DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbc1d15-17 and tbc1d9b

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_009305930.1	Gene:	tbc1d9b / 100332046	-ID:	-	Length:	1218	Species:	Danio rerio

Alignment Length:	782	Identity:	158/782 - (20%)
Similarity:	256/782 - (32%)	Gaps:	239/782 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 DVQNLPQQGTGNILFTHDGVLLKKASAEHIAD--LNTSGSLSLVEYSRSIAEMPRRRLLLEWQPN 91
            ||..|.:..|   |...:.:.:.....||...  ||.:.:..|:|   .:|.:..|:||    .|
Zfish   201 DVTQLDKNAT---LVFPESIRVSTRDTEHFFSMFLNINETFKLME---QLANIAMRQLL----DN 255

  Fly    92 DSIMIADDSQDQGDWALVDRISGRTRTTSECRAFNTRPIEPSGGATTRSRVMRAQLEDLSSVEVR 156
            :| ..||.|..:.....:..:|...|.. :.||.|.|         .|:.....|.|.|..
Zfish   256 ES-FAADRSLPKPANKTLKNVSALKRDL-DARAKNER---------YRALFRLTQDERLDG---- 305

  Fly   157 HRGQTI--RFMRKGANG---VHSEFF-FQHGNADL--FVRSMRDQHLIENAETSRSGGEVYAILT 213
            |...|:  .|.:....|   |.:.:. |.....||  .:..:|:..::|.|::|.......:|.|
Zfish   306 HTDCTLWTPFAKMHVVGQMFVSNNYICFTSREEDLCQLIIPLREVTIVEKADSSSVLPSPLSIST 370

  Fly   214 TENQKLKKTFAELDIGQIKASQLPRESWLPNKLAGILGNIPDYVQPPFQRSPKSRPGVLISGDRQ 278
                |.|.||.        .:.|....:|..:::..|           ||:|....|||.|.:..
Zfish   371 ----KNKMTFL--------FANLKDRDFLVQRISDFL-----------QRTPDGPCGVLQSENPS 412

  Fly   279 TS-PDNYQIIGLSGSTNSACSSNGQSRGGSAEKSPADSELETLNAQDEKIVNNLPDRQRVERGHP 342
            .| |.:..::.||.|        .|.:..|.....|...|..:..||  :...|..:...||
Zfish   413 PSTPPSPPVLSLSES--------AQMQHYSPSLPTARKGLLQIYQQD--VPEELGPKVTRER--- 464

  Fly   343 LTETQW----LEFQTPDGR---ISDSARIKELIFRGGVVQSLRPEVWKFLLNYYLWSDTHVERIE 400
            :.|..|    .||    ||   :..:::.:||:. .|:.:|||.|:|...........||.
Zfish   465 MKEESWKIHFFEF----GRGVCMYRTSKTRELVL-NGIPESLRGELWLLFSGAQNEMATHP---- 520

  Fly   401 RRKQKSIEYY-NMKAQWLAMTT--TQEANFCGYRERKCQIEKDVKRTDRSLQFFAGEDNPNLTLL 462
                   .|| |:..|.:...|  |:|            ||:|:.|:  ..:..|.::...:..|
Zfish   521 -------GYYGNLVEQAMGRCTLATEE------------IERDLHRS--MPEHHAFQNETGIAAL 564

  Fly   463 QGILMTYVMYNFDLGYVQGMSDLLAPILEIQVNEVDTFWCFVGFMELVFTNFD--------IDQA 519
            :.:|..|...|..:||.|.| :::..:|.:...|.:.||..|...|.:..::.        :||.
Zfish   565 RRVLTAYAYRNPGIGYCQAM-NIVTSVLLLYCTEEEAFWLLVALCERMLPDYYNTRVVGALVDQG 628

  Fly   520 GMKTQFAQIRRLIEFANAPLFNYMRSHDSD---NMYFCFRWLLVWYKRELNSEDVLKLWECLW-- 579
                .|.::.|    ...||   :..|..|   .......|.|..:...:..:..:.|.:|.:
Zfish   629 ----VFEELTR----ECLPL---LYEHMQDLGVISTISLSWFLTLFLSVMPFDSAVLLVDCFFYE 682

  Fly   580 ------------------------------TRL---------------PCPNFHLL--------- 590
                                          |.|               |.|:.|.|
Zfish   683 GIKVIFQVSLAVLHANMDQLLSCSDEGEAMTILGRYLDNVVNKQTVSPPIPHLHALLTSGNNPPP 747

  Fly   591 ----FSVAILDQE----TRVIIDSQYEFTEILKHVNELSGNIDVQK-------------TLQVAE 634
                |.:.....|    .|..:..|..|.:.||.:..|.   |..|             |::..|
Zfish   748 EIDVFELIKASYEKFGSLRADVIEQMRFKQRLKVIQSLE---DTAKRSVVRAIMTESAFTIEELE 809

  Fly   635 GIYLQLK---------GSETLPNDIRSIIGEPLLPAAAGEEIDGGMVDEEPTYSDDGFDELVKEL 690
            .:|:..|         |:.:.|.:..    :|.||......||.|.           |.:|...|
Zfish   810 ELYVLFKAKHIMSCYWGASSTPAERH----DPSLPYLEQYRIDCGQ-----------FVQLFSAL 859

  Fly   691 TP 692
            .|
Zfish   860 AP 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	35/163 (21%)
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	53/302 (18%)
tbc1d9b	XP_009305930.1	PH-GRAM1_TCB1D9_TCB1D9B	153..251	CDD:275420	12/55 (22%)
		PH-GRAM2_TCB1D9_TCB1D9B	300..395	CDD:270161	22/110 (20%)
		TBC	493..703	CDD:214540	46/247 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900