DRSC/TRiP Functional Genomics Resources

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Protein Alignment HSPA1L and Hsp70Ab

DIOPT Version :8

Sequence 1:NP_005518.3 Gene:HSPA1L / 3305 HGNCID:5234 Length:641 Species:Homo sapiens
Sequence 2:NP_524798.2 Gene:Hsp70Ab / 44920 FlyBaseID:FBgn0013276 Length:642 Species:Drosophila melanogaster

Alignment Length:641 Identity:476/641 - (74%)
Similarity:555/641 - (86%) Gaps:8/641 - (1%)


Human     8 AIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPQNTVFDA 72
            |||||||||||||||:|||||||||||||||||||||||||:||||||.|||||||||:||||||
  Fly     3 AIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVFDA 67

Human    73 KRLIGRKFNDPVVQADMKLWPFQVINEGGKPKVLVSYKGENKAFYPEEISSMVLTKLKETAEAFL 137
            |||||||::||.:..|||.|||:|:::|||||:.|.||||:|.|.|||||||||||:||||||:|
  Fly    68 KRLIGRKYDDPKIAEDMKHWPFKVVSDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAEAYL 132

Human   138 GHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKGGQGERHVLIFDL 202
            |..:|:|||||||||||||||||||||.|||||||||||||||||:||||||..:|||:||||||
  Fly   133 GESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFDL 197

Human   203 GGGTFDVSILTIDDG-IFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLR 266
            |||||||||||||:| :|||::|||||||||||||||||:|..:|||||:|||:..|.||:||||
  Fly   198 GGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLADEFKRKYKKDLRSNPRALRRLR 262

Human   267 TACERAKRTLSSSTQANLEIDSLYEGIDFYTSITRARFEELCADLFRGTLEPVEKALRDAKMDKA 331
            ||.|||||||||||:|.:|||:|:||.||||.::|||||||||||||.||:||||||.||||||.
  Fly   263 TAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKALNDAKMDKG 327

Human   332 KIHDIVLVGGSTRIPKVQRLLQDYFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSEKVQDLLLL 396
            :|||||||||||||||||.||||:|:|::||.|||||||||||||||||||.||:|.|:||:||:
  Fly   328 QIHDIVLVGGSTRIPKVQSLLQDFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDVLLV 392

Human   397 DVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRF 461
            ||||||||:||||||||.||:||..||.|||:.|:||:||||||.|||||||||||||||.||.|
  Fly   393 DVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYADNQPGVSIQVYEGERAMTKDNNALGTF 457

Human   462 DLTGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKVNKITITNDKGRLSKEEIERMVLDAEK 526
            ||:|||||||||||||||||:||||||||:|.:.||||...|||.|||||||:.||:|||.:|||
  Fly   458 DLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRMVNEAEK 522

Human   527 YKAEDEVQREKIAAKNALESYAFNMKSVVSDEGLKGKISESDKNKILDKCNELLSWLEVNQLAEK 591
            |..|||..|::|.::||||||.||:|..| ::...||:.|:|||.:|||||:.:.||:.|..|||
  Fly   523 YADEDEKHRQRITSRNALESYVFNVKQAV-EQAPAGKLDEADKNSVLDKCNDTIRWLDSNTTAEK 586

Human   592 DEFDHKRKELEQMCNPIITKLYQGGCTGPACGTGYVPGRPA------TGPTIEEVD 641
            :|||||.:||.:.|:||:||::|.|....|.|.|...|:.|      :|||:||||
  Fly   587 EEFDHKLEELTRHCSPIMTKMHQQGAGAGAGGPGANCGQQAGGFGGYSGPTVEEVD 642

Known Domains:


GeneSequenceDomainRegion External IDIdentity
HSPA1LNP_005518.3 Nucleotide-binding domain (NBD). {ECO:0000250|UniProtKB:P11142} 3..388 309/380 (81%)
HSP70 4..641 CDD:331774 474/639 (74%)
Substrate-binding domain (SBD). {ECO:0000250|UniProtKB:P11142} 396..511 90/114 (79%)
Hsp70AbNP_524798.2 PTZ00009 2..642 CDD:240227 474/639 (74%)
HSPA1-2_6-8-like_NBD 3..379 CDD:212675 306/375 (82%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
eggNOG 1 0.900 E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 FOG0000062
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 OOG5_126588
Panther 1 1.100 O PTHR19375
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.900

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