Protein Alignment HSPA1L and Hsp68

DIOPT Version :10

• Sequence 1: NP_005518.3
• Gene: HSPA1L / 3305
• HGNCID: 5234
• Length: 641
• Species: Homo sapiens
• Sequence 2: NP_524474.1
• Gene: Hsp68 / 42852
• FlyBaseID: FBgn0001230
• Length: 635
• Species: Drosophila melanogaster
• Alignment Length: 641
• Identity: 462/641 - (72%)
• Similarity: 551/641 - (85%)
• Gaps: 15/641 - (2%)

Human     8 AIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPQNTVFDA 72
            |||||||||||||||||:|||||||||||||||||||||||:||||||||||||||||:|:||||
  Fly     3 AIGIDLGTTYSCVGVFQYGKVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPKNSVFDA 67

Human    73 KRLIGRKFNDPVVQADMKLWPFQVINEGGKPKVLVSYKGENKAFYPEEISSMVLTKLKETAEAFL 137
            ||||||:|:|..:|.|:|.|||:|||:.||||:.|.:||.||.|.|||||||||||:||||||:|
  Fly    68 KRLIGRRFDDSKIQEDIKHWPFKVINDNGKPKISVEFKGANKCFSPEEISSMVLTKMKETAEAYL 132

Human   138 GHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKGGQGERHVLIFDL 202
            |..|.:|||||||||||||||||||||.|||:|||||||||||||:||||||..:|||:||||||
  Fly   133 GTTVKDAVITVPAYFNDSQRQATKDAGAIAGINVLRIINEPTAAALAYGLDKNLKGERNVLIFDL 197

Human   203 GGGTFDVSILTIDDG-IFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLR 266
            |||||||||||||:| :|||::|||||||||||||||||:||.||||||:|||:..|.||:||||
  Fly   198 GGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVNHFAEEFKRKYKKDLRSNPRALRRLR 262

Human   267 TACERAKRTLSSSTQANLEIDSLYEGIDFYTSITRARFEELCADLFRGTLEPVEKALRDAKMDKA 331
            ||.|||||||||||:|:||||:||||.|||:.::||||||||.||||.|||||||||:||||||:
  Fly   263 TAAERAKRTLSSSTEASLEIDALYEGHDFYSKVSRARFEELCGDLFRNTLEPVEKALKDAKMDKS 327

Human   332 KIHDIVLVGGSTRIPKVQRLLQDYFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSEKVQDLLLL 396
            :|||||||||||||||||.|||::|.|:.||.|||||||||||||:|||||.||||.:::|:||:
  Fly   328 QIHDIVLVGGSTRIPKVQNLLQNFFGGKTLNLSINPDEAVAYGAAIQAAILSGDKSSEIKDVLLV 392

Human   397 DVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRF 461
            ||||||||:||||||||.||:|||.||.||::.||||:||||.|.|||:|||||:|||||:||.|
  Fly   393 DVAPLSLGIETAGGVMTKLIERNSRIPCKQSKTFTTYADNQPAVTIQVFEGERALTKDNNVLGTF 457

Human   462 DLTGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKVNKITITNDKGRLSKEEIERMVLDAEK 526
            ||||:||||||||:|:||||:||||||||||.::.||....|||.|||||||:.:|:||:.:|||
  Fly   458 DLTGVPPAPRGVPKIDVTFDLDANGILNVTAKEQGTGNAKNITIKNDKGRLSQADIDRMLSEAEK 522

Human   527 YKAEDEVQREKIAAKNALESYAFNMKSVVSDEGLKGKISESDKNKILDKCNELLSWLEVNQLAEK 591
            |..|||..|::|||:|.||:|.|.:|....:.|  .:||.:||:.|:::|:|.:.||:.|..|||
  Fly   523 YAEEDERHRQRIAARNQLETYLFGVKEAAENGG--DRISAADKSSIVERCSEAMKWLDSNTTAEK 585

Human   592 DEFDHKRKELEQMCNPIITKLYQGGCTG---PACGT---GYVPGRPATGPTIEEVD 641
            :|:::|.|||||.|:||:||:::||..|   |..|.   ||      .|||:||||
  Fly   586 EEYEYKLKELEQFCSPIMTKMHKGGGDGQQAPNFGQQAGGY------KGPTVEEVD 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPA1L	NP_005518.3	Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	3..388		309/380 (81%)
		PTZ00009	4..641	CDD:240227	460/639 (72%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	396..511		85/114 (75%)
Hsp68	NP_524474.1	PTZ00009	2..635	CDD:240227	460/639 (72%)