DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbc1d15-17 and Tbc1d21

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_001014232.1	Gene:	Tbc1d21 / 363072	RGDID:	1310243	Length:	336	Species:	Rattus norvegicus

Alignment Length:	330	Identity:	75/330 - (22%)
Similarity:	142/330 - (43%)	Gaps:	33/330 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   329 NNLPDRQRV-----ERGHPLTETQWLEFQTPDGRISDSAR-IKELIFRGGVVQSLRPEVWKFLLN 387
            |:|..|:..     ::..|:.:.:|..|...:|.::.|.. |...|...|:...:|.:.||||..
  Rat     8 NSLSARRSATFILEKKNPPIDKAEWDSFFDENGHLAKSRDFICVNILERGLHPLVRADAWKFLTG 72

  Fly   388 YYLWSDTHVERI----ERRKQKSIEYYNMKAQWLAMTTTQEANFCG-YRERKCQIEKDVKRTDRS 447
            ||.|..:..||:    .||:.     ||...|..........|..| :.|.:..|..|:::
  Rat    73 YYSWQSSRDERLMVDSNRRRN-----YNSLCQMYEKIQPLLENLHGNFTETRNNIVYDIQK---- 128

  Fly   448 LQFFAGEDNPNL-----TLLQGILMTYVMYNFDLGYVQGMSDLLAPILEIQV-NEVDTFWCFVGF 506
              .:..:...|:     .|.:.:|::||. |....|.:|..:::. :.::.| ::.:|||.|..|
  Rat   129 --LYDKDPLGNVLVDKKKLEKTLLLSYVC-NTKAEYQRGFHEMVM-LFQLMVEHDHETFWLFQFF 189

  Fly   507 MELVFTNFDIDQAGMKTQFAQIRRLIEFANAPLFNYMRSHDSDNMYFCFRWLLVWYKRELNS-ED 570
            ::....:..|: .|:......:..||...:....::::...|..:...|.|..:.::|...| :|
  Rat   190 LQKTEHSCVIN-IGVGKNLDMLNNLITLLDPQFADHLKGKGSGAVQSLFPWFCLCFQRAFKSFDD 253

  Fly   571 VLKLWECLWTRLPCPNFHLLFSVAILDQETRVIIDSQYEFTEILKHVNELSGNIDVQKTLQVAEG 635
            |.:|||.|.|..||.||.:|.:.::|.......:........||...|:|. ::|..:.:..|..
  Rat   254 VWRLWEVLLTGKPCRNFQVLVAYSMLQMVREQALLESMSGDAILMACNKLI-DLDADELISAACV 317

  Fly   636 IYLQL 640
            :|.:|
  Rat   318 VYSEL 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	57/240 (24%)
Tbc1d21	NP_001014232.1	RabGAP-TBC	62..287	CDD:295329	56/238 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1495285at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920