DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbc1d15-17 and AgaP_AGAP003198

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_312896.5	Gene:	AgaP_AGAP003198 / 1273870	VectorBaseID:	AGAP003198	Length:	1131	Species:	Anopheles gambiae

Alignment Length:	958	Identity:	176/958 - (18%)
Similarity:	292/958 - (30%)	Gaps:	425/958 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 FNESQLSSVEED-VQNLPQQGTGNILFTHDGVL-LKKASAEHIADLNTSGSLSLVEYSRSIAEMP 80
            |..:.|:|..:| |::|.|.....:|:..:.|| |.|..:|.:     .|.|||.:..:|
Mosquito   259 FKSNSLASASKDYVESLHQNSRATLLYGKNNVLVLPKDVSEPM-----PGYLSLHQTVQS----- 313

  Fly    81 RRRLLLEWQPNDSIMIADDSQD---QGDWALVDRISGRTRTTSECRAFNTRPIEPSGGATTRSRV 142
               |.::|.||..:....:|::   ...||....::........|.       :..||.|
Mosquito   314 ---LTIKWTPNQLMNGYTESENIDKSSYWAYALNVNVDEIVYVHCH-------QARGGDT----- 363

  Fly   143 MRAQLEDLSSVEVRHRGQTIRFMRKGANGVHSEFFFQHGNADLFVRSMRDQHLIENAETSRSGGE 207
                            |.||..:  |.:||...                ..|..|       ||.
Mosquito   364 ----------------GGTIILV--GQDGVQRP----------------PIHFPE-------GGH 387

  Fly   208 VYAILTTENQKLKKTFAELDIGQIKASQLPRESWLPNKLAGILGNIPDYVQPPFQRSPKSR--PG 270
            :.|.|:.           |:.|.:...||....|....:..|.         |:.:..:.|  |.
Mosquito   388 MAAFLSC-----------LETGLLPHGQLDPPLWSQRGIGRIF---------PWPQKSRRRPLPS 432

  Fly   271 VLISGDRQTSPDNYQIIGLSGSTN----------------------SACSSNGQSRGGSAEKSPA 313
            :|.:.|.......::::. .|:|:                      |:||:|..|...|...|..
Mosquito   433 LLETNDEMPIDYVFRVVN-KGNTDEFLATHSILELGRTSPRYRAQLSSCSTNESSDCSSKSLSID 496

  Fly   314 DSELETLNAQDEK-----IVNNLPDRQRVERG--------------------------------- 340
            ...:::.|.|..:     :|.:...||.:.|.
Mosquito   497 AMSIDSPNPQTTQSTSIALVCSTMKRQIISRAFYGWLAYCRHLSTVRTHLSGLVNGRITPETGAE 561

  Fly   341 HPLTETQWLEFQTPDGRISDSARIKELIFRGGVVQSLRPEVWKFLLNYYLWSDTHVERIERRKQK 405
            ..||.::|......:|.::|...:..|::.|||...:|.|||.:||.:|.:..|..||.|..:..
Mosquito   562 QGLTRSRWESLHDGNGVVADDQEVYRLVYYGGVEHDIRKEVWPYLLGHYSFGSTPDERAELDETA 626

  Fly   406 SIEYYNMKAQWLAM--------------------------------------------------- 419
            ...|....::|||:
Mosquito   627 KHYYETTMSEWLAVEAIVRQRDKEKTAVAVAKLSSGSGSMENRSKTLDQDADGEQGEGEDEEEEM 691

  Fly   420 ---------------------------------TTT----------------------------- 422
                                             |.|
Mosquito   692 ENEVFEENGFSDMSEPEVEGEERSDAKVQLTKETITLPVVAQDALTVETAGGAGAAESADRGEEQ 756

  Fly   423 -QEANF---------------------------------------CGYRER-------------- 433
             ||.:|                                       .|..||
Mosquito   757 EQEQDFDSNKSSPSDSSYATVGNDFIDVADIISPMGEEDSGGARSLGAVERMQEGEDEDGVTSGE 821

  Fly   434 ----------------------------------------------------------------- 433

Mosquito   822 GGAGPDEEEDEPDSPKSLEQPRAVIVTDASIDVTMLLPGEVRELNNNHTLSTLAEEGGNQQQPAL 886

  Fly   434 --------KC------------------------QIEKDVKRTDRSLQFFAGEDNPNLTLLQGIL 466
                    .|                        :|||||:|.||:..:||   |.||..|:.::
Mosquito   887 DSLQEPKSACVSPASSNGGIYSSELLESFGLNLHRIEKDVQRCDRNYWYFA---NENLDKLRNVI 948

  Fly   467 MTYVMYNFDLGYVQGMSDLLAPILEIQVNEVDTFWCFVGFMELVFTNFDIDQAGMKTQFAQIRRL 531
            .|||..:.|:||:|||.||:||:|.|..:|..::.||..|||.:..||. :...|...||.:|.|
Mosquito   949 CTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYGCFCRFMERMIENFP-NGGAMDMHFANMRSL 1012

  Fly   532 IEFANAPLFNYMRSH-DSDNMYFCFRWLLVWYKRELNSEDVLKLWECLWT--RLPCPNFHLLFSV 593
            |:..::.:::.|.:| |..:.|||:||.|:.:||||...|:..:||.:|.  .:...:|.|..::
Mosquito  1013 IQILDSEMYDLMHAHGDYTHFYFCYRWFLLDFKRELIYADIFSVWEVIWAAKHVASAHFVLFLAL 1077

  Fly   594 AILDQETRVIIDSQYEFTEILKHVNELSGNIDVQKTLQVAEGIYLQLK 641
            |:|:....:|:.:..:||:|:|..||::...:....|::|..:.|||:
Mosquito  1078 ALLETYRDIILSNSMDFTDIIKFFNEMAERHNTPSVLKLARSLVLQLQ 1125

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	28/157 (18%)
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	91/495 (18%)
AgaP_AGAP003198	XP_312896.5	RUN	54..208	CDD:280855
		PH_RUTBC	281..452	CDD:275431	45/257 (18%)
		TBC	899..1063	CDD:214540	60/167 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810