DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbc1d15-17 and TBC1D25

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_001335191.1	Gene:	TBC1D25 / 4943	HGNCID:	8092	Length:	704	Species:	Homo sapiens

Alignment Length:	243	Identity:	87/243 - (35%)
Similarity:	141/243 - (58%)	Gaps:	6/243 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   342 PLTETQWLEFQTPDGRISDSARIKELIFRGGVVQSLRPEVWKFLLNYYLWSDTHVERIERRKQKS 406
            ||::.::..:...:|::|....::..|:.|||..|||..||::|||.|....|..||::..|:||
Human   214 PLSDAEFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKS 278

  Fly   407 IEYYNMKAQWLAMTTTQEANFCGYRERKCQIEKDVKRTDRSLQFFAG-EDNPNLTLLQGILMTYV 470
            .||..:|::|......::..|.     :..:.|||.||||:..::|| ||.|:|..|..:|.||.
Human   279 REYEQLKSEWAQRANPEDLEFI-----RSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYA 338

  Fly   471 MYNFDLGYVQGMSDLLAPILEIQVNEVDTFWCFVGFMELVFTNFDIDQAGMKTQFAQIRRLIEFA 535
            :.:..:.|.||||||.:|||.:..:|...|.||.|.|:.:..||..|...|.|:||.::.|:..|
Human   339 VTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHA 403

  Fly   536 NAPLFNYMRSHDSDNMYFCFRWLLVWYKRELNSEDVLKLWECLWTRLP 583
            :...:.|::...:|:::||:||||:..|||...:|.|::.|..|:.||
Human   404 DPDFYQYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLP 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	82/216 (38%)
TBC1D25	NP_001335191.1	TBC	241..470	CDD:214540	82/216 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1495285at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820