Protein Alignment Rpt6 and AFG3L2

DIOPT Version :10

• Sequence 1: NP_608447.1
• Gene: Rpt6 / 33105
• FlyBaseID: FBgn0020369
• Length: 405
• Species: Drosophila melanogaster
• Sequence 2: NP_006787.2
• Gene: AFG3L2 / 10939
• HGNCID: 315
• Length: 797
• Species: Homo sapiens
• Alignment Length: 293
• Identity: 117/293 - (39%)
• Similarity: 169/293 - (57%)
• Gaps: 28/293 - (9%)

  Fly   121 TLHKILPNKVDPLVSLMMVEKVPDSTYEMVGGLDKQIKEIKEVIELPVKHPELFDALGIAQPKGV 185
            |..|:|.:::             |..::.|.|.::...||.|.:.. :|:|:.:..||...|||.
Human   294 TTAKVLKDEI-------------DVKFKDVAGCEEAKLEIMEFVNF-LKNPKQYQDLGAKIPKGA 344

  Fly   186 LLYGPPGTGKTLLARAVAHHTECTFIRVSGSELVQKFIGEGSRMVRELFVMAREHAPSIIFMDEI 250
            :|.|||||||||||:|.|......||.|||||.::.|:|.|...||:||.:||::||.|:|:|||
Human   345 ILTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFIDEI 409

  Fly   251 DSIGSSRIESGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDPALLRPGRIDRKIE 315
            |::|..|.....||.||.:.|:.:||.::|||..|.|:.::..|||.||||||||||||.||:|.
Human   410 DAVGRKRGRGNFGGQSEQENTLNQLLVEMDGFNTTTNVVILAGTNRPDILDPALLRPGRFDRQIF 474

  Fly   316 FPPPNEEARLDILKIHSRKMNLTRGIN----LRKIAELMPGASGAEVKGVCTEAGMYALRERRVH 376
            ..||:.:.|..|.|:|.|.:.|...:.    .||:|.|.||.|||:|..||.||.:.|.|.....
Human   475 IGPPDIKGRASIFKVHLRPLKLDSTLEKDKLARKLASLTPGFSGADVANVCNEAALIAARHLSDS 539

  Fly   377 VTQEDFEMAV----------AKVMQKDSEKNMS 399
            :.|:.||.|:          .:|:|.:.:|.::
Human   540 INQKHFEQAIERVIGGLEKKTQVLQPEEKKTVA 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rpt6	NP_608447.1	PRK03992	23..399	CDD:179699	117/291 (40%)
AFG3L2	NP_006787.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	76..126
		HflB	151..747	CDD:440233	117/293 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	759..797