DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(2)gl and Llgl1

DIOPT Version :10

Sequence 1:NP_523439.2 Gene:l(2)gl / 33156 FlyBaseID:FBgn0002121 Length:1161 Species:Drosophila melanogaster
Sequence 2:NP_001152877.1 Gene:Llgl1 / 16897 MGIID:102682 Length:1062 Species:Mus musculus


Alignment Length:1132 Identity:416/1132 - (36%)
Similarity:625/1132 - (55%) Gaps:163/1132 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MLKF-IRGKGQQPSADRHRLQKDLFAYRKTAQHGFPHKPSALAYDPVLKLMAIGTQTGALKVFGQ 64
            |:|| .|.:|..|  .|.:|:::|||:.||.:||||::|||||:||.|::|||||::||:|::|.
Mouse     1 MMKFRFRRQGADP--QREKLKQELFAFHKTVEHGFPNQPSALAFDPELRIMAIGTRSGAVKIYGA 63

  Fly    65 PGVELYGQHTLLNNSASELNVQLLEWVYGTGRILSLTAANQLILWEPV----------GATLLPI 119
            ||||..|.|   .::|:   |..:.::.|.||:|:|...:.|.|||.:          |.:..|.
Mouse    64 PGVEFTGLH---RDAAT---VTQMHFLPGQGRLLTLLDDSSLHLWEIIHHNGCAHLEEGLSFHPP 122

  Fly   120 KTLPFDGKLKKVSSLCCSLSK---------DLLWIGTEGGNIYQLDLHTFTIKE-PVIYHDVVLE 174
            ....||.     :|...||::         :...:|||.|:|:.||:.|..:.| ..:..||||.
Mouse   123 SRPSFDN-----ASFPASLTRVTVVLLVAGNTAALGTESGSIFFLDVATLALLEGQTLSPDVVLR 182

  Fly   175 QVPPAYKLNP--GAIESIRQLPNSPSKLLVAYNRGLCVLWDFESASVQRAYIAPGHGQSVGLTVN 237
            .||..|:...  |.:||::.....|||:|:.|:|||.|:|...:.||...::  |:.|...|...
Mouse   183 SVPDDYRCGKALGPVESLQGHLQDPSKILIGYSRGLLVIWSQATQSVDNVFL--GNQQLESLCWG 245

  Fly   238 FEGSEFTWYHADGSYATWSIDNPEPPS---NVNYVPYGPDPCKSINR-LYKGKRRSNDVIVFSGG 298
            .:||.....|:|||||.||.|...||:   .|...||||.|||:||: |::.....:..|:||||
Mouse   246 RDGSSIISSHSDGSYAIWSTDTGSPPTLQPTVVTTPYGPFPCKAINKILWRSCESGDHFIIFSGG 310

  Fly   299 MPRSAYGDHNCVSVHASDGHKVCLDFTSKVIDFFVTF----ENNRDVAEVLVVLLEEELCAYDLT 359
            |||::|||.:||||..:: ..|.|||||:|||||...    |:..|..:.|.|||||||...||.
Mouse   311 MPRASYGDRHCVSVLRAE-TLVTLDFTSRVIDFFTVHSTQPEDECDNPQALAVLLEEELVVLDLQ 374

  Fly   360 DPNICAIKAPYLHSVHASAVTCNYLASEVVQSVYESILRAGDEQDID--YSNISWPITGGTLPDN 422
            .|...|:.||||..:|:||:||:...:.|...::..|:.||::|...  .|.:|||||||.   |
Mouse   375 TPGWPAVPAPYLAPLHSSAITCSAHVANVPSKLWARIVSAGEQQSPQPASSALSWPITGGR---N 436

  Fly   423 LEESVEEDATKLYEILLTGHEDGSVKFWDCTGVLLKPIYNFKTSSIFGSESDFRDDAAADMSAEQ 487
            |.:...:..     :||||||||:|:|||.:||.|:|:|...|:.:|.::.:.     ||..|:.
Mouse   437 LAQEPSQRG-----LLLTGHEDGTVRFWDASGVALRPLYKLSTAGLFQTDCEH-----ADSLAQA 491

  Fly   488 VDEGEPPFRKSGLFDPYSDDPRLAVKKIAFCPKTGQLIVGGTAGQIVIADFIDLPEKVSLKYISM 552
            |::..|||||.|.||||||||||.::|:|.|..|.|::|.|||||:::.:..::|.:.::...::
Mouse   492 VEDDWPPFRKVGCFDPYSDDPRLGIQKVALCKYTAQMVVAGTAGQVLVLELSEVPAEHAVSVANV 556

  Fly   553 NLVSDRDGFVWKGHDQLNVRSNLLDGEAIPTTERGVNISGVLQVLPPASITCMALEASWGLVSGG 617
            :|:.||:||.||||::||..:.||...|      |.....::|.||||::|.:.|.|.|.||:.|
Mouse   557 DLLQDREGFTWKGHERLNPHTGLLPWPA------GFQPRMLIQCLPPAAVTAVTLHAEWSLVAFG 615

  Fly   618 TAHGLVLFDFKNFVPVFHRCTLNPNDLTGAGEQLSRRKSFKKSLRESFRKLRKGR---------- 672
            |:||..|||::...||..||||:|||.......|||.||.|||||:|||::||.|          
Mouse   616 TSHGFGLFDYQRKSPVLARCTLHPNDSLAMEGPLSRVKSLKKSLRQSFRRIRKSRVSGKKRTPAA 680

  Fly   673 STRTNQSN------QVPTTLEARPVERQIEARCADDGLGSMVRCLLFAKTYVTNVNITSPTLWSA 731
            |::..::|      ..|..||..||:|:||.|.|||.|..:||||.||.|::.:.....||:|:.
Mouse   681 SSKLQEANAQLAEQTCPHDLEMTPVQRRIEPRSADDSLSGVVRCLYFADTFLRDATHHGPTMWAG 745

  Fly   732 TNASTVSVFLLHLPPAQTAATAVPSASGNAPPHMPRRISAQLAKEIQLKHRAPVVGISIFDQAGS 796
            ||:.:|..:.|.:|.|        :|.|...|.  :.:.|.|.||:||.||||||.|::.|..|.
Mouse   746 TNSGSVFAYALEVPAA--------TAGGEKRPE--QAVEAVLGKEVQLMHRAPVVAIAVLDGRGR 800

  Fly   797 PVDQ-------LNAGENGSPPHRVLIASEEQFKVFSLPQLKPINKYKLTANEGARIRRIHFGSFS 854
            |:.:       |....:....|.||||||||||||:||::....|:||||:||.|:|::...:|:
Mouse   801 PLPEPYEASRDLAQAPDMQGGHAVLIASEEQFKVFTLPKVSAKTKFKLTAHEGCRVRKVALATFA 865

  Fly   855 CRISPETLQSMHGCSPTKSTRSHGDGEADPNISGSLAVSRGDVYNETALICLTNMGDIMVLSVPE 919
            ..:|.:                                     |.||.|.||||:||:.|.|||.
Mouse   866 SVMSED-------------------------------------YAETCLACLTNLGDVHVFSVPG 893

  Fly   920 LKRQLNAAAVRREDINGVSSLCFTNSGEALYMMSSSELQRIALATSRVVQPTGVVPVE-PLENEE 983
            |:.|::.:.:|:|||:|::|..||..|:..|::|.||.:|.:|:...:.:|...:.:. |....:
Mouse   894 LRPQVHYSCIRKEDISGIASCVFTRHGQGFYLISPSEFERFSLSARNITEPLCSLDISWPQNATQ 958

  Fly   984 SVLEE----NDAENNKETYACDEVVNTYEIKNPSGISICTRPAEENVGRNSVQQ-----VNGVNI 1039
            ..|:|    :.|...::.....|             |....|:..:..|....:     ::.|:|
Mouse   959 PRLQESPKLSQANGTRDIILAPE-------------SCEGSPSSAHSKRADTMEPPEAALSPVSI 1010

  Fly  1040 SNSPNQANETISSSIGDITVDSVRDHL 1066
            .::  .:.:|:..:.||:||:.|:|.|
Mouse  1011 DSA--ASGDTMLDTTGDVTVEYVKDFL 1035

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)glNP_523439.2 WD40 repeat 39..78 CDD:293791 22/38 (58%)
WD40 repeat 84..126 CDD:293791 13/51 (25%)
WD40 repeat 131..174 CDD:293791 15/52 (29%)
WD40 repeat 188..224 CDD:293791 14/35 (40%)
LLGL 268..>338 CDD:462446 37/74 (50%)
Llgl1NP_001152877.1 WD40 repeat 38..73 CDD:293791 22/37 (59%)
WD 1 38..71 20/32 (63%)
WD 2 78..119 11/40 (28%)
WD40 repeat 116..174 CDD:293791 16/62 (26%)
WD 3 139..175 9/35 (26%)
WD40 repeat 182..234 CDD:293791 18/51 (35%)
WD 4 199..233 13/33 (39%)
WD40 repeat 239..282 CDD:293791 15/42 (36%)
WD 5 239..271 12/31 (39%)
LLGL 278..379 CDD:462446 49/101 (49%)
WD 6 289..331 18/42 (43%)
WD 7 339..373 15/33 (45%)
WD 8 395..473 34/85 (40%)
WD 9 517..592 27/80 (34%)
WD 10 601..662 32/60 (53%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 667..688 4/20 (20%)
WD 11 722..782 23/69 (33%)
WD 12 791..843 20/51 (39%)
WD 13 848..901 25/89 (28%)
WD 14 915..938 9/22 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 980..1002 4/34 (12%)

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