DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbc1d15-17 and tbc1d16

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_001006076.2	Gene:	tbc1d16 / 450056	ZFINID:	ZDB-GENE-041010-179	Length:	717	Species:	Danio rerio

Alignment Length:	771	Identity:	192/771 - (24%)
Similarity:	303/771 - (39%)	Gaps:	228/771 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 GVLLKKASAEH----IADLNTSGSLSLVE----YSRS---------IAEMPRRR----------- 83
            |.||::||::.    ..::.|.||.|:::    :|::         :..:|...
Zfish     4 GRLLRRASSKASDFLTFNVGTGGSRSVLDGEIIFSKNNVCVHPAEPLPGLPEHHPGYLCVHLEKD 68

  Fly    84 ------LLLEWQPNDSIMIADDSQDQGDWALVDRISGRTRTTSECRAFNTRPIEPSGGATTRSRV 142
                  |:|.|.||..|      |.|.:.||                   |.|.|......|:..
Zfish    69 ETLGSTLILTWVPNSRI------QRQDEEAL-------------------RYITPESSPVRRNPR 108

  Fly   143 MRAQLEDLSSVEVRHRGQTIRFMRKGANGVHSEFFFQHGNADLFVRSMRDQHLIENAETSRSGGE 207
            .||           ||.             ||                |.....|..|.:...|:
Zfish   109 RRA-----------HRS-------------HS----------------RPPAAPEEEEAADEEGQ 133

  Fly   208 VYAILTTENQKLKKTFAELDIG--QIKASQLPRESWLPNKLAGILGNIPDYVQPPFQRSP----- 265
                 ..:||.|   ..|.|.|  ::.|.::.|:|        .:|:..|....||..||
Zfish   134 -----EPQNQAL---LEEGDEGSCELSADEVSRDS--------TIGSDSDTFSSPFCLSPVSEAL 182

  Fly   266 -KSRPGVLISGDRQ--TSPDNYQIIGLSGSTNSACSSNGQSRGGSAEKSPADSELETLNA----- 322
             :|...|.:..:.:  ..|..:.....|...:.|.|.:..|:|...|:......||.|..
Zfish   183 GESSSSVFLDNESRECDEPMAHSASSASSLDSHAPSESSHSQGVRWEEQQNVMALEHLCGVFRVD 247

  Fly   323 -----------QDE----------------KIVN----------------------NLPDRQRVE 338
                       .||                ||::                      .|.|:...|
Zfish   248 LGHMRSLRLFFSDEACTCGQLVIASRESQYKILHFHHAGLDKLAEVFQQWKCCRETQLKDQVSDE 312

  Fly   339 RG----------------HP-------LTETQWLEFQTPDGRISDSARIKELIFRGGVVQSLRPE 380
            :.                ||       |..:.||......|::.:..::::.||.||:..|:|.|
Zfish   313 KSCMQFSIRRPTLPSAEMHPEERLYRRLDVSSWLRHLNNSGQVLEEYKLRKAIFFGGIDPSIRGE 377

  Fly   381 VWKFLLNYYLWSDTHVERIERRKQKSIEYYNMKAQWLAMTTTQEANFCGYRERKCQIEKDVKRTD 445
            ||.|||:||.:..|..||...|.||..||.:::.:.|:|:..:.:.|  :|:.:..::|||.|||
Zfish   378 VWPFLLHYYSYDSTSEEREAWRLQKRGEYQDIQQRRLSMSPEEHSEF--WRKVQFTVDKDVVRTD 440

  Fly   446 RSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPIL-EIQVNEVDTFWCFVGFME- 508
            ||..||.||:|||:.:::.||:.|.::|.|:||.||||||:||:| ||| :|.||||||||.||
Zfish   441 RSNMFFRGENNPNVEIMRRILLNYAVFNPDMGYCQGMSDLVAPLLTEIQ-DESDTFWCFVGLMEN 504

  Fly   509 LVFTNFDIDQAGMKTQFAQIRRLIEFANAPLFNY---MRSHDSDNMYFCFRWLLVWYKRELNSED 570
            .:|.:...|: .|:.|...:|.|:... .|.|:.   ....|...:.||.||:|:.:|||....:
Zfish   505 TIFISSPRDE-DMERQLMYLRELLRLM-LPRFHQHLTRLGEDGLQLLFCHRWVLLCFKREFPDAE 567

  Fly   571 VLKLWECLWTRLPCPNFHLLFSVAILDQETRVIIDSQYEFTEILKHVNELSGNIDVQKTLQVAEG 635
            .|::||..|.......|||...|||:......:.:.|....::|.|.:.||.:::.:..|:.|..
Zfish   568 ALRMWEACWAHYQTDYFHLFLCVAIIVLYGDDVTEQQLATDQMLLHFSNLSMHMNGELVLRKARS 632

  Fly   636 IYLQLKGSETLP---NDIRSIIGEPL-----LPA--AAGEEID------GGMVDEE 675
            :..|.:....:|   :|:..:.|..:     :||  .:||..|      ||....|
Zfish   633 LLYQFRLLPRIPCSLHDLCKLCGPGMWDSRYIPAIECSGEHPDSQSCPYGGTATPE 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	31/177 (18%)
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	97/233 (42%)
tbc1d16	NP_001006076.2	TBC	368..596	CDD:214540	96/232 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1495285at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820