Protein Alignment Rab35 and RAB40AL

DIOPT Version :10

• Sequence 1: NP_608373.1
• Gene: Rab35 / 33014
• FlyBaseID: FBgn0031090
• Length: 201
• Species: Drosophila melanogaster
• Sequence 2: NP_001027004.1
• Gene: RAB40AL / 282808
• HGNCID: 25410
• Length: 278
• Species: Homo sapiens
• Alignment Length: 200
• Identity: 74/200 - (37%)
• Similarity: 110/200 - (55%)
• Gaps: 11/200 - (5%)

  Fly     3 RGFDHLFKLLIIGDSGVGKSSLLIRFSDDTFSGSYITTIGVDFKIRTVDIEGMRVKLQIWDTAGQ 67
            :.:|.|.|.|::||..||||.:|....|.|....|....|:|:|..|:.::|.||||::|||:||
Human     9 QAYDFLLKFLLVGDRDVGKSEILESLQDGTAESPYSHLGGIDYKTTTILLDGQRVKLKLWDTSGQ 73

  Fly    68 ERFRTITSTYYRGTHGVIVVYDVTNGESFANVRRWLEEIQNNCDVVKKVLVGNKNDDPDRKVVIT 132
            .||.||..:|.||..|||:|||:.|..||..:.||:::|:.:...|.|:||||:.....::.|..
Human    74 GRFCTIFRSYSRGAQGVILVYDIANRWSFEGMDRWIKKIEEHAPGVPKILVGNRLHLAFKRQVPR 138

  Fly   133 EDAQRFAKQMDIELFETSAKDNINVENMFLSITRQV-LDHKLRTSPNEQQKDTLHLKPNPKGSKG 196
            |.||.:|:::.:..||.|...|.|:...|..:.|.| |.|:|....          :|:...|..
Human   139 EQAQAYAERLGVTFFEVSPLCNFNIIESFTELARIVLLRHRLNWLG----------RPSKVLSLQ 193

  Fly   197 GKCCR 201
            ..|||
Human   194 DLCCR 198

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab35	NP_608373.1	Rab35	3..201	CDD:133310	72/198 (36%)
RAB40AL	NP_001027004.1	P-loop containing Nucleoside Triphosphate Hydrolases	9..278	CDD:476819	73/199 (37%)
		Switch-I. /evidence=ECO:0000255|PROSITE-ProRule:PRU00753	41..49		1/7 (14%)
		Switch-II. /evidence=ECO:0000255|PROSITE-ProRule:PRU00753	72..88		9/15 (60%)
		SOCS_Rab40	187..228	CDD:239711	3/11 (27%)