DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbc1d15-17 and AgaP_AGAP007332

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_308497.4	Gene:	AgaP_AGAP007332 / 1269845	VectorBaseID:	AGAP007332	Length:	1190	Species:	Anopheles gambiae

Alignment Length:	491	Identity:	98/491 - (19%)
Similarity:	179/491 - (36%)	Gaps:	134/491 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 SSNGQSRGGSAEKSPADSELETLNAQDEKIVNNLPDRQRVERGHPLTETQ-----WLEFQTPDGR 357
            |::.||.....:.||.|...:    .||.:::...:..:......|.|.|     |.: :.|:
Mosquito   559 SASVQSMQDFDDPSPTDYSSD----GDEPLLSGTGEVSKNCSAAQLDEWQGIIVEWYQ-EGPE-- 616

  Fly   358 ISDSARIKEL--IFRGGVVQSLRPEVWKFLLNYYLWSDTHVERIERRKQKSIEYYNMKAQWLAMT 420
                .|.|.|  :.|.|:.:.||..:|                                |.||..
Mosquito   617 ----KRPKNLPALVRMGIPEPLRATIW--------------------------------QRLACV 645

  Fly   421 TTQEANFCGYR-----ERKCQ--IEKDVKRTDRSLQFF-----AGEDNPNLTLLQGILMTYVMYN 473
            ..:...|..||     |..|:  |::|:.||..:.:||     .|::|     |..:...|.:|:
Mosquito   646 ENRTEMFDSYRVLITKETSCESVIQRDINRTFPAHKFFKENGGTGQEN-----LYKVSKAYAVYD 705

  Fly   474 FDLGYVQGMSDLLAPILEIQVNEVDTFWCFVGFMELVFTNF---DIDQAGMKTQFA---QIRRLI 532
            .::||.||:|.:.|.:| :.:.|...|...|..|    .|:   |:.:.|.::.:.   |:.||:
Mosquito   706 TEVGYCQGLSFIAASLL-LHMPEEQAFCVLVALM----YNYGLRDMYKMGFESLYLRLYQLNRLM 765

  Fly   533 EFANAPLFNYMRSHDSDNMYFCFRWLLVWYKRELNSEDVLKLWEC-LWTRLPCPNFHLLFSVAI- 595
            :.....|:.:......::..|..:|.|..:........|..:.:. |...:|     :||.||:
Mosquito   766 KDQLPDLYEHFAQMGVESHMFASQWFLTLFTARFPLYFVFYILDVFLLDGIP-----VLFQVALT 825

  Fly   596 -----------LDQE-----TRVIIDSQYEFTEILKHVNELSGNIDVQKTLQVAEGIYL------ 638
                       ||.|     .||.:..:.......|.:.:||....|:| |:..|..||
Mosquito   826 LLSVCRKDLLELDFEGILKYFRVTLPKKCRSETQAKKLMKLSFECKVKK-LKKYELEYLAKKEET 889

  Fly   639 -----QLKGSETLPNDIRSIIGEPLLPAAAGEEID---------GGMVDE-----EPTYSDDG-- 682
                 :||..|....:.|:.:.:.::  |..|:|:         .|::.:     :...:::|
Mosquito   890 ERKEQELKQYEQRYGEERTKLQQEIV--ALNEKIEAMAREDRKNAGIIQDYKRIIQRQEAENGKL 952

  Fly   683 ---FDELVKELTPEEKVRQQALLEEACERSLFLQFH 715
               .|:|.|.::...|............:|....||
Mosquito   953 HTMLDDLTKTISTCSKCTASIPHSSPLHKSYGKNFH 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	53/259 (20%)
AgaP_AGAP007332	XP_308497.4	PTB_Rab6GAP	119..271	CDD:269922
		DUF3694	376..492	CDD:289256
		TBC	626..835	CDD:214540	52/255 (20%)
		DUF4200	871..969	CDD:290574	18/100 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810