Protein Alignment tty and TTYH3

DIOPT Version :10

• Sequence 1: NP_542443.4
• Gene: tty / 33109
• FlyBaseID: FBgn0015558
• Length: 970
• Species: Drosophila melanogaster
• Sequence 2: NP_079526.1
• Gene: TTYH3 / 80727
• HGNCID: 22222
• Length: 523
• Species: Homo sapiens
• Alignment Length: 531
• Identity: 151/531 - (28%)
• Similarity: 240/531 - (45%)
• Gaps: 59/531 - (11%)

  Fly    11 YKVPVIAKLLHALPHYNITFHKINSTFRPNDEIYLESLGILGSVPAALLIVSLLGLLFYLMTRCC 75
            |..|....|||.|||:::::...:|.|||.|..|.::|.:||:...|.|.:.||.||||....||
Human     6 YAAPWWVSLLHRLPHFDLSWEATSSQFRPEDTDYQQALLLLGAAALACLALDLLFLLFYSFWLCC 70

  Fly    76 DRKPRPAH---SITSLKVALSIVTVMCCAAIGLGLYGN----DDLHNGLLEVLTAGRKV----DN 129
            .|:....|   ........:.|.|::|.|.|.:|.|||    |.:|.....:..|.|.|    |.
Human    71 RRRKSEEHLDADCCCTAWCVIIATLVCSAGIAVGFYGNGETSDGIHRATYSLRHANRTVAGVQDR 135

  Fly   130 LVTTIRNQTHILE---NTLTNRI--RPQLVELADIFDQPVSNQTALSKLFVSLNIVQGNVTLATN 189
            :..|.....|..|   .||..::  ||          :|:.....|..|..:|......:....|
Human   136 VWDTAVGLNHTAEPSLQTLERQLAGRP----------EPLRAVQRLQGLLETLLGYTAAIPFWRN 190

  Fly   190 AASDIRRPLMGISMTHFLTRGDQWELIRWPGTVATLALLLVLCAVLLVGVARHSRCALILFSVCG 254
            .|         :|:.....:.|.::..||.|.:..|.|.:::|.::|||:.|.|:..|:...:.|
Human   191 TA---------VSLEVLAEQVDLYDWYRWLGYLGLLLLDVIICLLVLVGLIRSSKGILVGVCLLG 246

  Fly   255 LLAVTGSWLMSGLYLSSSVAVGDLCISPADFLVSTAPRD---LPTNVLLHYTQCEPGHTNPFTQR 316
            :||:..||...||.|:.||...|.|:.| |..|:....:   |..::|.:|..|.|...|||.|:
Human   247 VLALVISWGALGLELAVSVGSSDFCVDP-DAYVTKMVEEYSVLSGDILQYYLACSPRAANPFQQK 310

  Fly   317 LRESQNSLNNARSAMATVMKISLVLFKSSGLQPKLGAVNADLNSSERLLTQLTALVDCKAVHHNF 381
            |..|..:|...:..:|.:::  .|.::....:..|..|...||.:|..|..|||||||:::|.::
Human   311 LSGSHKALVEMQDVVAELLR--TVPWEQPATKDPLLRVQEVLNGTEVNLQHLTALVDCRSLHLDY 373

  Fly   382 LAAARGLCEGGLLGLVLMLIASFIAAILLTIMVWVDSHTWIYIRKRNDYAQVDEPSYISHPAP-Q 445
            :.|..|.|..|:.||:.:.:.||:.|::.:.:|....|||  .:||......:|.   :.|.| |
Human   374 VQALTGFCYDGVEGLIYLALFSFVTALMFSSIVCSVPHTW--QQKRGPDEDGEEE---AAPGPRQ 433

  Fly   446 NHQQM----MNAARTLPRNHNGHFSPPVISGSHTLQHPSKRQQHEMMAHAHIQQNMRAMGTHTLG 506
            .|..:    |.:..:...::....|.|  :.:||:   |.....|.|:.....||.|...|..:|
Human   434 AHDSLYRVHMPSLYSCGSSYGSETSIP--AAAHTV---SNAPVTEYMSQNANFQNPRCENTPLIG 493

  Fly   507 R---LPSHNHS 514
            |   .||:..|
Human   494 RESPPPSYTSS 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tty	NP_542443.4	Tweety_N	10..429	CDD:143653	129/436 (30%)
TTYH3	NP_079526.1	Tweety	8..435	CDD:461475	132/453 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	413..435		7/26 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	482..523		9/23 (39%)
		PY-motif, mediates interaction with NEDD4L. /evidence=ECO:0000250|UniProtKB:Q9BSA4	498..501		1/2 (50%)