Protein Alignment CG42399 and togaram1

DIOPT Version :10

• Sequence 1: NP_608498.3
• Gene: CG42399 / 33176
• FlyBaseID: FBgn0259818
• Length: 1655
• Species: Drosophila melanogaster
• Sequence 2: XP_002940589.3
• Gene: togaram1 / 100495084
• XenbaseID: XB-GENE-6031013
• Length: 1163
• Species: Xenopus tropicalis
• Alignment Length: 1214
• Identity: 273/1214 - (22%)
• Similarity: 468/1214 - (38%)
• Gaps: 281/1214 - (23%)

  Fly   596 SQRRSEDMDGNG---DGKALHATGNPSSSPTQPLISRTRSASTMSPVSPATPKSWEDLDIVNL-- 655
            ::|||..:|.:.   .|......||   |.|:|...:..|::..|.:.....::..:|....:
 Frog    25 ARRRSYTLDSSFRDIHGDIFEKRGN---SQTRPYSHKEHSSAVKSALIRDNSQNDSNLSFGVIPQ 86

  Fly   656 ---KTLLELRSGDWRNRLMGIGQLEL--------ALSSSSNLALVQPYLDSLLRTLLSSERHFEV 709
               ..||:::  |:::|...:.:|::        |:|.|:.::|:     :.|.||| .:::|.|
 Frog    87 ELHSRLLDMK--DYKSRTHAVEELKVLIQDCDFSAISHSNVVSLI-----NFLCTLL-DDKNFTV 143

  Fly   710 SDLKRELLVNLISRLPLDNLEERTPQILSGLCRQGN---AGANRVCKALMQRLPAGTIVAKLTSP 771
            ..:..::|.:|:..|.....:...|.|.|.:...|:   |......|..|:       :.|:..|
 Frog   144 VLVTLDVLNHLVLNLGHGVNDFLQPIIASTVKLLGDSKIAVKQEYMKIYMR-------LMKVVGP 201

  Fly   772 --------EFLHAKSSKFRDHALQMSIFALMTFPGTCFDISLLTTQAVYSLLNRKRRVRQAALEV 828
                    :.|..|:|:.|:..:.:.|.:|:|:|...|:::.|..:....|::.||:||.||||.
 Frog   202 HKILNILLDHLKHKNSRVREEVVNICIISLLTYPSEDFNLAYLACEIAPCLIDSKRKVRHAALEA 266

  Fly   829 LAVLADISSIKEVLTIVSETTDGVEL---GPMVLEATSVRLSRLQLPIVTPDSGVLFVFNQTDPP 890
            .||||  :::......:.:..|.|||   |..::.|...||:|..||.:|  |..|..:....|.
 Frog   267 FAVLA--ATMGTGKCNLFKAVDEVELQENGEGLMNAVQARLARKSLPKIT--SQGLVEYALPFPS 327

  Fly   891 GARRF------GADVDW------IHQGEGSASPNTIKRRRMRAASSQRNVLGGAEAKNKNDPFPS 943
            .||:.      |||.||      ||.|:..:..::.:..........|.:|...:.|||   ||.
 Frog   328 SARQRATPHLPGADTDWLLTGTRIHSGQYKSGDSSGRSTVPHIDPVVRRMLSAGKGKNK---FPW 389

  Fly   944 FRQVNESVHRHSFHSPPETLDMASPINDFSQRLSFGAKTNGGSQSFIERR----FLAKACSDTSM 1004
                 |:.|                              .|||..|:..:    .....|| :..
 Frog   390 -----ENQH------------------------------PGGSDIFLGNQPSVVMEPDQCS-SQF 418

  Fly  1005 DGRSTDSTTTTCSSGSATDSFIQLTSRTGGRLAGPNSRFPTMNQHADFVNNFMRSMQRGSKSHSV 1069
            |.|.|....|  .:....:|.|..|..:........|..|..|.....|...:..:....|..:.
 Frog   419 DTRHTPIVKT--PTAKTRNSSISQTLASSNINTEHQSAVPAKNGSTVPVKATLVRVPSARKDLNR 481

  Fly  1070 ERPNYP--KVSYSIPKSQQMIRKKFQHK------------------DSFTKLGDEPPGQSIENNK 1114
            .||..|  |.:.|:|.....|..|.::.                  |..||..|:..........
 Frog   482 SRPVPPITKGATSLPDISNAISSKAKNDSQKTDNINEDESIGIDLLDLHTKDDDDRDEMLSSLRH 546

  Fly  1115 FNESQRRKSGISTDHMESLDSKCADVIKSVDTETEVNGMTNGSPISAS---STSYSQKSTASAKS 1176
            ...|..:|....:..:..|||  .|.:| ::...:...:|: ||||.|   |..|||:|..|..|
 Frog   547 LRNSAAKKRAKISGSLSDLDS--PDSMK-MELNMDSPSLTS-SPISGSYSESGVYSQESWNSPVS 607

  Fly  1177 SISQ----NEMGK---------RPFSSTGLWNDCKVEVLNREHNPNEAFGELVVDAIKVQTESEP 1228
            ...|    :::.|         .|.|..|.   .|.:.|::..:.||....::...:..: ....
 Frog   608 PTPQPKKISDVTKSKSRPPRLPSPRSKDGY---KKTDGLHQGDSANEKQVRIIGQRLNYK-NGAV 668

  Fly  1229 TAHEELLK--LNGSLNSLHSKTES---------------------------------IKTQLEET 1258
            ...|::||  |:|.:.:|....:.                                 |...:.||
 Frog   669 DGEEDILKDILSGPMKNLIKDVQKQPLKPMKGIMASTTSFQQVSAFHCDLTEDSVAIIGKGVFET 733

  Fly  1259 TPQLSRAQSVKSLLIEEDIE-----------------SSNSFVVVEEV----------------E 1290
            .|...::.|..||...:|:.                 ..||..|..||                |
 Frog   734 LPPPYQSHSQSSLSATDDMTPAKQNIQPPAGIYGRAVQQNSHAVENEVKVTISKSAREKMRQRRE 798

  Fly  1291 N---ELESSPAKGEEEVPLQEELATPVKATKLENHTFGPKLVPTHDEIVIHSR---SVSLDSLYG 1349
            |   ||||...:.:|::|.|....|.      .|..|            :.||   |.||:|...
 Frog   799 NSLKELESREPEKKEQIPRQRLSQTE------PNWAF------------VESRRPASESLESFEI 845

  Fly  1350 TRPASKQGSMDTSTSTAENTSQTGSQIGNTSVPAKAQHTPLKHKSKTSYFLRAQRRISPSKQPIK 1414
            :.|:.|:      ||:.:.||              ||.:|.|           :|:.|.|:
 Frog   846 SPPSLKR------TSSLKRTS--------------AQGSPYK-----------ERKSSNSR---- 875

  Fly  1415 MSQAELFPQNMVRFDRPREALLKTFDQLDSSNWEVNVSGLKSMVRLIRYHAETLDNQMHMTCIQL 1479
             :...:.|..:....||..::.:.|..|...:||..:.||..:..|..:|::.|..::|...|.:
 Frog   876 -TSEVIDPFGLRELPRPENSVAEAFRLLADDDWEKKIEGLGLVRSLSVFHSDLLTERLHDLKIAV 939

  Fly  1480 TRSVRNLRSQVARASCQAAAELFSLKSTSLQQECDDLVCALLHRTADTNRFLRADANRALESMVD 1544
            .:.|:||||.|:||:.....::||....::..|.|:.|..|||:..::|.|:|.|.:|.|::||.
 Frog   940 IQEVKNLRSSVSRAAIVCLGDMFSSLKKNMDHELDNCVRMLLHKAGESNVFIREDVDRTLDAMVQ 1004

  Fly  1545 HAQPQKILNILATKGAQHQNALVRTTSAKLLFRLVERLGSDRIYAMGRESRDKFFVVGANLLLEG 1609
            :..|.:.|..|...|..|.|..|:..:|:.:..|||::|..||.:..|:..|:.....|....:|
 Frog  1005 NVTPARALAALINGGQSHLNNAVKKCAAQHMSDLVEKMGPGRILSGVRDITDRALAAIAKFAQDG 1069

  Fly  1610 SLETRSYAKSLFRALSENHNYQRLLLEVIPPRTYRNVEKTLRSI 1653
            |.|||.:.:.:...|..:.::.|:|.:.||.|....::..:::|
 Frog  1070 SQETRFFGRKMLHFLMSHPDFDRMLEKYIPDRDLPYIKDLIKNI 1113

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42399	NP_608498.3	PHA03307	387..>646	CDD:223039	12/52 (23%)
togaram1	XP_002940589.3	Adaptin_N	<103..>273	CDD:396262	46/184 (25%)
		HEAT repeat	128..153	CDD:293787	8/30 (27%)
		HEAT repeat	168..198	CDD:293787	7/36 (19%)
		HEAT repeat	203..230	CDD:293787	5/26 (19%)
		HEAT repeat	245..270	CDD:293787	10/24 (42%)