Protein Alignment RunxB and runx1

DIOPT Version :10

• Sequence 1: NP_001259745.1
• Gene: RunxB / 33051
• FlyBaseID: FBgn0259162
• Length: 663
• Species: Drosophila melanogaster
• Sequence 2: XP_012813452.1
• Gene: runx1 / 100485449
• XenbaseID: XB-GENE-483164
• Length: 500
• Species: Xenopus tropicalis
• Alignment Length: 599
• Identity: 186/599 - (31%)
• Similarity: 251/599 - (41%)
• Gaps: 182/599 - (30%)

  Fly   102 TPENLIERTVDVLLAEHPGELVKTGSPHVVCTTLPTHWRSNKTLPIAFKVLALGEVMDGTIVTIR 166
            |..|::|     :|::||||||:|.||:.:|:.||||||.||||||||||:|||:|.|||:||:.
 Frog    47 TDRNMVE-----VLSDHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVM 106

  Fly   167 AGNDENFCGELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTIVISTNPIQIATYTKAIKVTVD 231
            ||||||:..||||.||.||||||:||||||||||||||||||||.:.|||.|:|||.:|||:|||
 Frog   107 AGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVD 171

  Fly   232 GPREPRSKVRHQGFHPFAFGPQRFGPDPLMAGLPFKLPGFAHHLVGMHSHLHAPDWRAHMALGGR 296
            ||||||                |...||::.      ||    |||  ..:.|..:..: :||..
 Frog   172 GPREPR----------------RPKYDPIIG------PG----LVG--GQIQAEIYSIY-SLGKS 207

  Fly   297 PAAFTAAPFFGHHAAA-FPTASGLRGLSGDSQQHQQQQQQHQLATVGAAHSTTSPEGSPTTTTTS 360
            ..:.....|.||.... ..|.||.  ||...:..:.:..:.....|...|.|.:|  :|..|...
 Frog   208 ADSSCVGSFTGHRQKLDEQTKSGT--LSFSERLSELEHLRRTAMRVSPHHPTPTP--NPRATLNH 268

  Fly   361 GTQLSAFVQPPMTSSPPPVTSLQHDNNNNNSNNNNSSSHIDAGFESDSISVTGSPRKS------- 418
            .|   ||       :|.|.:.:|                       |:..|..||..|
 Frog   269 ST---AF-------NPQPQSQIQ-----------------------DTRQVQASPPWSYDQSYQY 300

  Fly   419 LGSPLTHDEEEAEAEAEAEAEAEAEAEEAEVGGLSRNGGGIQGPLHSESSPGSG----------- 472
            |||..|.....|...:...|.:.... .||:.  ||..|.  ..|.:.|.|..|
 Frog   301 LGSIATQSVHPATPISPGRASSMTSL-SAELS--SRLSGA--SDLTAFSDPRVGIDRQFSTLPSI 360

  Fly   473 --------GAFTALIQRSGKNPTELFGGF-----AAAGGNHFAPSGHSFNP-----ALAAQLFLQ 519
                    ||||       ..||.:..|.     |......:    |::.|     :..||   .
 Frog   361 SDPRMHYPGAFT-------YTPTPVTSGIGIGMSAMTSATRY----HTYLPPPYPGSSQAQ---S 411

  Fly   520 SPLLPQSSQWLYTQLYGSYSDLPWLRNAAAAAAANINPGQENSGIPPLGSNPDHDGVNLIKRCVT 584
            ||.  |:|...|...||:        :|.:....::..|.:.|  ||          .::..|
 Frog   412 SPF--QTSSPSYHLYYGT--------SAGSYHQFSMMSGGDRS--PP----------RILPPC-- 452

  Fly   585 LITHNPPDAENANPNASPPVSSTRRSPSPVETIDLDDVSTTSRSASGSSGHGGGVGGGGAVGPIR 649
              |:....:...|||.          |:..:.::.:...:.|.:..|:
 Frog   453 --TNASTGSTLLNPNL----------PNQNDVVEAEGSHSNSPTNMGT----------------- 488

  Fly   650 TRTPKPSADVWRPY 663
              ||:....|||||
 Frog   489 --TPRLEEAVWRPY 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RunxB	NP_001259745.1	Runt	115..239	CDD:459963	93/123 (76%)
runx1	XP_012813452.1	Runt	51..179	CDD:459963	94/148 (64%)
		RunxI	407..500	CDD:430037	27/150 (18%)