DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbc1d15-17 and AgaP_AGAP006116

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_316175.4	Gene:	AgaP_AGAP006116 / 1276785	VectorBaseID:	AGAP006116	Length:	1208	Species:	Anopheles gambiae

Alignment Length:	759	Identity:	138/759 - (18%)
Similarity:	256/759 - (33%)	Gaps:	198/759 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 THDGVLLKKASAEHIADLNTSGSLSLVEYSRSIAEMPRRRLLLEWQPNDSIMIADDSQDQGDWAL 108
            |.|.||..|.|...|.....|..|..    ...|::....::|:|                ||..
Mosquito    48 TLDNVLDTKPSPYRILHCQPSTGLCF----EIAADITLDAIMLDW----------------DWLA 92

  Fly   109 VD--RISGRTRTTSE------CR-----AFNTRPIEPSGGATT--------RSRVMRAQLEDLSS 152
            .:  |:.....|..|      |:     |.::||.|.....|:        |.:....:.|.|.:
Mosquito    93 KNLFRVINEMETEEEITNFTICKIQSLLAHSSRPAEEQNDPTSFQVAVCKFREKFRMPEDEKLVN 157

  Fly   153 V-------EVRHRGQ--------------------------------------TIRFMRKGANGV 172
            .       ::..:||                                      |:|..::|:...
Mosquito   158 YYYCSYFRKIPRQGQLYLSLNHICFYSYILGSESKLCFRYNELTDIKKSGNTITVRAGQQGSKEY 222

  Fly   173 HSEFFFQHGNADLFVRSMRD---QHLIENAETSRSGGEVYAILTTENQKLKKTF----------- 223
            ...|.:..|.|...:..:..   |.:|::.:......:...:...|....:||.
Mosquito   223 TFVFLYSPGEAYQLIEQLSKLTMQKMIQDPDRPIVDHDPVILKKMEKNVAQKTLLLRDLTARQQS 287

  Fly   224 -----------AELDIGQIKASQLPRESWLP---NKLAGILGNIPDYVQPPFQRSPKSRPGV--- 271
                       ||:..|.||||     .|.|   ..:.|:|....:|:  .|:....|...:
Mosquito   288 DEYRIHFRVPKAEILDGMIKAS-----LWAPYTKKHINGVLYLSQNYL--CFKSDVSSMVSLVIP 345

  Fly   272 ---LISGDRQTSPDN---YQIIGLSGSTNSACSSNGQSRGGSAEKSPADSELETLNAQDEKIVNN 330
               ::|.::...|.|   .:||..:...|.....:...|.....|.   |||.:......::.::
Mosquito   346 LSKIVSVEKNDDPHNRFSNRIIITTSDGNIFVLQHILDREFLITKI---SELLSKTVLPTRVPDD 407

  Fly   331 LPDRQRVERGHPLTET--------------QWLEFQTPDGRISDSARIKELI--FRGGVVQSLRP 379
            |...::....|...:|              :|.|..:..||.....|..:.|  ...|:...||.
Mosquito   408 LDWMKQEPLMHLYKDTNNRAFDDLQAEKMKRWEEHFSLYGRGISMFRTTDTINLVIEGIPDQLRR 472

  Fly   380 EVWKFLLNYYLWSDT-HVERIERRKQKSIEYYNMKAQWLAMTTTQEANFCGYRERKCQIEKDVKR 443
            |||      .::|.. |::.::.         |:..|.:|....|..  ..:.|    ||:|:
Mosquito   473 EVW------LIFSGAIHMKMMQP---------NLYQQLVAKAKDQSP--VSFEE----IERDL-- 514

  Fly   444 TDRSL-QFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILEIQVNEVDTFWCFVGFM 507
             .||| :..|.:.:..:|.|:.:|..|.:.|.::||.|.| ::::.:..|..:|.|.||......
Mosquito   515 -HRSLPEHPAFQTSIGITALRRVLQAYALRNPEIGYCQAM-NIVSSVFLIYCDEEDAFWILCCLC 577

  Fly   508 ELVFTNFDIDQ-AGMKTQFAQIRRLIEFANAPLFNYMRSHDSDNMYFCFRWLLVWYKRELNSEDV 571
            |.:..::..|: .|.:.....:..||. ::.|..:...:...........|.|..:...:..|..
Mosquito   578 ESLLPDYYNDRVVGAQIDQGLLDELIA-SHLPNLHVKLTELGVIRMISLSWFLTIFLSVMPYESA 641

  Fly   572 LKLWECLWTRLPCPNFHLLFSVAI----LDQETRVIIDSQYEFTEILKHVNELSG--NIDVQKTL 630
            |.:.:|..    |....::|.:|:    .:||..:......|..::|  ...|.|  |.:||:.:
Mosquito   642 LHIIDCFL----CDGAKVIFIIALKILEWNQEKLLNCSDDGEAMQLL--TTFLMGIFNDEVQRII 700

  Fly   631 QVAEGIYLQLKGSETLPNDIRSIIGEPLLPAAAGEEIDGGMVDE 674
             :.:....|:|.     ..::::|.|..|  ..|:.|....::|
Mosquito   701 -IEDKEKQQIKS-----QSVQTLIYEAYL--KFGKAITSQKIEE 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	34/212 (16%)
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	48/235 (20%)
AgaP_AGAP006116	XP_316175.4	PH-like	152..255	CDD:302622	12/102 (12%)
		PH-GRAM2_TCB1D9_TCB1D9B	300..395	CDD:270161	23/104 (22%)
		TBC	465..672	CDD:214540	50/236 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900