Protein Alignment l(2)gl and Stxbp5

DIOPT Version :10

• Sequence 1: NP_523439.2
• Gene: l(2)gl / 33156
• FlyBaseID: FBgn0002121
• Length: 1161
• Species: Drosophila melanogaster
• Sequence 2: NP_848035.1
• Gene: Stxbp5 / 81022
• RGDID: 708517
• Length: 1152
• Species: Rattus norvegicus
• Alignment Length: 1148
• Identity: 298/1148 - (25%)
• Similarity: 468/1148 - (40%)
• Gaps: 311/1148 - (27%)

  Fly    10 QQPSADR-----HRLQKDLFAYRKTAQHGFPHKPSALAYDPVLKLMAIGTQTGALKVFGQPGVEL 69
            |.|..:|     ..||.:.|...||.:||||::|||||:|||.|::|:|||||||::||:||||.
  Rat    28 QHPPGNREPEIQETLQSEHFQLCKTVRHGFPYQPSALAFDPVQKILAVGTQTGALRLFGRPGVEC 92

  Fly    70 YGQHTLLNNSASELNVQLLEWVYGTGRILSLTAANQLILW---EPVGATLLPIK---------TL 122
            |.||   ::.|:.:.:|.|   ...|.::|..|.:.|.||   :...|.|..:|         .|
  Rat    93 YCQH---DSGAAVIQLQFL---INEGALVSALADDTLHLWNLRQKRPAVLHSLKFCRERVTFCHL 151

  Fly   123 PFDGKLKKVSSLCCSLSKDLLWIGTEGGNIYQLDLHTFTIKEPVIYHDVVLEQVPPAYKLNPGAI 187
            ||..|              .|::|||.|||:.:::.:||:...||..:..:|.   :.|.:||.:
  Rat   152 PFQSK--------------WLYVGTERGNIHIVNVESFTLSGYVIMWNKAIEL---SSKSHPGPV 199

  Fly   188 ESIRQLPNSPSKLLVAYNRGLCVLWDFESASVQRAYIAPGHGQSVGLTVNFEGSEFTWYHADGSY 252
            ..|...|....|||:.:..|..||||.:|......|.......||..  :.||.:|...|:||:.
  Rat   200 VHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYTYDEAIHSVAW--HHEGKQFICSHSDGTL 262

  Fly   253 ATWSIDNPEPPSNVNYVPYG--------PDPCKSINRL-YKGKRRSNDVIVFSGGMPRSAYGDHN 308
            ..|::.:|..|.. ...|:|        |:|||.|.:: :|..|.....|:.|||:.....|...
  Rat   263 TIWNVRSPTKPVQ-TITPHGKQLKDGKKPEPCKPILKVEFKTTRSGEPFIILSGGLSYDTVGRRP 326

  Fly   309 CVSV-HASDGHKVCLDFTSKVIDFFVTFE----NNRDVAEVLVVLLEEELCAYDLTDPNICAIKA 368
            |::| |......:.:|::  ::||....|    |:......:|||||::|...||........:.
  Rat   327 CLTVMHGKSTAVLEMDYS--IVDFLTLCETPYPNDFQEPYAVVVLLEKDLVLIDLAQNGYPIFEN 389

  Fly   369 PYLHSVHASAVT-CNYLAS---EVVQSVYESILRAGDEQDIDYSNISWPITGGTLPDNLEESVEE 429
            ||..|:|.|.|| |.|.|.   :::.::|....|   ::...||...|||.||        :...
  Rat   390 PYPLSIHESPVTCCEYFADCPVDLIPALYSVGAR---QKRQGYSKKEWPINGG--------NWGL 443

  Fly   430 DATKLYEILLTGHEDGSVKFWDCTGVLLKPIYNFKTSSIFGSESDFRDDAAADMSAEQVDEGEPP 494
            .|....||::|||.|||:||||.:.:.|:.:|..|||.:| .:|..:||.   .:.:.|||
  Rat   444 GAQSYPEIIITGHADGSIKFWDASAITLQVLYKLKTSKVF-EKSRNKDDR---QNTDIVDE---- 500

  Fly   495 FRKSGLFDPYSDDPRLAVKKIAFCPKTGQLIVGGTAGQIVIADF---------IDLPEKVSLKYI 550
                   |||      |::.|::||::..|.:.|.:..::|..|         |.:.| |.|.|
  Rat   501 -------DPY------AIQIISWCPESRMLCIAGVSAHVIIYRFSKQEVVTEVIPMLE-VRLLY- 550

  Fly   551 SMNLVSDRDG-----------------FVWKGHDQLNVRSNLLDG--EAIPTTE---------RG 587
            .:|.|...:|                 ...:.|...:..|:  ||  :.:|..:         .|
  Rat   551 EINDVETPEGEQPPPLSTPVGSSTSQPIPPQSHPSTSSSSS--DGLRDNVPCLKVKNSPLKQSPG 613

  Fly   588 VNISGVLQVL-----PPASITCMALEASWGLVSGGTAHGLVLFDFKNFVPVFHRCTLNPNDLTGA 647
            .....|:|::     ||..||.:||.:|:|||..|.::|:.:.|:.....:.:..|:   :|.|:
  Rat   614 YQTELVIQLVWVGGEPPQQITSLALNSSYGLVVFGNSNGIAMVDYLQKAVLLNLSTI---ELYGS 675

  Fly   648 G-----EQLSRRKSFK----------------------------------------------KSL 661
            .     |..|.|||.:                                              |:.
  Rat   676 NDPYRREPRSPRKSRQPSGAGLCDITEGTVVPEDRCKSPTSGSSSPHNSDDEQKVNNFIEKVKTQ 740

  Fly   662 RESFRKLRKGRSTRTNQSNQVPTTLEARP---VERQIEARCADDGLGSM-------VRCLLFAKT 716
            ...|.|:......:.::...:||.|  :|   |:....:|.....:.|:       :..|.|.:|
  Rat   741 SRKFSKMVASDLAKMSRKLSLPTDL--KPDLDVKDNSFSRSRSSSVTSIDKESREAISALHFCET 803

  Fly   717 YVTNVNIT-SPTLWSATNASTVSVFLLHLP--PAQ-TAATAVPSASGN----------------- 760
            :....:.: ||.||..|...|..|..|:||  |.| .....:.|.||.
  Rat   804 FTRKADSSPSPCLWVGTTVGTAFVITLNLPLGPEQRLLQPVIVSPSGTILRLKGAILRMAFLDAA 868

  Fly   761 ----APPHMP---RRISAQLAKEIQLKHRAPVVGISIFDQAGSPVDQLNAGENGSPPHRVLIASE 818
                .|.:.|   ..:..:..::.:||.|.||        :.||.......||    ...:|.||
  Rat   869 GCLMPPAYEPWTEHNVPEEKDEKEKLKKRRPV--------SVSPSSSQEISEN----QYAVICSE 921

  Fly   819 EQFKVFSLPQLKPINKYKLTANEGARIRRIHFGSFSCRISPETLQSMHGCSPTKSTRSHGDGEAD 883
            :|.||.|||          |.|                           |:..:
  Rat   922 KQAKVISLP----------TQN---------------------------CAYKQ----------- 938

  Fly   884 PNISGSLAVSRGDVY---NETALICLTNMGDIMVLSVPELKRQLNAAAVRREDINGVSSLCFTNS 945
             ||:.:..|.|||:.   |...|.|....|.||..|:|.|:..|:...:...::....:.||.||
  Rat   939 -NITETSFVLRGDIVALSNSVCLACFCANGHIMTFSLPSLRPLLDVYYLPLTNMRIARTFCFANS 1002

  Fly   946 GEALYMMSSSELQRIALATSRVVQPTGVVPVEPLENEESVLEE 988
            |:|||::|.:|:||:..:.            |..||.:.:|.|
  Rat  1003 GQALYLVSPTEIQRLTYSQ------------ETCENLQEMLGE 1033

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)gl	NP_523439.2	WD40 repeat	39..78	CDD:293791	25/38 (66%)
		WD40 repeat	84..126	CDD:293791	14/53 (26%)
		WD40 repeat	131..174	CDD:293791	11/42 (26%)
		WD40 repeat	188..224	CDD:293791	11/35 (31%)
		LLGL	268..>338	CDD:462446	21/83 (25%)
Stxbp5	NP_848035.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	14..35		2/6 (33%)
		WD40	<49..281	CDD:441893	87/257 (34%)
		WD 1	62..95		23/32 (72%)
		WD40 repeat	62..95	CDD:293791	23/32 (72%)
		WD 2	102..141		10/41 (24%)
		WD40 repeat	103..141	CDD:293791	10/40 (25%)
		WD40 repeat	146..192	CDD:293791	16/62 (26%)
		WD 3	146..182		13/49 (27%)
		WD40 repeat	200..236	CDD:293791	11/35 (31%)
		WD 4	201..235		11/33 (33%)
		WD40 repeat	241..278	CDD:293791	11/39 (28%)
		WD 5	241..273		10/33 (30%)
		LLGL	276..385	CDD:462446	30/110 (27%)
		WD 6	295..337		11/41 (27%)
		WD 7	345..379		10/33 (30%)
		WD 8	401..478		28/87 (32%)
		WD 9	506..620		21/117 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	557..596		5/40 (13%)
		WD 10	634..696		18/64 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	675..731		5/55 (9%)
		WD 11	795..852		18/56 (32%)
		WD 12	861..935		22/122 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	879..907		7/35 (20%)
		WD 13	940..984		15/43 (35%)
		WD 14	998..1021		12/22 (55%)
		R-SNARE_STXBP5	1085..1145	CDD:277246