|
Fly 182 KSRAAAVKVISSLNPGKMPPVK----RVRPSPEPVREKVAEKPAEKVLDKEKPKAEQQITPPPAP 242
:|.|||.: ::...|...||.. :..|||.|:....| :.:::.
Human 22 RSAAAAAR-LAPAGPAAQPPAHFQPGKYFPSPLPMASHTA---SSRLMG---------------- 66
Fly 243 EESPASKVPKKTVQQAKKAKVESSLVQATVLTTTSAATSAPSSASTSKHTSTKNPGKKSAHSEQM 307
.||||.. ..:.:.|||..|.....:..::|.|..|....|.:|.... .:||.:.
Human 67 -SSPASSF--------MGSFLTSSLGSAASTHPSGPSSSPPEQAYRGSHPTTSQIW--FSHSHEA 120
Fly 308 PKKELSKLAKMGKPKKEANLVKSTARLPDSNTE---------------SVQMELEEIVSTPTVTP 357
| |.|:...:| ::..||.|:.: ..|.:...:.:.|
Human 121 P----------GYPRFSGSL--ASTFLPVSHLDHHGNSNVLYGQHRFYGTQKDNFYLRNLP---- 169
Fly 358 TPSATPTATPTPTATPTLTPTPTATRTRTPTPTLTPTPTPTSTPSSTAIAAGQPAPPPPPPGGAP 422
|.||..|.....|:..| |.|..|.|...
Human 170 ---------PQPTLLPANHNFPSVAR----------------------------AAPAHPMGSCS 197
Fly 423 KQRPKVKYTKTSAGSKGRMQQALNQKAPAASWSGAKDIYDFKSGSEDEEPIKMVLPSLKELREFS 487
:.|.: |..|.:|: |.||...|..|.|
Human 198 RDRDR--------GEAGSLQK------------GPKDFDRFLVGKE------------------- 223
Fly 488 DEDNKPLKLFERQAEKTKVQVQDEEEQPLVKKEEKPPSEKEVKVKSKEKEKEKEKDVDPL---SN 549
|...:|.|. .:.:|:|.:| ::..||:.|.|.|: .:
Human 224 --------LGREKAGKA------------AEGKERPAAE-------EDGGKERHKLVLPVPADGH 261
Fly 550 AQQSEPA--------AKHTTSTSTTSTTSITSVKKQAKRKIATPMPSSAGRKKKTVGKGKAAAAK 606
.::..|| .||.||....:......:.:.|....|..|....|....|.|: .||
Human 262 CREGGPAPRGACEGRPKHLTSCLLNTKVLNGEMGRAALASCAGGMLGRPGTGVVTSGR----CAK 322
Fly 607 EP--PPSGSSAESSSSEDERKL---SAYSGPKRHRMASLNALAKVQC------LYENESRTAHEL 660
|. ||....|.|...|..:.| ::|:||......:..:...:|. |...:.:...:|
Human 323 EAAGPPEPGPAFSECLERRQMLHHTASYAGPPPPLSTAAGSFPCLQLHGGPDGLCPLQDKAPRDL 387
Fly 661 GLSKATQQPPRIRTLD--------------GSDDDNHKDSPRHGDTDRDKGSVSPPHTSAAPPAA 711
..|..|..|......| |...|.|.: |:::|.| |||...
Human 388 KASGPTFVPSVGHLADKGRPFQAAEACAVAGEGKDRHLE-----------GTMAPDH--AAPYGV 439
Fly 712 PIAPPKEAEPRRELRYVPGGRGVGKHWEFDSDSETEELQ-LQQTLPPVKKKKLPKKAPPK----K 771
..|..| ||.:.|.| ||| :|...:...:.|. |....|......|||....| :
Human 440 SYAHLK-AEGKGERR--PGG------FEAALNPRLKGLDYLSSAGPEASFPGLPKSGLDKSGYFE 495
Fly 772 VASSETDAKRKKKSVQVEESDDEEAK--------EKEKEKEKPKPPKQLPKKRKTAFTEELIG-- 826
:.:|..|..|. ...|....| :|...||.|..|....|..:....:.|:.
Human 496 LPTSSQDCARP------GHQDPLGGKAPQACCTLDKTVGKEAPAGPPGAQKVARIRHQQHLMAAE 554
Fly 827 -DYKGILARKRMASLNASAI-----------------VAATYEVERHLDKNLASDCSSFESY--- 870
:..||.|..:..||..::: .|.....||.....|....|..:..
Human 555 VEQGGIGAEAKRKSLELASLGYSGPHLPPWGVQAGQGTAMAISEERKAGAYLDPFGSGLQQAALL 619
Fly 871 -DELDTMPTTTS------KVTSAAAI---KTEVIHI----------------KKEPKESKESLRE 909
.||...|...| |.:|.|.: |..::.: .|.|.:|:.....
Human 620 PQELPAPPDEVSAMKNLLKYSSQALVVGQKAPLVGLGGLKASCIQQEAKFLSSKGPGQSERPDCA 684
Fly 910 RERERESERRRERDNELKDSTVGKMSSHSIIEESNDSKYSKETKETNTDTTITTT-------GYR 967
|.||.:: ...|.|::...|| .:.::..:.:....|:....|||....... |.|
Human 685 RSREHDT---THGDGEVRQPPVG--IAVALARQKDTVSRSEAAYGTNTARQGRAAPAFKGGGGPR 744
Fly 968 DSAASTKDAK-------DCSRPTSSSVVIVQDTDVTITGVYVNASNGAAQEAYCKMQYRVQSSVT 1025
.:.|...:|: |.....:|..:::||:...:....::..:..
Human 745 STHALDLEAEEERTRLCDDRLGLASRELLLQDSKDRVEFARIHPPSSC----------------- 792
Fly 1026 EERVLRPGSVEP------------------------PKSYTPL------------SALSSMLPPG 1054
||.:.| |::.:|. .||...||||
Human 793 ------PGDLAPHLMMQSGQLGGDPAPHTHPHPPWLPRTRSPSLWMGGHSYGLGHPALHQNLPPG 851
Fly 1055 -ASSGLSEAHSSPPLPVHAAPTGPHVLLPGEHLSAGMYHAPDLGLHTEHALPDHHGPP---PPSY 1115
.:|......|..||| ..||| ..|:||.|... :.|| |||.|..... ||.|
Human 852 FPASVAGPVPSVFPLP-QDAPT-QLVILPSEPTP---HSAP-------HALADVMDQASLWPPMY 904
Fly 1116 AAAAAAAAAAAAYHAHQLAPGGGGVLHMHHQHQYAAHA---------AHAHHYQQAAEYHGGP-- 1169
. |.|...||.|..|...:: .:|...|:||::...|
Human 905 G-------------------GRGPASHMQHPGQLPVYSRPQLLRQQELYALQQQRAAQFQRKPED 950
Fly 1170 ---------------------------PPPPHHYGGP---PPQGH---YGPPPGAPVPVP-VAVP 1200
|..|....|| ||..| ..||..:|.|.| .:.|
Human 951 QHLDLEEPAQEKAPKSTHKPVALTPTAPGAPSPAAGPTKLPPCCHPPDPKPPASSPTPPPRPSAP 1015
Fly 1201 NTVTVPPERCDVGSPPPSYR--------------------------------------ASAYPPP 1227
.|:.| |...||.|..| ||..|..
Human 1016 CTLNV----CPASSPGPGSRVRSAEEKNGEGQQSTADIITSEPVARAHSVAHAGLEFLASNDPST 1076
Fly 1228 SS------VGMPP----PTLGGGSSAFCAPSPLHHHQHQH----QQPGPGVGPPHHDPSGYYQPA 1278
|: ..:|| |..|.| |..||.:|....:. |...||..| :|:..:.|.
Human 1077 SASQSFGITDLPPGYLRPMAGLG---FSLPSDVHSSNLEDPETMQTTAPGAQP---EPTRTFLPG 1135
Fly 1279 GP-------LISPHVI-----------AAPPP-----------PAQVKKLQE------------- 1301
.| |..|.:: |.|.| |:.::.|||
Human 1136 EPPPCSPRSLEEPGLLSGAREATQDLAATPYPTERGPQGKAADPSPLEGLQELQCAALLEAGGPE 1200
Fly 1302 ---------------------EDGPVSA---------AGSPTQLQQ--QQAAAEAAAAAADQAAA 1334
|.||.|. ||||..|:. :|.|.|......|:...
Human 1201 ATGQAHSTQGGAREERSREEGEQGPSSGASSQVLEQRAGSPGALEDEGEQPAPEEDELEEDELGQ 1265
Fly 1335 QSQSQSQGQSHGHAHSHAHNPQ------------------QAQHPPQPQPYPAGAVAAAAAAAAA 1381
||...|: :..|.|..::|.|: .:..||.||| .||:...:
Human 1266 QSMEDSE-EDCGGAPDNSHPPRALPGLDALVAATINLGDLPSDSPPDPQP-------PAASGPPS 1322
Fly 1382 HQGVPYSRSMH------------------------------------------------AAQMHY 1398
...:|:|..:| ||.:..
Human 1323 TVPLPHSSGIHGIALLSELADLAIQRQRSERTVPEEEEDVLAFNLQHLATLATAWSLVEAAGLDS 1387
Fly 1399 ST--GYPPNYYAPYPGEVM-----------CYSPPTYP--PY----------------------- 1425
|| ..||. ..|..|..: .::|.|.| |.
Human 1388 STAPAQPPT-ANPCSGPRLTPRMQILQRKDTWTPKTKPVCPLKAAIDRLDTQEVGMRVRLAELQR 1451
Fly 1426 -FSSKVYQ-----------------------PSHP-------AHPAAHPQGPPP----------- 1448
:..|..: |..| :.||..|.||.|
Human 1452 RYKEKQRELARLQRKHDHERDESSRSPARRGPGRPRKRKHSSSLPAPRPTGPLPRSDGKKVKAVR 1516
Fly 1449 -----------------PGAYRR------YPYYQHA----------------GPPPPHELYEQQP 1474
|...|. |...|.| .|...|.: .|.
Human 1517 TSLGLLCAELRGGSGGEPAKKRSKLERSVYAGLQTASVEKAQCKKSSCQGGLAPSVAHRV--AQL 1579
Fly 1475 PPPPVSSGSVSGPAQQQPPTSSPA-----------SVGAAGAGTAGAPSGSQLVPAHQQQHQQQH 1528
.|...|.|..:|.:..|...::|. |...:||.....|.| |..:.
Human 1580 KPKVKSKGLPTGLSSFQQKEATPGGRIREKLSRAKSAKVSGATRHPQPKG----------HGSRE 1634
Fly 1529 LEHYPGPPSYYAGYSPGGGASAGQCYTRGLQGPYMEYPPQCPCPMPQSCPKNVHTGPHIGSNIIS 1593
....|..||..|....|.|..:..| .||.| .|.| |:.....:|||..:..
Human 1635 TPRCPAQPSVAASQEAGSGYDSEDC--EGLLG--TEAP-------PREAGLLLHTGASVAV---- 1684
Fly 1594 NIDQSSSCSSSMLLSATSNSN--------IGGGSSSSSSSSSSTTLPACSSATTTTT-------- 1642
...|.||.:.:.|...:. :|....||..|.......:..:...||.
Human 1685 ---LGPSPSSVVKMEANQKAKKKKERQGLLGACRLSSPESEVKIKRRSVKAKVGTTLERAPGQRP 1746
Fly 1643 --ASALTTSRGPVK-------NVTPNNSNSSGHTSTNSCRSSNNSNNSSNSSCQTIEMTSWATAA 1698
|.....::|..| ..||:.......:...:||...:...|......|.:.|......
Human 1747 PGALGKKKAKGKAKGSLRAEPGATPSRDALFNPSRAFACREEGSQLASERLKRATRKGTVLQPVL 1811
Fly 1699 TNTTSTTATTATTGTQCQMLVKTELKGENPQVTKMQYEA----------HVMPPPTPPESYCASD 1753
.......:.|..|.....:| |:..:::|::::| .:: ||:...:
Human 1812 RRKNGALSITLATRNAKAIL------GKGRKLSKVKHKAGKQGKGRAVSRLL------ESFAVEE 1864
Fly 1754 EKLLDD-----QEQEAELELRLRLGLGLEKSHGGQQHIEAYDLTCSTPPPVTVPQAAAVPRKARI 1813
:...|| :|:|.|.| |:...| |::..|:||:.|...|
Human 1865 DFEFDDNSSFSEEEEDEEE---------EEEDSG---------------PLSAEQSAALARSCAI 1905
Fly 1814 GKSMARE-----------MVYAA---------------------QQQLLPEKQLKQPKEAAAKLE 1846
.|...|: ::||. :|::...:||.| .|.|:
Human 1906 HKEDLRDGLPVLIPKEDSLLYAGSVRTLQPPDIYSIVIEGERGNRQRIYSLEQLLQ----EAVLD 1966
Fly 1847 AEPEMPFVLKA---------------------------EIKAETKIKIEHDGEAQASTHISQLPD 1884
..|:....|.. |.:....:.:|.|........:|.:..
Human 1967 VRPQSSRYLPPGTRVCAYWSQKSRCLYPGNVVRGASGDEDEDLDSVVVEFDDGDTGHIAVSNVRL 2031
Fly 1885 LKPTIK---TEPEQEL--EQEAASVPSVAKTEPQPEVEVEREQQEPPVDEEQQPTPGGSKQRFNL 1944
|.|..| |||...| .........|:...|.|. |...|.:..:.|..|...|
Human 2032 LPPDFKIQCTEPSPALLVSSSCRRTKKVSSEAPPPS-----EAATPSLSPKAQDGPEALK----- 2086
Fly 1945 LALSSGNKKTKTNNSYKSLIKQAEPKSYLCPGRRFIRRHGR-----APAKYVKRRQMILTQRQQQ 2004
:.|.|....:.:.|:.:..:..||.......|:.|.|. :.....||:.:....:...
Human 2087 ---TPGKKSISKDKAGKAELLTSGAKSPTGASDHFLGRRGSPLLSWSAVAQTKRKAVAAASKGPG 2148
Fly 2005 RMR-LQRREQQQQRRQQREAAAEVVAGAVVTPSLAGNPIEQAGSEVSIVKDQAPNSSAT----PS 2064
.:: |.:.....::.:.|||...| .:|.|| :.||.. :|.|..|:....||....| |.
Human 2149 VLQNLFQLNGSSKKLRAREALFPV--HSVATP-IFGNGF-RADSFSSLASSYAPFVGGTGPGLPR 2209
Fly 2065 ASPKRARPRKQEIAALHLLEGLDTTLSRGYFSDPELNHSSRKQAPTAVGGLYAASSPLTTATDHR 2129
.:.|..|.:|.| |.:|.. ||...|........||.
Human 2210 GAHKLLRAKKAE----------------------------RVEAEK--GGRRRAGGEFLVKLDHE 2244
Fly 2130 GKQTTAEKRSKSETKKPPSGE---SSESGLPCKKPR-KEPAGKVKGKGKKTTA-------GAAAT 2183
|..:...|..|:.. .|: |.:.|.|...|. ..|| :.||.||..| |.|..
Human 2245 GVTSPKNKTCKALL----MGDKDFSPKLGRPLPSPSYVHPA--LVGKDKKGRAPIPPLPMGLALR 2303
Fly 2184 TIASTAETQTEAVNAITASNQETNNNEYQTADLQAQKFRECPAVTDAKVAGTATSTSTAS----- 2243
..|..||......:...:|..:.:.:....|.....:|....:|:.:. :|::||:|:.|
Human 2304 KYAGQAEFPLPYDSDCHSSFSDEDEDGPGLAAGVPSRFLARLSVSSSS-SGSSTSSSSGSVSTSS 2367
Fly 2244 -----QQQNQQHSDEQHQFLVPSQPATASATAALAATPPPSR-QGQATHTKRTR---SRCKF--- 2296
.:.:...||::...|: .|.........|.|.|...| :|...|....| ||...
Human 2368 LCSSDNEDSSYSSDDEDPALL-LQTCLTHPVPTLLAQPEALRSKGSGPHAHAQRCFLSRATVAGT 2431
Fly 2297 -------GNRKRQRHRPGGVSY----ELDVTQPPATKANVVPKWN------NGWMWAGKAFQGAV 2344
.:.|.:..|...:|: ||...|.|.:..| .||.: ..|.|:|...|...
Human 2432 GAGSGPSSSSKSKLKRKEALSFSKAKELSRRQRPPSVEN-RPKISAFLPARQLWKWSGNPTQRRG 2495
Fly 2345 FLNSDDPLVLRTCYPAMRHVEG-DIIRIRDC-VLLKANEDNELPYVAKVAHLWQNPEDGEMMMSL 2407
.......|. |.|: |.| :.:|:.|| |.|.|...| |||:.::..:|:: ....|::.:
Human 2496 MKGKARKLF----YKAI--VRGEETLRVGDCAVFLSAGRPN-LPYIGRIESMWES-WGSNMVVKV 2552
Fly 2408 LWYYRPEHTDQGRQRNDCPDEVYASRHRDHNSVACVEDKCYVLTFSEYCRYRRRLRAAEEDVEDV 2472
.|:|.||.|..|:::.|..:.:|.|.|.|.|.|..:..||.|:...:|.:..|..:. :|.:|:
Human 2553 KWFYHPEETKLGKRQCDGKNALYQSCHEDENDVQTISHKCQVVAREQYEQMARSRKC--QDRQDL 2615
Fly 2473 SIV-----PRRPSIATAPGFPV 2489
..: |....:.||.|.|:
Human 2616 YYLAGTYDPTTGRLVTADGVPI 2637
| 
