DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbc1d15-17 and Tbc1d4

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_038949896.1	Gene:	Tbc1d4 / 306117	RGDID:	1561609	Length:	1300	Species:	Rattus norvegicus

Alignment Length:	708	Identity:	140/708 - (19%)
Similarity:	257/708 - (36%)	Gaps:	182/708 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LPQQGTGNILFTHDGVLLKKA------SAEHIADLNTS------GSLSLVEYSRSIAE------- 78
            :|:..|....|..| ||..||      |.|:|.....:      ||:...|.|.|:|.
  Rat   553 IPENSTSGGRFKLD-VLKNKAKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNSLASEKDFSPG 616

  Fly    79 ------MPRRRLLLEWQ--PNDSIMIADDSQDQGDWALVDRISGRTRTTSECRAFNTRPIEPSGG 135
                  .|...|...|.  |.:.   :|..|          ...|..|.|...:.:.|.:....|
  Rat   617 GSPPGTPPASPLSSAWHTFPEED---SDSPQ----------FRRRAHTFSHPPSSSRRKLNLQDG 668

  Fly   136 AT--TRSRVMRAQLEDLSSVEVRHRGQTIRFMRKGAN------GVHSEFFFQHGNADLFVRSMRD 192
            ..  .||.::|....:..||.     .:.|.|.|.:|      .:|:.|......|..|::|.
  Rat   669 KAHGLRSPLLRQNSSEQCSVL-----PSARRMCKESNSSSSLPSLHTSFSAPSFTASSFLKSF-- 726

  Fly   193 QHLIENAETSRSGGEV---YAILTTENQKLKKTFAELDIGQIKASQLP----RESWLPN---KLA 247
                     .:|.|.:   |....::.:..|:|.:......:.|...|    |.||...   ::|
  Rat   727 ---------YQSSGRLSPQYENEISDGEGRKRTSSTCSNESLSAGGTPVTPRRISWRQRIFLRVA 782

  Fly   248 GILGNIPDYVQPPFQRSPKSRPGVL-ISGDRQTSPDNYQIIGLSGSTNSACSSNGQSRGGSAEKS 311
            ..:...|..:|.  |:....|..:| :|....|..:...:|.|||..::.          ..|:.
  Rat   783 SPVNKSPSAMQQ--QKDGLDRTELLPLSPLSPTMEEEPLVIFLSGDEDTE----------KVEEK 835

  Fly   312 PADSELETL--NAQDEKIVNNLPDRQRVERGHPLTETQWLEFQTPDGRISDSARI----KELI-- 368
            ....|:::|  .|..::|:     ..|:|:.:...|.:..|.|:...:: |...:    ||::
  Rat   836 KKSKEIKSLWKKAIHQQIL-----LLRMEKENQKLEARRDELQSRKVKL-DYEEVGTCQKEVLIA 894

  Fly   369 ----------------------FRGGVVQSLRPEVWKFL-LNYYLWSDTHVERIERRKQ-KSIEY 409
                                  .:.||.:|.|.|:|:|| |.|.|   .|  |:..:.| ....|
  Rat   895 WDKKLLNCRTKIRCDMEDIHTSLKEGVPKSRRGEIWQFLALQYRL---RH--RLPNKHQPPDTSY 954

  Fly   410 YNMKAQWLAMTTTQEANFCGYRERKCQIEKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNF 474
            ..:..|   :|..|.|           |..|:.||..:..:|:.:.......|..:|..|.:.:.
  Rat   955 KELLKQ---LTAQQHA-----------ILVDLGRTFPTQPYFSVQLGAGQLSLFNLLKAYSLLDK 1005

  Fly   475 DLGYVQGMSDLLAPILEIQVNEVDTFWCFVGFMELVFTNFDI--------DQAGMKTQFAQIRRL 531
            ::||.||:| .:|.:|.:.::|..      .|..|.|..:|:        |...::.|..|:.||
  Rat  1006 EVGYCQGIS-FVAGVLLLHMSEEQ------AFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRL 1063

  Fly   532 IEFANAPLFNYMRSHDSDNMYFCFRWLLVWYKRELNSEDVLKLWECLWTRLPCPNFHLLFSVA-- 594
            :...:..|:|::..::.....:...|.|..:..:.....|.::::.::.:    ...::|.||
  Rat  1064 LHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFPLGFVARVFDIIFLQ----GTEVIFKVALS 1124

  Fly   595 ILDQETRVIIDSQ-----YEF----------TEILKHVNELSGNIDVQKTLQVAEGIY 637
            :|..:..::::.:     .||          ||:.|.:.::. .:|:.|.|...|..|
  Rat  1125 LLSSQEALVMECENFENIVEFLKSTLPDMNTTEMEKIITQVF-EMDISKQLHAYEVEY 1181

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	41/188 (22%)
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	53/240 (22%)
Tbc1d4	XP_038949896.1	PTB	31..190	CDD:214675
		PTB_TBC1D1_like	193..446	CDD:269967
		DUF3350	803..866	CDD:403130	14/77 (18%)
		TBC	920..1130	CDD:214540	53/239 (22%)
		PTZ00440	<1134..>1265	CDD:240419	10/49 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910