DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbc1d15-17 and Tbc1d22b

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_001020230.1	Gene:	Tbc1d22b / 502414	RGDID:	1564987	Length:	505	Species:	Rattus norvegicus

Alignment Length:	533	Identity:	119/533 - (22%)
Similarity:	214/533 - (40%)	Gaps:	133/533 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 DQHLIENAETSRSGGEVYAILTTENQK-------LKKTFAELDIGQIKASQL--PRESWLPNKL- 246
            |..|.:|....||  :|.:: ..:|:|       .:.|....|||..:...|  |....|.:|:
  Rat    32 DPRLTKNFIKERS--KVNSV-PLKNKKASSFHEFARNTSDAWDIGDDEEEDLSSPSLQTLNSKVA 93

  Fly   247 ----AGILGNIPDY-VQPPFQRSPKSRPGVLISGDRQTSPDNYQIIGLSGSTNSACSSNGQSRGG 306
                |.:|.|.... |:|  :||..:...|         |.||::|
  Rat    94 LATAAQVLENHSKLRVKP--ERSQSTTSDV---------PANYKVI------------------- 128

  Fly   307 SAEKSPADSELETLNAQDEKIVNNLPDRQRVERGHPLTETQWLEFQTPDG----RISDSARIKEL 367
               ||.:|::| :.|:.|..:.|.|..:|.:.....:.....:..|...|    .:.:..|:::
  Rat   129 ---KSSSDAQL-SRNSSDTCLRNTLHKQQSLPLRPIIPLVARISDQNASGAPPMTVREKTRLEK- 188

  Fly   368 IFR------------------GGVVQSLRPEVWKFLLNYYLWSDTHVERIERRK----QKSIEYY 410
             ||                  .||.:.:||..|: ||:.||.::|     ||||    :|..||:
  Rat   189 -FRQLLSSHNTDLDELRKWSWPGVPREVRPVTWR-LLSGYLPANT-----ERRKLTLQRKREEYF 246

  Fly   411 NMKAQWLAMTTTQEANFCGYRERKCQIEKDVKRTDRSLQFFAGEDNPNL-TLLQGILMTYVMYNF 474
            ....|:.. :..:|.:...||    ||..|:.||:..:..|   ..|.: .:.:.||..:.:.:.
  Rat   247 GFIEQYYD-SRNEEHHQDTYR----QIHIDIPRTNPLIPLF---QQPLVQEIFERILFIWAIRHP 303

  Fly   475 DLGYVQGMSDLLAPILEIQVN-----------------------EVDTFWCFVGFMELVFTNFDI 516
            ..|||||::||:.|...:.::                       |.|:|||....::.:..|:..
  Rat   304 ASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGIQDNYTF 368

  Fly   517 DQAGMKTQFAQIRRLIEFANAPLFNYMRSHDSDNMYFCFRWLLVWYKRELNSEDVLKLWECLWTR 581
            .|.|::.:...:..|:...:..:.::.|.::.:.:.|.|||:.....|||.....::||:...:.
  Rat   369 AQPGIQKKVKALEELVSRIDEQVHSHFRRYEVEYLQFAFRWMNNLLMRELPLRCTIRLWDTYQSE 433

  Fly   582 LPCP----NFHLLFSVAILDQETRVIIDSQYEFTEILKHVNELS----GNIDVQKTLQVAEGIYL 638
               |    :|||....|.|.:..:.|:|.: :|..:|..:..|.    ||.::  .|.:||...|
  Rat   434 ---PEGFSHFHLYVCAAFLIKWRKEILDEE-DFQGLLMLLQNLPTIHWGNEEI--GLLLAEAYRL 492

  Fly   639 QLKGSETLPNDIR 651
            :...::. ||..|
  Rat   493 KYMFADA-PNHYR 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	65/278 (23%)
Tbc1d22b	NP_001020230.1	TBC	207..457	CDD:214540	63/266 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910