DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hers and Tnrc18

DIOPT Version :9

Sequence 1:NP_001245771.1 Gene:Hers / 33000 FlyBaseID:FBgn0052529 Length:2529 Species:Drosophila melanogaster
Sequence 2:XP_038945299.1 Gene:Tnrc18 / 304302 RGDID:1307540 Length:2952 Species:Rattus norvegicus


Alignment Length:3375 Identity:613/3375 - (18%)
Similarity:960/3375 - (28%) Gaps:1366/3375 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 AAAAAAATASSTQGKKRPGKQTK-----------------ASGGGGDEADDKKSASKTDSAAKKP 72
            ||.|....:|...|...|||...                 |||.|       .|||...|....|
  Rat    32 AATAGRLPSSGLPGPPPPGKYMAGLNLHPHPGEAFLGSFVASGMG-------PSASSQGSPVSLP 89

  Fly    73 A----KDPTGSSGVSTATTEGGAGNGGGKQTTSTTTSSTS-STTAPSASASASASNSLKLSPEER 132
            :    :.||.|:..........|..|.....:....|... :...|.:|.|...|...:.|..:.
  Rat    90 SDLSFRSPTPSNLPMVHLWAAHAHEGFSHLPSGLYPSYLHLNHLEPPSSGSPLLSQLGQPSIFDT 154

  Fly   133 HEDGKARAINKMLKSLDIKIHGFDNLLPSGEERLNDGVLKSSISENVKTKSRAAAVKVISSLNPG 197
            .:||........|.:     |...:..|||..  :.|..|.|..|.. .|.|        |...|
  Rat   155 QKDGFYLPAPGTLHA-----HTPSSRTPSGHS--SGGTAKGSSREGT-GKDR--------SSRGG 203

  Fly   198 KMPPVKRVRPSPEPVREKVAEKPAEKVLDKEKPKAEQQITPP------------PAPEESPASKV 250
            ..||                      :..|:.|:|.::::.|            ...::..:|::
  Rat   204 DPPP----------------------LFGKKDPRAREEVSGPRGVVDLTQEVRAEGRQDRGSSRL 246

  Fly   251 PKKTVQQAKKAKVESSLVQATVLTTTSAATSAPSSASTSKHTSTKNPGKKSAHSEQMPKKELSKL 315
            .::......:||.:.:| |.:.|:..:....|...|..|     :...|:.|..|     |.::|
  Rat   247 AERLSPFLAEAKAKGAL-QPSALSLCNGVVDAGLVAELS-----RGGAKEVARQE-----ENARL 300

  Fly   316 AKMGKPKKEANLVKSTARLPDSNTESVQMELEEIVSTPTVTPTPSATPTATPT-PTATPTLTPTP 379
                       |.::.|.||              .:.|..:|.|...|...|. |.|.|:.||..
  Rat   301 -----------LRRAEALLP--------------AARPCGSPLPPPPPPLPPKGPPAPPSSTPAG 340

  Fly   380 TATRTRTP-------TPTLTPT---------PTPTSTPSSTAIA----AGQPAPPPPPPGGAPKQ 424
            ..|..|.|       .||..|:         |...::.:....|    .|:|.....|||....:
  Rat   341 VYTVFREPGREHRVVAPTFVPSVEAFDERVGPIQIASQARDVRAREREPGRPGVLQGPPGSPRLE 405

  Fly   425 RPKVKYTKTSAGSKGRMQQALNQKAPAASWSGAKDIYDFKSGSEDEEPIKMVLPSLKELREFSDE 489
            ||:|...|:|      :.::|.:..|:.....|:       .|......:..||. |||.: .:.
  Rat   406 RPEVLREKSS------VIRSLKRPPPSDGPPAAR-------SSRSSPDARAYLPP-KELLK-PEA 455

  Fly   490 DNKPLKLFERQAEKTKVQVQDEEEQPLVKKEEKPPSEKEVKVKSKEKEKEKEKDVDPLSNAQQSE 554
            |.:|.:...|....:..|   :..:....:..:||.         .:.|.|..::...:..|.:.
  Rat   456 DPRPCERAPRGPSSSAAQ---QAAKLFGLEPSRPPG---------PEHKWKPFELGNFATTQMAV 508

  Fly   555 PAAKHTTSTSTTSTTSITSVKKQAKRKIATPMPSSAGRKKKTVGKGKA---AAAKEPPPSGSSAE 616
            .||:|..::......::.:..|:|.......||    |...|.|:..|   :||...|...|:.:
  Rat   509 LAAQHHHASRAEEEAAVATASKKAYLDPGGAMP----RASATCGRPGADLHSAAAHGPGEASAMQ 569

  Fly   617 SSSSEDERKLSAYSGPKRHRMASLNALAKVQCLYENESRTAHELGLSKATQQPPRIRTLDGSDDD 681
            |        |..|||.                 :..|:......|..                  
  Rat   570 S--------LIKYSGS-----------------FAREAVAVRPGGCG------------------ 591

  Fly   682 NHKDSPRHGDTDRDKGSVSPP--HTSAAPPAAPIAPPKEAEPRRELRYVP---GGRGVGKHWEFD 741
              |.||..|     .|::.|.  .|||.||        .|:.|.....||   |||         
  Rat   592 --KKSPFGG-----LGTMKPEPIPTSAGPP--------RAQARLTHPGVPTAGGGR--------- 632

  Fly   742 SDSETEELQLQQTLPPVKKKKLPKKAPPKKVASSETDAKRKKKSVQVEESDDEEAKEKEKEKEKP 806
                    ||              |..|::..|::|..:              |....:.|.|..
  Rat   633 --------QL--------------KRDPERPESAKTFGR--------------EGSGAQGEAEVR 661

  Fly   807 KPPKQLP---KKRKTAFTEELIGDYKGILARKRMASLNASAIVAATYEVERHLDKNLASDCSSFE 868
            .||..:.   .::|.:.:...:|  .|::.::|..|||         .|:.|  .....||    
  Rat   662 HPPVGIAVAVARQKDSGSSSRLG--PGLIDQERSLSLN---------NVKGH--GRTEDDC---- 709

  Fly   869 SYDELDTMPTTTSKVTSAAAIKTEVIHIKKEPKESKESLRERERERESE---RRRERDNELKDST 930
                                                    :|.|.||..   .|.:||.|     
  Rat   710 ----------------------------------------DRARHREDRLLGTRLDRDQE----- 729

  Fly   931 VGKMSSHSIIEESNDSKYSKETKETNTDTTITTTGYRDSAASTKDAKDCSR--PTSSSVVIVQDT 993
                   .::.||                              |:..|.:|  |||.:...: :.
  Rat   730 -------KLLRES------------------------------KELADLARLHPTSCAPNGL-NP 756

  Fly   994 DVTITGVYVNASNG------AAQEAYCKMQYRVQSSVTEERVLRPGSVE-----------PPKSY 1041
            ::.:||....|.:|      ||..|            |...:.|.||..           ||..:
  Rat   757 NLMVTGGPTLAGSGRWSADPAAHLA------------THPWLPRSGSTSMWLAGHPYGLGPPSLH 809

  Fly  1042 TPLSALSSMLPPGASSGLSEAHSSPPLPVHAAPTGPHVLLPGEHLSAGMYHAPDLGLHTEHALPD 1106
               ..::...|||....|..|:..    |....:|..|::|.:||                    
  Rat   810 ---QGMAPAFPPGLGGSLPSAYQF----VRDPQSGQLVVIPSDHL-------------------- 847

  Fly  1107 HHGPPPPSYAAAAAAAAAAAAYHAHQLAPGGGGVLH-------MHHQH-----------QYAAHA 1153
                  |.:|.....|.....:.|  |.|.|...||       ...||           |.||.|
  Rat   848 ------PHFAELMERATVPPLWPA--LYPPGRSPLHHAQQLQLFSQQHFLRQQELLYLQQQAAQA 904

  Fly  1154 AHAHHYQQ------AAEYH-----------------------GGPPPPPHHYGG--PPPQGHYG- 1186
            .......|      .|:.|                       .||...|....|  ..|.|.:| 
  Rat   905 LELQRSAQLVQERLKAQEHRTEMEEKITKRGLETTGKAGLSATGPGLLPQKSAGLATGPTGTHGK 969

  Fly  1187 --PPPGAPVPVPVAVPNTVTVPPERCDVGSPP-------PSYRASAYPPPSSVGMPPPTLGGGSS 1242
              .||.:|...||.......:.... ||..||       ||...|: |||:|   |||| .|.:.
  Rat   970 AMSPPPSPRASPVTSLKAKVIQKVE-DVSKPPAYTYPATPSSHPSS-PPPAS---PPPT-PGLTR 1028

  Fly  1243 AFCAPSPLHHHQH---QHQQPGPGVG-----PPHHD----PSGYYQPAGPLISPHVIA-----AP 1290
            ...||..:...:.   :.:.|.|...     ||.:.    |..|.:|...|:.|...|     ||
  Rat  1029 KEEAPENVVEKKDLELEKEAPSPFQALFTDIPPRYPFQALPPHYGRPYPFLLQPTAAADADGLAP 1093

  Fly  1291 --PPPAQVKK---LQEEDGPVSAAGSPTQLQQQQAAAEAAAAAAD-QAAAQSQSQSQGQSHGHAH 1349
              |.||...:   |..||.|:..  ||:::.:....::.....|| :..|:.:...:|.:     
  Rat  1094 DVPLPADGPERLALSPEDKPICL--SPSKIPEPPRDSQEEERLADREVKAEIEDIEEGPT----- 1151

  Fly  1350 SHAHNPQQAQHP---PQPQPY----PAGAVAA----AAAAAAAHQG------------------- 1384
                ...:.:.|   |.|:..    |||....    |.|.:.|..|                   
  Rat  1152 ----ELPRLESPLALPVPETMVAVSPAGGCGGSPLEAQALSTAGPGCREPSEVSDFAQVAEPQIE 1212

  Fly  1385 VPYSRSMHAAQMHYSTGYPPNYYAPY------PGEVMCYSPPTYPPYFSSKVYQPSHPAHPAAHP 1443
            :|.....|.|.:...|...|.   |.      |.||....|...|  .:....:.|.|..|...|
  Rat  1213 LPSRTEPHMAALELGTQLTPE---PLVEAKEEPVEVPLDVPMEEP--VAETGPEDSLPQPPLTEP 1272

  Fly  1444 QGPP-----------PPGAYRRYPYYQHAGPPPPHELYEQQPP-------PPPVSSGSVSGPAQQ 1490
              ||           |.|...... .|.|.|.|.....|:..|       ..|::..:....|.:
  Rat  1273 --PPSLELSDCDLPVPEGQCLNLE-AQEAAPAPASTYLEETHPESLLPGLDDPLAGMNALAAAAE 1334

  Fly  1491 QPPTSSPASVGAAGAGTAGAPSGSQL---------------------------------VPAHQ- 1521
            .|......|:|      .|.|.|.:|                                 ||..: 
  Rat  1335 LPQARPLPSLG------TGVPGGEKLDTAPSLVLEHSFLQGITLLSEIAELELDRRGQEVPGPEP 1393

  Fly  1522 ----------------------------------------------------------------- 1521
                                                                             
  Rat  1394 NLVVRPSLESLLAASSHMLKEVLESPLSDSLKNLRLPRELNSNKKYSWMQKKEERMFAMKSSLED 1458

  Fly  1522 ------------------------------------QQHQQQHLE-------------HYP---G 1534
                                                .:|:..|..             |.|   .
  Rat  1459 MDALELDFRMRLAEVQRRYKEKQRELVKLQRRRDSGDRHEDAHRSLTRRGPGRPRKRTHTPSALS 1523

  Fly  1535 PPSYYAGYSPGGGASAGQC------YTRGL------QGPYMEYPPQCPCPMPQSCPKNVHTGPHI 1587
            ||........|.|..:.:.      |..|.      :||  |...:....|.::..:|.....|.
  Rat  1524 PPCKRGKSHSGSGKLSSKSLLTSDDYDLGAGIRKRHKGP--EEEQEALVSMGKARSRNQSWDDHE 1586

  Fly  1588 GSN-------------------IISNIDQSSSCSSSMLLSATSNSNIGGGSSSSSSSSSSTTLPA 1633
            .|:                   :.|.:|::.|.:....|.:....:...|....:|......|..
  Rat  1587 SSSDFMSQLKIKKKKMSSDQEQLASKLDRALSLTKQDKLKSPFKFSDSPGGKWKTSGGCGRFLTQ 1651

  Fly  1634 CSS-------ATTTTTASALTTSR-GPVKNVTPNNSNSSGHTSTNSCRS---------SNNSNNS 1681
            |.|       |.......:|..|| |..|..:.......|..:....:|         |::|.|:
  Rat  1652 CDSLLGKDRKALAKGLGLSLKPSREGKHKRASKARKMEGGFKARGQPKSVHSPFASEVSSHSYNT 1716

  Fly  1682 SNSSCQTIEMTSWATAATNTTSTTATTATTGTQCQMLVKTELKGENPQVTKMQYEAHVMPPPTPP 1746
            .:...:.:...||  :|...:|:..|::..|    |:.|.......|::||.        .|:.|
  Rat  1717 DSDEDEDLLKNSW--SAQGPSSSKLTSSLLG----MVAKNSKPATGPKLTKR--------GPSGP 1767

  Fly  1747 ------------ESYC----------------ASDEKLLDDQEQEAELELR-------------L 1770
                        :|:|                |.|....||..:|.|.||.             .
  Rat  1768 RTLKPKEATSRKQSFCLLLREAEAHSSFSDSSAEDSFDQDDSSEEEEEELEEEEEDEEEEGIGSY 1832

  Fly  1771 RLGLG-------LEKSHGGQQHIEAYDLTCSTPPPVTVPQAAAV----PRKARIGKSMAREMVYA 1824
            |||.|       ||:|..|   :.|.....:.|.||..|..:.|    .:|||  |...|:.:..
  Rat  1833 RLGAGEQALSPSLEESGLG---LLARFAASALPSPVVGPPLSVVQLEAEQKAR--KKEERQSLMG 1892

  Fly  1825 AQQQLL-PEKQLKQPKEAAAKL------EAEPEMPFVL--------------KAEIKAE------ 1862
            .:.:.. .|.::|.||::.|.|      ..||......              ||::.:|      
  Rat  1893 TEFEYTDSESEVKVPKQSPAGLLRPKKGAGEPGQSLAAPVPGTRASGPTSPDKAKLASEKGRKAR 1957

  Fly  1863 ----------------------TKIKIE----HDGEAQASTHISQLPDLKPT------------- 1888
                                  |:.:.|    ||..|......:..|..||:             
  Rat  1958 KIRGSKEPGFEAGPEASDDDLWTRRRSERIFLHDASAAVQAPSNAAPATKPSRCGRGGAPSPRKD 2022

  Fly  1889 -----IKTEPEQELE-QEAASVPSVAKTEPQPEV---------------------------EVER 1920
                 .:.:|.::.. :||.|    |.|.|.|.|                           |.::
  Rat  2023 TGRAKDRKDPRKKKRGKEAGS----AATLPSPRVSTLPDSRAPHPGALATAKRSKAKARGKEAKK 2083

  Fly  1921 EQQ-------------------EPPVD----EEQQPTPGGSKQR-------------------FN 1943
            |.:                   ||..|    |::....||:.:|                   ..
  Rat  2084 ENRGKGGAVSKLMECMAAEEDFEPNQDSSFSEDEHLPRGGATERPLTPAPRSCIIDKEELKDGLR 2148

  Fly  1944 LL------ALSSGNKKT--------------KTNNSY----KSLIKQA----EPKS--------- 1971
            :|      .|.:|:.:|              :.|..:    :.|:::|    .|.|         
  Rat  2149 VLIPMDDKLLYAGHVQTVHSPDIYRVVVEGERGNRPHIYCLEQLLQEAIIDVRPASTRFLPQGTR 2213

  Fly  1972 --------YLC--PGRRFIR-------------------RHGRAPAKYVK------------RRQ 1995
                    |.|  || ..:|                   ..||.|..:::            ...
  Rat  2214 IAAYWSQQYRCLYPG-TVVRGLLDLEDDGDLITVEFDDGDTGRIPLSHIRLLPPDYKIQCAEPSP 2277

  Fly  1996 MILTQRQQQRMRLQRREQQQQRRQQREAAAEVVAG------------------AVVTPSLAGNPI 2042
            .:|....::|.|...::..:.:........|...|                  .|:....|.|.:
  Rat  2278 ALLVPSAKRRSRKTSKDTGEGKEGAATGPQEATGGKARGRGRKPSTKAKADRAVVLEEGAATNEL 2342

  Fly  2043 EQAGSEVSIVKDQAPNS-SATPSASPKRARPRKQEIAALHLLEGLDTTLSRGYFSDPELNHSSRK 2106
            ..|  .:::.....||| .:||....||||..|....::....|..|     :.|.|        
  Rat  2343 PSA--PLALEPVSTPNSKKSTPEPVDKRARAPKARSVSVQPSPGPPT-----FSSCP-------- 2392

  Fly  2107 QAPTAVGGL-YAASSPLTT----------------AT---------------------DHRGKQT 2133
             ||...|.| ..|::||.|                ||                     ||.|..:
  Rat  2393 -APEPFGELPTPATAPLVTMPVTMPATRPKPKKARATEGSGAKGPRRPGEDDELLVKLDHEGVMS 2456

  Fly  2134 TAEKRSKS-----ETKKP----------------PSGESSE------------------SGLP-- 2157
            ...|::|.     |...|                |:..|||                  .|||  
  Rat  2457 PKSKKAKEALLLREDPGPGAWPESTGLLSLGSYSPTVGSSEPKATWPKGLDGDLTQEPGPGLPLE 2521

  Fly  2158 ----CKKPRKEPAGKVKGKGKKTTAGAAATTIASTAETQTEAVNAITASNQETNNNEYQTADLQA 2218
                .|.|.|..|.:...:..:||:.:::::.:|::.:.:.:.::.::|..||...|      .|
  Rat  2522 DPGNSKSPDKAQAEQDGAEESETTSSSSSSSSSSSSSSSSSSSSSSSSSGSETEGEE------DA 2580

  Fly  2219 QKFRE---------C---------PAVTDAKVAGTATSTSTASQQQNQQHS-------------- 2251
            :|.||         |         ||.:.:..:.:::|:|::|...:...|              
  Rat  2581 EKNREDGRGAGGRTCSAASSRASSPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2645

  Fly  2252 --------DEQH------------------QFLVPSQ----PATASATA------ALAAT-PPPS 2279
                    ||..                  |..:|::    |:.|.|:|      |...| |||.
  Rat  2646 SSSSSSTTDEDSSCSSDDEAAPAPAAGPSTQPALPTKVSKPPSKARASAHSPGKKAPPTTQPPPQ 2710

  Fly  2280 RQGQATHTKRTRSRCKFGNRKRQRHRPGGVSYELDVTQPPATKANVVPKWNNG------------ 2332
            ...|...|.:.:::...|.:.|.:.|.|   ..|..|:..| |...:|...|.            
  Rat  2711 PPPQPQQTLQPKTQTGAGAKSRPKKREG---VHLPTTKELA-KRQRLPSVENRPKIAAFLPARQL 2771

  Fly  2333 WMWAGKAFQGAVFLNSDDPLVLRTCYPAMRHVEG-DIIRIRDC-VLLKANEDNELPYVAKVAHLW 2395
            |.|.||..|..........|.    |.|:  |.| ::|||.|| |.|.|...| |||:.::..:|
  Rat  2772 WKWFGKPTQRRGMKGKARKLF----YKAI--VRGKEMIRIGDCAVFLSAGRPN-LPYIGRIQSMW 2829

  Fly  2396 QNPEDGEMMMSLLWYYRPEHTDQGR------------------------QRNDCPDE-VYASRHR 2435
            :: ....|::.:.|:|.||.|..|:                        ||.|..:. :|.|.|.
  Rat  2830 ES-WGNNMVVRVKWFYHPEETSPGKQFHEGQHWDQKSGHNLPAALRASSQRKDFMERALYQSSHV 2893

  Fly  2436 DHNSVACVEDKCYVLTFSEYCRYRRRLRAAE-EDVEDV-----SIVPRRPSIATAPGFPV 2489
            |.|.|..|..||.|:...:   |.:.|:..: :|.|.:     :..|....|.:..|.||
  Rat  2894 DENDVQTVSHKCLVVGLEQ---YEQMLKTKKYQDSEGLYYLAGTYEPTTGMIFSTDGVPV 2950

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HersNP_001245771.1 BAH_BAHCC1 2366..2519 CDD:240065 43/157 (27%)
Tnrc18XP_038945299.1 PHA03247 <383..641 CDD:223021 73/377 (19%)
pneumo_PspA <1089..>1165 CDD:411490 17/86 (20%)
Tudor_SF 2204..2270 CDD:413384 9/66 (14%)
PHA03307 2274..>2524 CDD:223039 47/265 (18%)
BAH_BAHCC1 2800..2944 CDD:240065 39/148 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1886
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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