Protein Alignment: tty and TTYH3

• Sequence 1: NP_542443.4
• Gene: tty
• FlyBaseID: FBgn0015558
• Length: 970
• Species: Drosophila melanogaster
• Sequence 2: XP_011513837.1
• Gene: TTYH3
• HGNCID: 22222
• Length: 526
• Species: Homo sapiens
• Alignment Length: 558
• Identity: 156/559 (28%)
• Similarity: 249/559 (45%)
• Gaps: 66/559 (12%)

  Fly    11 YKVPVIAKLLHALPHYNITFHKINSTFRPNDEIYLESLGILGSVPAALLIVSLLGLLFYLMTRCC 75
            |..|....|||.|||:::::...:|.|||.|..|.::|.:||:...|.|.:.||.||||....||
Human     6 YAAPWWVSLLHRLPHFDLSWEATSSQFRPEDTDYQQALLLLGAAALACLALDLLFLLFYSFWLCC 70

  Fly    76 DRKPRPAH---SITSLKVALSIVTVMCCAAIGLGLYGN----DDLHNGLLEVLTAGRKV----DN 129
            .|:....|   ........:.|.|::|.|.|.:|.|||    |.:|.....:..|.|.|    |.
Human    71 RRRKSEEHLDADCCCTAWCVIIATLVCSAGIAVGFYGNGETSDGIHRATYSLRHANRTVAGVQDR 135

  Fly   130 LVTTIRNQTHILE---NTLTNRI--RPQLVELADIFDQPVSNQTALSKLFVSLNIVQGNVTLATN 189
            :..|.....|..|   .||..::  ||          :|:.....|..|..:|......:....|
Human   136 VWDTAVGLNHTAEPSLQTLERQLAGRP----------EPLRAVQRLQGLLETLLGYTAAIPFWRN 190

  Fly   190 AASDIRRPLMGISMTHFLTRGDQWELIRWPGTVATLALLLVLCAVLLVGVARHSRCALILFSVCG 254
            .|         :|:.....:.|.::..||.|.:..|.|.:::|.::|||:.|.|:..|:...:.|
Human   191 TA---------VSLEVLAEQVDLYDWYRWLGYLGLLLLDVIICLLVLVGLIRSSKGILVGVCLLG 246

  Fly   255 LLAVTGSWLMSGLYLSSSVAVGDLCISPADFLVSTAPRD---LPTNVLLHYTQCEPGHTNPFTQR 316
            :||:..||...||.|:.||...|.|:.| |..|:....:   |..::|.:|..|.|...|||.|:
Human   247 VLALVISWGALGLELAVSVGSSDFCVDP-DAYVTKMVEEYSVLSGDILQYYLACSPRAANPFQQK 310

  Fly   317 LRESQNSLNNARSAMATVMKISLVLFKSSGLQPKLGAVNADLNSSERLLTQLTALVDCKAVHHNF 381
            |..|..:|...:..:|.:::  .|.::....:..|..|...||.:|..|..|||||||:::|.::
Human   311 LSGSHKALVEMQDVVAELLR--TVPWEQPATKDPLLRVQEVLNGTEVNLQHLTALVDCRSLHLDY 373

  Fly   382 LAAARGLCEGGLLGLVLMLIASFIAAILLTIMVWVDSHTWIYIRKRNDYAQVDEPSYISHPAP-Q 445
            :.|..|.|..|:.||:.:.:.||:.|::.:.:|....|||  .:||......:|.   :.|.| |
Human   374 VQALTGFCYDGVEGLIYLALFSFVTALMFSSIVCSVPHTW--QQKRGPDEDGEEE---AAPGPRQ 433

  Fly   446 NHQQM----MNAARTLPRNHNGHFSPPVISGSHTLQHPSKRQQHEMMAHAHIQQNMRAMGTHTLG 506
            .|..:    |.:..:...::....|.|  :.:||:   |.....|.|:.....||.|...|..:|
Human   434 AHDSLYRVHMPSLYSCGSSYGSETSIP--AAAHTV---SNAPVTEYMSQNANFQNPRCENTPLIG 493

  Fly   507 RLPSHNHSPTHMTGPNN-AAAVAAAANAAANMPPTTQA 543
            |     .||.    |:. .||:.:.::|.....|...|
Human   494 R-----ESPP----PSRYLAALDSGSHAGWQFKPMDSA 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tty	NP_542443.4	Tweety_N	10..429	CDD:143653	129/437 (30%)
TTYH3	XP_011513837.1	Tweety	25..431	CDD:282726	123/433 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C45056311
eggNOG	1	0.900				E1_KOG4433
Hieranoid	1	1.000
Homologene	1	1.000				H18431
Inparanoid	1	1.050	196	1.000	Inparanoid score	I3756
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010
OrthoDB	1	1.010				D318605at33208
OrthoFinder	1	1.000				FOG0000756
OrthoInspector	1	1.000				T130239
orthoMCL	1	0.900				OOG5_134193
Panther	1	1.100			O	PTHR12424
Phylome	1	0.910		0.857	Consistency score
RoundUp	0	0.000	Not matched by this tool.
TreeFam	1	0.960
User_Submission	0	0.000	Not matched by this tool.
	13	12.770