DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hers and Bahd1

DIOPT Version :9

Sequence 1:	NP_001245771.1	Gene:	Hers / 33000	FlyBaseID:	FBgn0052529	Length:	2529	Species:	Drosophila melanogaster
Sequence 2:	XP_006499328.1	Gene:	Bahd1 / 228536	MGIID:	2139371	Length:	781	Species:	Mus musculus

Alignment Length:	871	Identity:	231/871 - (26%)
Similarity:	329/871 - (37%)	Gaps:	235/871 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1715 CQMLVKTELKGENPQVTKMQYEAHVMPP--PTPPESYCASDE--------------------KLL 1757
            |::|: |.|  ||....:...||..:||  |.||....:|::                    .||
Mouse    79 CKVLL-TRL--ENVAGPRSADEADELPPDLPKPPSPTSSSEDAGLVQPRKRRLASLNAEALNNLL 140

  Fly  1758 DDQEQEAELELRLRLGLGLEKSHGGQQHIEAYDLTCSTPPPVTVPQAAAVPRKARIGKSMAREMV 1822
            .::|:.:.|       .|..:|.||..|......|.|.      ..:...||...:|:. :|::
Mouse   141 LEREETSSL-------AGARRSRGGDPHRSRDRATGSW------SFSKKRPRLGDLGEG-SRDL- 190

  Fly  1823 YAAQQQLLPEKQLKQ-----PKEAAA-------KLEAEPEMPFVLKAEIKAETKIKIEHDGEAQA 1875
               ..:|.|::..::     ||..|:       ||..|.|:|.       ..::.:.|.||.
Mouse   191 ---SPELAPDEGARRDGDPAPKRLASLNAAAFLKLSQERELPL-------RPSRAQAEADGR--- 242

  Fly  1876 STHISQLPDLKPTIKTEPEQELEQEAASVPSVA--KTEPQPEVEVEREQQEPPVDEEQQPT---P 1935
            ||.......|:|.:..:...:..|.|.|..:..  ..:.||.   ||....||.....||:   |
Mouse   243 STEPLAPRILRPKVNGKNCPKARQGAGSGEATGPPNWQEQPN---ERWPSAPPHGPPTQPSHQAP 304

  Fly  1936 GGSKQ---RFNLLALSSGNKKTKTNNSYKSLIKQAEPKSYLCPGRRFIRRHGRAPAKYVKRRQMI 1997
            |.:.:   |.||..|..|....|           .||..   ||.       .:||
Mouse   305 GKALENPLRPNLPLLMGGQAALK-----------PEPGR---PGE-------ESPA--------- 339

  Fly  1998 LTQRQQQRMRLQRREQQQQRRQQREAAAEVVAGAVVTP-SLAGNPIEQAGSEVSIVKDQAPNSSA 2061
                           .:|:..|....|.:      ::| .:.|||.:.:|
Mouse   340 ---------------PKQELHQPSFPAPQ------LSPLPMPGNPADYSG--------------- 368

  Fly  2062 TPSASPKRARPRKQEIAAL---HLLEGLDTTLSRGYFSDPELNHSSRKQAPTAV--GGLYAASSP 2121
             |...|        |:.||   :|..|.|......|...|.|...  |.:|.|.  .||..|.|.
Mouse   369 -PCGGP--------ELTALGSFYLYCGQDGLQCGAYSPCPMLPEG--KLSPVAAPNEGLLMAPSS 422

  Fly  2122 LTTATDHRGKQTTAEKRSKSETKKPPSGESSESGLPCKKPRKEPAGKVKGKGKKTTAGAAATTIA 2186
            :.:....:....:|.:...|| ....:|.|....||.....   .|        ||.|.....:.
Mouse   423 VPSGVPFQHPPWSAPRYCSSE-DTGANGYSICGVLPLSLTH---IG--------TTCGGCPYKMP 475

  Fly  2187 STAETQTEAVNAITASNQETNNNEYQTADL-----QAQKFRECPAVTDAKVAGTATSTSTASQQQ 2246
            .|||           ..:.....|:...:.     .|.....||..:....|.......|..
Mouse   476 FTAE-----------GCRSLGQLEFPLPEAGHPASPAHPLLGCPVPSVPPAAEPIPHLQTPI--- 526

  Fly  2247 NQQHSDEQHQFLVPSQPATASATAALAATPPP-SRQGQATHTKRTRSRCKFGNRKRQRHRPGGVS 2310
                          |:|.|.:.....:|.||. |:.|     .||.|.|:...|.:...||.
Mouse   527 --------------SEPQTVARACPQSAKPPSGSKSG-----LRTGSSCRHAVRSKAARRPS--- 569

  Fly  2311 YELDVTQPPATKANVVP-----KWNNGWMWAGKAFQGAVFLNSDDPLVLRTCYPAM-RHVEGDII 2369
               ...||.|.:..  |     :..|||:..|.|.:.||::..:....:|..|.|: ||  |:.|
Mouse   570 ---HPKQPRAQRPR--PRRRRRRRTNGWVPVGAACEKAVYVLDEPEPAIRKSYQAVERH--GETI 627

  Fly  2370 RIRDCVLLKAN-EDNELPYVAKVAHLWQNPEDGEMMMSLLWYYRPEHTDQGR---QRNDCPDEVY 2430
            |:||.||||:. .....|||||::.||:|||.||:||||||||||||...||   ......:||:
Mouse   628 RVRDTVLLKSGPRKTSTPYVAKISALWENPESGELMMSLLWYYRPEHLQGGRSPSMHEPLQNEVF 692

  Fly  2431 ASRHRDHNSVACVEDKCYVLTFSEYCRYRRRLRAAEEDV--EDVSIVPRRPSIATAPGFPVRTVP 2493
            ||||:|.|||||:|:|||||||:||||:....:...|.:  ...::||.....:|.|.   ||||
Mouse   693 ASRHQDQNSVACIEEKCYVLTFAEYCRFCAMAKRRGEGLPSRKTALVPPSADYSTPPH---RTVP 754

  Fly  2494 EHTNPELVMFCRRAYEFRTRRLLKLP 2519
            |.|:||||..||..|:||..|:||.|
Mouse   755 EDTDPELVFLCRHVYDFRHGRILKNP 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hers	NP_001245771.1	BAH_BAHCC1	2366..2519	CDD:240065	82/158 (52%)
Bahd1	XP_006499328.1	PHA03247	<158..378	CDD:223021	61/318 (19%)
		PHA03307	288..>572	CDD:223039	79/411 (19%)
		BAH_BAHCC1	624..734	CDD:240065	60/109 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I5716
eggNOG	1	0.900	-	-		E1_KOG1886
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005583
OrthoInspector	1	1.000	-	-		oto92638
orthoMCL	1	0.900	-	-		OOG6_107965
Panther	1	1.100	-	-	LDO	PTHR46576
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5045
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.890