DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbc1d15-17 and usp6nl

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_031754908.1	Gene:	usp6nl / 100135167	XenbaseID:	XB-GENE-998647	Length:	844	Species:	Xenopus tropicalis

Alignment Length:	318	Identity:	69/318 - (21%)
Similarity:	122/318 - (38%)	Gaps:	74/318 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   309 EKSPADSELETLNAQDEKIVNNLPDRQRVERGHPLTETQWLEFQTPDGRISDSARIKELIFRGGV 373
            |:.|...|:    ||.:|::       .:||     .|:|::......:..:|.::...|::|..
Frog    79 EELPIHDEV----AQKQKLL-------EIER-----TTKWVKMIKSWDKYKNSEKLHRRIYKGIP 127

  Fly   374 VQSLRPEVWKFLLNYYLWSDTHVERIERRKQKSIEYYNMKAQWLAMTTTQEANFCGYRERKCQIE 438
            :| ||.|||..:|        .|.:::..::........||:.|:....             ||:
Frog   128 LQ-LRGEVWSLIL--------EVSKLKEERKDLYLVLKQKARRLSADIR-------------QID 170

  Fly   439 KDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILEIQVNEVDTFWCF 503
            .||.||.|....|..........|..:|..|.:||.::||.||||.:.| :|.:.:||.|.||..
Frog   171 LDVNRTFRDHIMFRERYGVKQQALFHVLAAYSLYNTEVGYCQGMSQITA-LLLMYMNEEDAFWAL 234

  Fly   504 VGFMELVFTNFDIDQAGMK--------TQFAQIRRLIEFANAPLFNYM---RSHDSDNMYFCFRW 557
            |...           :|.|        ..|.::.|..|..:..|..:|   :.|......:...:
Frog   235 VKLF-----------SGPKHAMHGFFVPGFPKLLRFQEHHDRILKKFMPKLKQHFETQELYTSLY 288

  Fly   558 LLVWYKRELNSEDVLKLWECLWTRLPCPNFHLLFSVAILDQETRVIIDSQYEFTEILK 615
            .:.|:            ::|...|.|......::.:.||:.| |::....|...::.|
Frog   289 TMKWF------------FQCFLDRTPFTLNLRIWDIYILEGE-RILTAMSYAILKLHK 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	53/239 (22%)
usp6nl	XP_031754908.1	TBC	122..337	CDD:214540	58/259 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910