Protein Alignment l(2)gl and Llgl2

DIOPT Version :10

• Sequence 1: NP_523439.2
• Gene: l(2)gl / 33156
• FlyBaseID: FBgn0002121
• Length: 1161
• Species: Drosophila melanogaster
• Sequence 2: XP_006247786.3
• Gene: Llgl2 / 360661
• RGDID: 1560307
• Length: 1078
• Species: Rattus norvegicus
• Alignment Length: 1121
• Identity: 389/1121 - (34%)
• Similarity: 587/1121 - (52%)
• Gaps: 196/1121 - (17%)

  Fly     1 MLKFIRGKGQQPSADRHRLQKDLFAYRKTAQHGFPHKPSALAYDPVLKLMAIGTQTGALKVFGQP 65
            |.:|:| .|..|:  |.||::|||.:.||.:|||||:||||.|.|.|:::||||::||:|::|.|
  Rat    52 MRRFLR-TGHDPA--RERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAVKLYGAP 113

  Fly    66 GVELYGQHTLLNNSASELNVQLLEWVYGTGRILSLTAANQLILWE-------------------- 110
            |||..|.|.  .|:|    |..:.::.|..::::|...|.|.||.
  Rat   114 GVEFMGLHK--ENNA----VLQIHFLPGQCQLVTLLDDNSLHLWSLKVKGGVSELQEEESFTLRG 172

  Fly   111 PVGATLLPIKTLPFDGKLKKVSSLCCSLSKDLLWIGTEGGNIYQLDLHTF-TIKEPVIYHDVVLE 174
            |.||.  |..|        :::.:....|.:||::|||.|:::.:.|..| .:.:..|..|.||:
  Rat   173 PPGAA--PSAT--------QITEILPHSSGELLYLGTESGSVFVVRLPGFCALHDRTISSDEVLQ 227

  Fly   175 QVPP------AYKLNPGAIESIRQLPNSPSKLLVAYNRGLCVLWDFESASVQRAYIAPGHGQSVG 233
            .:|.      .:::    :|::::.|..|:::|:.|:|||.|:||..::.|...:::  |.|...
  Rat   228 WLPEEARHRRVFEM----VEALQEHPRDPNQILIGYSRGLVVIWDLRASRVLSHFLS--HQQLEN 286

  Fly   234 LTVNFEGSEFTWYHADGSYATWSI----DNPEPPSNVNYVPYGPDPCKSINRLY-KGKRRSNDVI 293
            ::...:|......|:|||:..||:    .:|||..  :.|||||.|||:|.::: ...|:.....
  Rat   287 VSWQRDGCLIVTCHSDGSHCQWSVPSDTQSPEPLR--SSVPYGPFPCKAITKIFWLTTRQGLPFT 349

  Fly   294 VFSGGMPRSAYGDHNCVSVHASDGHKVCLDFTSKVIDFFVTFENNR----DVAEVLVVLLEEELC 354
            :|.|||||::|||.:|:|| ..:|.:...||||:||||.|..|.:.    |....||||.||||.
  Rat   350 IFQGGMPRASYGDRHCISV-VHNGQQTAFDFTSRVIDFTVLMEADPVAAFDDPYALVVLAEEELV 413

  Fly   355 AYDLTDPNICAIKAPYLHSVHASAVTCNYLASEVVQSVYESILRAGDEQDIDYSNISWPITGGT- 418
            ..||..|....::.|||.|:|.||:||::..|.:...::|.|:.||..|:..:|.:.|||.|||
  Rat   414 VIDLQTPGWPPVQLPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQNSHFSTMEWPIDGGTS 478

  Fly   419 -LPDNLEESVEEDATKLYEILLTGHEDGSVKFWDCTGVLLKPIYNFKTSSIFGSESDFRDDAAAD 482
             .|...:.          ::||||||||:|:|||.:||.|:.:|...|..:|.:::|..:    :
  Rat   479 LAPPPPQR----------DLLLTGHEDGTVRFWDASGVCLRLLYKLSTVRVFLTDTDLSE----N 529

  Fly   483 MSAEQVDEGEPPFRKSGLFDPYSDDPRLAVKKIAFCPKTGQLIVGGTAGQIVIADFIDLPEKVSL 547
            :||:..||. ||.||.|.||||||||||.::||..|..:|.|.|.|||||:::.:..|...:.::
  Rat   530 LSAQGEDEW-PPLRKVGSFDPYSDDPRLGIQKIFLCKYSGYLAVAGTAGQVLVLELNDEAAEHAV 593

  Fly   548 KYISMNLVSDRDGFVWKGHDQLNVRSNLLDGEAIPTTERGVNISGVLQVLPPASITCMALEASWG 612
            :.:..:|:.|::|:.||||::|..|...:..||      |.....::|..|||.:|.:||.:.|.
  Rat   594 EQVEADLLQDQEGYRWKGHERLAARPGPVRFEA------GFQPFVLVQCQPPAVVTSLALHSEWR 652

  Fly   613 LVSGGTAHGLVLFDFKNFVPVFHRCTLNPNDLTGAGEQLSRRKSFKKSLRESFRKLRKGRSTRTN 677
            ||:.||:||..|||.:....||.:|||:|:|.......|||.||.|||||:|||::|:.|::...
  Rat   653 LVAFGTSHGFGLFDHQQRRQVFVKCTLHPSDQLALEGPLSRVKSLKKSLRQSFRRMRRSRASSHK 717

  Fly   678 QSNQVPT------------------TLEARPVERQIEARCADDGLGSMVRCLLFAKTYVTNVNIT 724
            :....||                  .:|..||:|:||||.|:|.....||.|.||.||:.:.:..
  Rat   718 RRPGGPTGEAQAQAVNTKAERTGLQNMELAPVQRKIEARSAEDSFTGFVRTLYFADTYLRDSSRH 782

  Fly   725 SPTLWSATNASTVSVFLLHLPPAQTAATAVPSASGNAPPHMPRRISAQLAKEIQLKHRAPVVGIS 789
            .|:||:.||..||..|.|.:|||:..|        :.|      :.|:.||||||.||||||||.
  Rat   783 CPSLWAGTNGGTVYAFSLRVPPAERRA--------DEP------VRAEQAKEIQLMHRAPVVGIL 833

  Fly   790 IFDQAGSPVDQ-------LNAGENGSPPHRVLIASEEQFKVFSLPQLKPINKYKLTANEGARIRR 847
            :.|....|:.:       |:...:....|::|:.||||||||:||::....|.||||.||:|:||
  Rat   834 VLDGHNVPLPEPLEVAHDLSKSPDMQGSHQLLVVSEEQFKVFTLPKVSAKLKLKLTALEGSRVRR 898

  Fly   848 I---HFGSFSCRISPETLQSMHGCSPTKSTRSHGDGEADPNISGSLAVSRGDVYNETALICLTNM 909
            :   ||||               |                         |.:.|.|..|..|||:
  Rat   899 VGVAHFGS---------------C-------------------------RAEDYGEHHLAVLTNL 923

  Fly   910 GDIMVLSVPELKRQLNAAAVRREDINGVSSLCFTNSGEALYMMSSSELQRIALATSRVVQPTGVV 974
            |||.|:|||.||.|:..:.:||||::|::|..||..|:..|::|.||.:|.:|:|..:|:|..:|
  Rat   924 GDIQVVSVPLLKPQVRYSCIRREDVSGIASCVFTKYGQGFYLISPSEFERFSLSTKWLVEPRCLV 988

  Fly   975 PVEPLENEESVLEENDAENNKETYACDEVVNTYEIKNPSGISICTRPAEENVGRNSVQQVNGVNI 1039
            ......|      .|...|...|..          |..||           ..|||..|.:|...
  Rat   989 DSAKARN------HNRPSNGNSTGP----------KRTSG-----------QVRNSRSQSDGAET 1026

  Fly  1040 SNSPNQANETISSSIG 1055
            ...|...:..:|.:.|
  Rat  1027 KPGPVMEHALLSDASG 1042

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)gl	NP_523439.2	WD40 repeat	39..78	CDD:293791	20/38 (53%)
		WD40 repeat	84..126	CDD:293791	12/61 (20%)
		WD40 repeat	131..174	CDD:293791	12/43 (28%)
		WD40 repeat	188..224	CDD:293791	12/35 (34%)
		LLGL	268..>338	CDD:462446	33/70 (47%)
Llgl2	XP_006247786.3	None