Protein Alignment Rpt6 and PSMC5

DIOPT Version :10

• Sequence 1: NP_608447.1
• Gene: Rpt6 / 33105
• FlyBaseID: FBgn0020369
• Length: 405
• Species: Drosophila melanogaster
• Sequence 2: NP_002796.4
• Gene: PSMC5 / 5705
• HGNCID: 9552
• Length: 406
• Species: Homo sapiens
• Alignment Length: 400
• Identity: 372/400 - (93%)
• Similarity: 386/400 - (96%)
• Gaps: 1/400 - (0%)

  Fly     6 RMEIESAYHKGEGFRSYYIQKIEELQLVVAEKHQNLRRLQAQRNELNAKVRMLREELQLLQEQGS 70
            :||:|.. ..|.|.|.||:.|||||||:|.:|.||||||||||||||||||:|||||||||||||
Human     8 QMELEEG-KAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLREELQLLQEQGS 71

  Fly    71 YVGEVVKPMDKKKVLVKVHPEGKFVVDLDKNIDINDVTPNCRVALRNESYTLHKILPNKVDPLVS 135
            ||||||:.|||||||||||||||||||:|||||||||||||||||||:|||||||||||||||||
Human    72 YVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDSYTLHKILPNKVDPLVS 136

  Fly   136 LMMVEKVPDSTYEMVGGLDKQIKEIKEVIELPVKHPELFDALGIAQPKGVLLYGPPGTGKTLLAR 200
            ||||||||||||||:||||||||||||||||||||||||:|||||||||||||||||||||||||
Human   137 LMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLAR 201

  Fly   201 AVAHHTECTFIRVSGSELVQKFIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRIESGSGGD 265
            ||||||:|||||||||||||||||||:||||||||||||||||||||||||||||||:|.|||||
Human   202 AVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGD 266

  Fly   266 SEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDPALLRPGRIDRKIEFPPPNEEARLDILKI 330
            ||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||
Human   267 SEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKI 331

  Fly   331 HSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSE 395
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Human   332 HSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSE 396

  Fly   396 KNMSIKKLWK 405
            ||||||||||
Human   397 KNMSIKKLWK 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rpt6	NP_608447.1	PRK03992	23..399	CDD:179699	357/375 (95%)
PSMC5	NP_002796.4	PRK03992	24..400	CDD:179699	357/375 (95%)
		May mediate interaction with PRPF9. /evidence=ECO:0000250|UniProtKB:P62196	186..406		214/219 (98%)