Protein Alignment HSPA1L and CG7182

DIOPT Version :10

• Sequence 1: NP_005518.3
• Gene: HSPA1L / 3305
• HGNCID: 5234
• Length: 641
• Species: Homo sapiens
• Sequence 2: NP_648212.1
• Gene: CG7182 / 38944
• FlyBaseID: FBgn0035878
• Length: 513
• Species: Drosophila melanogaster
• Alignment Length: 533
• Identity: 144/533 - (27%)
• Similarity: 240/533 - (45%)
• Gaps: 99/533 - (18%)

Human    10 GIDLGTTYSCVG-VFQHGKVEIIANDQGNRTTPSYVAFTDTERL-IGDAAKNQVAMNPQNTV--- 69
            ||.:|.:..|:. |...||.|:|||.||:|.:.:.:.:.....: .|..||.::|..|:..|
  Fly     6 GIKIGNSTLCIAHVRADGKAEVIANKQGDRVSQACLLWDGASEIECGLTAKQKMANRPRQAVAHS 70

Human    70 -------------------------FDAKRLIGRKFNDPVVQADMKLWPFQVINEGGKPKVLVSY 109
                                     ||.:.|:.|.  :..|.:|.:....:|:.
  Fly    71 FQLLQPKEELTEEKLSSALREIPCDFDKEELVFRM--EHTVPSDREDQDDRVVT----------- 122

Human   110 KGENKAFYPEEISSMVLTKLKETAEAFLGH---------PVTNAVITVPAYFNDSQRQATKDAGV 165
                     :::|:..:|.....||..|.|         |:  ||:::|:|:..|..:...||..
  Fly   123 ---------KDLSAYQVTVELLRAELELAHQYHTDGEQAPI--AVLSIPSYYPASAYKLLADAAQ 176

Human   166 IAGLNVLRIINEPTAAAIAYGL-DKGGQGERHVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTH 229
            .||.:|.:||.|||||.:.|.: ::..:..||||....||...|::..::.:|:|...||.|...
  Fly   177 TAGFHVAQIITEPTAAVLGYSIGEEQTEQRRHVLTIKCGGLYSDIAFYSVQNGLFVQLATFGPFP 241

Human   230 LGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQANLEIDSLYEGID 294
            :||..|...||....|||:||:|.|..:::|:|.::|||....|..|::.....|.||||.:|:|
  Fly   242 IGGRQFTEALVQFICEEFRRKYKLDPHESRRSVAKIRTAAANCKHILTTMPSTQLYIDSLMDGVD 306

Human   295 FYTSITRARFEELCADLFRGTLEPVEKALRDAKMDK---AKIHDIVLVGGSTRIPKVQRLLQDYF 356
            :...::|||||.|...:....::.:.:.:..|:.:.   :||.||||:|.:.:|||:|..:...|
  Fly   307 YNAQMSRARFESLIQPVINNLIQQLGECVEQAQKEHPGLSKIDDIVLLGATMQIPKLQAAVGARF 371

Human   357 NGRDLNKSINPDEAVAYGAAVQAAIL---MGDKSEKVQDLLLLD------------VAPLSLGLE 406
            ....|:.|.:.||.||.|.|.||..|   :..:..|.:|.::.:            .|.|.||
  Fly   372 PDAKLHNSHSADEVVAIGCARQAVCLIDPLEQQLHKEEDCVVAEDDLFIWHGNDESNAKLVLG-- 434

Human   407 TAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPG-VLIQVYEGERAMTKDNNLLGRFDLTGIPPAP 470
                       |.|.:|.| .:|....|:...| .:.:.....:..|.::.:|.|...:.||  .
  Fly   435 -----------RGSVLPAK-IRISLPQSEEGKGDDVSKAAASFKLRTGESEILARLPDSTIP--E 485

Human   471 RGVPQIEVTFDID 483
            .|:.|:||..|:|
  Fly   486 DGLYQLEVEVDVD 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPA1L	NP_005518.3	Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	3..388		120/423 (28%)
		PTZ00009	4..641	CDD:240227	144/533 (27%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	396..511		22/101 (22%)
CG7182	NP_648212.1	ASKHA_ATPase-like	5..394	CDD:483947	117/411 (28%)