DRSC/TRiP Functional Genomics Resources

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Protein Alignment HSPA1L and Hsc70-2

DIOPT Version :8

Sequence 1:NP_005518.3 Gene:HSPA1L / 3305 HGNCID:5234 Length:641 Species:Homo sapiens
Sequence 2:NP_524339.1 Gene:Hsc70-2 / 41609 FlyBaseID:FBgn0001217 Length:633 Species:Drosophila melanogaster

Alignment Length:635 Identity:456/635 - (71%)
Similarity:536/635 - (84%) Gaps:9/635 - (1%)


Human     8 AIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPQNTVFDA 72
            |||||||||||||||:|:.||||||||||||||||||||.:|||||||.||||||||.:||||||
  Fly     6 AIGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKNTVFDA 70

Human    73 KRLIGRKFNDPVVQADMKLWPFQVINEGGKPKVLVSYKGENKAFYPEEISSMVLTKLKETAEAFL 137
            ||||||||:|..:|.|:|||||:||||.||||:.|.:|||.|.|.|||||||||||::|.||.:|
  Fly    71 KRLIGRKFDDKKIQEDLKLWPFKVINEKGKPKIEVEFKGERKRFAPEEISSMVLTKMREIAEVYL 135

Human   138 GHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKGGQGERHVLIFDL 202
            |..|.:||:||||||||||||||||||.|||||||||||||||||:||||||..:|||:||||||
  Fly   136 GGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFDL 200

Human   203 GGGTFDVSILTIDDG-IFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLR 266
            ||||||||:|:||:| :||||||||||||||||||||||:||.||||||||.||..|.||:||||
  Fly   201 GGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDIKGNARALRRLR 265

Human   267 TACERAKRTLSSSTQANLEIDSLYEGIDFYTSITRARFEELCADLFRGTLEPVEKALRDAKMDKA 331
            ||||||||||||||:|:||||:|:||||||:.|:|||||||..||||.|::|||:||.||||||.
  Fly   266 TACERAKRTLSSSTEASLEIDALHEGIDFYSKISRARFEELNMDLFRSTMQPVERALSDAKMDKK 330

Human   332 KIHDIVLVGGSTRIPKVQRLLQDYFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSEKVQDLLLL 396
            .|||:|||||||||||:|:||||.|.|:.||.|||||||||||||||||||.|..|.::|||||:
  Fly   331 AIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGSSQIQDLLLV 395

Human   397 DVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRF 461
            ||||||||:||||||||.|::||:.||.||.||||||||||..|.||||||||||||||||||.|
  Fly   396 DVAPLSLGIETAGGVMTNLVERNARIPCKQQQIFTTYSDNQNAVTIQVYEGERAMTKDNNLLGTF 460

Human   462 DLTGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKVNKITITNDKGRLSKEEIERMVLDAEK 526
            :||||||||||||||||.||::|:|||||.|.|.||||..||||:||||||||.||:||:.:|||
  Fly   461 NLTGIPPAPRGVPQIEVAFDLNADGILNVNAKDNSTGKSEKITISNDKGRLSKAEIDRMLSEAEK 525

Human   527 YKAEDEVQREKIAAKNALESYAFNMKSVVSDEGLKGKISESDKNKILDKCNELLSWLEVNQLAEK 591
            ||.||:.|||::.:||.||:|.:..:..| |:...|.:||::::|:.|||:...|||:.|.||||
  Fly   526 YKVEDDRQRERVQSKNNLEAYIYACRQAV-DDAPSGVLSETERSKVRDKCSSEASWLDKNSLAEK 589

Human   592 DEFDHKRKELEQMCNPIITKLYQGGCTGPACGTGYVPGRPATGPTIEEVD 641
            :||:...||.:::|.||::|::.|.....:.|.|       :.||:||||
  Fly   590 EEFESHLKECQRICTPIMSKIHGGKKGKSSMGKG-------SHPTVEEVD 632

Known Domains:


GeneSequenceDomainRegion External IDIdentity
HSPA1LNP_005518.3 Nucleotide-binding domain (NBD). {ECO:0000250|UniProtKB:P11142} 3..388 302/380 (79%)
HSP70 4..641 CDD:331774 454/633 (72%)
Substrate-binding domain (SBD). {ECO:0000250|UniProtKB:P11142} 396..511 90/114 (79%)
Hsc70-2NP_524339.1 PTZ00009 1..632 CDD:240227 454/633 (72%)
HSPA1-2_6-8-like_NBD 6..382 CDD:212675 300/375 (80%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
eggNOG 1 0.900 E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 D180577at33208
OrthoFinder 1 1.000 FOG0000062
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 OOG5_126588
Panther 1 1.100 O PTHR19375
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.910

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