DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbc1d15-17 and tbc-2

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_495156.1	Gene:	tbc-2 / 173986	WormBaseID:	WBGene00022880	Length:	908	Species:	Caenorhabditis elegans

Alignment Length:	715	Identity:	146/715 - (20%)
Similarity:	248/715 - (34%)	Gaps:	199/715 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 QLSSVEEDVQNLPQQGTGNILFTHDGVLLKK----------------ASAEHIADLNTSGSLSLV 70
            ::||:||.|.:|   ....:|...:...|:|                .....:.:|:.|.|::
Worm   292 KVSSLEEVVDSL---RAALLLAQRNNEALQKIEDMGDNKEEMREYILEKERQVTELHISNSMN-- 351

  Fly    71 EYSRSIAEMPRRRLLLEWQPNDSIMIADDSQDQGDWALVDRISGRTRTTSE-----CRAFNTRPI 130
              :|.:.::..:.:.||    |:|   :|.|..     |:......||..|     |...|...:
Worm   352 --ARRVRDLEDQNVRLE----DTI---NDLQQS-----VEAFRESLRTKEELILRMCEEENREDL 402

  Fly   131 ------------EPSGGATTRSRVMRAQLEDLSSVEVRHRGQTIRFMRKGANGVHSEFFFQHGNA 183
                        ..:.|..:...|....|.|:|||:.....:.:         :..|.....|..
Worm   403 LGSISERSSNIPADANGLVSDVEVPEGILVDVSSVDCEEATRKV---------LDEENVRDIGEL 458

  Fly   184 DLFVRSMRDQHLIENAETSRSGGEVYAILTTENQKLKKTF-AELDIGQIKASQLPRESWLPNKLA 247
            ...|...|.|:...|||..:......::...|.:.:::.| .|....|:|:..|
Worm   459 QDLVEGYRTQNQFLNAEIVQLHAITQSLEDREKKLIRQNFDLEACYYQLKSRYL----------- 512

  Fly   248 GILGNIPDYVQPPFQRSPKSRPGVLISGDRQTSPDNYQIIGLSGSTNSACSSNGQSRGGSAEK-- 310
                .:.::.:.|.:......||||           .:::..|..|......|...:.|..:|
Worm   513 ----MVLNHFKSPTKPGKIMEPGVL-----------KELLEESARTPRESQQNLTDQLGFYKKDD 562

  Fly   311 -SPADSELET--------------------------LNAQDEKIVNNLPDRQRVERGHPLTETQW 348
             |.:|..|:|                          |.:.|..:|||...||..
Worm   563 FSESDDLLDTATFYMKKAGDVVEATKLEQSEEYMKWLQSWDAFLVNNTVSRQTA----------- 616

  Fly   349 LEFQTPDGRISDSARIKELIFRGGVVQSLRPEVWKFLLNYYLWSDTHVERIERRKQKSIE----Y 409
                     |..|..:|.|| |.||..:.|..|||.::.:::            |.|..|    |
Worm   617 ---------IMSSPDLKTLI-RTGVPPAYRGRVWKIIVTHWV------------KDKQAELGNGY 659

  Fly   410 YNMKAQWLAMTTTQEANFCGYRERKCQIEKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNF 474
            |....: .|.|..|:.:   |.....||:.|:.||..:.:.|...|:.|:..|:.:|..:..:|.
Worm   660 YQSMLR-KAGTKKQDGS---YDAAIKQIDLDLARTLPTNKLFDEPDSANIEKLRNVLYAFRYHNS 720

  Fly   475 DLGYVQGMSDLLAPILEIQVNEVDTFWCFVGFMELV-----FTNFDIDQAGMKTQFAQIRRLIEF 534
            .:||.||: :.||.|..:.::|.|:||..|..:|.:     :|:..|   |.......:|.|:..
Worm   721 HVGYCQGL-NRLAAIALLNLDEQDSFWFLVACVEHLQPEGYYTSSLI---GAVADQKVLRDLVAE 781

  Fly   535 ANAPLFNYMRSHDSDNMYFCFRWLLVWYKRELNSEDVLKLWEC-------LWTRLPCPNF----- 587
            ....|..::|:.:.|...|...|.|..:...|.....|.:::.       :..|.....|
Worm   782 KLPKLAAHLRALEVDLSLFALSWFLTCFVDVLPHSIYLTIFDAFLYEGNKVLFRFALALFKICEP 846

  Fly   588 HLLFSVAI------LDQETRVIID----SQYEFTEILKHVNELSGNIDVQKTLQVAEGIYL-QLK 641
            |:|....|      |.:....|||    :|..|.|:         |...|||::....:|| |||
Worm   847 HVLQCKTIGTVHQCLSKAQEHIIDFKSLAQVAFNEL---------NPFPQKTIETKRQLYLTQLK 902

Fly 642 641
Worm 903 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	29/186 (16%)
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	59/255 (23%)
tbc-2	NP_495156.1	PH_TBC1D2A	20..119	CDD:269966
		PH	20..111	CDD:278594
		ATG16	235..400	CDD:285778	25/126 (20%)
		DUF1664	<289..368	CDD:285172	15/86 (17%)
		TBC	627..849	CDD:214540	57/242 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810