Protein Alignment Tbc1d15-17 and tbc1d16

DIOPT Version :10

• Sequence 1: NP_608503.1
• Gene: Tbc1d15-17 / 33184
• FlyBaseID: FBgn0031233
• Length: 715
• Species: Drosophila melanogaster
• Sequence 2: XP_068072870.1
• Gene: tbc1d16 / 450056
• ZFINID: ZDB-GENE-041010-179
• Length: 728
• Species: Danio rerio
• Alignment Length: 771
• Identity: 192/771 - (24%)
• Similarity: 303/771 - (39%)
• Gaps: 228/771 - (29%)

  Fly    47 GVLLKKASAEH----IADLNTSGSLSLVE----YSRS---------IAEMPRRR----------- 83
            |.||::||::.    ..::.|.||.|:::    :|::         :..:|...
Zfish    15 GRLLRRASSKASDFLTFNVGTGGSRSVLDGEIIFSKNNVCVHPAEPLPGLPEHHPGYLCVHLEKD 79

  Fly    84 ------LLLEWQPNDSIMIADDSQDQGDWALVDRISGRTRTTSECRAFNTRPIEPSGGATTRSRV 142
                  |:|.|.||..|      |.|.:.||                   |.|.|......|:..
Zfish    80 ETLGSTLILTWVPNSRI------QRQDEEAL-------------------RYITPESSPVRRNPR 119

  Fly   143 MRAQLEDLSSVEVRHRGQTIRFMRKGANGVHSEFFFQHGNADLFVRSMRDQHLIENAETSRSGGE 207
            .||           ||.             ||                |.....|..|.:...|:
Zfish   120 RRA-----------HRS-------------HS----------------RPPAAPEEEEAADEEGQ 144

  Fly   208 VYAILTTENQKLKKTFAELDIG--QIKASQLPRESWLPNKLAGILGNIPDYVQPPFQRSP----- 265
                 ..:||.|   ..|.|.|  ::.|.::.|:|        .:|:..|....||..||
Zfish   145 -----EPQNQAL---LEEGDEGSCELSADEVSRDS--------TIGSDSDTFSSPFCLSPVSEAL 193

  Fly   266 -KSRPGVLISGDRQ--TSPDNYQIIGLSGSTNSACSSNGQSRGGSAEKSPADSELETLNA----- 322
             :|...|.:..:.:  ..|..:.....|...:.|.|.:..|:|...|:......||.|..
Zfish   194 GESSSSVFLDNESRECDEPMAHSASSASSLDSHAPSESSHSQGVRWEEQQNVMALEHLCGVFRVD 258

  Fly   323 -----------QDE----------------KIVN----------------------NLPDRQRVE 338
                       .||                ||::                      .|.|:...|
Zfish   259 LGHMRSLRLFFSDEACTCGQLVIASRESQYKILHFHHAGLDKLAEVFQQWKCCRETQLKDQVSDE 323

  Fly   339 RG----------------HP-------LTETQWLEFQTPDGRISDSARIKELIFRGGVVQSLRPE 380
            :.                ||       |..:.||......|::.:..::::.||.||:..|:|.|
Zfish   324 KSCMQFSIRRPTLPSAEMHPEERLYRRLDVSSWLRHLNNSGQVLEEYKLRKAIFFGGIDPSIRGE 388

  Fly   381 VWKFLLNYYLWSDTHVERIERRKQKSIEYYNMKAQWLAMTTTQEANFCGYRERKCQIEKDVKRTD 445
            ||.|||:||.:..|..||...|.||..||.:::.:.|:|:..:.:.|  :|:.:..::|||.|||
Zfish   389 VWPFLLHYYSYDSTSEEREAWRLQKRGEYQDIQQRRLSMSPEEHSEF--WRKVQFTVDKDVVRTD 451

  Fly   446 RSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPIL-EIQVNEVDTFWCFVGFME- 508
            ||..||.||:|||:.:::.||:.|.::|.|:||.||||||:||:| ||| :|.||||||||.||
Zfish   452 RSNMFFRGENNPNVEIMRRILLNYAVFNPDMGYCQGMSDLVAPLLTEIQ-DESDTFWCFVGLMEN 515

  Fly   509 LVFTNFDIDQAGMKTQFAQIRRLIEFANAPLFNY---MRSHDSDNMYFCFRWLLVWYKRELNSED 570
            .:|.:...|: .|:.|...:|.|:... .|.|:.   ....|...:.||.||:|:.:|||....:
Zfish   516 TIFISSPRDE-DMERQLMYLRELLRLM-LPRFHQHLTRLGEDGLQLLFCHRWVLLCFKREFPDAE 578

  Fly   571 VLKLWECLWTRLPCPNFHLLFSVAILDQETRVIIDSQYEFTEILKHVNELSGNIDVQKTLQVAEG 635
            .|::||..|.......|||...|||:......:.:.|....::|.|.:.||.:::.:..|:.|..
Zfish   579 ALRMWEACWAHYQTDYFHLFLCVAIIVLYGDDVTEQQLATDQMLLHFSNLSMHMNGELVLRKARS 643

  Fly   636 IYLQLKGSETLP---NDIRSIIGEPL-----LPA--AAGEEID------GGMVDEE 675
            :..|.:....:|   :|:..:.|..:     :||  .:||..|      ||....|
Zfish   644 LLYQFRLLPRIPCSLHDLCKLCGPGMWDSRYIPAIECSGEHPDSQSCPYGGTATPE 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_608503.1	TBC	369..598	CDD:214540	97/233 (42%)
tbc1d16	XP_068072870.1	PH_RBD	46..>93	CDD:432305	5/46 (11%)
		TBC	379..607	CDD:214540	96/232 (41%)