Protein Alignment CG42399 and CLASP

DIOPT Version :10

• Sequence 1: NP_608498.3
• Gene: CG42399 / 33176
• FlyBaseID: FBgn0259818
• Length: 1655
• Species: Drosophila melanogaster
• Sequence 2: NP_849997.2
• Gene: CLASP / 816539
• AraportID: AT2G20190
• Length: 1439
• Species: Arabidopsis thaliana
• Alignment Length: 1603
• Identity: 295/1603 - (18%)
• Similarity: 501/1603 - (31%)
• Gaps: 599/1603 - (37%)

  Fly     3 FRRVLDSARNHLPP------KSTTESPAVHYYSEDSESVTYVSGAVDCEVKDSNNN--------- 52
            ||..|.  |:|||.      .:..|.......|.|..|..:|..    |||.|:.|
plant   194 FREELQ--RHHLPSYMVKDINARLERIEPQLRSTDGRSAHHVVN----EVKASSVNPKKSSPRAK 252

  Fly    53 -----QSAVGAGAPLPAIMKIQRRAEAPIGAVQLTPLWEHILRTRRLPETIFPSAMYAEFHERLQ 112
                 .|..|..|.:         .|.||..:::....|.|....::..|:.|
plant   253 APTRENSLFGGDADI---------TEKPIEPIKVYSEKELIREFEKIAATLVP------------ 296

  Fly   113 DPEWQVRQHALRVLVDVLVVMQDEADGHME-------REQLIGLLVENLGHQAPTVRKGA--LDC 168
            :.:|.:|..|:| .|:.||     |.|..:       .:||:|.|...|..:..|:.|.|  |.|
plant   297 EKDWSMRISAMR-RVEGLV-----AGGATDYSCFRGLLKQLVGPLSTQLADRRSTIVKQACHLLC 355

  Fly   169 LRVYLAETAIPETVMLGILDAGLTKQVPADSEHMGRLSCGVLLSVPALLQSIMHTAQRHRIVHST 233
            |                     |:|::..|.|     :|.... :|.|.:.::
plant   356 L---------------------LSKELLGDFE-----ACAETF-IPVLFKLVV------------ 381

  Fly   234 VERVVAHMDQVVQQEITVKVLSK-----IRELLGVHEFEEIMGNVGRGDTLSRYYQLSQVYGVSG 293
                           |||.|:::     |:.:|.
plant   382 ---------------ITVLVIAESADNCIKTMLR------------------------------- 400

  Fly   294 KSKTGGEVKAGAWRALPR--EQGWRNGNAVQNLDTTLQIQSNCLDMGKIIME---------TEIK 347
                    ...|.|.|||  |....:.||:        :::.|.:...:.:|         ..:.
plant   401 --------NCKAARVLPRIAESAKHDRNAI--------LRARCCEYALLTLEHWPDAPEIQRSVD 449

  Fly   348 INDDTVTMRILEADTETEES-------------DSPTRIFS----------NEEDGTDLICHPLS 389
            :.:|.:...:.:|.:|...:             |...|:||          |||||.....|...
plant   450 LYEDLIRCCVADAMSEVRATARMCYRMFAKTWPDRSRRLFSSFDPVIQRLINEEDGGIHRRHASP 514

  Fly   390 SSGSTHQEPNI----------GAGIVKVISDSELDEPHIKAGSVSEPGTPSRGL-----KRVTFG 439
            |....|.:|:.          |.|...:::   :|    ::.::|..|:.|.||     |.|..|
plant   515 SVRERHSQPSFSQTSAPSNLPGYGTSAIVA---MD----RSSNLSSGGSLSSGLLLSQSKDVNKG 572

  Fly   440 GEIVKMRTPDSDAASSTNNSRSPTQTNQSITVSSSEDAAISDLVSSDEKSTLSRPVNDKRTTALV 504
            .|                      ::.:|:..||.:.      ||:.|.......::|::..|.:
plant   573 SE----------------------RSLESVLQSSKQK------VSAIESMLRGLHISDRQNPAAL 609

  Fly   505 LEIPFDNTKPLPQDR-------SLCSQPHRHQSNAQSEPSSNSPRNR---------------QEN 547
            .....|.....|..|       :..|..|...:.|:|..|.|...||               .::
plant   610 RSSSLDLGVDPPSSRDPPFHAVAPASNSHTSSAAAESTHSINKGSNRNGGLGLSDIITQIQASKD 674

  Fly   548 KARLS-----PSPSSPGFRSRSTSPTGS--NNISPKVPHKQIEVLHNLQRDPSPRSQRRSEDMDG 605
            ..|.|     .|.|.|.| |..|:..||  |..|            :|:.....|..||.  |.|
plant   675 SGRSSYRGNLLSESHPTF-SSLTAKRGSERNERS------------SLEESNDAREVRRF--MAG 724

  Fly   606 NGDGKALHAT--------GNPSSSPT--QPLISRTRSASTMSPVSPATPKSWEDLDIVNLKTLLE 660
            :.|.:.:...        .|.|..|.  :||:.:    :....:|....:|::|         .:
plant   725 HFDRQQMDTAYRDLTFRESNASHVPNFQRPLLRK----NVGGRMSAGRRRSFDD---------SQ 776

  Fly   661 LRSGDWRNRLMGIGQLELAL-----SSSSNLALVQPYLDSLLRTLLS------------------ 702
            |:.||..|.:.|...|..||     |||...|.|..:  :.|:|||.
plant   777 LQIGDISNFVDGPASLNEALNDGLNSSSDWCARVAAF--NFLQTLLQQGPKGAQEVIQSFEKVMK 839

  Fly   703 ------SERHFEVSDLKRELLVNLI--SRLPLDNLEERT-PQILSGLCRQGNAGANRVCKALMQR 758
                  .:.|.:|:......|.:||  .|.|.::..||. |.:.|.|...... ..:.|.:.::
plant   840 LFLRHLDDPHHKVAQAALSTLADLIPSCRKPFESYMERVLPHVFSRLIDPKEV-VRQPCSSTLE- 902

  Fly   759 LPAGTIVAKLTS-----PEFLHA----KSSKFRDHALQMSIFALMTFPGTCFDISLLTTQAVYSL 814
                 ||:|..|     |..|.:    :|.|.:...::.:|.:...:.|.
plant   903 -----IVSKTYSVDSLLPALLRSLDEQRSPKAKLAVIEFAINSFNRYAGN--------------- 947

  Fly   815 LNRKRRVRQAALEVLAVLADISSIKEVLTIVSETTDGVELGPMVLEATSVRLSRLQLPIVTPDSG 879
                              .:||....:|.:..     .:|.|:    |..:.::|:...:|   .
plant   948 ------------------PEISGNSGILKLWL-----AKLTPL----TRDKNTKLKEASIT---C 982

  Fly   880 VLFVFNQTDPPGARRFGADVDWIHQGEGSASPNTIKRR-RMRAASSQRNVLGGAEAKNKNDPFPS 943
            ::.|:|..|..|...:...:....|       |:::|. :......:.::|...::|.:.....|
plant   983 IISVYNHYDSAGLLNYILSLSVEEQ-------NSLRRALKQYTPRIEVDLLNYMQSKKEKQRIKS 1040

  Fly   944 FRQVNESVHRHSFHSPPETLDMASPINDFSQRLSFGAKTNGGSQSFIERRFLAKACSDTSMDGRS 1008
            :                   |.:..|...|:....||..        :..||.:      ..|.|
plant  1041 Y-------------------DPSDAIGTSSEEGYAGASK--------KNIFLGR------YSGGS 1072

  Fly  1009 TDSTTTTCSSGSATDSFIQLTSRTGGRLAGPNSRFPTMNQHADFVNNFMRSMQRGSKSHSVERPN 1073
            .||     .||....|..:.|..|||  .|.|                        .|...:...
plant  1073 IDS-----DSGRKWSSSQEPTMITGG--VGQN------------------------VSSGTQEKL 1106

  Fly  1074 YPKVSYSIPKSQQMIRKKFQHKDS---FTKLGDE-----PPGQSIEN----NKFNESQRRKSGIS 1126
            |..|...|..:..::..    |||   |...|..     .|..|.||    :..:.....|:|::
plant  1107 YQNVRTGISSASDLLNP----KDSDYTFASAGQNSISRTSPNGSSENIEILDDLSPPHLEKNGLN 1167

  Fly  1127 TDHMESLDSKCA-DVIKSVD------TETEVN-------------GMTNGSPISASSTSYSQKST 1171
            ...::||:.:.. :|.:.:|      |..:||             .|.|||..|.||   |:||
plant  1168 LTSVDSLEGRHENEVSRELDLGHYMLTSIKVNTTPESGPSIPQILHMINGSDGSPSS---SKKS- 1228

  Fly  1172 ASAKSSISQNEMGKRPFSSTGLWNDCKVEVLNREHNPNEAFGELVVDAIKVQTESEPTAHEELLK 1236
                                ||....:..|.|.|....:.|.:::...::|..:.:.:..|..|.
plant  1229 --------------------GLQQLIEASVANEESVWTKYFNQILTVVLEVLDDEDFSIKELALS 1273

  Fly  1237 LNGSLNSLHSKTESIKTQLE-----------ETTPQLS--RAQSVKSLLIEEDIESSNSFVV--- 1285
            |...:  |.|:.::::..:|           :|.|::|  ..|.:.::|.:.|.....|.:|
plant  1274 LISEM--LKSQKDAMEDSVEIVIEKLLHVSKDTVPKVSTEAEQCLTTVLSQYDPFRCLSVIVPLL 1336

  Fly  1286 VEEVENELESS--------PAKGEEEVPLQEELATPVKATKLENHTFGPKLVPTHDEIV------ 1336
            |.|.|..|.:.        ....:||  |.::|::.:.|.   ...||.:.......:|
plant  1337 VTEDEKTLVACINCLTKLVGRLSQEE--LMDQLSSFLPAV---FEAFGSQSADVRKTVVFCLVDI 1396

  Fly  1337 --------------IHSRSVSLDSLYGTR--PASKQGSMDTST 1363
                          ::|..|.|.::|..|  .|.....:|..|
plant  1397 YIMLGKAFLPYLEGLNSTQVRLVTIYANRISQARNGAPIDADT 1439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42399	NP_608498.3	PHA03307	387..>646	CDD:223039	59/312 (19%)
CLASP	NP_849997.2	HEAT	16..186	CDD:441023
		HEAT repeat	39..70	CDD:293787
		HEAT repeat	82..112	CDD:293787
		HEAT repeat	121..144	CDD:293787
		HEAT repeat	155..186	CDD:293787
		CLASP_N	283..501	CDD:432496	53/336 (16%)
		HEAT repeat	796..818	CDD:293787	7/23 (30%)
		HEAT repeat	837..865	CDD:293787	4/27 (15%)
		HEAT repeat	877..903	CDD:293787	5/32 (16%)
		HEAT repeat	912..940	CDD:293787	5/27 (19%)
		HEAT repeat	951..986	CDD:293787	7/46 (15%)
		HSH155	<1249..>1434	CDD:227508	34/191 (18%)
		HEAT repeat	1253..1277	CDD:293787	4/23 (17%)
		HEAT repeat	1293..1321	CDD:293787	4/27 (15%)
		HEAT repeat	1331..1357	CDD:293787	5/25 (20%)
		HEAT repeat	1369..1395	CDD:293787	4/28 (14%)