSCLSCSSSSSPYATPSHCSCIPDRLPLRLLCESMKRQIVSRAFYGWLAYCRHLSTVR 559

  Fly   322 AQDEKIV-NNL--PDRQRVERGHPLTETQWLEFQTPDGRISDSARIKEL-----IFRGGVVQSLR 378
            .....:| :|:  |||.....| .||:..|.::|      .|....|||     ::.|||...:|
Mouse   560 THLSALVHHNIIPPDRPPGASG-GLTKDVWSKYQ------KDEKNYKELELLRQVYYGGVEHEIR 617

  Fly   379 PEVWKFLLNYYL-------------------------WS-------------------------- 392
            .:||.|||.:|.                         |.
Mouse   618 KDVWPFLLGHYKFGMSKKEMEQVDTAVAARYQQVLAEWKACEVVVRQREREAHPATLTKFSSGSS 682

  Fly   393 -DTHVERIERR--------------------------------------------KQKSIEY--- 409
             |:||:|:..|                                            :|:|:|:
Mouse   683 IDSHVQRLVHRDSTISNDVFISVDDLEPSGPQDLEDSKPKREQEPGAGTPGIAAAEQQSVEFDSP 747

  Fly   410 ---------YNMKAQWLAMTTTQEANFCGYRE--------------------------------- 432
                     |::.:.  ..::..||...|:.:
Mouse   748 DSGLPSSRNYSVASG--IQSSLDEAQSVGFEDDGAGEDGSEGPATAAHTFPGPHDPGQETLAPAS 810

  Fly   433 ---------RKC-----------------QIEKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVM 471
                     ..|                 :|:|||:|.||:..:|.   ..||..|:.|:.:||.
Mouse   811 ELEAGQELAAVCAAAYTIELLDTVALNLHRIDKDVQRCDRNYWYFT---TSNLERLRDIMCSYVW 872

  Fly   472 YNFDLGYVQGMSDLLAPILEIQVNEVDTFWCFVGFMELVFTNFDIDQAGMKTQFAQIRRLIEFAN 536
            .:.|:||||||.|||||:|.|..|:...:.||...|:.:..||....| |.:.||.:|.||:..:
Mouse   873 EHLDMGYVQGMCDLLAPLLVILDNDQLAYSCFSHLMKRMGQNFPSGGA-MDSHFANMRSLIQILD 936

  Fly   537 APLFNYMRSH-DSDNMYFCFRWLLVWYKRELNSEDVLKLWECLWT--RLPCPNFHLLFSVAILDQ 598
            :.||..|..: |..:.|||:||.|:.:||||..|||..:||.:|.  |:...:|.|..::|:::.
Mouse   937 SELFELMHQNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAARRISSEHFVLFIALALVEA 1001

  Fly   599 ETRVIIDSQYEFTEILKHVNELSGNIDVQKTLQVAEGI 636
            ...:|.|:..:||:|:|..||.:...|.|:.|::|..:
Mouse  1002 YREIIRDNNMDFTDIIKFFNERAERHDAQEILRIARDL 1039

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_608503.1	TBC	369..598	CDD:214540	89/398 (22%)
Sgsm2	NP_001361617.1	RUN_SGSM2	18..197	CDD:439066
		PH_RUTBC	256..424	CDD:275431	40/200 (20%)
		TBC	<838..1006	CDD:214540	65/171 (38%)