Protein Alignment unc and F54A3.2

DIOPT Version :9

• Sequence 1: NP_001285512.1
• Gene: unc / 33093
• FlyBaseID: FBgn0003950
• Length: 1386
• Species: Drosophila melanogaster
• Sequence 2: NP_494219.4
• Gene: F54A3.2 / 186196
• WormBaseID: WBGene00018781
• Length: 748
• Species: Caenorhabditis elegans
• Alignment Length: 735
• Identity: 135/735 - (18%)
• Similarity: 246/735 - (33%)
• Gaps: 228/735 - (31%)

  Fly   349 CVEARPEVDTTGLYQTEEHELILGADGRSVFVGGRVSQSLHSVEQQLNQLIKNLRHLAKSCAPPV 413
            |.:..|::.   ..:|....::..:....|.|..:..|:|.|:::.:...|
 Worm   167 CRQCTPDIQ---FIKTIAPLIVKASSESDVTVRDKACQALGSIKRLIGDTI-------------- 214

  Fly   414 EVISSTKFEDLLMKELRERERL----LKAGQAFNPGEPVIKIATGDKEEEHEVTS-GRNQKDVVH 473
                 |.|...:..|..:.|::    .:|.:.|...:.....|.||...|:...: ..||::...
 Worm   215 -----TAFIGPISTETAKIEKINQYQQEAAEEFKKFQETQPKAGGDGGAENSAENLDENQENSPE 274

  Fly   474 SNLGPIQVPALDVTIPQ--------------LPRLHSEQLASLAVIRQSLEKVQKKSRQPQGRMY 524
            ....|..:.|.::..|:              :.:...|:||....:::|:|..        ||:.
 Worm   275 KAEKPQVLDAWELLEPEDCSKKIDKSVETQLIDKNWKERLAGAENVKKSMENA--------GRIE 331

  Fly   525 VSMERMETLMGDVCGCVQLLSNVLNLSMEQEHSVGMHKGFKWGYREGFAHGHFMGLQEGQKLEQL 589
            :| ||:..           :|.:|...:|::.:|.                  :|....|.|.::
 Worm   332 IS-ERLTE-----------ISKLLMKIVEKDVNVN------------------VGAISAQILAEI 366

  Fly   590 EQKKWQKERPL----------PEKRESSVQTESTIPTASIATQTSRKSAHNESVITQTEQKQLKD 644
            .:|......||          ..|.:.::..::.:.....|..|:..||::|:|||....|. ..
 Worm   367 AKKSRFSFAPLALRAFPVVFDKLKDKKAILRDALVEFCDEAANTTPLSAYSEAVITALSNKN-PQ 430

  Fly   645 AGNQ---------ASCEPPTFQKSYEQWIHEMLHSSSGQVFLERVELSLNKALELQKV------- 693
            |..|         |..:|.|.:....:.:.|.:..:|.....|..|.:|.....:||.
 Worm   431 ARQQTALFLSRFFAKNDPKTVETEAVKQLAEHILKTSNDADKEVREAALRIVAAVQKCLGEGVAK 495

  Fly   694 -RLNELFQVKLRHQAEMLRLSKRQNSWRTLCKRVERDSQSSAEARDLVQQIFRLLEHYEAHHQQL 757
             .|.|::..||:  ||.|         ..|.:.:|::..|||.     .::.||.:||:
 Worm   496 RLLAEVYDDKLK--AEKL---------PPLIEELEKEFGSSAS-----PEMLRLAKHYK------ 538

  Fly   758 AEKIQQTELAAEQAARIMPMWADGAAVGSASVNWNTAMSTTLISSGICTPPPAQPAADGALNVGK 822
                                      :|::|.                :.||...||
 Worm   539 --------------------------IGASST----------------SAPPKTTAA-------- 553

  Fly   823 THVEQHTYPDLGYPYQLLALAPPGGVPVAGTFVPVTHLP---AHLLGASEH-PVPLVPVARIYSD 883
                       |.|.:..:...|...|.|.. .|....|   |.::..:.. |.|..|||.:  .
 Worm   554 -----------GAPKRPSSAVAPRRAPPASA-APTRRAPSPKAPVVAPTRRAPSPKAPVASV--A 604

  Fly   884 PMKTS-------------RRLLSPSSVPADNDSAHRAAGETNAFTFQGGPVSGDLHPTENRNQAP 935
            |:|..             |..::|:..|.....| .||...:....:..|::    |...||.||
 Worm   605 PVKPKPFVARPAPSFGKPRAAVAPARAPQITQRA-PAATRPSTSAIRVTPIA----PNVVRNGAP 664

  Fly   936 ATQGQQFPVPLPVPAPRGPS-------PSVQSVLPSTASPALPPPDETVPQPGPSQSSIPLKPSM 993
            .|..|....|:.:..|:..|       |..:..:|:|:|.:|      ..:||.:.||:|..|:.
 Worm   665 TTAQQAPRKPIGIARPQTSSGIAAPGAPRSRIAMPTTSSSSL------ARRPGSASSSVPRVPTG 723

  Fly   994 HSVATNTITPVPPKATPLKP 1013
            .:..|::....||.....:|
 Worm   724 AASMTSSSRIRPPSRPGSRP 743

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc	NP_001285512.1	LisH_2	225..252	CDD:292664
F54A3.2	NP_494219.4	HEAT repeat	103..132	CDD:293787
		HEAT repeat	138..164	CDD:293787
		HEAT repeat	177..206	CDD:293787	5/28 (18%)
		HEAT repeat	301..325	CDD:293787	4/23 (17%)
		HEAT repeat	335..371	CDD:293787	9/64 (14%)
		HEAT repeat	380..402	CDD:293787	1/21 (5%)
		Treslin_N	<387..>489	CDD:291938	22/102 (22%)
		HEAT repeat	413..442	CDD:293787	9/29 (31%)
		HEAT repeat	453..485	CDD:293787	5/31 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	1	0.960