Protein Alignment HSPA1L and CG7182

DIOPT Version :8

• Sequence 1: NP_005518.3
• Gene: HSPA1L / 3305
• HGNCID: 5234
• Length: 641
• Species: Homo sapiens
• Sequence 2: NP_001286979.1
• Gene: CG7182 / 38944
• FlyBaseID: FBgn0035878
• Length: 513
• Species: Drosophila melanogaster
• Alignment Length: 533
• Identity: 144/534 (27%)
• Similarity: 240/534 (45%)
• Gaps: 99/534 (19%)

Human    10 GIDLGTTYSCVG-VFQHGKVEIIANDQGNRTTPSYVAFTDTERL-IGDAAKNQVAMNPQNTV--- 69
            ||.:|.:..|:. |...||.|:|||.||:|.:.:.:.:.....: .|..||.::|..|:..|
  Fly     6 GIKIGNSTLCIAHVRADGKAEVIANKQGDRVSQACLLWDGASEIECGLTAKQKMANRPRQAVAHS 70

Human    70 -------------------------FDAKRLIGRKFNDPVVQADMKLWPFQVINEGGKPKVLVSY 109
                                     ||.:.|:.|.  :..|.:|.:....:|:.
  Fly    71 FQLLQPKEELTEEKLSSALREIPCDFDKEELVFRM--EHTVPSDREDQDDRVVT----------- 122

Human   110 KGENKAFYPEEISSMVLTKLKETAEAFLGH---------PVTNAVITVPAYFNDSQRQATKDAGV 165
                     :::|:..:|.....||..|.|         |:  ||:::|:|:..|..:...||..
  Fly   123 ---------KDLSAYQVTVELLRAELELAHQYHTDGEQAPI--AVLSIPSYYPASAYKLLADAAQ 176

Human   166 IAGLNVLRIINEPTAAAIAYGL-DKGGQGERHVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTH 229
            .||.:|.:||.|||||.:.|.: ::..:..||||....||...|::..::.:|:|...||.|...
  Fly   177 TAGFHVAQIITEPTAAVLGYSIGEEQTEQRRHVLTIKCGGLYSDIAFYSVQNGLFVQLATFGPFP 241

Human   230 LGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQANLEIDSLYEGID 294
            :||..|...||....|||:||:|.|..:::|:|.::|||....|..|::.....|.||||.:|:|
  Fly   242 IGGRQFTEALVQFICEEFRRKYKLDPHESRRSVAKIRTAAANCKHILTTMPSTQLYIDSLMDGVD 306

Human   295 FYTSITRARFEELCADLFRGTLEPVEKALRDAKMDK---AKIHDIVLVGGSTRIPKVQRLLQDYF 356
            :...::|||||.|...:....::.:.:.:..|:.:.   :||.||||:|.:.:|||:|..:...|
  Fly   307 YNAQMSRARFESLIQPVINNLIQQLGECVEQAQKEHPGLSKIDDIVLLGATMQIPKLQAAVGARF 371

Human   357 NGRDLNKSINPDEAVAYGAAVQAAIL---MGDKSEKVQDLLLLD------------VAPLSLGLE 406
            ....|:.|.:.||.||.|.|.||..|   :..:..|.:|.::.:            .|.|.||
  Fly   372 PDAKLHNSHSADEVVAIGCARQAVCLIDPLEQQLHKEEDCVVAEDDLFIWHGNDESNAKLVLG-- 434

Human   407 TAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPG-VLIQVYEGERAMTKDNNLLGRFDLTGIPPAP 470
                       |.|.:|.| .:|....|:...| .:.:.....:..|.::.:|.|...:.||  .
  Fly   435 -----------RGSVLPAK-IRISLPQSEEGKGDDVSKAAASFKLRTGESEILARLPDSTIP--E 485

Human   471 RGVPQIEVTFDID 483
            .|:.|:||..|:|
  Fly   486 DGLYQLEVEVDVD 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPA1L	NP_005518.3	Nucleotide-binding domain (NBD). {ECO:0000250|UniProtKB:P11142}	3..388		120/424 (28%)
		HSP70	4..641	CDD:331774	144/534 (27%)
		Substrate-binding domain (SBD). {ECO:0000250|UniProtKB:P11142}	396..511		22/102 (22%)
CG7182	NP_001286979.1	NBD_sugar-kinase_HSP70_actin	5..394	CDD:302596	118/412 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900