DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hers and Tnrc18

DIOPT Version :9

Sequence 1:	NP_001245771.1	Gene:	Hers / 33000	FlyBaseID:	FBgn0052529	Length:	2529	Species:	Drosophila melanogaster
Sequence 2:	XP_038945299.1	Gene:	Tnrc18 / 304302	RGDID:	1307540	Length:	2952	Species:	Rattus norvegicus

Alignment Length:	3375	Identity:	613/3375 - (18%)
Similarity:	960/3375 - (28%)	Gaps:	1366/3375 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 AAAAAAATASSTQGKKRPGKQTK-----------------ASGGGGDEADDKKSASKTDSAAKKP 72
            ||.|....:|...|...|||...                 |||.|       .|||...|....|
  Rat    32 AATAGRLPSSGLPGPPPPGKYMAGLNLHPHPGEAFLGSFVASGMG-------PSASSQGSPVSLP 89

  Fly    73 A----KDPTGSSGVSTATTEGGAGNGGGKQTTSTTTSSTS-STTAPSASASASASNSLKLSPEER 132
            :    :.||.|:..........|..|.....:....|... :...|.:|.|...|...:.|..:.
  Rat    90 SDLSFRSPTPSNLPMVHLWAAHAHEGFSHLPSGLYPSYLHLNHLEPPSSGSPLLSQLGQPSIFDT 154

  Fly   133 HEDGKARAINKMLKSLDIKIHGFDNLLPSGEERLNDGVLKSSISENVKTKSRAAAVKVISSLNPG 197
            .:||........|.:     |...:..|||..  :.|..|.|..|.. .|.|        |...|
  Rat   155 QKDGFYLPAPGTLHA-----HTPSSRTPSGHS--SGGTAKGSSREGT-GKDR--------SSRGG 203

  Fly   198 KMPPVKRVRPSPEPVREKVAEKPAEKVLDKEKPKAEQQITPP------------PAPEESPASKV 250
            ..||                      :..|:.|:|.::::.|            ...::..:|::
  Rat   204 DPPP----------------------LFGKKDPRAREEVSGPRGVVDLTQEVRAEGRQDRGSSRL 246

  Fly   251 PKKTVQQAKKAKVESSLVQATVLTTTSAATSAPSSASTSKHTSTKNPGKKSAHSEQMPKKELSKL 315
            .::......:||.:.:| |.:.|:..:....|...|..|     :...|:.|..|     |.::|
  Rat   247 AERLSPFLAEAKAKGAL-QPSALSLCNGVVDAGLVAELS-----RGGAKEVARQE-----ENARL 300

  Fly   316 AKMGKPKKEANLVKSTARLPDSNTESVQMELEEIVSTPTVTPTPSATPTATPT-PTATPTLTPTP 379
                       |.::.|.||              .:.|..:|.|...|...|. |.|.|:.||..
  Rat   301 -----------LRRAEALLP--------------AARPCGSPLPPPPPPLPPKGPPAPPSSTPAG 340

  Fly   380 TATRTRTP-------TPTLTPT---------PTPTSTPSSTAIA----AGQPAPPPPPPGGAPKQ 424
            ..|..|.|       .||..|:         |...::.:....|    .|:|.....|||....:
  Rat   341 VYTVFREPGREHRVVAPTFVPSVEAFDERVGPIQIASQARDVRAREREPGRPGVLQGPPGSPRLE 405

  Fly   425 RPKVKYTKTSAGSKGRMQQALNQKAPAASWSGAKDIYDFKSGSEDEEPIKMVLPSLKELREFSDE 489
            ||:|...|:|      :.::|.:..|:.....|:       .|......:..||. |||.: .:.
  Rat   406 RPEVLREKSS------VIRSLKRPPPSDGPPAAR-------SSRSSPDARAYLPP-KELLK-PEA 455

  Fly   490 DNKPLKLFERQAEKTKVQVQDEEEQPLVKKEEKPPSEKEVKVKSKEKEKEKEKDVDPLSNAQQSE 554
            |.:|.:...|....:..|   :..:....:..:||.         .:.|.|..::...:..|.:.
  Rat   456 DPRPCERAPRGPSSSAAQ---QAAKLFGLEPSRPPG---------PEHKWKPFELGNFATTQMAV 508

  Fly   555 PAAKHTTSTSTTSTTSITSVKKQAKRKIATPMPSSAGRKKKTVGKGKA---AAAKEPPPSGSSAE 616
            .||:|..::......::.:..|:|.......||    |...|.|:..|   :||...|...|:.:
  Rat   509 LAAQHHHASRAEEEAAVATASKKAYLDPGGAMP----RASATCGRPGADLHSAAAHGPGEASAMQ 569

  Fly   617 SSSSEDERKLSAYSGPKRHRMASLNALAKVQCLYENESRTAHELGLSKATQQPPRIRTLDGSDDD 681
            |        |..|||.                 :..|:......|..
  Rat   570 S--------LIKYSGS-----------------FAREAVAVRPGGCG------------------ 591

  Fly   682 NHKDSPRHGDTDRDKGSVSPP--HTSAAPPAAPIAPPKEAEPRRELRYVP---GGRGVGKHWEFD 741
              |.||..|     .|::.|.  .|||.||        .|:.|.....||   |||
  Rat   592 --KKSPFGG-----LGTMKPEPIPTSAGPP--------RAQARLTHPGVPTAGGGR--------- 632

  Fly   742 SDSETEELQLQQTLPPVKKKKLPKKAPPKKVASSETDAKRKKKSVQVEESDDEEAKEKEKEKEKP 806
                    ||              |..|::..|::|..:              |....:.|.|..
  Rat   633 --------QL--------------KRDPERPESAKTFGR--------------EGSGAQGEAEVR 661

  Fly   807 KPPKQLP---KKRKTAFTEELIGDYKGILARKRMASLNASAIVAATYEVERHLDKNLASDCSSFE 868
            .||..:.   .::|.:.:...:|  .|::.::|..|||         .|:.|  .....||
  Rat   662 HPPVGIAVAVARQKDSGSSSRLG--PGLIDQERSLSLN---------NVKGH--GRTEDDC---- 709

  Fly   869 SYDELDTMPTTTSKVTSAAAIKTEVIHIKKEPKESKESLRERERERESE---RRRERDNELKDST 930
                                                    :|.|.||..   .|.:||.|
  Rat   710 ----------------------------------------DRARHREDRLLGTRLDRDQE----- 729

  Fly   931 VGKMSSHSIIEESNDSKYSKETKETNTDTTITTTGYRDSAASTKDAKDCSR--PTSSSVVIVQDT 993
                   .::.||                              |:..|.:|  |||.:...: :.
  Rat   730 -------KLLRES------------------------------KELADLARLHPTSCAPNGL-NP 756

  Fly   994 DVTITGVYVNASNG------AAQEAYCKMQYRVQSSVTEERVLRPGSVE-----------PPKSY 1041
            ::.:||....|.:|      ||..|            |...:.|.||..           ||..:
  Rat   757 NLMVTGGPTLAGSGRWSADPAAHLA------------THPWLPRSGSTSMWLAGHPYGLGPPSLH 809

  Fly  1042 TPLSALSSMLPPGASSGLSEAHSSPPLPVHAAPTGPHVLLPGEHLSAGMYHAPDLGLHTEHALPD 1106
               ..::...|||....|..|:..    |....:|..|::|.:||
  Rat   810 ---QGMAPAFPPGLGGSLPSAYQF----VRDPQSGQLVVIPSDHL-------------------- 847

  Fly  1107 HHGPPPPSYAAAAAAAAAAAAYHAHQLAPGGGGVLH-------MHHQH-----------QYAAHA 1153
                  |.:|.....|.....:.|  |.|.|...||       ...||           |.||.|
  Rat   848 ------PHFAELMERATVPPLWPA--LYPPGRSPLHHAQQLQLFSQQHFLRQQELLYLQQQAAQA 904

  Fly  1154 AHAHHYQQ------AAEYH-----------------------GGPPPPPHHYGG--PPPQGHYG- 1186
            .......|      .|:.|                       .||...|....|  ..|.|.:|
  Rat   905 LELQRSAQLVQERLKAQEHRTEMEEKITKRGLETTGKAGLSATGPGLLPQKSAGLATGPTGTHGK 969

  Fly  1187 --PPPGAPVPVPVAVPNTVTVPPERCDVGSPP-------PSYRASAYPPPSSVGMPPPTLGGGSS 1242
              .||.:|...||.......:.... ||..||       ||...|: |||:|   |||| .|.:.
  Rat   970 AMSPPPSPRASPVTSLKAKVIQKVE-DVSKPPAYTYPATPSSHPSS-PPPAS---PPPT-PGLTR 1028

  Fly  1243 AFCAPSPLHHHQH---QHQQPGPGVG-----PPHHD----PSGYYQPAGPLISPHVIA-----AP 1290
            ...||..:...:.   :.:.|.|...     ||.:.    |..|.:|...|:.|...|     ||
  Rat  1029 KEEAPENVVEKKDLELEKEAPSPFQALFTDIPPRYPFQALPPHYGRPYPFLLQPTAAADADGLAP 1093

  Fly  1291 --PPPAQVKK---LQEEDGPVSAAGSPTQLQQQQAAAEAAAAAAD-QAAAQSQSQSQGQSHGHAH 1349
              |.||...:   |..||.|:..  ||:::.:....::.....|| :..|:.:...:|.:
  Rat  1094 DVPLPADGPERLALSPEDKPICL--SPSKIPEPPRDSQEEERLADREVKAEIEDIEEGPT----- 1151

  Fly  1350 SHAHNPQQAQHP---PQPQPY----PAGAVAA----AAAAAAAHQG------------------- 1384
                ...:.:.|   |.|:..    |||....    |.|.:.|..|
  Rat  1152 ----ELPRLESPLALPVPETMVAVSPAGGCGGSPLEAQALSTAGPGCREPSEVSDFAQVAEPQIE 1212

  Fly  1385 VPYSRSMHAAQMHYSTGYPPNYYAPY------PGEVMCYSPPTYPPYFSSKVYQPSHPAHPAAHP 1443
            :|.....|.|.:...|...|.   |.      |.||....|...|  .:....:.|.|..|...|
  Rat  1213 LPSRTEPHMAALELGTQLTPE---PLVEAKEEPVEVPLDVPMEEP--VAETGPEDSLPQPPLTEP 1272

  Fly  1444 QGPP-----------PPGAYRRYPYYQHAGPPPPHELYEQQPP-------PPPVSSGSVSGPAQQ 1490
              ||           |.|...... .|.|.|.|.....|:..|       ..|::..:....|.:
  Rat  1273 --PPSLELSDCDLPVPEGQCLNLE-AQEAAPAPASTYLEETHPESLLPGLDDPLAGMNALAAAAE 1334

  Fly  1491 QPPTSSPASVGAAGAGTAGAPSGSQL---------------------------------VPAHQ- 1521
            .|......|:|      .|.|.|.:|                                 ||..:
  Rat  1335 LPQARPLPSLG------TGVPGGEKLDTAPSLVLEHSFLQGITLLSEIAELELDRRGQEVPGPEP 1393

  Fly  1522 ----------------------------------------------------------------- 1521

  Rat  1394 NLVVRPSLESLLAASSHMLKEVLESPLSDSLKNLRLPRELNSNKKYSWMQKKEERMFAMKSSLED 1458

  Fly  1522 ------------------------------------QQHQQQHLE-------------HYP---G 1534
                                                .:|:..|..             |.|   .
  Rat  1459 MDALELDFRMRLAEVQRRYKEKQRELVKLQRRRDSGDRHEDAHRSLTRRGPGRPRKRTHTPSALS 1523

  Fly  1535 PPSYYAGYSPGGGASAGQC------YTRGL------QGPYMEYPPQCPCPMPQSCPKNVHTGPHI 1587
            ||........|.|..:.:.      |..|.      :||  |...:....|.::..:|.....|.
  Rat  1524 PPCKRGKSHSGSGKLSSKSLLTSDDYDLGAGIRKRHKGP--EEEQEALVSMGKARSRNQSWDDHE 1586

  Fly  1588 GSN-------------------IISNIDQSSSCSSSMLLSATSNSNIGGGSSSSSSSSSSTTLPA 1633
            .|:                   :.|.:|::.|.:....|.:....:...|....:|......|..
  Rat  1587 SSSDFMSQLKIKKKKMSSDQEQLASKLDRALSLTKQDKLKSPFKFSDSPGGKWKTSGGCGRFLTQ 1651

  Fly  1634 CSS-------ATTTTTASALTTSR-GPVKNVTPNNSNSSGHTSTNSCRS---------SNNSNNS 1681
            |.|       |.......:|..|| |..|..:.......|..:....:|         |::|.|:
  Rat  1652 CDSLLGKDRKALAKGLGLSLKPSREGKHKRASKARKMEGGFKARGQPKSVHSPFASEVSSHSYNT 1716

  Fly  1682 SNSSCQTIEMTSWATAATNTTSTTATTATTGTQCQMLVKTELKGENPQVTKMQYEAHVMPPPTPP 1746
            .:...:.:...||  :|...:|:..|::..|    |:.|.......|::||.        .|:.|
  Rat  1717 DSDEDEDLLKNSW--SAQGPSSSKLTSSLLG----MVAKNSKPATGPKLTKR--------GPSGP 1767

  Fly  1747 ------------ESYC----------------ASDEKLLDDQEQEAELELR-------------L 1770
                        :|:|                |.|....||..:|.|.||.             .
  Rat  1768 RTLKPKEATSRKQSFCLLLREAEAHSSFSDSSAEDSFDQDDSSEEEEEELEEEEEDEEEEGIGSY 1832

  Fly  1771 RLGLG-------LEKSHGGQQHIEAYDLTCSTPPPVTVPQAAAV----PRKARIGKSMAREMVYA 1824
            |||.|       ||:|..|   :.|.....:.|.||..|..:.|    .:|||  |...|:.:..
  Rat  1833 RLGAGEQALSPSLEESGLG---LLARFAASALPSPVVGPPLSVVQLEAEQKAR--KKEERQSLMG 1892

  Fly  1825 AQQQLL-PEKQLKQPKEAAAKL------EAEPEMPFVL--------------KAEIKAE------ 1862
            .:.:.. .|.::|.||::.|.|      ..||......              ||::.:|
  Rat  1893 TEFEYTDSESEVKVPKQSPAGLLRPKKGAGEPGQSLAAPVPGTRASGPTSPDKAKLASEKGRKAR 1957

  Fly  1863 ----------------------TKIKIE----HDGEAQASTHISQLPDLKPT------------- 1888
                                  |:.:.|    ||..|......:..|..||:
  Rat  1958 KIRGSKEPGFEAGPEASDDDLWTRRRSERIFLHDASAAVQAPSNAAPATKPSRCGRGGAPSPRKD 2022

  Fly  1889 -----IKTEPEQELE-QEAASVPSVAKTEPQPEV---------------------------EVER 1920
                 .:.:|.::.. :||.|    |.|.|.|.|                           |.::
  Rat  2023 TGRAKDRKDPRKKKRGKEAGS----AATLPSPRVSTLPDSRAPHPGALATAKRSKAKARGKEAKK 2083

  Fly  1921 EQQ-------------------EPPVD----EEQQPTPGGSKQR-------------------FN 1943
            |.:                   ||..|    |::....||:.:|                   ..
  Rat  2084 ENRGKGGAVSKLMECMAAEEDFEPNQDSSFSEDEHLPRGGATERPLTPAPRSCIIDKEELKDGLR 2148

  Fly  1944 LL------ALSSGNKKT--------------KTNNSY----KSLIKQA----EPKS--------- 1971
            :|      .|.:|:.:|              :.|..:    :.|:::|    .|.|
  Rat  2149 VLIPMDDKLLYAGHVQTVHSPDIYRVVVEGERGNRPHIYCLEQLLQEAIIDVRPASTRFLPQGTR 2213

  Fly  1972 --------YLC--PGRRFIR-------------------RHGRAPAKYVK------------RRQ 1995
                    |.|  || ..:|                   ..||.|..:::            ...
  Rat  2214 IAAYWSQQYRCLYPG-TVVRGLLDLEDDGDLITVEFDDGDTGRIPLSHIRLLPPDYKIQCAEPSP 2277

  Fly  1996 MILTQRQQQRMRLQRREQQQQRRQQREAAAEVVAG------------------AVVTPSLAGNPI 2042
            .:|....::|.|...::..:.:........|...|                  .|:....|.|.:
  Rat  2278 ALLVPSAKRRSRKTSKDTGEGKEGAATGPQEATGGKARGRGRKPSTKAKADRAVVLEEGAATNEL 2342

  Fly  2043 EQAGSEVSIVKDQAPNS-SATPSASPKRARPRKQEIAALHLLEGLDTTLSRGYFSDPELNHSSRK 2106
            ..|  .:::.....||| .:||....||||..|....::....|..|     :.|.|
  Rat  2343 PSA--PLALEPVSTPNSKKSTPEPVDKRARAPKARSVSVQPSPGPPT-----FSSCP-------- 2392

  Fly  2107 QAPTAVGGL-YAASSPLTT----------------AT---------------------DHRGKQT 2133
             ||...|.| ..|::||.|                ||                     ||.|..:
  Rat  2393 -APEPFGELPTPATAPLVTMPVTMPATRPKPKKARATEGSGAKGPRRPGEDDELLVKLDHEGVMS 2456

  Fly  2134 TAEKRSKS-----ETKKP----------------PSGESSE------------------SGLP-- 2157
            ...|::|.     |...|                |:..|||                  .|||
  Rat  2457 PKSKKAKEALLLREDPGPGAWPESTGLLSLGSYSPTVGSSEPKATWPKGLDGDLTQEPGPGLPLE 2521

  Fly  2158 ----CKKPRKEPAGKVKGKGKKTTAGAAATTIASTAETQTEAVNAITASNQETNNNEYQTADLQA 2218
                .|.|.|..|.:...:..:||:.:::::.:|::.:.:.:.::.::|..||...|      .|
  Rat  2522 DPGNSKSPDKAQAEQDGAEESETTSSSSSSSSSSSSSSSSSSSSSSSSSGSETEGEE------DA 2580

  Fly  2219 QKFRE---------C---------PAVTDAKVAGTATSTSTASQQQNQQHS-------------- 2251
            :|.||         |         ||.:.:..:.:::|:|::|...:...|
  Rat  2581 EKNREDGRGAGGRTCSAASSRASSPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2645

  Fly  2252 --------DEQH------------------QFLVPSQ----PATASATA------ALAAT-PPPS 2279
                    ||..                  |..:|::    |:.|.|:|      |...| |||.
  Rat  2646 SSSSSSTTDEDSSCSSDDEAAPAPAAGPSTQPALPTKVSKPPSKARASAHSPGKKAPPTTQPPPQ 2710

  Fly  2280 RQGQATHTKRTRSRCKFGNRKRQRHRPGGVSYELDVTQPPATKANVVPKWNNG------------ 2332
            ...|...|.:.:::...|.:.|.:.|.|   ..|..|:..| |...:|...|.
  Rat  2711 PPPQPQQTLQPKTQTGAGAKSRPKKREG---VHLPTTKELA-KRQRLPSVENRPKIAAFLPARQL 2771

  Fly  2333 WMWAGKAFQGAVFLNSDDPLVLRTCYPAMRHVEG-DIIRIRDC-VLLKANEDNELPYVAKVAHLW 2395
            |.|.||..|..........|.    |.|:  |.| ::|||.|| |.|.|...| |||:.::..:|
  Rat  2772 WKWFGKPTQRRGMKGKARKLF----YKAI--VRGKEMIRIGDCAVFLSAGRPN-LPYIGRIQSMW 2829

  Fly  2396 QNPEDGEMMMSLLWYYRPEHTDQGR------------------------QRNDCPDE-VYASRHR 2435
            :: ....|::.:.|:|.||.|..|:                        ||.|..:. :|.|.|.
  Rat  2830 ES-WGNNMVVRVKWFYHPEETSPGKQFHEGQHWDQKSGHNLPAALRASSQRKDFMERALYQSSHV 2893

  Fly  2436 DHNSVACVEDKCYVLTFSEYCRYRRRLRAAE-EDVEDV-----SIVPRRPSIATAPGFPV 2489
            |.|.|..|..||.|:...:   |.:.|:..: :|.|.:     :..|....|.:..|.||
  Rat  2894 DENDVQTVSHKCLVVGLEQ---YEQMLKTKKYQDSEGLYYLAGTYEPTTGMIFSTDGVPV 2950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hers	NP_001245771.1	BAH_BAHCC1	2366..2519	CDD:240065	43/157 (27%)
Tnrc18	XP_038945299.1	PHA03247	<383..641	CDD:223021	73/377 (19%)
		pneumo_PspA	<1089..>1165	CDD:411490	17/86 (20%)
		Tudor_SF	2204..2270	CDD:413384	9/66 (14%)
		PHA03307	2274..>2524	CDD:223039	47/265 (18%)
		BAH_BAHCC1	2800..2944	CDD:240065	39/148 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1886
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810