DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbc1d15-17 and TBC1D3E

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_001278395.1	Gene:	TBC1D3E / 102723859	HGNCID:	27071	Length:	549	Species:	Homo sapiens

Alignment Length:	194	Identity:	42/194 - (21%)
Similarity:	82/194 - (42%)	Gaps:	39/194 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   314 DSELETLNAQDEKIVNNLPDRQRVERGHPLTETQWLEFQTPDGRISDSARIKELIFRGGVVQSLR 378
            ::||..|.|::.|.:     |:.:.|     :::|::......:...|.::.:..:: |:..::|
Human    54 ETELPPLTAREAKQI-----RREISR-----KSKWVDMLGDWEKYKSSRKLIDQAYK-GMPMNIR 107

  Fly   379 PEVWKFLLN---YYLWSDTHVERIERRKQKSIEYYNMKAQWLAMTTTQEANFCGYRERKCQIEKD 440
            ..:|..|||   ..|.:....:.::.:.:||.|:..                        :|::|
Human   108 GPMWSVLLNTEEMKLKNPGRYQIMKEKGKKSSEHIQ------------------------RIDRD 148

  Fly   441 VKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILEIQVNEVDTFWCFV 504
            |..|.|...||..........|..||:.|..||.::||.:.:|.:.|..| :.:.|.|.||..|
Human   149 VSGTLRKHIFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFL-LYLPEEDAFWALV 211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	33/139 (24%)
TBC1D3E	NP_001278395.1	TBC	99..312	CDD:214540	33/139 (24%)
TBC1D3E	NP_001278395.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	350..419
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900