Protein Alignment: Hers and Tnrc18

• Sequence 1: NP_001245771.1
• Gene: Hers
• FlyBaseID: FBgn0052529
• Length: 2529
• Species: Drosophila melanogaster
• Sequence 2: NP_001100593.1
• Gene: Tnrc18
• RGDID: 1307540
• Length: 2900
• Species: Rattus norvegicus
• Alignment Length: 2961
• Identity: 556/2962 (19%)
• Similarity: 895/2962 (30%)
• Gaps: 1005/2962 (34%)

  Fly     7 SNAAERVQRSTATAAAAAAAAAAAATASSTQGKKRPGKQT-KASGGGGDEADDKKSASK------ 64
            |.|.|....:||:..|......|...||:|.|  |||... .|:..|..||...:|..|
  Rat   465 SRAEEEAAVATASKKAYLDPGGAMPRASATCG--RPGADLHSAAAHGPGEASAMQSLIKYSGSFA 527

  Fly    65 TDSAAKKPA----KDPTGSSGV----------------STATTEGGAGNGGGKQTTSTTTSSTSS 109
            .::.|.:|.    |.|.|..|.                :..|..|....|||:|.........|:
  Rat   528 REAVAVRPGGCGKKSPFGGLGTMKPEPIPTSAGPPRAQARLTHPGVPTAGGGRQLKRDPERPESA 592

  Fly   110 TTAPSASASASASNSLKLSP-------EERHEDGKARAINKML----KSL---DIKIHG------ 154
            .|.....:.|.....::..|       ..:.:.|.:..:...|    :||   ::|.||
  Rat   593 KTFGREGSGAQGEAEVRHPPVGIAVAVARQKDSGSSSRLGPGLIDQERSLSLNNVKGHGRTEDDC 657

  Fly   155 ------FDNLLPSGEERLNDGVLKSS--ISENVKTKSRAAAVKVISSLNPGKM------------ 199
                  .|.||.:..:|..:.:|:.|  :::..:....:.|.   :.|||..|
  Rat   658 DRARHREDRLLGTRLDRDQEKLLRESKELADLARLHPTSCAP---NGLNPNLMVTGGPTLAGSGR 719

  Fly   200 ---------------------------------PPVKRVRPSP------------------EPVR 213
                                             ||......:|                  :|..
  Rat   720 WSADPAAHLATHPWLPRSGSTSMWLAGHPYGLGPPSLHQGMAPAFPPGLGGSLPSAYQFVRDPQS 784

  Fly   214 EKVAEKPAEKVLDKEKPKAEQQITPPPAPEESPASKVPKKTVQQAKKAKVESSLVQATVLTTTSA 278
            .::...|::. |.......|:...||..|...|..:.|....||.:....:..|.|..:|.....
  Rat   785 GQLVVIPSDH-LPHFAELMERATVPPLWPALYPPGRSPLHHAQQLQLFSQQHFLRQQELLYLQQQ 848

  Fly   279 ATSAPSSASTSK--HTSTKNPGKKSAHSEQMPKKELSKLAKMG--------KPKKEANLVKSTAR 333
            |..|.....:::  ....|....::...|::.|:.|....|.|        .|:|.|.|
  Rat   849 AAQALELQRSAQLVQERLKAQEHRTEMEEKITKRGLETTGKAGLSATGPGLLPQKSAGL------ 907

  Fly   334 LPDSNTESVQMELEEIVSTPTVTPTPSATPTATPTPTATPTLTPTPTATRTR--------TPTPT 390
                            .:.||.|...:.:|  .|:|.|:|.     |:.:.:        :..|.
  Rat   908 ----------------ATGPTGTHGKAMSP--PPSPRASPV-----TSLKAKVIQKVEDVSKPPA 949

  Fly   391 LTPTPTPTSTPSSTAIAAGQPAPPPPPPG-----GAPK---QRPKVKYTKTSAG----------- 436
            .|...||:|.|||.     .||.|||.||     .||:   ::..::..|.:..
  Rat   950 YTYPATPSSHPSSP-----PPASPPPTPGLTRKEEAPENVVEKKDLELEKEAPSPFQALFTDIPP 1009

  Fly   437 ---------SKGRMQQALNQKAPAASWSG-AKDIYDFKSGSE------DEEPIKMVLPSLKELRE 485
                     ..||....|.|...||...| |.|:.....|.|      :::||.:....:.|...
  Rat  1010 RYPFQALPPHYGRPYPFLLQPTAAADADGLAPDVPLPADGPERLALSPEDKPICLSPSKIPEPPR 1074

  Fly   486 FSDEDNKPLKLFERQAEK-TKVQVQDEEEQPLVKKEEKPPSEKEVKVKSKEKEKEKEKDVDPLSN 549
            .|.|:       ||.|:: .|.:::|.||.|    .|.|..|..:.:...|....    |.|...
  Rat  1075 DSQEE-------ERLADREVKAEIEDIEEGP----TELPRLESPLALPVPETMVA----VSPAGG 1124

  Fly   550 AQQS--EPAAKHTTSTSTTSTTSITSVKKQAKRKIATPM---PSSAGRKKKT-VGKGKAAAAKEP 608
            ...|  |..|..|........:.::...:.|:.:|..|.   |..|..:..| :.......|||.
  Rat  1125 CGGSPLEAQALSTAGPGCREPSEVSDFAQVAEPQIELPSRTEPHMAALELGTQLTPEPLVEAKEE 1189

  Fly   609 P---PSGSSAESSSSEDERKLSAYSGPKRHRMASLN------ALAKVQCLYENESRTAHELGLSK 664
            |   |.....|...:|...:.|....|......||.      .:.:.|||         .|...:
  Rat  1190 PVEVPLDVPMEEPVAETGPEDSLPQPPLTEPPPSLELSDCDLPVPEGQCL---------NLEAQE 1245

  Fly   665 ATQQPPRIRTLDGSDDDNHKDSPRHGDTDRDKGSVSPPHTSAAPPAAPIAPPKEAEPRRELRYVP 729
            |...|.....     ::.|.:|...|..|...|..:....:..|.|.|:......        ||
  Rat  1246 AAPAPASTYL-----EETHPESLLPGLDDPLAGMNALAAAAELPQARPLPSLGTG--------VP 1297

  Fly   730 GGRGVGKHWEFDSD----------------SETEELQLQ---QTLPPVKKKKLPKKAPPKKVASS 775
            ||.      :.|:.                ||..||:|.   |.:|..:...:.:.:....:|:|
  Rat  1298 GGE------KLDTAPSLVLEHSFLQGITLLSEIAELELDRRGQEVPGPEPNLVVRPSLESLLAAS 1356

  Fly   776 -----------------------ETDAKRKKKSVQVEES---------DDEEAKE---------- 798
                                   |.::.:|...:|.:|.         :|.:|.|
  Rat  1357 SHMLKEVLESPLSDSLKNLRLPRELNSNKKYSWMQKKEERMFAMKSSLEDMDALELDFRMRLAEV 1421

  Fly   799 KEKEKEKPKPPKQLPKKRKTAFTEELIGDYKGILARK-----RMASLNASAIVAATYEVERHLDK 858
            :.:.|||.:...:|.::|.:....|   |....|.|:     |..:...||:.......:.|...
  Rat  1422 QRRYKEKQRELVKLQRRRDSGDRHE---DAHRSLTRRGPGRPRKRTHTPSALSPPCKRGKSHSGS 1483

  Fly   859 NLASDCSSFESYDELDTMPTTTSKVTSAAAIKTEVIHIKKEPKESKESLRERERERESERRRERD 923
            ...|..|...| |:.|.          .|.|:..    .|.|:|.:|:|....:.| |..:...|
  Rat  1484 GKLSSKSLLTS-DDYDL----------GAGIRKR----HKGPEEEQEALVSMGKAR-SRNQSWDD 1532

  Fly   924 NELKDSTVG-------KMSSHSIIEESNDSKYSKETKETNTDTTITTTGYRDS-AASTKDAKDCS 980
            :|.....:.       ||||.   :|...||..:....|..|...:...:.|| ....|.:..|.
  Rat  1533 HESSSDFMSQLKIKKKKMSSD---QEQLASKLDRALSLTKQDKLKSPFKFSDSPGGKWKTSGGCG 1594

  Fly   981 R-PTSSSVVIVQDTDVTITGV-----------YVNASNGAAQEAYCKMQ---------------- 1017
            | .|....::.:|......|:           :..||.....|...|.:
  Rat  1595 RFLTQCDSLLGKDRKALAKGLGLSLKPSREGKHKRASKARKMEGGFKARGQPKSVHSPFASEVSS 1659

  Fly  1018 --YRVQSSVTEERVLRPGSVEPPKSYTPLSALSSMLPPGASSGLSEAHSSP---PLPVHAAPTGP 1077
              |...|...|:.:....|.:.|.|    |.|:|.|     .|:...:|.|   |......|:||
  Rat  1660 HSYNTDSDEDEDLLKNSWSAQGPSS----SKLTSSL-----LGMVAKNSKPATGPKLTKRGPSGP 1715

  Fly  1078 HVLLPGEHLSAGMYHAPDLGLHTEHALPDHHGPPPPSYAAAAAAAAAAAAYHAHQLAPGGGGVLH 1142
            ..|.|.|..|.                       ..|:......|.|.:::       .......
  Rat  1716 RTLKPKEATSR-----------------------KQSFCLLLREAEAHSSF-------SDSSAED 1750

  Fly  1143 MHHQHQYAAHAAHAHHYQQAAEYHGGPPPPPHHYGGPPPQGHYGPPPGAPVPVPVAVPNTVTVPP 1207
            ...|...:.........::..|...|
  Rat  1751 SFDQDDSSEEEEEELEEEEEDEEEEG--------------------------------------- 1776

  Fly  1208 ERCDVGSPPPSYRASAYPPPSSVGMPPPTL---GGGSSAFCAPSPLHHHQHQHQQPGPGVGPPHH 1269
                :|    |||..|.....|     |:|   |.|..|..|.|.|         |.|.||||.
  Rat  1777 ----IG----SYRLGAGEQALS-----PSLEESGLGLLARFAASAL---------PSPVVGPPL- 1818

  Fly  1270 DPSGYYQPAGPLISPHVIAAPPPPAQVKKLQEEDGPVSAAGSPTQLQQQQAAAEAAAAAADQAAA 1334
                                                     |..||:.:|.|
  Rat  1819 -----------------------------------------SVVQLEAEQKA------------- 1829

  Fly  1335 QSQSQSQGQS-HGHAHSHAHNPQQAQHPPQPQPYPAGAVAAAAAAAAAHQGVPYSRSMHAAQMHY 1398
              :.:.:.|| .|....:..:..:.:.|.|.   |||.:.....|....|.:.
  Rat  1830 --RKKEERQSLMGTEFEYTDSESEVKVPKQS---PAGLLRPKKGAGEPGQSLA------------ 1877

  Fly  1399 STGYPPNYYAPYPGEVMCYSPPTYPPYFSSKVYQPSHPAHPAAHPQGPPPPGAYRRYPYYQHAGP 1463
                     ||.||...  |.||.|    .|....|.....|...:|...||.        .|||
  Rat  1878 ---------APVPGTRA--SGPTSP----DKAKLASEKGRKARKIRGSKEPGF--------EAGP 1919

  Fly  1464 PPPHE------------LYEQQPPPPPVSSGSVSGPAQQQPPTSSPASVGAAGAGTAGAPSGSQL 1516
            ....:            |::        :|.:|..|:...|.| .|:..|..||.:....:|.
  Rat  1920 EASDDDLWTRRRSERIFLHD--------ASAAVQAPSNAAPAT-KPSRCGRGGAPSPRKDTGR-- 1973

  Fly  1517 VPAHQQQHQQQHLEHYPGPPSYYAGYSPGGGASAGQCYTRGLQGPYMEYPPQCPCPMPQSCPKNV 1581
              |..::..::...                |..||...|             .|.|...:.|.:
  Rat  1974 --AKDRKDPRKKKR----------------GKEAGSAAT-------------LPSPRVSTLPDS- 2006

  Fly  1582 HTGPHIGSNIISNIDQSSSCSSSMLLSATSNSNIGGGSSSSSSSSSSTTLPACSSATTTTTASAL 1646
             ..||.|:  ::...:|.:.:..   ......|.|.|.:.|.       |..|.:|.
  Rat  2007 -RAPHPGA--LATAKRSKAKARG---KEAKKENRGKGGAVSK-------LMECMAAE-------- 2050

  Fly  1647 TTSRGPVKNVTPNNSNSSGHTSTNSCRSSNNSNNSSNSSCQTIEMTSWATAATNTTSTTATTATT 1711
                   ::..||                   .:||.|..:.:.    ...||....|.|..:
  Rat  2051 -------EDFEPN-------------------QDSSFSEDEHLP----RGGATERPLTPAPRS-- 2083

  Fly  1712 GTQCQMLVKTELKGE----NPQVTKMQYEAHVMPPPTP--------------PESYCASDEKLLD 1758
               | ::.|.|||..    .|...|:.|..||....:|              |..||.  |:||
  Rat  2084 ---C-IIDKEELKDGLRVLIPMDDKLLYAGHVQTVHSPDIYRVVVEGERGNRPHIYCL--EQLL- 2141

  Fly  1759 DQEQEAELELR------LRLGLGLEKSHGGQQ--------------------------------- 1784
               |||.:::|      |..|..: .::..||
  Rat  2142 ---QEAIIDVRPASTRFLPQGTRI-AAYWSQQYRCLYPGTVVRGLLDLEDDGDLITVEFDDGDTG 2202

  Fly  1785 -----HIEA----YDLTCSTP-PPVTVPQAAAVPRKARIGKSMAREMVYAAQQQLLPEKQLKQPK 1839
                 ||..    |.:.|:.| |.:.||.|....||.                    .|...:.|
  Rat  2203 RIPLSHIRLLPPDYKIQCAEPSPALLVPSAKRRSRKT--------------------SKDTGEGK 2247

  Fly  1840 EAAA---------KLEAEPEMPFVLKAEIKAETKIKIEHDGEAQASTHISQLPDLKPTIKTEPEQ 1895
            |.||         |.......|   ..:.||:..:.:|   |..|:..:             |..
  Rat  2248 EGAATGPQEATGGKARGRGRKP---STKAKADRAVVLE---EGAATNEL-------------PSA 2293

  Fly  1896 ELEQEAASVPSVAKTEPQPEVEVEREQQEPPV-DEEQQPTPGGSKQRFNLLALSSGNKKTKTNNS 1959
            .|..|..|.|:..|:.|:|   |::..:.|.. ....||:||
  Rat  2294 PLALEPVSTPNSKKSTPEP---VDKRARAPKARSVSVQPSPG----------------------- 2332

  Fly  1960 YKSLIKQAEPKSYLCPG-RRFIRRHGRAPAKYVKRR-QMILTQRQQQRMRLQRREQQQQRR---Q 2019
                    .|....||. ..|......|.|..|... .|..|:.:.::.|.......:..|   :
  Rat  2333 --------PPTFSSCPAPEPFGELPTPATAPLVTMPVTMPATRPKPKKARATEGSGAKGPRRPGE 2389

  Fly  2020 QREAAAEVVAGAVVTPSLAGNPIEQAGSEVSIVKDQAPNS-----------SATP---SASPKRA 2070
            ..|...::....|::|.     .::|...:.:.:|..|.:           |.:|   |:.|...
  Rat  2390 DDELLVKLDHEGVMSPK-----SKKAKEALLLREDPGPGAWPESTGLLSLGSYSPTVGSSEPIAT 2449

  Fly  2071 RPRKQEIAALHLLEGLDTTLS-----RGYFSDPELNHSSRKQAPTAVGGLYAASSPLTTATDHRG 2130
            .|:           |||..|:     ..:::||. |..|..:|.....|  |..|..|:::....
  Rat  2450 WPK-----------GLDGDLTIVNTLNAWYNDPG-NSKSPDKAQAEQDG--AEESETTSSSSSSS 2500

  Fly  2131 KQTTAEKRSKSETKKPPSGESSESGLPCKKPRKEPAGKVKGKGKKTTAGAA--ATTIASTAETQT 2193
            ..:::...|.|.:....||..:|.....:|.|::.    :|.|.:|.:.|:  |::.||::.:.:
  Rat  2501 SSSSSSSSSSSSSSSSSSGSETEGEEDAEKNREDG----RGAGGRTCSAASSRASSPASSSSSSS 2561

  Fly  2194 EAVNAITASNQETNNNEYQTADLQAQKFRECPAVTDAKVAGTATSTSTASQQQNQQHSDE----- 2253
            .:.::.::|:..::::...::...:         :.:..:.:::|:||..:..:....||
  Rat  2562 SSSSSSSSSSSSSSSSSSSSSSSSS---------SSSSSSSSSSSSSTTDEDSSCSSDDEAAPAP 2617

  Fly  2254 ----QHQFLVPSQ----PATASATA------ALAAT-PPPSRQGQATHTKRTRSRCKFGNRKRQR 2303
                ..|..:|::    |:.|.|:|      |...| |||....|...|.:.:::...|.:.|.:
  Rat  2618 AAGPSTQPALPTKVSKPPSKARASAHSPGKKAPPTTQPPPQPPPQPQQTLQPKTQTGAGAKSRPK 2682

  Fly  2304 HRPGGVSYELDVTQPPATKANVVPKWNNG------------WMWAGKAFQGAVFLNSDDPLVLRT 2356
            .|.|   ..|..|:..| |...:|...|.            |.|.||..|..........|.
  Rat  2683 KREG---VHLPTTKELA-KRQRLPSVENRPKIAAFLPARQLWKWFGKPTQRRGMKGKARKLF--- 2740

  Fly  2357 CYPAMRHVEG-DIIRIRDC-VLLKANEDNELPYVAKVAHLWQNPEDGEMMMSLLWYYRPEHTDQG 2419
             |.|:  |.| ::|||.|| |.|.|...| |||:.::..:|:: ....|::.:.|:|.||.|..|
  Rat  2741 -YKAI--VRGKEMIRIGDCAVFLSAGRPN-LPYIGRIQSMWES-WGNNMVVRVKWFYHPEETSPG 2800

  Fly  2420 R------------------------QRNDCPDE-VYASRHRDHNSVACVEDKCYVLTFSEYCRYR 2459
            :                        ||.|..:. :|.|.|.|.|.|..|..||.|:...:   |.
  Rat  2801 KQFHEGQHWDQKSGHNLPAALRASSQRKDFMERALYQSSHVDENDVQTVSHKCLVVGLEQ---YE 2862

  Fly  2460 RRLRAAE-EDVEDV-----SIVPRRPSIATAPGFPV 2489
            :.|:..: :|.|.:     :..|....|.:..|.||
  Rat  2863 QMLKTKKYQDSEGLYYLAGTYEPTTGMIFSTDGVPV 2898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hers	NP_001245771.1	BAH_BAHCC1	2366..2519	CDD:240065	43/158 (27%)
Tnrc18	NP_001100593.1	BAH_BAHCC1	2748..2892	CDD:240065	39/149 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_KOG1886
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900