DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment l(2)gl and Stxbp5

DIOPT Version :10

Sequence 1:NP_523439.2 Gene:l(2)gl / 33156 FlyBaseID:FBgn0002121 Length:1161 Species:Drosophila melanogaster
Sequence 2:XP_036012001.1 Gene:Stxbp5 / 78808 MGIID:1926058 Length:1180 Species:Mus musculus


Alignment Length:1182 Identity:303/1182 - (25%)
Similarity:466/1182 - (39%) Gaps:351/1182 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 QQPSADR-----HRLQKDLFAYRKTAQHGFPHKPSALAYDPVLKLMAIGTQTGALKVFGQPGVEL 69
            |.|..:|     ..||.:.|...||.:||||::|||||:|||.|::|:|||||||::||:||||.
Mouse    28 QHPPGNREPEIQETLQSEHFQLCKTVRHGFPYQPSALAFDPVQKILAVGTQTGALRLFGRPGVEC 92

  Fly    70 YGQHTLLNNSASELNVQLLEWVYGTGRILSLTAANQLILW---EPVGATLLPIK---------TL 122
            |.||   ::.|:.:.:|.|   ...|.::|..|.:.|.||   :...|.|..:|         .|
Mouse    93 YCQH---DSGAAVIQLQFL---INEGALVSALADDTLHLWNLRQKRPAVLHSLKFCRERVTFCHL 151

  Fly   123 PFDGKLKKVSSLCCSLSKDLLWIGTEGGNIYQLDLHTFTIKEPVIYHDVVLEQVPPAYKLNPGAI 187
            ||..|              .|::|||.|||:.:::.:||:...||..:..:|.   :.|.:||.:
Mouse   152 PFQSK--------------WLYVGTERGNIHIVNVESFTLSGYVIMWNKAIEL---SSKAHPGPV 199

  Fly   188 ESIRQLPNSPSKLLVAYNRGLCVLWDFESASVQRAYIAPGHGQSVGLTVNFEGSEFTWYHADGSY 252
            ..|...|....|||:.:..|..||||.:|......|.......||..  :.||.:|...|:||:.
Mouse   200 VHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYTYDEAIHSVAW--HHEGKQFICSHSDGTL 262

  Fly   253 ATWSIDNPEPPSNVNYVPYG--------PDPCKSINRL-YKGKRRSNDVIVFSGGMPRSAYGDHN 308
            ..|::.:|..|.. ...|:|        |:|||.|.:: .|..|.....|:.|||:.....|...
Mouse   263 TIWNVRSPAKPVQ-TITPHGKQLKDGKKPEPCKPILKVELKTTRSGEPFIILSGGLSYDTVGRRP 326

  Fly   309 CVSV-HASDGHKVCLDFTSKVIDFFVTFE----NNRDVAEVLVVLLEEELCAYDLTDPNICAIKA 368
            |::| |......:.:|::  ::||....|    |:......:|||||::|...||........:.
Mouse   327 CLTVMHGKSTAVLEMDYS--IVDFLTLCETPYPNDFQEPYAVVVLLEKDLVLIDLAQNGYPIFEN 389

  Fly   369 PYLHSVHASAVT-CNYLAS---EVVQSVYESILRAGDEQDIDYSNISWPITGGTLPDNLEESVEE 429
            ||..|:|.|.|| |.|.|.   :::.::|....|   ::...||...|||.||        :...
Mouse   390 PYPLSIHESPVTCCEYFADCPVDLIPALYSVGAR---QKRQGYSKKEWPINGG--------NWGL 443

  Fly   430 DATKLYEILLTGHEDGSVKFWDCTGVLLKPIYNFKTSSIFGSESDFRDDAAADMSAEQVDEGEPP 494
            .|....||::|||.||||||||.:.:.|:.:|..|||.:| .:|..:||.   .:.:.|||    
Mouse   444 GAQSYPEIIITGHADGSVKFWDASAITLQVLYKLKTSKVF-EKSRNKDDR---QNTDIVDE---- 500

  Fly   495 FRKSGLFDPYSDDPRLAVKKIAFCPKTGQLIVGGTAGQIVIADF--------------------- 538
                   |||      |::.|::||::..|.:.|.:..::|..|                     
Mouse   501 -------DPY------AIQIISWCPESRMLCIAGVSAHVIIYRFSKQEVLTEVIPMLEVRLLYEI 552

  Fly   539 --IDLPE-----KVSLKYISMN------------LVSDRDGFVWKGHDQLNVRSNL--LDGEAIP 582
              :|.||     .:|....|.|            ..|..||          :|.|:  |..:..|
Mouse   553 NDVDTPEGEQPPPLSTPVGSSNPQPIPPQSHPSTSSSSSDG----------LRDNVPCLKVKNSP 607

  Fly   583 TTER-GVNISGVLQVL-----PPASITCMALEASWGLVSGGTAHGLVLFDFKNFVPVFHRCTLNP 641
            ..:. |.....|:|::     ||..||.:||.:|:|||..|..:|:.:.|:.....:.:..|:  
Mouse   608 LKQSPGYQTELVIQLVWVGGEPPQQITSLALNSSYGLVVFGNCNGIAMVDYLQKAVLLNLSTI-- 670

  Fly   642 NDLTGAG-----EQLSRRKSFKKS----------------LRESFRKLR---------------- 669
             :|.|:.     |..|.|||.:.|                ..||.:|||                
Mouse   671 -ELYGSNDPYRREPRSPRKSRQPSGGMLLGTPCMCGLSSLYSESVKKLRSSVITGLCDITEGTVV 734

  Fly   670 ---------KGRSTRTNQSNQ---------------------------------VPTTLEARP-- 690
                     .|.|:..|..::                                 :||.|  :|  
Mouse   735 PEDRCKSPTSGSSSPHNSDDEQKVNNFIEKVKTQSRKFSKMVANDLAKMSRKLSLPTDL--KPDL 797

  Fly   691 -VERQIEARCADDGLGSM-------VRCLLFAKTYVTNVNIT-SPTLWSATNASTVSVFLLHLPP 746
             |:....:|.....:.|:       :..|.|.:|.....:.: ||.||..|...|..|..|:|||
Mouse   798 DVKDNSFSRSRSSSVTSIDKESRETISALHFCETLTRKADSSPSPCLWVGTTVGTAFVITLNLPP 862

  Fly   747 AQTAATAVP---SASGN---------------------APPHMP---RRISAQLAKEIQLKHRAP 784
            ........|   |.||.                     :|.:.|   ..::.:..::.:||.|.|
Mouse   863 GPEQRLLQPVIVSPSGTILRLKGAILRMAFLDATGCLMSPAYEPWKEHNVAEEKDEKEKLKKRRP 927

  Fly   785 VVGISIFDQAGSPVDQLNAGENGSPPHRVLIASEEQFKVFSLPQLKPINKYKLTANEGARIRRIH 849
            |        :.||.......||    ...:|.||:|.||.|||                      
Mouse   928 V--------SVSPSSSQEISEN----QYAVICSEKQAKVMSLP---------------------- 958

  Fly   850 FGSFSCRISPETLQSMHGCSPTKSTRSHGDGEADPNISGSLAVSRGDVY---NETALICLTNMGD 911
              :.||...                         .||:.:..|.|||:.   |...|.|....|.
Mouse   959 --TQSCAYK-------------------------QNITETSFVLRGDIVALSNSVCLACFCANGH 996

  Fly   912 IMVLSVPELKRQLNAAAVRREDINGVSSLCFTNSGEALYMMSSSELQRIALATSRVVQPTGVVPV 976
            ||..|:|.|:..|:...:...::....:.||.|:|:|||::|.:|:||:..:.            
Mouse   997 IMTFSLPSLRPLLDVYYLPLTNMRIARTFCFANNGQALYLVSPTEIQRLTYSQ------------ 1049

  Fly   977 EPLENEESVLEE 988
            |..||.:.:|.|
Mouse  1050 ETCENLQEMLGE 1061

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)glNP_523439.2 WD40 repeat 39..78 CDD:293791 25/38 (66%)
WD40 repeat 84..126 CDD:293791 14/53 (26%)
WD40 repeat 131..174 CDD:293791 11/42 (26%)
WD40 repeat 188..224 CDD:293791 11/35 (31%)
LLGL 268..>338 CDD:462446 21/83 (25%)
Stxbp5XP_036012001.1 WD40 <49..281 CDD:441893 87/257 (34%)
WD40 repeat 62..95 CDD:293791 23/32 (72%)
WD40 repeat 103..141 CDD:293791 10/40 (25%)
WD40 repeat 146..192 CDD:293791 16/62 (26%)
WD40 repeat 200..236 CDD:293791 11/35 (31%)
WD40 repeat 241..276 CDD:293791 11/37 (30%)
LLGL 276..385 CDD:462446 30/110 (27%)
R-SNARE_STXBP5 1113..1173 CDD:277246
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.