DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pmp70 and abcd3a

DIOPT Version :9

Sequence 1:	NP_001259732.1	Gene:	Pmp70 / 32992	FlyBaseID:	FBgn0031069	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_998647.1	Gene:	abcd3a / 406803	ZFINID:	ZDB-GENE-040426-2868	Length:	656	Species:	Danio rerio

Alignment Length:	668	Identity:	378/668 - (56%)
Similarity:	490/668 - (73%)	Gaps:	15/668 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAPALSKLANNQSAIVGVAGMTAALWIIAYGKMS---NKKRKPGYEDKIQYTIAEKKDKKAGKAH 62
            ||.....|....||:.|  |:...|:|:...:.:   |:|:....|      :..:||.|..:|.
Zfish     1 MAAVSKYLTAKNSAVAG--GVLLVLYILKQRRRAAALNRKKGSANE------LNSEKDGKKERAA 57

  Fly    63 VNSVFFKQLRQLLPILIPGFWSVETGLLFLVAAALIGRSVSDIWMIQNATVVESTIIHMNRTKFK 127
            |:.:||.::.::|.|::|.|:|.||..|.|:|..|:.|:..|:|||||.|::||.||..:...||
Zfish    58 VDKLFFIRISRILKIMVPKFFSKETWYLLLIAVMLVTRTYCDVWMIQNGTMIESAIIGRSTKGFK 122

  Fly   128 TALLKYLTALPAISVVTNVLKWSLGELKLRFRTNLTHHLYSQYLNGYTYYKMSNLDNRIANADQL 192
            ..|..::||:|..::|.|.||..|.||||.||..||.|||.:||.|||||||.||||||||||||
Zfish   123 KYLFNFMTAMPISALVNNFLKLGLNELKLCFRVRLTKHLYDEYLKGYTYYKMGNLDNRIANADQL 187

  Fly   193 LTTDIDKFCESATDLYSNISKPVLDIFIYVYRLTVNLGGKTPSILMLYLLFAGVFLTRLRRPTGR 257
            ||.|:::||.|..|||||:|||:|||.:|:::||..:|.:.|:.:|.|||.:|:||||||||.|:
Zfish   188 LTQDVERFCNSVVDLYSNLSKPLLDIGLYIFKLTTAIGAQGPATMMAYLLISGLFLTRLRRPIGK 252

  Fly   258 LTVEEQKLEGEFRYVNSRLITNSEEVAFYQGNVREKLTLLASYSKLRSHLRKFLEFRVSMGIIDN 322
            :||.|||.|||:|||||||||||||:|||.||.|||.|:.:::.||..||..|:.||.|||::|:
Zfish   253 MTVTEQKYEGEYRYVNSRLITNSEEIAFYNGNTREKQTIHSTFKKLVDHLHNFIFFRFSMGMVDS 317

  Fly   323 IIGKYFASIVGFYAVSIPFFSENHPLLSGENSGQRLQAYYTYGRMLVKLAEAIGRLVLAGREMSR 387
            ||.||||::||:..||.||.:.:|......:..:.|:.||..||||:::::|:||:|||||||:|
Zfish   318 IIAKYFATVVGYLVVSRPFLNLSHSRHLNSSHAELLEDYYQSGRMLLRMSQALGRIVLAGREMTR 382

  Fly   388 LAGFTARMTELIKVLSDLNKGTYERTMVNGNNLAQNAVGSASSNFGPNKGIMCFEDNIIRFEKVP 452
            |:|||||:|||::||.:||.|.||||||:.:.  ::|  |......|..|.:...||||:|:..|
Zfish   383 LSGFTARITELMRVLKELNSGKYERTMVSQSE--KDA--SEKLTLVPGSGRIINIDNIIKFDHTP 443

  Fly   453 LVTPNGDVLLQELSFEVKSGTNVLVCGPNGCGKSSLFRILGELWPTWGGKVTKPSRGKLFYVPQR 517
            |.|||||||:::|.||||||||||||||||||||||||:||||||.:||.:|||.||||||||||
Zfish   444 LATPNGDVLIRDLCFEVKSGTNVLVCGPNGCGKSSLFRVLGELWPLFGGNLTKPERGKLFYVPQR 508

  Fly   518 PYMTLGTLRDQIIYPHTRDDMRRLGHSDEDLMHYLDIVQLTYLEQRENGLDSIEDWIDVLSGGEK 582
            ||||||:||||:|||.|.:..::.|.||..|..|||.|||.::..||...|:::||:||||||||
Zfish   509 PYMTLGSLRDQVIYPDTHESQKKKGISDLVLKEYLDNVQLGHILDREGSWDTVQDWMDVLSGGEK 573

  Fly   583 QRIAMARLFYHKPQFAILDECTSAVSVDVEGKMYSYCREVGITLFTVSHRKSLWAHHDYYLQFDG 647
            ||:|||||||||||||||||||||||||||..:||:||:|||||||||||||||.||:|||..||
Zfish   574 QRMAMARLFYHKPQFAILDECTSAVSVDVEDYIYSHCRKVGITLFTVSHRKSLWKHHEYYLHMDG 638

  Fly   648 RGSYEFATIDQDKDHFGS 665
            ||:|||..|..:...|||
Zfish   639 RGNYEFKPITPETVEFGS 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pmp70	NP_001259732.1	3a01203	3..653	CDD:273360	370/652 (57%)
		ABC_membrane_2	63..342	CDD:284003	157/278 (56%)
		ABCD_peroxisomal_ALDP	446..651	CDD:213190	151/204 (74%)
abcd3a	NP_998647.1	3a01203	1..644	CDD:273360	372/654 (57%)
		ABC_membrane_2	58..337	CDD:284003	157/278 (56%)
		ABCD_peroxisomal_ALDP	437..642	CDD:213190	151/204 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594201
Domainoid	1	1.000	329	1.000	Domainoid score	I1140
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2140
Inparanoid	1	1.050	758	1.000	Inparanoid score	I534
OMA	1	1.010	-	-		QHG53776
OrthoDB	1	1.010	-	-		D146647at33208
OrthoFinder	1	1.000	-	-		FOG0000393
OrthoInspector	1	1.000	-	-		otm26475
orthoMCL	1	0.900	-	-		OOG6_100236
Panther	1	1.100	-	-	LDO	PTHR11384
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X313
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910