DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RunxB and RUNX2

DIOPT Version :9

Sequence 1:	NP_001259745.1	Gene:	RunxB / 33051	FlyBaseID:	FBgn0259162	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	NP_001019801.3	Gene:	RUNX2 / 860	HGNCID:	10472	Length:	521	Species:	Homo sapiens

Alignment Length:	687	Identity:	200/687 - (29%)
Similarity:	277/687 - (40%)	Gaps:	233/687 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 AEVSSTTSNQIQQQQQQHQQQQQHQLLQHQQQQTATTTTTKRRNAESSASSNNNNNNNTSTTNNN 69
            ::||...:.|.||||||.|||||.|..|.|||:.|.........|.::|:
Human    40 SDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAA--------------- 89

  Fly    70 NTNNNNNSTTNNNNNNNNNNVKTKPVDTSPYLTPENLIERTVDVLLAEHPGELVKTGSPHVVCTT 134
                                        .|.|.|.: ..||:..::|:||.|||:|.||:.:|:.
Human    90 ----------------------------VPRLRPPH-DNRTMVEIIADHPAELVRTDSPNFLCSV 125

  Fly   135 LPTHWRSNKTLPIAFKVLALGEVMDGTIVTIRAGNDENFCGELRNCTAVMKNQVAKFNDLRFVGR 199
            ||:|||.|||||:||||:|||||.|||:||:.||||||:..||||.:||||||||:|||||||||
Human   126 LPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGR 190

  Fly   200 SGRGKSFTLTIVISTNPIQIATYTKAIKVTVDGPREPRSKVRHQ----GFHPFAFGPQRFG---- 256
            |||||||||||.:.|||.|:|||.:|||||||||||||   ||:    ...|..|..:...
Human   191 SGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPR---RHRQKLDDSKPSLFSDRLSDLGRI 252

  Fly   257 PDPLM-AGLPFKLPGFAHHLVGMHSHLHAPDWRAHMALGGRPAAFTA-APFFGHHAAAFPTASGL 319
            |.|.| .|:|.:.|                          ||:..:| :||
Human   253 PHPSMRVGVPPQNP--------------------------RPSLNSAPSPF-------------- 277

  Fly   320 RGLSGDSQQHQQQQQQHQLATVGAAHSTTSPEGSPTTTTTSGTQLSAFVQPPMTSSPPPVTSLQH 384
             ...|.||....:|.|            :||..|...:..|  .||....|.:.|:.|
Human   278 -NPQGQSQITDPRQAQ------------SSPPWSYDQSYPS--YLSQMTSPSIHSTTP------- 320

  Fly   385 DNNNNNSNNNNSSSHIDAGFESDSISVTGSPRKSLGSPLTHDEEEAEAE-----AEAEAEAEAEA 444
                       .||....|..    ::|..||:      ..|::.|.::     :....:::|.|
Human   321 -----------LSSTRGTGLP----AITDVPRR------ISDDDTATSDFCLWPSTLSKKSQAGA 364

  Fly   445 EEAEVGGLSRNGGGIQGPLHSESSPGSGGAFTALIQRSGKNPTELFGGFAAAGGNHFAPSGHSFN 509
            .|.             ||.   |.|....:.::|.:....||.           .|: |:..::.
Human   365 SEL-------------GPF---SDPRQFPSISSLTESRFSNPR-----------MHY-PATFTYT 401

  Fly   510 PALAAQLFL-----------QSPLLPQSSQWLYTQLYGSY--SDLPWLRNAAAAAAANINPGQEN 561
            |.:.:.:.|           ..|..|.|||    ...|.:  |..|:|....::.:...
Human   402 PPVTSGMSLGMSATTHYHTYLPPPYPGSSQ----SQSGPFQTSSTPYLYYGTSSGSYQF------ 456

  Fly   562 SGIPPLGSNPDHDGVNLIKRCVTLITHNPPDAENANPNASPPVSSTRRSPSPVETIDLDDVSTTS 626
                |:....|.....::..|.|  |.|  .:...|||.          |:..:.:|.|...::|
Human   457 ----PMVPGGDRSPSRMLPPCTT--TSN--GSTLLNPNL----------PNQNDGVDADGSHSSS 503

  Fly   627 RSASGSSGHGGGVGGGGAVGPIRTRTPKPSADVWRPY 663
            .:...|||                   :....|||||
Human   504 PTVLNSSG-------------------RMDESVWRPY 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RunxB	NP_001259745.1	Runt	118..239	CDD:279225	91/120 (76%)
RUNX2	NP_001019801.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..59		9/18 (50%)
		polyglutamine repeat	49..71		15/21 (71%)
		polyalanine repeat	73..89		2/15 (13%)
		Runt	109..230	CDD:307137	91/123 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	222..340		42/203 (21%)
		Required for interaction with FOXO1. /evidence=ECO:0000250	242..258		3/15 (20%)
		Herpes_BLLF1	<266..481	CDD:330317	57/343 (17%)
		Interaction with KAT6A. /evidence=ECO:0000250	336..439		24/140 (17%)
		Interaction with KAT6B. /evidence=ECO:0000269\|PubMed:11965546	374..468		18/119 (15%)
		RunxI	430..521	CDD:312115	25/137 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	460..521		18/93 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	212	1.000	Domainoid score	I2778
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000993
OrthoInspector	1	1.000	-	-		mtm8468
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11950
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X738
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	6.010