DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tty and Ttyh1

DIOPT Version :9

Sequence 1:	NP_542443.4	Gene:	tty / 33109	FlyBaseID:	FBgn0015558	Length:	970	Species:	Drosophila melanogaster
Sequence 2:	XP_017444381.1	Gene:	Ttyh1 / 292597	RGDID:	1310103	Length:	458	Species:	Rattus norvegicus

Alignment Length:	438	Identity:	116/438 - (26%)
Similarity:	212/438 - (48%)	Gaps:	34/438 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 YKVPVIAKLLHALPHYNITFHKINSTFRPNDEIYLESLGILGSVPAALLIVSLLGLLFYLMTRCC 75
            |:......|||.||..:.....:.|.|.|.|:.|.::|.::.::....|.:||:.:..||:..||
  Rat     7 YRPSAWVHLLHQLPRADFQLRPVPSGFAPRDQEYQQALLLVAALAGLGLGLSLIFIAVYLIRFCC 71

  Fly    76 DRKPRPAHS---------ITSLKVALSIVTVMCCAAIGLGLYGNDDLHNGLLEVLTAGRKVDNLV 131
            .|.|.|..:         :|...:|..:|.   ||.||:|.|||.:..:|:.::.:|.:..::.:
  Rat    72 CRPPEPPGAKSPPPGGGCVTWSCIAALLVG---CAGIGIGFYGNSETSDGVSQLSSALQHANHTL 133

  Fly   132 TTIRNQTHILENT--LTNRIRPQLVELADIFDQPVSNQTALSKLFVSLNIVQGNVTLATNAASDI 194
            :||.:.  :||..  |...:|.:|..|.::..:.|....|          .:|....|..||..:
  Rat   134 STIDDL--VLETVERLGEAVRTELTTLEEVLSERVELVAA----------TRGARRQAEAAAQHL 186

  Fly   195 RRPL--MGISMTHFLTRGDQW--ELIRWPGTVATLALLLVLCAVLLVGVARHSRCALILFSVCGL 255
            :...  .|:|::......|..  |..||...|..|.|:|::|...|:|:|:.|:..:::.:...|
  Rat   187 QGLAFWQGVSLSPVQVAEDVTFVEEYRWLAYVLLLLLVLLVCLFTLLGLAKQSKWLVVVMTAMSL 251

  Fly   256 LAVTGSWLMSGLYLSSSVAVGDLCISPADFLVSTAPRD--LPTNVLLHYTQCEPGHTNPFTQRLR 318
            |.:..||...||..:::|.:.|.|.:|..::::....:  :.:::|.:|..|....:|||.|||.
  Rat   252 LVLVLSWGSMGLEAATAVGLSDFCSNPDTYVLNLTQEETGISSDILNYYFLCNQAVSNPFQQRLT 316

  Fly   319 ESQNSLNNARSAMATVMKISLVLFKSSGLQPKLGAVNADLNSSERLLTQLTALVDCKAVHHNFLA 383
            .||.:|.:..|.:..:.:.:...|.::  |..|.::...||.:||...||.||:.|:::|.::.:
  Rat   317 LSQRALASIHSQLQGLEREASPQFPAA--QKPLLSLEETLNVTERSFHQLVALLHCRSLHKDYGS 379

  Fly   384 AARGLCEGGLLGLVLMLIASFIAAILLTIMVWVDSHTWIYIRKRNDYA 431
            |.|||||..|.||:.:::.|.::|..|...:......|.....||..|
  Rat   380 ALRGLCEDALEGLLFLMLFSLLSAGALATTLCSLPRAWALFPPRNPSA 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tty	NP_542443.4	Tweety_N	10..429	CDD:143653	114/434 (26%)
Ttyh1	XP_017444381.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348973
Domainoid	1	1.000	170	1.000	Domainoid score	I3662
eggNOG	1	0.900	-	-		E1_KOG4433
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	187	1.000	Inparanoid score	I3821
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D318605at33208
OrthoFinder	1	1.000	-	-		FOG0000987
OrthoInspector	1	1.000	-	-		mtm9152
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12424
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X806
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.900